MICHAEL NACHMAN

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. pmc Recombination rate variation and speciation: theoretical predictions and empirical results from rabbits and mice
    Michael W Nachman
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Philos Trans R Soc Lond B Biol Sci 367:409-21. 2012
  2. pmc Ecological character displacement in the face of gene flow: evidence from two species of nightingales
    Radka Reifová
    Department of Zoology, Faculty of Science, Charles University, Prague, Czech Republic
    BMC Evol Biol 11:138. 2011
  3. ncbi request reprint The genetic basis of adaptation: lessons from concealing coloration in pocket mice
    Michael W Nachman
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Genetica 123:125-36. 2005
  4. ncbi request reprint Variation in recombination rate across the genome: evidence and implications
    Michael W Nachman
    Department of Ecology and Evolutionary Biology, Biosciences West Bldg, University of Arizona, Tucson, Arizona 85721, USA
    Curr Opin Genet Dev 12:657-63. 2002
  5. pmc Estimate of the mutation rate per nucleotide in humans
    M W Nachman
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 156:297-304. 2000
  6. pmc Contrasting evolutionary histories of two introns of the duchenne muscular dystrophy gene, Dmd, in humans
    M W Nachman
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 155:1855-64. 2000
  7. ncbi request reprint Y chromosome variation of mice and men
    M W Nachman
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson 85721, USA
    Mol Biol Evol 15:1744-50. 1998
  8. pmc DNA variability and recombination rates at X-linked loci in humans
    M W Nachman
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 150:1133-41. 1998
  9. pmc The genetic basis of adaptive melanism in pocket mice
    Michael W Nachman
    Department of Ecology and Evolutionary Biology, Biosciences West Building, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 100:5268-73. 2003
  10. ncbi request reprint Haldane and the first estimates of the human mutation rate
    Michael W Nachman
    Department of Ecology and Evolutionary Biology, P O Box 210088, Biosciences West Building, University of Arizona, Tucson, AZ 85721, USA
    J Genet 83:231-3. 2004

Research Grants

  1. Natural selection and DNA sequence variation in Mus
    MICHAEL NACHMAN; Fiscal Year: 2009
  2. Natural selection and DNA sequence variation in Mus
    Michael W Nachman; Fiscal Year: 2010

