Research Topics
Genomes and Genes
| Martin G MyersSummaryAffiliation: University of Michigan Country: USA Publications
Research Grants
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Detail Information
Publications
STAT3 signalling is required for leptin regulation of energy balance but not reproductionSarah H Bates
Research Division, Joslin Diabetes Center, Harvard Medical School, 1 Joslin Place, Boston, Massachusetts 02215, USA
Nature 421:856-9. 2003..LRb-STAT3 signalling thus mediates the effects of leptin on melanocortin production and body energy homeostasis, whereas distinct LRb signals regulate NPY and the control of fertility, growth and glucose homeostasis...
How Is the Hungry Brain like a Sieve?Martin G Myers
Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, 6317 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105, USA Electronic address
Cell Metab 17:467-8. 2013..New findings reveal that fasting promotes "leakiness" of some hypothalamic blood vessels, increasing the access of circulating factors to certain hypothalamic neurons that control feeding (Langlet et al., 2013)...- Central nervous system control of metabolismMartin G Myers
Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48105, USA
Nature 491:357-63. 2012..The brain's contributions to metabolic control are more readily revealed and play a crucial part in catabolic states or in hormone deficiencies that mimic starvation... 
Challenges and opportunities of defining clinical leptin resistanceMartin G Myers
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA
Cell Metab 15:150-6. 2012..Further advances require biomarkers that can be used to identify patients who may benefit from leptin therapy and that are useful for understanding the determinants of clinical leptin responsiveness...- Obesity and leptin resistance: distinguishing cause from effectMartin G Myers
Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Trends Endocrinol Metab 21:643-51. 2010..We suggest a framework for approaching these issues and important avenues for future investigation... - Molecular mapping of the neural pathways linking leptin to the neuroendocrine reproductive axisGwendolyn W Louis
Division of Metabolism, Endocrinology and Diabetes, Department of Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA
Endocrinology 152:2302-10. 2011..Taken together, these findings suggest that leptin communicates with the neuroendocrine reproductive axis via multiple populations of LepRb neurons that lie afferent to both Kiss1 and GnRH neurons... - Mechanisms of leptin action and leptin resistanceMartin G Myers
Division of Metabolism, Endocrinology and Diabetes, Department of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Annu Rev Physiol 70:537-56. 2008..Other mechanisms that govern feeding behavior and food reward may also underlie the inception of obesity... - The geometry of leptin action in the brain: more complicated than a simple ARCMartin G Myers
Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Cell Metab 9:117-23. 2009.... - Outstanding Scientific Achievement Award Lecture 2010: deconstructing leptin: from signals to circuitsMartin G Myers
Department of Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan, USA
Diabetes 59:2708-14. 2010..In 1998, Dr. Myers received the American Diabetes Association's Career Development Award for his scientific abilities. Dr. Myers' current support includes the National Institute of Diabetes and Digestive and Kidney Diseases MERIT Award... - Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional statusEneida C Villanueva
Division of Metabolism, Department of Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
Endocrinology 150:4541-51. 2009..The regulation of mTORC1 in the basomedial hypothalamus thus varies by cell and stimulus type, as opposed to responding in a uniform manner to nutritional and hormonal perturbations... - Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balanceGina M Leinninger
Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Cell Metab 14:313-23. 2011..Thus, LHA LepRb(Nts) neurons mediate physiologic leptin action on OX neurons and the mesolimbic DA system, and contribute importantly to the control of energy balance... - Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdalaRebecca L Leshan
Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 30:5713-23. 2010..Thus, LepRb VTA neurons represent a subclass of VTA DA neurons that specifically innervates and controls the extCeA; we hypothesize that these neurons primarily modulate CeA-directed behaviors... - Insufficiency of Janus kinase 2-autonomous leptin receptor signals for most physiologic leptin actionsScott Robertson
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA
Diabetes 59:782-90. 2010..We therefore determined the potential role in leptin action for signals that are activated by Jak2 independently of LepRb phosphorylation (Jak2-autonomous signals)... - Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neuronsGwendolyn W Louis
Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, and Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 30:11278-87. 2010..These findings thus reveal a major role for LHA leptin action in the modulation of OX neurons, suggesting the importance of LHA LepRb neurons in the regulation of OX signaling that is crucial to leptin action and metabolic control... - Hyperphagia and obesity in female mice lacking tissue inhibitor of metalloproteinase-1Isabelle Gerin
Department of Molecular and Integrative Physiology, Ann Arbor, Michigan 48109 0622, USA
Endocrinology 150:1697-704. 2009.... - Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleusRebecca L Leshan
Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 29:3138-47. 2009..These results are consistent with a role for LepRb PMv neurons in regulating the reproductive axis in response to metabolic and odorant stimuli... - The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanismsYusong Gong
Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
J Biol Chem 282:31019-27. 2007..Dissecting the contributions of these individual pathways to leptin action will be important for our ultimate understanding of the processes that regulate energy balance in vivo... - Mice lacking inhibitory leptin receptor signals are lean with normal endocrine functionMarie Björnholm
Departments of Internal Medicine and Molecular and Integrative Physiology, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
J Clin Invest 117:1354-60. 2007..Thus, leptin activates autoinhibitory signals via LRb Tyr985 to attenuate the anti-adiposity effects of leptin, especially in females, potentially contributing to leptin insensitivity in obesity... - Leptin receptor signaling and action in the central nervous systemRebecca L Leshan
Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Obesity (Silver Spring) 14:208S-212S. 2006..Understanding the regulation and physiological function of these myriad sites of central leptin action will be a crucial next step in the quest to understand mechanisms of leptin action and energy balance... - Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balanceRebecca L Leshan
Department of Internal Medicine, University of Michigan, Ann Arbor, USA
Nat Med 18:820-3. 2012..Thus, hypothalamic LepRb(NOS1) neurons are a key site of action of the leptin-mediated control of systemic energy balance... - Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signalingHeike Munzberg
Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 27:69-74. 2007.... - Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activityLawrence S Argetsinger
Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, Michigan 48109 5622, USA
Mol Endocrinol 24:1062-76. 2010..g. phosphorylation, binding to a ligand-bound cytokine receptor, and/or binding to Src-homology 2B1, may be essential for JAK2 to assume a maximally active conformation... - Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feedingGina M Leinninger
Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Cell Metab 10:89-98. 2009..Thus, these findings reveal that LHA LepRb neurons link anorexic leptin action to the mesolimbic DA system... - Molecular and anatomical determinants of central leptin resistanceHeike Munzberg
Division of Metabolism, Endocrinology and Diabetes, Department of Medicine, University of Michigan Medical School, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109, USA
Nat Neurosci 8:566-70. 2005..We highlight data regarding the expression of SOCS3 (a potential mediator of leptin resistance) in the arcuate nucleus of the hypothalamus... - Ablation of leptin receptor-mediated ERK activation impairs host defense against Gram-negative pneumoniaPeter Mancuso
Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA
J Immunol 189:867-75. 2012..These results demonstrate that leptin receptor-mediated ERK activation plays an essential role in host defense against bacterial pneumonia and in leukocyte antibacterial effector functions... - Leptin promotes dopamine transporter and tyrosine hydroxylase activity in the nucleus accumbens of Sprague-Dawley ratsMaura L Perry
Chemistry Department, University of Michigan, Ann Arbor, MI 48109, USA
J Neurochem 114:666-74. 2010..Thus, leptin modulates the mesolimbic DA system via multiple acute mechanisms, and increases AMPH-mediated DA efflux in normal animals... - Leptin receptor-induced STAT3-independent signaling pathways are protective against atherosclerosis in a murine model of obesity and hyperlipidemiaWei Luo
University of Michigan, Department of Internal Medicine, Ann Arbor, MI, USA
Atherosclerosis 214:81-5. 2011..The primary aim of this study was to determine the effects of leptin receptor signaling pathways on atherosclerosis in the setting of obesity and hyperlipidemia... - Modulation of the mesolimbic dopamine system by leptinDarren M Opland
Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Brain Res 1350:65-70. 2010.... - Testosterone interacts with the feedback mechanisms engaged by Tyr985 of the leptin receptor and diet-induced obesityJoshua A Johnson
School of Kinesiology, University of Michigan, 3730 Central Campus Recreational Building, 401 Washtenaw Avenue, Ann Arbor, MI 48109, USA
J Steroid Biochem Mol Biol 132:212-9. 2012.... - Leptin regulates neointima formation after arterial injury through mechanisms independent of blood pressure and the leptin receptor/STAT3 signaling pathways involved in energy balancePeter F Bodary
Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, USA
Arterioscler Thromb Vasc Biol 27:70-6. 2007..The relevant cellular leptin receptor pools and signaling pathways involved in leptin-related vascular phenotypes in vivo are unclear... - Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasisSarah H Bates
Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
Cell Metab 1:169-78. 2005..Thus, in addition to LRb/STAT3-mediated adiposity signals, non-LRb/STAT3 leptin signals mediate an important adiposity-independent role in promoting glycemic control... - Critical role for hypothalamic mTOR activity in energy balanceHiroyuki Mori
Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
Cell Metab 9:362-74. 2009..Thus, ongoing mTOR activation in Pomc neurons blocks the catabolic function of these neurons to promote nutrient intake and increased adiposity... - Critical role of STAT3 in leptin's metabolic actionsChristoph Buettner
