Jay A Nadel

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint IL-13-induced Clara cell secretory protein expression in airway epithelium: role of EGFR signaling pathway
    Suil Kim
    Cardiovascular Research Institute and Department of Medicine, University of California, San Francisco, California 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 283:L67-75. 2002
  2. ncbi request reprint Innate immune mucin production via epithelial cell surface signaling: relationship to allergic disease
    Jay A Nadel
    Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    Curr Opin Allergy Clin Immunol 7:57-62. 2007
  3. doi request reprint Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium
    Jonathan L Koff
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 294:L1068-75. 2008
  4. ncbi request reprint Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme
    Matt X G Shao
    Cardiovascular Research Institute and Departments of Medicine and Physiology, University of California San Francisco, San Francisco, California 94143, USA
    J Immunol 175:4009-16. 2005
  5. doi request reprint CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells
    Suil Kim
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    J Immunol 186:3392-400. 2011
  6. pmc Fibrinogen binding to ICAM-1 promotes EGFR-dependent mucin production in human airway epithelial cells
    Suil Kim
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 297:L174-83. 2009
  7. ncbi request reprint Regulation of interleukin-8 via an airway epithelial signaling cascade
    Takashi Nakanaga
    Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, California 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1289-96. 2007
  8. doi request reprint Epidermal growth factor receptor reactivation induced by E-prostanoid-3 receptor- and tumor necrosis factor-alpha-converting enzyme-dependent feedback exaggerates interleukin-8 production in airway cancer (NCI-H292) cells
    Suil Kim
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143 0130, USA
    Exp Cell Res 317:2650-60. 2011
  9. ncbi request reprint Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-alpha-converting enzyme in human airway epithelial (NCI-H292) cells
    Matt X G Shao
    Department of Medicine and Physiology, University of California San Francisco, San Francisco, CA 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 287:L420-7. 2004
  10. ncbi request reprint Pseudomonas lipopolysaccharide accelerates wound repair via activation of a novel epithelial cell signaling cascade
    Jonathan L Koff
    Cardiovascular Research Institute, Department of Medicine, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    J Immunol 177:8693-700. 2006

Collaborators

  • Suil Kim
  • Lewis L Lanier
  • Pierre Regis Burgel
  • Linda Martin
  • George D Leikauf
  • Michael T Borchers
  • Matt X G Shao
  • Iris F Ueki
  • Jonathan L Koff
  • Hitesh S Deshmukh
  • Takashi Nakanaga
  • Lisa M Case
  • Scott C Wesselkamper
  • Laetitia Finzi
  • Kazuhiro Kohri
  • Eric Ballon-Landa
  • Gundula Min-Oo
  • April Kalinowski
  • Maggie Dietsch
  • Colleen Shaver
  • Thomas R Korfhagen
  • Massimo Corradi
  • William D Hardie
  • Veronique Barbu
  • Chantal Housset
  • Elizabeth C Wick
  • François Paye
  • Jean Yves Scoazec
  • Kimberly S Kirkwood
  • Frederique Peschaud
  • Martine Mergey
  • Howard G Shertzer

