Srinivas Nagaraj

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. pmc Reciprocal relationship between myeloid-derived suppressor cells and T cells
    Srinivas Nagaraj
    Department of Internal Medicine, University of South Florida, Tampa, FL 33612, USA
    J Immunol 191:17-23. 2013
  2. pmc Regulation of suppressive function of myeloid-derived suppressor cells by CD4+ T cells
    Srinivas Nagaraj
    Department of Internal Medicine, University of South Florida, Tampa, FL 33612, United States
    Semin Cancer Biol 22:282-8. 2012
  3. ncbi request reprint Antigen-specific CD4(+) T cells regulate function of myeloid-derived suppressor cells in cancer via retrograde MHC class II signaling
    Srinivas Nagaraj
    Department of Internal Medicine, University of South Florida, Tampa, Florida 33612, USA
    Cancer Res 72:928-38. 2012
  4. pmc Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer
    Srinivas Nagaraj
    H Lee Moffitt Cancer Center, University of South Florida, 12902 Magnolia Drive, Tampa, Florida 33647, USA
    Nat Med 13:828-35. 2007
  5. pmc Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein
    Pingyan Cheng
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    J Exp Med 205:2235-49. 2008
  6. pmc Lipid accumulation and dendritic cell dysfunction in cancer
    Donna L Herber
    Department of Immunology, H Lee Moffitt Cancer Center, Tampa, Florida, USA
    Nat Med 16:880-6. 2010
  7. pmc Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice
    Rupal Ramakrishnan
    H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Clin Invest 120:1111-24. 2010
  8. pmc Mechanism of T cell tolerance induced by myeloid-derived suppressor cells
    Srinivas Nagaraj
    Department of Immunology, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    J Immunol 184:3106-16. 2010
  9. pmc Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer
    Srinivas Nagaraj
    H Lee Moffitt Cancer Center, Tampa, Florida 33647, USA
    Clin Cancer Res 16:1812-23. 2010
  10. pmc Myeloid-derived suppressor cells as regulators of the immune system
    Dmitry I Gabrilovich
    Department of Oncologic Sciences, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
    Nat Rev Immunol 9:162-74. 2009

