Affiliation: University of Arizona
Nachman M. The genetic basis of adaptation: lessons from concealing coloration in pocket mice. Genetica. 2005;123:125-36 pubmed
Nachman M. Y chromosome variation of mice and men. Mol Biol Evol. 1998;15:1744-50 pubmed
..There is at most only a modest reduction in variability that may be attributed to natural selection (either genetic hitchhiking or background selection). ..
Nachman M, Crowell S. Contrasting evolutionary histories of two introns of the duchenne muscular dystrophy gene, Dmd, in humans. Genetics. 2000;155:1855-64 pubmed
..These results are best explained by positive directional selection acting at or near intron 7 and demonstrate that even genes in regions of high recombination may be influenced by selection at linked sites. ..
Nachman M, Hoekstra H, D Agostino S. The genetic basis of adaptive melanism in pocket mice. Proc Natl Acad Sci U S A. 2003;100:5268-73 pubmed
..Interestingly, another melanic population of these mice on a different lava flow shows no association with Mc1r mutations, indicating that adaptive dark color has evolved independently in this species through changes at different genes. ..
Nachman M, Payseur B. Recombination rate variation and speciation: theoretical predictions and empirical results from rabbits and mice. Philos Trans R Soc Lond B Biol Sci. 2012;367:409-21 pubmed publisher
..We suggest fruitful areas of research that might help distinguish between different models. ..
Nachman M, Bauer V, Crowell S, Aquadro C. DNA variability and recombination rates at X-linked loci in humans. Genetics. 1998;150:1133-41 pubmed
..However, there was a positive correlation between heterozygosity and rate of recombination, suggesting that the joint effects of selection and linkage are important in shaping patterns of nucleotide variation in humans. ..
Nachman M, D Agostino S, Tillquist C, Mobasher Z, Hammer M. Nucleotide variation at Msn and Alas2, two genes flanking the centromere of the X chromosome in humans. Genetics. 2004;167:423-37 pubmed
..These observations are difficult to reconcile with a simple demographic model but may be consistent with positive and/or purifying selection acting on loci within this large region of low recombination. ..