Detail Information

Publications46

  1. pmc Recombination rate variation and speciation: theoretical predictions and empirical results from rabbits and mice
    Michael W Nachman
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Philos Trans R Soc Lond B Biol Sci 367:409-21. 2012
    ..We suggest fruitful areas of research that might help distinguish between different models...
  2. pmc Ecological character displacement in the face of gene flow: evidence from two species of nightingales
    Radka Reifová
    Department of Zoology, Faculty of Science, Charles University, Prague, Czech Republic
    BMC Evol Biol 11:138. 2011
    ..Here we studied patterns of morphological variation in sympatric and allopatric populations of two hybridizing species of birds, the Common Nightingale (Luscinia megarhynchos) and the Thrush Nightingale (L. luscinia)...
  3. ncbi request reprint The genetic basis of adaptation: lessons from concealing coloration in pocket mice
    Michael W Nachman
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Genetica 123:125-36. 2005
    ....
  4. ncbi request reprint Variation in recombination rate across the genome: evidence and implications
    Michael W Nachman
    Department of Ecology and Evolutionary Biology, Biosciences West Bldg, University of Arizona, Tucson, Arizona 85721, USA
    Curr Opin Genet Dev 12:657-63. 2002
    ....
  5. pmc Estimate of the mutation rate per nucleotide in humans
    M W Nachman
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 156:297-304. 2000
    ..This high rate is difficult to reconcile with multiplicative fitness effects of individual mutations and suggests that synergistic epistasis among harmful mutations may be common...
  6. pmc Contrasting evolutionary histories of two introns of the duchenne muscular dystrophy gene, Dmd, in humans
    M W Nachman
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 155:1855-64. 2000
    ..These results are best explained by positive directional selection acting at or near intron 7 and demonstrate that even genes in regions of high recombination may be influenced by selection at linked sites...
  7. ncbi request reprint Y chromosome variation of mice and men
    M W Nachman
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson 85721, USA
    Mol Biol Evol 15:1744-50. 1998
    ..There is at most only a modest reduction in variability that may be attributed to natural selection (either genetic hitchhiking or background selection)...
  8. pmc DNA variability and recombination rates at X-linked loci in humans
    M W Nachman
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 150:1133-41. 1998
    ..However, there was a positive correlation between heterozygosity and rate of recombination, suggesting that the joint effects of selection and linkage are important in shaping patterns of nucleotide variation in humans...
  9. pmc The genetic basis of adaptive melanism in pocket mice
    Michael W Nachman
    Department of Ecology and Evolutionary Biology, Biosciences West Building, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 100:5268-73. 2003
    ..Interestingly, another melanic population of these mice on a different lava flow shows no association with Mc1r mutations, indicating that adaptive dark color has evolved independently in this species through changes at different genes...
  10. ncbi request reprint Haldane and the first estimates of the human mutation rate
    Michael W Nachman
    Department of Ecology and Evolutionary Biology, P O Box 210088, Biosciences West Building, University of Arizona, Tucson, AZ 85721, USA
    J Genet 83:231-3. 2004
  11. pmc Nucleotide variation at Msn and Alas2, two genes flanking the centromere of the X chromosome in humans
    Michael W Nachman
    Department of Ecology and Evolutionary Biology, Division of Biotechnology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 167:423-37. 2004
    ..These observations are difficult to reconcile with a simple demographic model but may be consistent with positive and/or purifying selection acting on loci within this large region of low recombination...
  12. ncbi request reprint Local adaptation in the rock pocket mouse (Chaetodipus intermedius): natural selection and phylogenetic history of populations
    H E Hoekstra
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Heredity (Edinb) 94:217-28. 2005
    ..Together, the results suggest that color variation can evolve very rapidly over small geographic scales and that gene flow can both hinder and promote local adaptation...
  13. doi request reprint Reduced introgression of the Y chromosome between subspecies of the European rabbit (Oryctolagus cuniculus) in the Iberian Peninsula
    A Geraldes
    CIBIO, Centro de Investigacao em Biodiversidade e Recursos Geneticos, Universidade do Porto, Campus Agrário de Vairão, 4485 661 Vairão, Portugal
    Mol Ecol 17:4489-99. 2008
    ..Taken together, these data indicate that there is a clear dichotomy in the rabbit genome and that some loci remain highly differentiated despite extensive gene flow following secondary contact...
  14. ncbi request reprint Single nucleotide polymorphisms and recombination rate in humans
    M W Nachman
    Dept of Ecology and Evolutionary Biology, University of Arizona, Tuscon 85721, USA
    Trends Genet 17:481-5. 2001
    ..Regional differences in the rate of recombination explain a substantial fraction of the variation in levels of nucleotide polymorphism, consistent with the widespread action of natural selection at the molecular level...
  15. pmc The frequency of multiple paternity suggests that sperm competition is common in house mice (Mus domesticus)
    M D Dean
    University of Arizona, Ecology and Evolution, 333 Biosciences West, Tucson, AZ 85721, USA
    Mol Ecol 15:4141-51. 2006
    ..This study suggests that sperm competition is an important aspect of postcopulatory sexual selection in house mice...
  16. pmc Microsatellite variation and recombination rate in the human genome
    B A Payseur
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 156:1285-98. 2000
