I Nachamkin

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. doi request reprint Anti-ganglioside antibody induction by swine (A/NJ/1976/H1N1) and other influenza vaccines: insights into vaccine-associated Guillain-Barré syndrome
    Irving Nachamkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    J Infect Dis 198:226-33. 2008
  2. ncbi request reprint Patterns of Guillain-Barre syndrome in children: results from a Mexican population
    I Nachamkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, 4th Floor Gates Building, Philadelphia, PA 19104 4283, USA
    Neurology 69:1665-71. 2007
  3. pmc Increasing fluoroquinolone resistance in Campylobacter jejuni, Pennsylvania, USA,1982-2001
    Irving Nachamkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Emerg Infect Dis 8:1501-3. 2002
  4. pmc Campylobacter jejuni from patients with Guillain-Barré syndrome preferentially expresses a GD(1a)-like epitope
    Irving Nachamkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    Infect Immun 70:5299-303. 2002
  5. ncbi request reprint Chronic effects of Campylobacter infection
    Irving Nachamkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 4th Floor Gates Building, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Microbes Infect 4:399-403. 2002
  6. ncbi request reprint Molecular population genetic analysis of Campylobacter jejuni HS:19 associated with Guillain-Barré syndrome and gastroenteritis
    I Nachamkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    J Infect Dis 184:221-6. 2001
  7. pmc Agilent 2100 bioanalyzer for restriction fragment length polymorphism analysis of the Campylobacter jejuni flagellin gene
    I Nachamkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    J Clin Microbiol 39:754-7. 2001
  8. pmc Utilization of tests for Lyme disease antibody at a university hospital
    I Nachamkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 4283, USA
    Clin Diagn Lab Immunol 3:287-9. 1996
  9. ncbi request reprint Ganglioside GM1 mimicry in Campylobacter strains from sporadic infections in the United States
    I Nachamkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    J Infect Dis 179:1183-9. 1999
  10. pmc Campylobacter species and Guillain-Barré syndrome
    I Nachamkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    Clin Microbiol Rev 11:555-67. 1998

Research Grants

  1. 13th International Campylobacter/Helicobacter workshop
    Irving Nachamkin; Fiscal Year: 2005
  2. 14th International CHRO Workshop
    Irving Nachamkin; Fiscal Year: 2007

Collaborators

Detail Information

Publications59

  1. doi request reprint Anti-ganglioside antibody induction by swine (A/NJ/1976/H1N1) and other influenza vaccines: insights into vaccine-associated Guillain-Barré syndrome
    Irving Nachamkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    J Infect Dis 198:226-33. 2008
    ....
  2. ncbi request reprint Patterns of Guillain-Barre syndrome in children: results from a Mexican population
    I Nachamkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, 4th Floor Gates Building, Philadelphia, PA 19104 4283, USA
    Neurology 69:1665-71. 2007
    ..Previous clinical studies suggested that AMAN also occurs in Mexican children. The purpose of this study was to describe the subtypes of GBS in children from Mexico City...
  3. pmc Increasing fluoroquinolone resistance in Campylobacter jejuni, Pennsylvania, USA,1982-2001
    Irving Nachamkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Emerg Infect Dis 8:1501-3. 2002
    ..jejuni were not observed from 1982 to 1992; however, resistance increased to 40.5% in 2001. Resistance to erythromycin remains at a low level (<5%)...
  4. pmc Campylobacter jejuni from patients with Guillain-Barré syndrome preferentially expresses a GD(1a)-like epitope
    Irving Nachamkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    Infect Immun 70:5299-303. 2002
    ..GD(1a)-like epitope expression may be an important virulence phenotype associated with the risk of developing GBS following campylobacter infection...
  5. ncbi request reprint Chronic effects of Campylobacter infection
    Irving Nachamkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 4th Floor Gates Building, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Microbes Infect 4:399-403. 2002
    ..While little is known about reactive arthritis following Campylobacter infection, our knowledge on the pathogenesis of Campylobacter-induced GBS is expanding rapidly and is summarized in this review...
  6. ncbi request reprint Molecular population genetic analysis of Campylobacter jejuni HS:19 associated with Guillain-Barré syndrome and gastroenteritis
    I Nachamkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    J Infect Dis 184:221-6. 2001
    ..The results of this study show that HS:19 strains comprise a clonal, although not monomorphic, population, which is distinct from non-HS:19 strains within C. jejuni. A unique clone associated with GBS was not identified by use of MLEE...