Detail Information

Publications22

  1. ncbi request reprint IL-13-induced Clara cell secretory protein expression in airway epithelium: role of EGFR signaling pathway
    Suil Kim
    Cardiovascular Research Institute and Department of Medicine, University of California, San Francisco, California 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 283:L67-75. 2002
    ..These findings indicate that IL-13 induces CCSP expression via an EGFR- and leukocyte-dependent pathway...
  2. ncbi request reprint Innate immune mucin production via epithelial cell surface signaling: relationship to allergic disease
    Jay A Nadel
    Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    Curr Opin Allergy Clin Immunol 7:57-62. 2007
    ..Here the focus is the EGFR cascades leading to immune mucin responses. The review is timely because recent discoveries implicate these pathways in multiple innate immune defenses in addition to mucin production...
  3. doi request reprint Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium
    Jonathan L Koff
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 294:L1068-75. 2008
    ..These results show for the first time that multiple TLRs in airway epithelial cells produce innate immune responses by activating EGFR via an epithelial cell signaling cascade...
  4. ncbi request reprint Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme
    Matt X G Shao
    Cardiovascular Research Institute and Departments of Medicine and Physiology, University of California San Francisco, San Francisco, California 94143, USA
    J Immunol 175:4009-16. 2005
    ..We conclude that HNE induces MUC5AC mucin expression via a cascade involving PKC-ROS-TACE in human airway epithelial cells...
  5. doi request reprint CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells
    Suil Kim
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    J Immunol 186:3392-400. 2011
    ..These findings have potentially important therapeutic implications in obstructive airway diseases...
  6. pmc Fibrinogen binding to ICAM-1 promotes EGFR-dependent mucin production in human airway epithelial cells
    Suil Kim
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 297:L174-83. 2009
    ....
  7. ncbi request reprint Regulation of interleukin-8 via an airway epithelial signaling cascade
    Takashi Nakanaga
    Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, California 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1289-96. 2007
    ..This pathway, which also regulates mucin production in human airways, provides mechanisms for killing foreign organisms and for their clearance...
  8. doi request reprint Epidermal growth factor receptor reactivation induced by E-prostanoid-3 receptor- and tumor necrosis factor-alpha-converting enzyme-dependent feedback exaggerates interleukin-8 production in airway cancer (NCI-H292) cells
    Suil Kim
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143 0130, USA
    Exp Cell Res 317:2650-60. 2011
    ..Thus, we conclude that a positive feedback pathway involving COX-2/PGE2/EP3 receptor-dependent EGFR reactivation exaggerates IL-8 production in NCI-H292 cancer cells but not in NHBE (normal) cells...
  9. ncbi request reprint Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-alpha-converting enzyme in human airway epithelial (NCI-H292) cells
    Matt X G Shao
    Department of Medicine and Physiology, University of California San Francisco, San Francisco, CA 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 287:L420-7. 2004
    ..These results implicate TACE in smoking-induced mucin overproduction via the TACE-proligand-EGFR signal pathway in NCI-H292 cells...
  10. ncbi request reprint Pseudomonas lipopolysaccharide accelerates wound repair via activation of a novel epithelial cell signaling cascade
    Jonathan L Koff
    Cardiovascular Research Institute, Department of Medicine, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    J Immunol 177:8693-700. 2006
    ..Thus, LPS accelerates wound repair in airway epithelial cells via a novel TLR-4-->protein kinase C alphabeta-->dual oxidase 1-->reactive oxygen species-->TACE-->TGF-alpha-->EGFR phosphorylation pathway...
  11. pmc Respiratory virus-induced EGFR activation suppresses IRF1-dependent interferon λ and antiviral defense in airway epithelium
    Iris F Ueki
    Department of Medicine, 2 Cardiovascular Research Institute, 3 Department of Microbiology and Immunology, and 4 Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94122
    J Exp Med 210:1929-36. 2013
    ..These findings describe a novel mechanism that viruses use to suppress endogenous antiviral defenses, and provide potential targets for future therapies. ..