    ..Together, these results indicate that background selection is not a major determinant of microsatellite variation in humans...
  17. ncbi request reprint The origin of a Robertsonian chromosomal translocation in house mice inferred from linked microsatellite markers
    C Riginos
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson 85721, USA
    Mol Biol Evol 16:1763-73. 1999
    ..15 metacentric chromosomes found in the three Rb populations. These results suggest that cytologically indistinguishable mutations have arisen independently in natural populations of house mice...
  18. pmc Deleterious mutations at the mitochondrial ND3 gene in South American marsh rats (Holochilus)
    P Kennedy
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 150:359-68. 1998
    ..In general, an excess of rare sites was observed, consistent with either a recent selective sweep or with populations not at mutation-drift equilibrium...
  19. ncbi request reprint Deleterious mutations in animal mitochondrial DNA
    M W Nachman
    Department of Ecology and Evolutionary Biology, Biosciences, University of Arizona, Tucson 85721, USA
    Genetica 102:61-9. 1998
    ..These observations are best explained by a substantial number of mildly deleterious amino acid mutations that contribute to heterozygosity but rarely become fixed...
  20. pmc Patterns of DNA variability at X-linked loci in Mus domesticus
    M W Nachman
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson 85721, USA
    Genetics 147:1303-16. 1997
    ....
  21. ncbi request reprint Different genes underlie adaptive melanism in different populations of rock pocket mice
    H E Hoekstra
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Mol Ecol 12:1185-94. 2003
    ..These results indicate that adaptive melanism has arisen at least twice in C. intermedius and that these similar phenotypic changes have a different genetic basis...
  22. ncbi request reprint Population subdivision in marine environments: the contributions of biogeography, geographical distance and discontinuous habitat to genetic differentiation in a blennioid fish, Axoclinus nigricaudus
    C Riginos
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson 85721, USA
    Mol Ecol 10:1439-53. 2001
    ..nigricaudus cannot be explained by a single factor, but are due to the combined influences of biogeography, geographical distance and availability of suitable habitat...
  23. pmc The molecular basis of high-altitude adaptation in deer mice
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, United States of America
    PLoS Genet 3:e45. 2007
    ....
  24. pmc Human adaptive evolution at Myostatin (GDF8), a regulator of muscle growth
    Matthew A Saunders
    Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA
    Am J Hum Genet 79:1089-97. 2006
    ..Both mutations are rare among non-Africans yet are at frequencies of up to 31% in sub-Saharan Africans. These signatures of selection at the molecular level suggest that human variation at GDF8 is associated with functional differences...
  25. pmc A complex genetic basis to X-linked hybrid male sterility between two species of house mice
    Jeffrey M Good
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 179:2213-28. 2008
    ..musculus X chromosome involved in hybrid male sterility. Only a handful of spermatogenic genes are within this region, including one of the most rapidly evolving genes on the mouse X chromosome...
  26. pmc Nucleotide variation in wild and inbred mice
    Tovah Salcedo
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 177:2277-91. 2007
    ..Together these results suggest that wild mice will be a valuable complement to laboratory strains for studying the genetics of complex traits...
  27. pmc The genetics of adaptive coat color in gophers: coding variation at Mc1r is not responsible for dorsal color differences
    Gabriela Wlasiuk
    The Department of Ecology and Evolutionary Biology, Biosciences West Building, The University of Arizona, Tucson, AZ 85721, USA
    J Hered 98:567-74. 2007
    ..bottae. These results demonstrate that similar phenotypic variation may have a different genetic basis among different mammalian species...
  28. pmc Linkage disequilibrium in wild mice
    Cathy C Laurie
    Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 3:e144. 2007
    ....
  29. pmc Asymmetry and polymorphism of hybrid male sterility during the early stages of speciation in house mice
    Jeffrey M Good
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Evolution 62:50-65. 2008
    ..These data build on previous studies of speciation in house mice and show that the genetic basis of hybrid male sterility is fairly complex, even at this early stage of divergence...
  30. pmc Genome-wide patterns of gene flow across a house mouse hybrid zone
    Katherine C Teeter
    Museum of Zoology, University of Michigan, Ann Arbor, Michigan 48109 1079, USA
    Genome Res 18:67-76. 2008
    ..These data highlight the complex genetic architecture underlying speciation even at early stages of divergence and point to some of the biological processes that may govern this architecture...
  31. pmc Adaptive evolution of proteins secreted during sperm maturation: an analysis of the mouse epididymal transcriptome
    Matthew D Dean
    Department of Ecology and Evolutionary Biology, University of Arizona, USA
    Mol Biol Evol 25:383-92. 2008
    ..Immunity and protein modification functions were significantly overrepresented among epididymis-specialized, secreted genes. These analyses identified a group of genes likely to be important in male reproductive success...
  32. pmc Contrasting patterns of introgression at X-linked loci across the hybrid zone between subspecies of the European rabbit (Oryctolagus cuniculus)
    Armando Geraldes
    CIBIO, Centro de Investigacao em Biodiversidade e Recursos Geneticos, Vairao, Spain
    Genetics 173:919-33. 2006
    ..These observations support a view of speciation where genomic incompatibilities at different loci in the genome create localized differences in levels of gene flow between nascent species...