  7. pmc Agilent 2100 bioanalyzer for restriction fragment length polymorphism analysis of the Campylobacter jejuni flagellin gene
    I Nachamkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    J Clin Microbiol 39:754-7. 2001
    ..Overall, the bioanalyzer has the potential to replace conventional RFLP analysis by gel electrophoresis, but improvements in the chip separation are needed...
  8. pmc Utilization of tests for Lyme disease antibody at a university hospital
    I Nachamkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 4283, USA
    Clin Diagn Lab Immunol 3:287-9. 1996
    ..Inappropriate testing of patients without indications of Lyme disease is frequently performed, and the ordering practices of physicians should be reassessed...
  9. ncbi request reprint Ganglioside GM1 mimicry in Campylobacter strains from sporadic infections in the United States
    I Nachamkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    J Infect Dis 179:1183-9. 1999
    ....
  10. pmc Campylobacter species and Guillain-Barré syndrome
    I Nachamkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    Clin Microbiol Rev 11:555-67. 1998
    ..The purpose of this review is to summarize our current knowledge about the clinical, epidemiological, pathogenetic, and laboratory aspects of campylobacter-associated GBS...
  11. pmc Prevalence of CTX-M beta-lactamases in Philadelphia, Pennsylvania
    Shannon E McGettigan
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
    J Clin Microbiol 47:2970-4. 2009
    ..A new panprimer set increases the ability to detect CTX-M-producing strains. CTX-M-positive bacteria are common in our geographic region, are often invasive, and, with the exception of P. mirabilis, are multiclonal...
  12. ncbi request reprint Chloramphenicol resistance in vancomycin-resistant enterococcal bacteremia: impact of prior fluoroquinolone use?
    Carolyn V Gould
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Infect Control Hosp Epidemiol 25:138-45. 2004
    ..The prevalence of vancomycin-resistant enterococci (VRE) has increased markedly during the past decade. Few data exist regarding the epidemiology of resistance of VRE to chloramphenicol, one of the few therapeutic options...
  13. doi request reprint Fluoroquinolone resistance in pediatric bloodstream infections because of Escherichia coli and Klebsiella species
    Jason Y Kim
    Division of Infectious Diseases, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Am J Infect Control 36:70-3. 2008
    ..28-83.8). A case control study revealed no significant risk factors (including prior antibiotic use) for FQ resistance among ESBL E coli and Klebsiella species (ESBL-EK)...
  14. pmc Use of BBL CHROMagar MRSA medium for identification of methicillin-resistant Staphylococcus aureus directly from blood cultures
    John Pape
    Clinical Microbiology Laboratory, Hospital of the University of Pennsylvania, School of Medicine, 4th Floor, Gates Building, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
    J Clin Microbiol 44:2575-6. 2006
    ..BBL CHROMagar MRSA medium was highly sensitive (97.6% [121/124] at 18 to 24 h of incubation and 100% [124/124] at 48 h) and 99.9% specific for identifying MRSA from positive blood cultures...
  15. ncbi request reprint Risk factors for and outcomes of bloodstream infection caused by extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species in children
    Theoklis E Zaoutis
    Division of Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatrics 115:942-9. 2005
    ..The objective of this study was to define the risk factors and outcomes associated with ESBL-EK bloodstream infections in children...
  16. ncbi request reprint Campylobacter jejuni cst-II polymorphisms and association with development of Guillain-Barré syndrome
    John B Hye
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Neurology 68:1633-4. 2007
  17. ncbi request reprint Identification of optimal combinations for empirical dual antimicrobial therapy of Pseudomonas aeruginosa infection: potential role of a Combination Antibiogram
    Mari Mizuta
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Infect Control Hosp Epidemiol 27:413-5. 2006
    ..Drug combinations with the broadest coverage were consistently composed of an aminoglycoside and a beta-lactam...
  18. ncbi request reprint Common and variable domains of the flagellin gene, flaA, in Campylobacter jejuni
    S H Fischer
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104 4283
    Mol Microbiol 5:1151-8. 1991
    ..Several areas within the V1 region correspond to predicted surface-exposed regions and may represent areas in which surface epitopes are located...