  12. ncbi request reprint Neutrophil elastase induces mucin production by ligand-dependent epidermal growth factor receptor activation
    Kazuhiro Kohri
    Cardiovascular Research Institute, University of California San Francisco, 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 283:L531-40. 2002
    ..From these results, we conclude that HNE-induced MUC5AC mucin production occurs via its proteolytic activation of an EGFR signaling cascade involving TGF-alpha...
  13. doi request reprint Twenty-five years of airway research: personal thoughts
    Jay A Nadel
    Cardiovascular Research Institute and Department of Medicine, University of California, San Francisco, 513 Parnassus Avenue, Room S1183, San Francisco, CA 94143 0130, USA
    Proc Am Thorac Soc 7:338-42. 2010
    ..I finish with accolades to those who seek to learn from a variety of sources, including artists; I am proud and grateful that I became an early convert from cardiology to pulmonology. It continues to be an exciting experience...
  14. ncbi request reprint Role of neutrophils in mucus hypersecretion in COPD and implications for therapy
    Suil Kim
    Cardiovascular Research Institute, Cancer Center, and Department of Medicine, University of California San Francisco, 94143 0130, USA
    Treat Respir Med 3:147-59. 2004
    ..Interventions that target EGFR, neutrophil elastase, and reactive oxygen species exist and can be evaluated as treatments for neutrophil-dependent mucus hypersecretion...
  15. ncbi request reprint E-cadherin promotes EGFR-mediated cell differentiation and MUC5AC mucin expression in cultured human airway epithelial cells
    Suil Kim
    Cardiovascular Research Institute, Box 0130, University of California San Francisco, San Francisco, CA 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 289:L1049-60. 2005
    ..Thus E-cadherin promotes EGFR-mediated cell differentiation and MUC5AC production, and our results suggest that this occurs via a pathway involving protein tyrosine phosphatase-dependent EGFR dephosphorylation...
  16. pmc Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells
    Matt X G Shao
    Cardiovascular Research Institute and Departments of Medicine and Physiology, University of California, San Francisco, CA 94143 0130, USA
    Proc Natl Acad Sci U S A 100:11618-23. 2003
    ..From these results, we conclude that TACE plays a critical role in mucin production by airway epithelial cells by means of a TACE ligand-EGFR cascade in response to various stimuli...
  17. pmc Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells
    Matt X G Shao
    Cardiovascular Research Institute and Department of Medicine, University of California, San Francisco, CA 94143 0130, USA
    Proc Natl Acad Sci U S A 102:767-72. 2005
    ..From these results, we conclude that Duox1 plays a critical role in mucin expression by airway epithelial cells through PKCdelta/PKC-Duox1-ROS-TACE-pro-ligand-EGF receptor cascade...
  18. ncbi request reprint fMLP causes degranulation followed by regranulation in rat nasal glands
    Seon Tae Kim
    Cardiovascular Research Institute and Department of Medicine, University of California, San Francisco 94143 0130, USA
    Laryngoscope 113:1998-2003. 2003
    ..To determine the mechanism of mucus production by nasal glands...
  19. pmc Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production
    Hitesh S Deshmukh
    Center for Environmental Genetics, University of Cincinnati, Cincinnati, USA
    Am J Respir Cell Mol Biol 38:446-54. 2008
    ..Augmentation of hMMP9 activity, in turn, could contribute to persistent excessive mucin production...
  20. pmc MUC5AC, a gel-forming mucin accumulating in gallstone disease, is overproduced via an epidermal growth factor receptor pathway in the human gallbladder
    Laetitia Finzi
    INSERM U680, Faculté de Médecine Pierre et Marie Curie Université Pierre et Marie Curie Paris 6, site Saint Antoine, 27 rue Chaligny, 75571 Paris Cedex 12, France
    Am J Pathol 169:2031-41. 2006
    ..The ability to interrupt this cascade is of potential interest in the prevention of cholesterol gallstones...
  21. pmc A morphometric study of mucins and small airway plugging in cystic fibrosis
    Pierre Regis Burgel
    Service de Pneumologie, Hopital Cochin, Universite Rene Descartes, 27 rue du Faubourg St Jacques, 75 679 Paris Cedex 14, France
    Thorax 62:153-61. 2007
    ..Little knowledge exists on structural changes and plugging in small airways in cystic fibrosis...
  22. ncbi request reprint Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation
    Hitesh S Deshmukh
    University of Cincinnati, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Am J Respir Crit Care Med 171:305-14. 2005
    ..In addition, a prolonged effect of acrolein may be mediated by altering MMP9 and TIMP3 transcription...