D G Myszka

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi Energetics of the HIV gp120-CD4 binding reaction
    D G Myszka
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 97:9026-31. 2000
  2. ncbi BIACORE J: a new platform for routine biomolecular interaction analysis
    R L Rich
    Center for Biomolecular Interaction Analysis, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
    J Mol Recognit 14:223-8. 2001
  3. ncbi Equilibrium analysis of high affinity interactions using BIACORE
    D G Myszka
    Huntsman Cancer Institute, University of Utah, 15 N 2030 E, Room 2100, Salt Lake City, Utah, 84112 5330, USA
    Anal Biochem 265:326-30. 1998
  4. ncbi Improving biosensor analysis
    D G Myszka
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84132, USA
    J Mol Recognit 12:279-84. 1999
  5. ncbi Survey of the 1998 optical biosensor literature
    D G Myszka
    University of Utah, Salt Lake City, UT 84132, USA
    J Mol Recognit 12:390-408. 1999
  6. ncbi Advances in surface plasmon resonance biosensor analysis
    R L Rich
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84132, USA
    Curr Opin Biotechnol 11:54-61. 2000
  7. ncbi Two of the five zinc fingers in the Zap1 transcription factor DNA binding domain dominate site-specific DNA binding
    M V Evans-Galea
    Department of Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Biochemistry 42:1053-61. 2003
  8. ncbi Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding
    J E Garrus
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Cell 107:55-65. 2001
  9. ncbi Survey of the year 2000 commercial optical biosensor literature
    R L Rich
    Center for Biomolecular Interaction Analysis, University of Utah, Salt Lake City, UT 84132, USA
    J Mol Recognit 14:273-94. 2001
  10. ncbi The ABRF-MIRG'02 study: assembly state, thermodynamic, and kinetic analysis of an enzyme/inhibitor interaction
    D G Myszka
    University of Utah, Salt Lake City, Utah 84132, USA
    J Biomol Tech 14:247-69. 2003

Collaborators

  • R L Rich
  • O Byron
  • P D Kwong
  • F Schwarz
  • D J Eide
  • Zhongjion Xie
  • J C Reed
  • Yu Min Huang
  • H Wu
  • M V Evans-Galea
  • C L Baird
  • J E Garrus
  • P S Katsamba
  • G Xu
  • I A Laird-Offringa
  • S Park
  • Y C Park
  • W I Sundquist
  • J K Stuart
  • S Yoo
  • A J Bird
  • E Blankman
  • D R Winge
  • D A Wettstein
  • H E Wang
  • O W Pornillos
  • M Cote
  • M Cirilli
  • K M Stray
  • K H Zavitz
  • U K von Schwedler
  • S G Morham
  • H Ye
  • H C Liou
  • C Hsia
  • D Segal
  • M Yu
  • S J Littler
  • L Joss
  • R S Mitchell
  • S M McDonald
  • K R Ely
  • S Takayama
  • C Yeh
  • C P Hill
  • M McMurray
  • C G Brouillette
  • I M Chaiken
  • S W Tendian
  • R W Sweet
  • W A Hendrickson

