Sua Myong

Summary

Affiliation: University of Illinois
Country: USA

Publications

  1. ncbi request reprint Real-time observation of RecA filament dynamics with single monomer resolution
    Chirlmin Joo
    Howard Hughes Medical Institute and Department of Physics, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Cell 126:515-27. 2006
  2. pmc Spring-loaded mechanism of DNA unwinding by hepatitis C virus NS3 helicase
    Sua Myong
    Physics Department, University of Illinois, 1110 West Green Street, Urbana, IL 61801, USA
    Science 317:513-6. 2007
  3. pmc Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA
    Sua Myong
    Institute for Genomic Biology, University of Illinois at Urbana Champaign, 1206 West Gregory Drive, Champaign, IL 61801, USA
    Science 323:1070-4. 2009
  4. pmc Single-molecule nanopositioning: structural transitions of a helicase-DNA complex during ATP hydrolysis
    Hamza Balci
    Physics Department, University of Illinois, Urbana, Illinois, USA
    Biophys J 101:976-84. 2011
  5. pmc Single molecule nanocontainers made porous using a bacterial toxin
    Burak Okumus
    Center for Biophysics and Computational Biology, University of Illinois, Urbana, Illinois 61801, USA
    J Am Chem Soc 131:14844-9. 2009
  6. ncbi request reprint Repetitive shuttling of a motor protein on DNA
    Sua Myong
    Physics Department, University of Illinois, Urbana Champaign, Urbana, Illinois 61801, USA
    Nature 437:1321-5. 2005
  7. pmc PcrA helicase dismantles RecA filaments by reeling in DNA in uniform steps
    Jeehae Park
    Center for Biophysics and Computational Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Cell 142:544-55. 2010
  8. pmc Srs2 prevents Rad51 filament formation by repetitive motion on DNA
    Yupeng Qiu
    Department of Bioengineering, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Nat Commun 4:2281. 2013
  9. ncbi request reprint Bridging conformational dynamics and function using single-molecule spectroscopy
    Sua Myong
    Department of Physics, University of Illinois, Urbana Champaign, Urbana, Illinois 61801, USA
    Structure 14:633-43. 2006
  10. pmc Substrate recognition and specificity of double-stranded RNA binding proteins
    Lela Vuković
    Department of Physics, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, United States
    Biochemistry 53:3457-66. 2014