  19. pmc The impact of household transmission on duration of outpatient colonization with methicillin-resistant Staphylococcus aureus
    E Lautenbach
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Epidemiol Infect 138:683-5. 2010
    ..There was a borderline significant association between having a concurrent colonized household member and a longer duration of colonization (mean 44 days vs. 26 days, P=0.08)...
  20. ncbi request reprint Phenotypic and genotypic characterization of fecal Escherichia coli isolates with decreased susceptibility to fluoroquinolones: results from a large hospital-based surveillance initiative
    Ebbing Lautenbach
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    J Infect Dis 194:79-85. 2006
    ..The prevalence of fecal colonization with Escherichia coli that has reduced susceptibility to fluoroquinolones is unknown. A detailed characterization of such isolates is limited...
  21. ncbi request reprint Fluoroquinolone-resistant Pseudomonas aeruginosa: assessment of risk factors and clinical impact
    Leanne B Gasink
    Division of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia, Penn 19104 6021, USA
    Am J Med 119:526.e19-25. 2006
    ..Pseudomonas aeruginosa infections have been associated with considerable morbidity and mortality. Fluoroquinolones (FQ) are the only oral therapy available for P. aeruginosa infections, but resistance is increasingly prevalent...
  22. ncbi request reprint Imipenem resistance among pseudomonas aeruginosa isolates: risk factors for infection and impact of resistance on clinical and economic outcomes
    Ebbing Lautenbach
    Division of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104 6021, USA
    Infect Control Hosp Epidemiol 27:893-900. 2006
    ..To identify risk factors for infection with imipenem-resistant Pseudomonas aeruginosa and determine the impact of imipenem resistance on clinical and economic outcomes among patients infected with P. aeruginosa...
  23. pmc Clinical and economic outcomes of decreased fluconazole susceptibility in patients with Candida glabrata bloodstream infections
    Ingi Lee
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Am J Infect Control 38:740-5. 2010
    ..The impact of reduced fluconazole susceptibility on clinical and economic outcomes in patients with Candida glabrata bloodstream infections (BSI) is unknown...
  24. pmc Duration of outpatient fecal colonization due to Escherichia coli Isolates with decreased susceptibility to fluoroquinolones: longitudinal study of patients recently discharged from the hospital
    Ebbing Lautenbach
    University of Pennsylvania School of Medicine, Center for Clinical Epidemiology and Biostatistics, 825 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Antimicrob Agents Chemother 50:3939-43. 2006
    ..07) but was not associated with other resistance mechanisms, demographics, or antibiotic use...
  25. ncbi request reprint Evaluation of mannitol salt agar, CHROMagar Staph aureus and CHROMagar MRSA for detection of meticillin-resistant Staphylococcus aureus from nasal swab specimens
    Zhuolin Han
    Department of Hospital Epidemiology and Infection Control, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Med Microbiol 56:43-6. 2007
    ..7 versus 87.2 %) and at 48 h (94.9 versus 94.9 %). When combined with Staphaurex slide confirmation testing, both CSA and CSA-MRSA were highly specific (100 %) media for detecting MRSA from nasal swab specimens...
  26. doi request reprint In situ hybridization for Coccidioides immitis 5.8S ribosomal RNA sequences in formalin-fixed, paraffin-embedded pulmonary specimens using a locked nucleic acid probe: a rapid means for identification in tissue sections
    Kathleen T Montone
    Department of Pathology and Laboratory Medicine, Division of Thoracic Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Diagn Mol Pathol 19:99-104. 2010
    ..ISH with an LNA oligonucleotide probe targeting Coccidioides sp. ribosomal RNA is useful for rapid ISH. ISH could be rapidly performed when fungal pathogens are observed in tissue but cultures are negative or have not been performed...
  27. doi request reprint Risk factors for fluconazole resistance in patients with Candida glabrata bloodstream infection: potential impact of control group selection on characterizing the association between previous fluconazole use and fluconazole resistance
    Ingi Lee
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Infect Control 38:456-60. 2010
    ..Although Candida glabrata is an emerging infection, risk factors for fluconazole resistance in patients with C glabrata bloodstram infection (BSI) have not been well elucidated...