Collaborators

Detail Information

Publications19

  1. pmc Reciprocal relationship between myeloid-derived suppressor cells and T cells
    Srinivas Nagaraj
    Department of Internal Medicine, University of South Florida, Tampa, FL 33612, USA
    J Immunol 191:17-23. 2013
    ..In this review we discuss the nature of the complex relationship between MDSCs and the different populations of CD4(+) T cells. ..
  2. pmc Regulation of suppressive function of myeloid-derived suppressor cells by CD4+ T cells
    Srinivas Nagaraj
    Department of Internal Medicine, University of South Florida, Tampa, FL 33612, United States
    Semin Cancer Biol 22:282-8. 2012
    ..Myeloid derived suppressor cells play a critical role in T cell suppression in cancer. Here, we discuss the mechanisms of how MDSC suppress CD4(+) or CD8(+) T cells in an antigen dependent or non-dependent manner...
  3. ncbi request reprint Antigen-specific CD4(+) T cells regulate function of myeloid-derived suppressor cells in cancer via retrograde MHC class II signaling
    Srinivas Nagaraj
    Department of Internal Medicine, University of South Florida, Tampa, Florida 33612, USA
    Cancer Res 72:928-38. 2012
    ....
  4. pmc Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer
    Srinivas Nagaraj
    H Lee Moffitt Cancer Center, University of South Florida, 12902 Magnolia Drive, Tampa, Florida 33647, USA
    Nat Med 13:828-35. 2007
    ..These data identify a previously unknown mechanism of T-cell tolerance in cancer that is also pertinent to many pathological conditions associated with accumulation of MDSCs...
  5. pmc Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein
    Pingyan Cheng
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    J Exp Med 205:2235-49. 2008
    ..This study demonstrates that tumor-induced up-regulation of S100A9 protein is critically important for accumulation of MDSCs and reveals a novel molecular mechanism of immunological abnormalities in cancer...
  6. pmc Lipid accumulation and dendritic cell dysfunction in cancer
    Donna L Herber
    Department of Immunology, H Lee Moffitt Cancer Center, Tampa, Florida, USA
    Nat Med 16:880-6. 2010
    ..These findings suggest that immune responses in cancer can be improved by manipulating the lipid levels in DCs...
  7. pmc Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice
    Rupal Ramakrishnan
    H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Clin Invest 120:1111-24. 2010
    ..In addition, these results provide a strong rationale for combining these modalities for the treatment of patients with advanced cancers...
  8. pmc Mechanism of T cell tolerance induced by myeloid-derived suppressor cells
    Srinivas Nagaraj
    Department of Immunology, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    J Immunol 184:3106-16. 2010
    ..MDSCs caused dissociation between TCR and CD3zeta molecules, disrupting TCR complexes on T cells. Thus, these data describe a novel mechanism of Ag-specific CD8(+) T cell tolerance in cancer...
  9. pmc Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer
    Srinivas Nagaraj
    H Lee Moffitt Cancer Center, Tampa, Florida 33647, USA
    Clin Cancer Res 16:1812-23. 2010
    ..Myeloid-derived suppressor cells (MDSC) are one of the major factors responsible for immune suppression in cancer. Therefore, it would be important to identify effective therapeutic means to modulate these cells...
  10. pmc Myeloid-derived suppressor cells as regulators of the immune system
    Dmitry I Gabrilovich
    Department of Oncologic Sciences, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
    Nat Rev Immunol 9:162-74. 2009
    ..In this Review, we discuss the origin, mechanisms of expansion and suppressive functions of MDSCs, as well as the potential to target these cells for therapeutic benefit...
  11. pmc Subsets of myeloid-derived suppressor cells in tumor-bearing mice
    Je In Youn
    H Lee Moffitt Cancer Center and Research Institute and Department of Molecular Medicine, University of South Florida, Tampa, FL 33612, USA
    J Immunol 181:5791-802. 2008
    ..These data indicate that suppressive features of MDSC is caused not by expansion of a specific subset but more likely represent a functional state of these cells...
  12. ncbi request reprint Myeloid-derived suppressor cells
    Srinivas Nagaraj
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA
    Adv Exp Med Biol 601:213-23. 2007
    ..In recent years, it has become increasingly evident that MDSCs bring about antigen-specific T cell tolerance by various mechanisms, which is the focus of this chapter...
  13. ncbi request reprint Dendritic cell-based full-length survivin vaccine in treatment of experimental tumors
    Srinivas Nagaraj
    H Lee Moffitt Cancer Center and Department of Interdisciplinary Oncology, University of South Florida, Tampa, FL 33612, USA
    J Immunother 30:169-79. 2007
    ..Despite the fact that combination of 2 vaccines generated potent antigen specific T-cell responses against both molecules they did not result in the improvement of antitumor effect in any of the tested experimental tumor models...
  14. pmc Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway
    Yulia Nefedova
    Department of Interdisciplinary Oncology, University of South Florida, Tampa, FL 33612, USA
    Cancer Res 65:9525-35. 2005
    ..This indicates that pharmacologic inhibition of the JAK2/STAT3 pathway can be an important new therapeutic strategy to enhance antitumor activity of cancer immunotherapy...
  15. doi request reprint Tumor escape mechanism governed by myeloid-derived suppressor cells
    Srinivas Nagaraj
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612, USA
    Cancer Res 68:2561-3. 2008
    ..Elucidation of this mechanism of T-cell tolerance offers new opportunities for therapeutic corrections of immune escape in cancer...
  16. pmc Mechanism and therapeutic reversal of immune suppression in cancer
    Donna L Herber
    H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Cancer Res 67:5067-9. 2007
  17. doi request reprint Myeloid-derived suppressor cells in human cancer
    Srinivas Nagaraj
    Division of Translational Medicine, Department of Internal Medicine, University of South Florida, Tampa, FL, USA
    Cancer J 16:348-53. 2010
    ..Here, we give an overview of the myeloid-derived suppressor cells field focusing primarily on the studies in cancer patients and current and future therapeutic options targeting these cells...
  18. ncbi request reprint Dynamic change and impact of myeloid-derived suppressor cells in allogeneic bone marrow transplantation in mice
    Dapeng Wang
    Department of Immunology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Biol Blood Marrow Transplant 19:692-702. 2013
    ..These results indicate that MDSCs can regulate the immune response in acute GVHD, and possibly tumor relapse, subsequent to allogeneic BMT...
  19. pmc Tumor-associated CD8+ T cell tolerance induced by bone marrow-derived immature myeloid cells
    Sergei Kusmartsev
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    J Immunol 175:4583-92. 2005
    ..Thus, this is a first demonstration that in tumor-bearing mice CD8+ T cell tolerance is induced primarily by ImC that may have direct implications for cancer immunotherapy...