  33. pmc The beta -globin recombinational hotspot reduces the effects of strong selection around HbC, a recently arisen mutation providing resistance to malaria
    Elizabeth T Wood
    Division of Biotechnology, University of Arizona, Tucson, AZ 85721, USA
    Am J Hum Genet 77:637-42. 2005
    ..The rapid decay in LD upstream of the HbC allele demonstrates the large effect the ss-globin hotspot has in mitigating the effects of positive selection on linked variation...
  34. ncbi request reprint Searching for evidence of positive selection in the human genome using patterns of microsatellite variability
    Bret A Payseur
    Department of Ecology and Evolutionary Biology, Biosciences West Building, University of Arizona, Tucson, Arizona 85721, USA
    Mol Biol Evol 19:1143-53. 2002
    ..These results also suggest that the effects of positive selection may be more pronounced on the X chromosome than on the autosomes in humans...
  35. ncbi request reprint Natural selection at linked sites in humans
    Bret A Payseur
    Department of Ecology and Evolutionary Biology, Biosciences West Building, University of Arizona, Tucson, AZ 85721, USA
    Gene 300:31-42. 2002
    ..These results contrast with those obtained for Drosophila, where the signals of positive selection are stronger...
  36. pmc Nucleotide variability at G6pd and the signature of malarial selection in humans
    Matthew A Saunders
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 162:1849-61. 2002
    ....
  37. ncbi request reprint Natural selection on protein polymorphism in the rodent genus Peromyscus: evidence from interlocus contrasts
    Jay F Storz
    Department of Ecology and Evolutionary Biology, University of Arizona, Biosciences West, Tucson, Arizona 85721, USA
    Evolution 57:2628-35. 2003
    ..Interestingly, the albumin locus was implicated as a candidate gene for local adaptation in four different species of Peromyscus. The results also demonstrate that selection can severely bias marker-based estimates of neutral parameters...
  38. ncbi request reprint Genome scans of DNA variability in humans reveal evidence for selective sweeps outside of Africa
    Jay F Storz
    Department of Ecology and Evolutionary Biology, Biosciences West, University of Arizona, AZ, USA
    Mol Biol Evol 21:1800-11. 2004
    ..A disproportionate number of these loci exhibited reduced levels of relative variability in non-African populations alone, suggesting that recent episodes of positive selection have been more prevalent outside of sub-Saharan Africa...
  39. ncbi request reprint Ecological genetics of adaptive color polymorphism in pocket mice: geographic variation in selected and neutral genes
    Hopi E Hoekstra
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Evolution 58:1329-41. 2004
    ..Together these results suggest that natural selection acts to match pocket mouse coat color to substrate color, despite high levels of gene flow between light and melanic populations...
  40. pmc Heterogeneous patterns of variation among multiple human x-linked Loci: the possible role of diversity-reducing selection in non-africans
    Michael F Hammer
    Genomic Analysis and Technology Core, Division of Biotechnology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 167:1841-53. 2004
    ....
  41. ncbi request reprint Adaptive reptile color variation and the evolution of the Mc1r gene
    Erica Bree Rosenblum
    Museum of Vertebrate Zoology, University of California, Berkeley, California 94720, USA
    Evolution 58:1794-808. 2004
    ..This study provides comparative data on a nuclear gene in reptiles and highlights the utility of a candidate-gene approach for understanding the evolution of genes involved in vertebrate adaptation...
  42. ncbi request reprint Differential patterns of introgression across the X chromosome in a hybrid zone between two species of house mice
    Bret A Payseur
    Department of Ecology and Evolutionary Biology, Biosciences West Building, University of Arizona, Tucson, Arizona 85721, USA
    Evolution 58:2064-78. 2004
    ..This study highlights the utility of natural populations of hybrids for mapping speciation genes and suggests that the middle of the X chromosome may be important for reproductive isolation between species of house mice...
  43. ncbi request reprint Rates of protein evolution are positively correlated with developmental timing of expression during mouse spermatogenesis
    Jeffrey M Good
    Department of Ecology and Evolutionary Biology, University of Arizona, USA
    Mol Biol Evol 22:1044-52. 2005
    ..Overall, these data suggest that the intensity of positive selection associated with the evolution of male gametes varies considerably across development and acts primarily on phenotypes that develop late in spermatogenesis...
  44. pmc Human population structure and its effects on sampling Y chromosome sequence variation
    Michael F Hammer
    Genomic Analysis and Technology Core, Division of Biotechnology, Biosciences West Building, University of Arizona, Tucson, AZ 85721, USA
    Genetics 164:1495-509. 2003
    ....
  45. pmc The extent of linkage disequilibrium caused by selection on G6PD in humans
    Matthew A Saunders
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 171:1219-29. 2005
    ..1 < s < 0.2). These results also show that selection can lead to nonrandom associations among SNPs over great physical and genetic distances, even in African populations...
  46. ncbi request reprint Gene density and human nucleotide polymorphism
    Bret A Payseur
    Mol Biol Evol 19:336-40. 2002

Research Grants5

  1. Natural selection and DNA sequence variation in Mus
    MICHAEL NACHMAN; Fiscal Year: 2009
    ..domesticus and M. musculus and will provide a clear picture of the relationship between variation among commonly used inbred strains and variation in natural populations. ..
  2. Natural selection and DNA sequence variation in Mus
    Michael W Nachman; Fiscal Year: 2010
    ..domesticus and M. musculus and will provide a clear picture of the relationship between variation among commonly used inbred strains and variation in natural populations. ..