  28. pmc The prevalence of fluoroquinolone resistance mechanisms in colonizing Escherichia coli isolates recovered from hospitalized patients
    Ebbing Lautenbach
    Divisions of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Clin Infect Dis 51:280-5. 2010
    ..Fluoroquinolones are the most commonly prescribed antimicrobials. The epidemiology of fecal colonization with Escherichia coli demonstrating reduced susceptibility to fluoroquinolones remains unclear...
  29. ncbi request reprint Risk factors for and impact of infection or colonization with aztreonam-resistant Pseudomonas aeruginosa
    Leanne B Gasink
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Infect Control Hosp Epidemiol 28:1175-80. 2007
    ..To identify risk factors for infection or colonization with aztreonam-resistant Pseudomonas aeruginosa and examine the impact of this organism on mortality...
  30. pmc Risk factors for fluconazole-resistant Candida glabrata bloodstream infections
    Ingi Lee
    MSCE, Division of Infectious Diseases, Department of Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Arch Intern Med 169:379-83. 2009
    ..Candida glabrata is often associated with resistance to fluconazole therapy. However, to our knowledge, risk factors for fluconazole-resistant C glabrata BSIs have not been studied...
  31. pmc Gastrointestinal tract colonization with fluoroquinolone-resistant Escherichia coli in hospitalized patients: changes over time in risk factors for resistance
    Ebbing Lautenbach
    Division of Infectious Diseases, Department of Medicine, the Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Infect Control Hosp Epidemiol 30:18-24. 2009
    ..The objective of this study was to identify the prevalence of and risk factors for FQREC colonization among hospitalized patients...
  32. ncbi request reprint Analysis and presentation of cumulative antimicrobial susceptibility data (antibiograms): substantial variability across medical centers in the United States
    Ebbing Lautenbach
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Infect Control Hosp Epidemiol 27:409-12. 2006
    ....
  33. ncbi request reprint Changes in the prevalence of vancomycin-resistant enterococci in response to antimicrobial formulary interventions: impact of progressive restrictions on use of vancomycin and third-generation cephalosporins
    Ebbing Lautenbach
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Clin Infect Dis 36:440-6. 2003
    ..The association between clindamycin use and the prevalence of VRE suggests that restriction of this and perhaps other antianaerobic agents might be an important component of future antimicrobial interventions...
  34. ncbi request reprint Self-collected versus provider-collected vaginal swabs for the diagnosis of bacterial vaginosis: an assessment of validity and reliability
    Deborah B Nelson
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 921 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    J Clin Epidemiol 56:862-6. 2003
    ..These study results support the use of self-collected vaginal swabs for diagnosing BV and document the reliability of BV assessment among pregnant women...
  35. ncbi request reprint Longitudinal trends in fluoroquinolone resistance among Enterobacteriaceae isolates from inpatients and outpatients, 1989-2000: differences in the emergence and epidemiology of resistance across organisms
    Ebbing Lautenbach
    Division of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Clin Infect Dis 38:655-62. 2004
    ..Efforts to elucidate the epidemiology of FQ resistance and identify targets for intervention must recognize and account for the variability of FQ resistance across organisms and clinical settings...
  36. ncbi request reprint Emergence of resistance to chloramphenicol among vancomycin-resistant enterococcal (VRE) bloodstream isolates
    Ebbing Lautenbach
    Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 825 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Int J Antimicrob Agents 23:200-3. 2004
    ..The correlation between both chloramphenicol use and quinolone use and the prevalence of CR-VRE suggests that efforts to preserve the utility of chloramphenicol in VRE infections may depend on optimizing the use of these agents...
  37. ncbi request reprint Clinicians required very high sensitivity of a bacteremia prediction rule
    Ebbing Lautenbach
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Epidemiol 57:1104-6. 2004
    ..However, no such models have been accepted into general clinical use. The goal of this study was to determine physicians' criteria for acceptability of a bacteremia clinical prediction rule...
  38. pmc Test characteristics of perirectal and rectal swab compared to stool sample for detection of fluoroquinolone-resistant Escherichia coli in the gastrointestinal tract
    Ebbing Lautenbach
    Division of Infectious Diseases, Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Antimicrob Agents Chemother 49:798-800. 2005
    ..For rectal swab, the sensitivity was 90% (95% CI, 68 to 99%) and the specificity was 100% (95% CI, 91 to 100%)...