Detail Information

Publications21

  1. ncbi Energetics of the HIV gp120-CD4 binding reaction
    D G Myszka
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 97:9026-31. 2000
    ..These results indicate considerable conformational flexibility within gp120, which may relate to viral mechanisms for triggering infection and disguising conserved receptor-binding sites from the immune system...
  2. ncbi BIACORE J: a new platform for routine biomolecular interaction analysis
    R L Rich
    Center for Biomolecular Interaction Analysis, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
    J Mol Recognit 14:223-8. 2001
    ..The BIACORE J is easy to operate and useful in diverse applications, making SPR technology widely accessible as a research tool...
  3. ncbi Equilibrium analysis of high affinity interactions using BIACORE
    D G Myszka
    Huntsman Cancer Institute, University of Utah, 15 N 2030 E, Room 2100, Salt Lake City, Utah, 84112 5330, USA
    Anal Biochem 265:326-30. 1998
    ..This method of analysis is a simple and convenient way of directly measuring equilibrium dissociation constants for very high affinity interactions...
  4. ncbi Improving biosensor analysis
    D G Myszka
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84132, USA
    J Mol Recognit 12:279-84. 1999
    ..It is possible to globally fit high-quality biosensor data with simple bimolecular reaction models, which validates the technology as a biophysical tool for interaction analysis...
  5. ncbi Survey of the 1998 optical biosensor literature
    D G Myszka
    University of Utah, Salt Lake City, UT 84132, USA
    J Mol Recognit 12:390-408. 1999
    ..This review provides suggestions on how to collect, analyze and report biosensor data...
  6. ncbi Advances in surface plasmon resonance biosensor analysis
    R L Rich
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84132, USA
    Curr Opin Biotechnol 11:54-61. 2000
    ..SPR biosensors are poised to make a significant impact in basic research and pharmaceutical discovery...
  7. ncbi Two of the five zinc fingers in the Zap1 transcription factor DNA binding domain dominate site-specific DNA binding
    M V Evans-Galea
    Department of Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Biochemistry 42:1053-61. 2003
    ....
  8. ncbi Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding
    J E Garrus
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Cell 107:55-65. 2001
    ..These observations suggest that retroviruses bud by appropriating cellular machinery normally used in the Vps pathway to form multivesicular bodies...
  9. ncbi Survey of the year 2000 commercial optical biosensor literature
    R L Rich
    Center for Biomolecular Interaction Analysis, University of Utah, Salt Lake City, UT 84132, USA
    J Mol Recognit 14:273-94. 2001
    ..In addition, the experimental design and data processing steps necessary to achieve high-quality biosensor data are described and examples of well-performed kinetic analysis are provided...
  10. ncbi The ABRF-MIRG'02 study: assembly state, thermodynamic, and kinetic analysis of an enzyme/inhibitor interaction
    D G Myszka
    University of Utah, Salt Lake City, Utah 84132, USA
    J Biomol Tech 14:247-69. 2003
    ..The results from this study provide a benchmark for comparing the capabilities of individual laboratories and for defining the utility of the different instrumentation...
  11. ncbi Kinetic analysis of a protein antigen-antibody interaction limited by mass transport on an optical biosensor
    D G Myszka
    Department of Molecular Immunology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA
    Biophys Chem 64:127-37. 1997
    ....
  12. ncbi High-resolution and high-throughput protocols for measuring drug/human serum albumin interactions using BIACORE
    R L Rich
    Center for Biomolecular Interaction Analysis, University of Utah, 50 North Medical Drive, Room 4A417, Salt Lake City, Utah 84132, USA
    Anal Biochem 296:197-207. 2001
    ..The ability to examine directly the binding of small molecules (130-800 Da), coupled with minimal sample requirements and automated instrumentation, makes BIACORE technology applicable for evaluating drug/HSA interactions...
  13. ncbi Molecular recognition in the HIV-1 capsid/cyclophilin A complex
    S Yoo
    Department of Biochemistry, University of Utah, Salt Lake City 84132, USA
    J Mol Biol 269:780-95. 1997
    ..These studies reveal that the active site of CypA, which can catalyze the isomerization of proline residues in vitro, also functions as a sequence-specific, protein-binding motif in HIV-1 replication...
  14. ncbi Current and emerging commercial optical biosensors
    C L Baird
    Center for Biomolecular Interaction Analysis, University of Utah, Salt Lake City, UT 84132, USA
    J Mol Recognit 14:261-8. 2001
    ..We provide a preview of some of the emerging commercial systems that are dedicated to drug discovery, proteomics, clinical diagnostics and routine biomolecular interaction analysis...
  15. ncbi Characterization of interactions between the anti-apoptotic protein BAG-1 and Hsc70 molecular chaperones
    J K Stuart
    Burnham Institute, Cancer Research Center, La Jolla, California 92037, USA
    J Biol Chem 273:22506-14. 1998
    ..Molecular modeling permitted a comparison of structural features between the functionally homologous BAG-1 and GrpE proteins. These data were used to propose a mechanism for BAG-1 in the regulation of Hsp70/Hsc70 chaperone activity...
  16. ncbi Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding
    H Wu
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 93:15030-5. 1996
    ..Together, the structural and kinetic data confirm that F43V is a critical residue in gp120 recognition site, which may also include main chain interactions at residue Gly-47...
  17. ncbi Two functionally distinct steps mediate high affinity binding of U1A protein to U1 hairpin II RNA
    P S Katsamba
    Norris Cancer Center/Keck School of Medicine, University of Southern California, Los Angeles, California 90089-9176, USA
    J Biol Chem 276:21476-81. 2001
    ..Our observations explain the extraordinary affinity of U1A for its target and may suggest a general mechanism for high affinity RNA/protein interactions...
  18. ncbi Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex
    G Xu
    Department of Biochemistry, Weill Medical College of Cornell University, New York, New York, 10021 USA
    Nature 410:494-7. 2001
    ..We demonstrate a new molecular mechanism of caspase inhibition, as well as protease inhibition in general...
  19. ncbi A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction
    Y C Park
    Department of Biochemistry, Weill Medical College and Graduate School of Medical Sciences of Cornell University, New York, New York 10021, USA
    Cell 101:777-87. 2000
    ..The stronger affinity and unique specificity of the TRADD-TRAF2 interaction are crucial for the suppression of apoptosis and provide a mechanistic basis for the perturbation of TRAF recruitment in sensitizing cell death induction...
  20. ncbi HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA
    S Park
    Norris Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles 90089 9176, USA
    Mol Cell Biol 20:4765-72. 2000
    ....
  21. ncbi Identification by photoaffinity labeling of fatty acid-binding protein as a potential warfarin receptor in rat liver
    D G Myszka
    Department of Biochemistry, Ohio State University, Columbus 43210
    J Biol Chem 266:20725-31. 1991
    ....