Andrea G Nackley

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. doi request reprint Assessing potential functionality of catechol-O-methyltransferase (COMT) polymorphisms associated with pain sensitivity and temporomandibular joint disorders
    Andrea G Nackley
    Center for Neurosensory Disorders, University of North Carolina, Chapel Hill, NC, USA
    Methods Mol Biol 617:375-93. 2010
  2. pmc Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors
    Andrea Gail Nackley
    Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7450, USA
    Pain 128:199-208. 2007
  3. ncbi request reprint Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli
    Luda Diatchenko
    Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, NC, USA
    Pain 125:216-24. 2006
  4. pmc Signaling pathways mediating beta3-adrenergic receptor-induced production of interleukin-6 in adipocytes
    Inna E Tchivileva
    The Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Immunol 46:2256-66. 2009
  5. pmc Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs
    Andrea G Nackley
    Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 4:e5237. 2009
  6. pmc Cytokine biomarkers and chronic pain: association of genes, transcription, and circulating proteins with temporomandibular disorders and widespread palpation tenderness
    Gary D Slade
    Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7450, USA
    Pain 152:2802-12. 2011
  7. pmc Excess risk of temporomandibular disorder associated with cigarette smoking in young adults
    Anne E Sanders
    Department of Dental Ecology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7450, USA
    J Pain 13:21-31. 2012
  8. pmc A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism
    Pavel Gris
    Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Pain 6:33. 2010
  9. pmc Characterization of NF-kB-mediated inhibition of catechol-O-methyltransferase
    Inna E Tchivileva
    Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7455, USA
    Mol Pain 5:13. 2009
  10. ncbi request reprint Genetic architecture of human pain perception
    Luda Diatchenko
    Center for Neurosensory Disorders, University of North Carolina, 2190 Old Dental Building, Chapel Hill, NC 27599, USA
    Trends Genet 23:605-13. 2007

Collaborators

Detail Information

Publications14

  1. doi request reprint Assessing potential functionality of catechol-O-methyltransferase (COMT) polymorphisms associated with pain sensitivity and temporomandibular joint disorders
    Andrea G Nackley
    Center for Neurosensory Disorders, University of North Carolina, Chapel Hill, NC, USA
    Methods Mol Biol 617:375-93. 2010
    ..The protocols applied to the study of these molecular genetic mechanisms are detailed herein...
  2. pmc Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors
    Andrea Gail Nackley
    Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7450, USA
    Pain 128:199-208. 2007
    ....
  3. ncbi request reprint Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli
    Luda Diatchenko
    Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, NC, USA
    Pain 125:216-24. 2006
    ..Here, we propose a mechanism whereby these two genetic polymorphisms differentially affect pain perception...
  4. pmc Signaling pathways mediating beta3-adrenergic receptor-induced production of interleukin-6 in adipocytes
    Inna E Tchivileva
    The Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Immunol 46:2256-66. 2009
    ....
  5. pmc Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs
    Andrea G Nackley
    Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 4:e5237. 2009
    ..Thus, both minor synonymous and nonsynonymous SNPs in the coding region are markers of functional APS and HPS haplotypes rather than independent contributors to COMT activity...
  6. pmc Cytokine biomarkers and chronic pain: association of genes, transcription, and circulating proteins with temporomandibular disorders and widespread palpation tenderness
    Gary D Slade
    Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7450, USA
    Pain 152:2802-12. 2011
    ..Furthermore, they identify MCP-1, IL-1ra, IL-8, and TGFβ1 as potential diagnostic markers and therapeutic targets for pain in patients with TMD...
  7. pmc Excess risk of temporomandibular disorder associated with cigarette smoking in young adults
    Anne E Sanders
    Department of Dental Ecology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7450, USA
    J Pain 13:21-31. 2012
    ..The main finding was reproduced with secondary analyses of 2 nationally representative surveys of adults conducted in the US and Australia...
  8. pmc A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism
    Pavel Gris
    Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Pain 6:33. 2010
    ..Several hypotheses have been advanced to explain these phenomena, yet the molecular mechanisms underlying tolerance and OIH remain poorly understood...
  9. pmc Characterization of NF-kB-mediated inhibition of catechol-O-methyltransferase
    Inna E Tchivileva
    Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7455, USA
    Mol Pain 5:13. 2009
    ..Specifically, low COMT activity is associated with heightened pain perception and development of musculoskeletal pain in humans as well as increased experimental pain sensitivity in rodents...
  10. ncbi request reprint Genetic architecture of human pain perception
    Luda Diatchenko
    Center for Neurosensory Disorders, University of North Carolina, 2190 Old Dental Building, Chapel Hill, NC 27599, USA
    Trends Genet 23:605-13. 2007
    ..We propose how both rare deleterious genetic variants and common genetic polymorphisms are mediators of human pain perception and clinical pain phenotypes...
  11. ncbi request reprint Idiopathic pain disorders--pathways of vulnerability
    Luda Diatchenko
    Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27514 7455, USA
    Pain 123:226-30. 2006
  12. ncbi request reprint Basal and carrageenan-induced pain behavior in Sprague-Dawley, Lewis and Fischer rats
    Karamarie Fecho
    Department of Anesthesiology, Division of Pain Medicine, School of Medicine, The University of North Carolina at Chapel Hill, CB 7010, 451 MacNider Hall, Chapel Hill, North Carolina 27599 7010, USA
    Physiol Behav 85:177-86. 2005
    ..The results further demonstrate that basal pain sensitivity can be predictive of inflammatory pain sensitivity, with the direction of the effect dependent upon the pain measure...
  13. ncbi request reprint Genetic basis for individual variations in pain perception and the development of a chronic pain condition
    Luda Diatchenko
    Comprehensive Center for Inflammatory Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Hum Mol Genet 14:135-43. 2005
    ..Thus, COMT activity substantially influences pain sensitivity, and the three major haplotypes determine COMT activity in humans that inversely correlates with pain sensitivity and the risk of developing TMD...
  14. ncbi request reprint Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms
    Kai Soo Tan
    The Comprehensive Center for Inflammatory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA
    Cell Signal 19:251-60. 2007
    ....