  39. pmc Surveillance cultures for detection of methicillin-resistant Staphylococcus aureus: diagnostic yield of anatomic sites and comparison of provider- and patient-collected samples
    Ebbing Lautenbach
    Division of Infectious Diseases of the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Infect Control Hosp Epidemiol 30:380-2. 2009
    ..Groin and perineum samples yielded positive results significantly more often for community-onset MRSA than for hospital-onset MRSA. Agreement rates between provider- and patient-collected swab specimens were excellent...
  40. ncbi request reprint Risk factors for increasing multidrug resistance among extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species
    Emily P Hyle
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Clin Infect Dis 40:1317-24. 2005
    ..Increased reliance on carbapenems has led to increasing carbapenem resistance. Efforts to maintain current therapeutic options for ESBL-EK infections are essential...
  41. ncbi request reprint Reemergence of gram-negative health care-associated bloodstream infections
    Svenja J Albrecht
    Division of Infectious Diseases, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Arch Intern Med 166:1289-94. 2006
    ..Whereas gram-negative organisms were the leading cause before the 1970s, gram-positive organisms have been the predominant microbial isolates since then...
  42. pmc Sequence-based identification of Mycobacterium species using the MicroSeq 500 16S rDNA bacterial identification system
    J B Patel
    Department of Pathology, The University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Clin Microbiol 38:246-51. 2000
    ..The MicroSeq identification system is an accurate and rapid method for the identification of Mycobacterium spp...
  43. ncbi request reprint Differential distribution of HLA-DQ beta/DR beta epitopes in the two forms of Guillain-Barré syndrome, acute motor axonal neuropathy and acute inflammatory demyelinating polyneuropathy (AIDP): identification of DQ beta epitopes associated with susceptibil
    Eleni E Magira
    Department of Pediatrics, University of Pennsylvania School of Medicine and Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Immunol 170:3074-80. 2003
    ....
  44. ncbi request reprint Impact of inadequate initial antimicrobial therapy on mortality in infections due to extended-spectrum beta-lactamase-producing enterobacteriaceae: variability by site of infection
    Emily P Hyle
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Arch Intern Med 165:1375-80. 2005
    ..Infections due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species (ESBL-EK) have increased markedly in recent years. Risk factors for mortality among ESBL-EK infections have not been studied...
  45. ncbi request reprint Characteristics and pregnancy outcomes of pregnant women asymptomatic for bacterial vaginosis
    Deborah B Nelson
    Department of Public Health College of Health Professions, Temple University, 1700 North Broad Street, Room 304F, Philadelphia, PA 19122, USA
    Matern Child Health J 12:216-22. 2008
    ..For this study, 1916 pregnant women who were 12 weeks' gestation or less were enrolled. Interviewers facilitated vaginal swab collection for BV assessment, and completed the baseline questionnaire. BV was identified by Gram stain...
  46. pmc Bacteremia caused by a novel isolate resembling leptotrichia species in a neutropenic patient
    J B Patel
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Clin Microbiol 37:2064-7. 1999
    ..However, it is more fastidious than previously reported isolates of Leptotrichia and may represent a novel species...
  47. ncbi request reprint Performance of two rapid, single-use immunoassays for the detection of Clostridium difficile toxin A
    J B Patel
    Clinical Microbiology Laboratory, Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Diagn Microbiol Infect Dis 39:21-4. 2001
    ..difficile-associated disease...
  48. ncbi request reprint Growth inhibition of Trichophyton species by Pseudomonas aeruginosa
    James Treat
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Arch Dermatol 143:61-4. 2007
    ..To assess the ability of Pseudomonas aeruginosa to inhibit the growth of Trichophyton mentagrophytes (TM) and Trichophyton rubrum (TR)...
  49. ncbi request reprint Limiting the emergence of extended-spectrum Beta-lactamase-producing enterobacteriaceae: influence of patient population characteristics on the response to antimicrobial formulary interventions
    Adam D Lipworth
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104 6021, USA
    Infect Control Hosp Epidemiol 27:279-86. 2006
    ..Variations in the patient populations at different hospitals may influence the effect of antimicrobial formulary interventions...