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Real-time observation of RecA filament dynamics with single monomer resolution
    Chirlmin Joo
    Howard Hughes Medical Institute and Department of Physics, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Cell 126:515-27. 2006
    ..This supports the proposal for a passive role of RecA-loading machineries in SSB removal...
  2. pmc Spring-loaded mechanism of DNA unwinding by hepatitis C virus NS3 helicase
    Sua Myong
    Physics Department, University of Illinois, 1110 West Green Street, Urbana, IL 61801, USA
    Science 317:513-6. 2007
    ..Such repetitive unwinding behavior over a short stretch of duplex may help to keep secondary structures resolved during viral genome replication...
  3. pmc Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA
    Sua Myong
    Institute for Genomic Biology, University of Illinois at Urbana Champaign, 1206 West Gregory Drive, Champaign, IL 61801, USA
    Science 323:1070-4. 2009
    ..This functional integration of two RNA molecular patterns may provide a means to specifically sense and counteract replicating viruses...
  4. pmc Single-molecule nanopositioning: structural transitions of a helicase-DNA complex during ATP hydrolysis
    Hamza Balci
    Physics Department, University of Illinois, Urbana, Illinois, USA
    Biophys J 101:976-84. 2011
    ..We discuss the possible implications of this newly observed conformation...
  5. pmc Single molecule nanocontainers made porous using a bacterial toxin
    Burak Okumus
    Center for Biophysics and Computational Biology, University of Illinois, Urbana, Illinois 61801, USA
    J Am Chem Soc 131:14844-9. 2009
    ..Moreover, engineered mutants of the utilized toxin can potentially be exploited in the future applications...
  6. ncbi request reprint Repetitive shuttling of a motor protein on DNA
    Sua Myong
    Physics Department, University of Illinois, Urbana Champaign, Urbana, Illinois 61801, USA
    Nature 437:1321-5. 2005
    ..Thus, the binding of a single Rep monomer to a stalled replication fork can lead to repetitive shuttling along the single-stranded region, possibly keeping the DNA clear of toxic recombination intermediates...
  7. pmc PcrA helicase dismantles RecA filaments by reeling in DNA in uniform steps
    Jeehae Park
    Center for Biophysics and Computational Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Cell 142:544-55. 2010
    ....
  8. pmc Srs2 prevents Rad51 filament formation by repetitive motion on DNA
    Yupeng Qiu
    Department of Bioengineering, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Nat Commun 4:2281. 2013
    ..Srs2's DNA-unwinding activity is greatly suppressed when Rad51 filaments form on duplex DNA. Taken together, our results reveal an exquisite and highly specific mechanism by which Srs2 regulates the Rad51 filament formation. ..
  9. ncbi request reprint Bridging conformational dynamics and function using single-molecule spectroscopy
    Sua Myong
    Department of Physics, University of Illinois, Urbana Champaign, Urbana, Illinois 61801, USA
    Structure 14:633-43. 2006
    ....
  10. pmc Substrate recognition and specificity of double-stranded RNA binding proteins
    Lela Vuković
    Department of Physics, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, United States
    Biochemistry 53:3457-66. 2014
    ..Our study reveals the structural and molecular basis of protein-RNA interaction that gives rise to the observed substrate specificity of dsRNA binding proteins. ..
  11. ncbi request reprint DNA-binding orientation and domain conformation of the E. coli rep helicase monomer bound to a partial duplex junction: single-molecule studies of fluorescently labeled enzymes
    Ivan Rasnik
    Department of Physics, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Mol Biol 336:395-408. 2004
    ..Therefore, the closed form of Rep bound to a partial duplex DNA appears to be an inhibited form of the enzyme...
  12. pmc ATP-independent diffusion of double-stranded RNA binding proteins
    Hye Ran Koh
    Department of Physics, University of Illinois, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 110:151-6. 2013
    ..These results implicate the dsRNA-specific diffusion activity of TRBP that contributes to enhancing siRNA and miRNA processing by Dicer...
  13. pmc Protein induced fluorescence enhancement as a single molecule assay with short distance sensitivity
    Helen Hwang
    Bioengineering Department, University of Illinois, Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 108:7414-8. 2011
    ..The high spatio-temporal resolution data and sensitivity to short distances combined with the ability to bypass protein labeling makes this assay an effective alternative or a complement to FRET...
  14. pmc Telomeric overhang length determines structural dynamics and accessibility to telomerase and ALT-associated proteins
    Helen Hwang
    Bioengineering Department, University of Illinois, 1304 West Springfield Avenue, Urbana, IL 61801, USA Medical Scholars Program, University of Illinois, 506 South Matthews Avenue, Urbana, IL 61801, USA
    Structure 22:842-53. 2014
    ..Our results suggest that the telomeric overhang length and dynamics may contribute to the regulation of telomere extension via telomerase action and the ALT mechanism. ..
  15. ncbi request reprint POT1-TPP1 regulates telomeric overhang structural dynamics
    Helen Hwang
    Bioengineering Department, University of Illinois, Urbana, IL 61801, USA
    Structure 20:1872-80. 2012
    ..The sliding motion is specific to POT1-TPP1, as POT1 and ssDNA binding protein gp32 cannot recapitulate this activity. Our results reveal fundamental molecular steps and dynamics involved in telomere structure regulation...
  16. pmc Stepwise translocation of nucleic acid motors
    Sua Myong
    Department of Bioengineering, University of Illinois at Urbana Champaign, IL, USA
    Curr Opin Struct Biol 20:121-7. 2010
    ..Spontaneous dynamics displayed by ribosome ratcheting and SSB (single stranded DNA binding protein) diffusing on DNA were rectified by interacting cofactors and proteins, EF-G and RecA, respectively...
  17. ncbi request reprint Repetitive RNA unwinding by RNA helicase A facilitates RNA annealing
    Hye Ran Koh
    Department of Physics, University of Illinois, Urbana, IL 61801, USA Institute for Genomic Biology, University of Illinois, Urbana, IL 61801, USA
    Nucleic Acids Res 42:8556-64. 2014
    ..The complex and unusual mechanism displayed by RHA may help in explaining how the repetitive unwinding of helicases contributes to their biological functions. ..
  18. ncbi request reprint Protein induced fluorescence enhancement (PIFE) for probing protein-nucleic acid interactions
    Helen Hwang
    Bioengineering Department, University of Illinois at Urbana Champaign, USA
    Chem Soc Rev 43:1221-9. 2014
    ..Unlike FRET where two dyes are required, PIFE employs a single dye attached to DNA or RNA to which an unlabeled protein is applied. We discuss both ensemble and single molecule studies in which PIFE was utilized. ..
  19. pmc Unraveling helicase mechanisms one molecule at a time
    Ivan Rasnik
    Department of Physics, Emory University, Atlanta, GA 30322, USA
    Nucleic Acids Res 34:4225-31. 2006
    ..Unexpected phenomena have also been observed from individual molecules suggesting extended or alternative functionality of helicases in vivo...