  50. pmc First trimester bacterial vaginosis, individual microorganism levels, and risk of second trimester pregnancy loss among urban women
    Deborah B Nelson
    Department of Public Health and Obstetrics Gynecology, Temple University, Philadelphia, PA 19122, USA
    Fertil Steril 88:1396-403. 2007
    ..To examine the role of first trimester bacterial vaginosis (BV) and level of BV-associated microorganisms, diagnosed using the Nugent gram stain criteria and the risk of second trimester pregnancy loss among urban women...
  51. ncbi request reprint Comparison of unit-specific and hospital-wide antibiograms: potential implications for selection of empirical antimicrobial therapy
    Shawn Binkley
    Division of Infectious Diseases, Department of Pharmacy, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Infect Control Hosp Epidemiol 27:682-7. 2006
    ..To identify differences between unit-specific and hospital-wide antibiograms and to determine the potential impact of these differences on selection of empirical antimicrobial therapy...
  52. doi request reprint 2008 ACLPS panel discussion on resident education in clinical pathology
    Eline T Luning Prak
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Clin Pathol 131:618-22. 2009
    ..Recommendations of the panel include the incorporation of active learning, clinical consultation, and competency assessment into CP resident training. A summary of the panel discussion is presented herein...
  53. ncbi request reprint Disseminated Mycoplasma orale infection in a patient with common variable immunodeficiency syndrome
    Michelle Paessler
    Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Diagn Microbiol Infect Dis 44:201-4. 2002
    ..This case demonstrates the importance of molecular technology in the diagnosis of difficult infectious disease problems...
  54. ncbi request reprint Asaia bogorensis peritonitis identified by 16S ribosomal RNA sequence analysis in a patient receiving peritoneal dialysis
    Richard W Snyder
    Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19131, USA
    Am J Kidney Dis 44:e15-7. 2004
    ..This organism was identified by sequence analysis of the 16S ribosomal RNA gene. Unusual microbial agents may cause peritonitis, and molecular microbiological techniques are important tools for identifying these agents...
  55. ncbi request reprint Legionella maceachernii pneumonia in a patient with HIV infection
    Kimberly Dumoff
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Diagn Microbiol Infect Dis 50:141-5. 2004
    ..Infection with L. maceachernii was attributable to the deaths of all cases. Issues related to the clinical aspects, laboratory identification of this unusual species, and detection of Legionnaires' diseases are discussed...
  56. ncbi request reprint Molecular mimicry in Campylobacter jejuni: role of the lipo-oligosaccharide core oligosaccharide in inducing anti-ganglioside antibodies
    Viraj N Perera
    Department of Biotechnology and Environmental Biology, RMIT University, Bundoora, Victoria, Australia
    FEMS Immunol Med Microbiol 50:27-36. 2007
    ..The waaF mutant also showed reduced adherence to and invasion of INT-407 cells. The results indicate that the LOS of C. jejuni HB93-13 is essential for adherence and invasion as well as for anti-ganglioside antibody induction...
  57. ncbi request reprint Central nervous system infections due to Abiotrophia and Granulicatella species: an emerging challenge?
    Elizabeth Cerceo
    University of Medicine and Dentistry of New Jersey, Newark, NJ 07107 3000, USA
    Diagn Microbiol Infect Dis 48:161-5. 2004
    ..Given the significant negative clinical impact of Abiotrophia/Granulicatella infections, elucidation of the emerging epidemiology of CNS infections with these bacteria is warranted...
  58. pmc Comparison of Campylobacter jejuni isolates implicated in Guillain-Barré syndrome and strains that cause enteritis by a DNA microarray
    Edward E Leonard
    Department of Microbiology and Immunology, Stanford University, Stanford, California 94305, USA
    Infect Immun 72:1199-203. 2004
    ..We found that specific GBS genes or regions were not identified, and microarray analysis confirmed significant genomic heterogeneity among the isolates...
  59. ncbi request reprint Rabbit model of Guillain-Barré syndrome
    Irving Nachamkin
    Ann Neurol 52:127-8; author reply 128-9. 2002

Research Grants2

  1. 13th International Campylobacter/Helicobacter workshop
    Irving Nachamkin; Fiscal Year: 2005
    ..abstract_text> ..
  2. 14th International CHRO Workshop
    Irving Nachamkin; Fiscal Year: 2007
    ..abstract_text> ..