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cell Metab 4:49-60. 2006..Our results demonstrate that the activation of the hypothalamic STAT3 pathway is an absolute requirement for the effects of leptin on food intake and hepatic glucose metabolism... - The role of leptin-->STAT3 signaling in neuroendocrine function: an integrative perspectiveSarah H Bates
Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
J Mol Med 82:12-20. 2004..We discuss these findings in the context of the hypothalamic neuroendocrine system as it is presently understood... - Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuitsSebastien G Bouret
The Saban Research Institute, Developmental Neuroscience Program, Children s Hospital Los Angeles, University of Southern California, Los Angeles, California 90027, USA
J Neurosci 32:1244-52. 2012..Thus, the developmental actions of leptin on feeding circuits are dependent on LepRb, and distinct signaling pathways are responsible for directing formation of NPY and POMC projections... - Ectopic expression of Col2.3 and Col3.6 promoters in the brain and association with leptin signalingErica L Scheller
University of Michigan School of Dentistry, Ann Arbor, Mich, USA
Cells Tissues Organs 194:268-73. 2011..6(Cre+F/F) mice. Our analysis indicates that neural ObRb deletion, while present, is likely not the sole driver of femoral changes through traditional sympathetic circuits... - Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) ratsGregory J Morton
Department of Medicine, Harborview Medical Center and University of Washington, Seattle, Washington 98104, USA
Endocrinology 144:2016-24. 2003..Adenoviral gene therapy is thus a viable strategy with which to study the physiological importance of specific molecules acting in discrete brain areas... - Role reversal: brain insulin and liver STAT3Martin G Myers
Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
Cell Metab 3:231-2. 2006..Inoue et al. (2006) have now identified an IL-6/STAT3-dependent pathway in the liver that mediates a portion of the hepatic metabolic response to CNS insulin... - Regulation of Jak2 function by phosphorylation of Tyr317 and Tyr637 during cytokine signalingScott A Robertson
Department of Internal Medicine, University of Michigan Medical School, 5560 MSRB II, MSP5678, 1150 W Medical Center Dr, Ann Arbor, MI 48109, USA
Mol Cell Biol 29:3367-78. 2009..The phosphorylation of Tyr(317) and Tyr(637) act in concert with other regulatory events to maintain appropriate control of Jak2 activity and cytokine signaling... - Disruption of leptin receptor-STAT3 signaling enhances leukotriene production and pulmonary host defense against pneumococcal pneumoniaPeter Mancuso
Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA
J Immunol 186:1081-90. 2011..These data provide novel insights into the intracellular signaling events by which leptin contributes to host defense against bacterial pneumonia... - SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation-dependent and -independent mechanismsZhiqin Li
Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0622, USA
Mol Endocrinol 21:2270-81. 2007..SH2B1-IRS1 interaction facilitates IRS1 phosphorylation by recruiting IRS1 to JAK2 and/or by protecting IRS1 from dephosphorylation, thus specifically enhancing leptin stimulation of the phosphatidylinositol 3-kinase pathway... - Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cellsChrista M Patterson
Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, 1000 Wall St, Brehm Tower, Ann Arbor, MI 48105, USA
Brain Res 1378:18-28. 2011..In some nuclei that contained both soma and projections, the distribution of soma and projections differed, suggesting that these areas transmit leptin-encoded information in a neuroanatomically directional manner... - Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brainBarton Wicksteed
Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Chicago, Chicago, llinois, USA
Diabetes 59:3090-8. 2010..The objective of this study was to examine whether mouse transgenic Cre lines, used to mediate β-cell- or pancreas-specific recombination, also drive Cre expression in the brain... - Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3Sarah L Dunn
Division of Metabolism, Endocrinology and Diabetes, Department of Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0638, USA
Mol Endocrinol 19:925-38. 2005.... - Molecular and neural mediators of leptin actionScott A Robertson
Division of Metabolism, Endocrinology and Diabetes, Department of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0678, USA
Physiol Behav 94:637-42. 2008..Here, we review the status of knowledge regarding the molecular mediators of leptin action and the neural substrate via which leptin acts to regulate physiologic processes... - A simple qPCR-based method to detect correct insertion of homologous targeting vectors in murine ES cellsGhada A Soliman
Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Transgenic Res 16:665-70. 2007..We have utilized such easily designed and validated qPCR LOH assays to rapidly and accurately identify insertions in multiple target sites (including the Lepr and mTOR loci) in murine ES cells, in order to generate transgenic animals... - Cardiovascular and sympathetic effects of disrupting tyrosine 985 of the leptin receptorShannon M Harlan
Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
Hypertension 57:627-32. 2011..These findings provide important insight into the molecular mechanisms underlying leptin's effects on the sympathetic cardiovascular function and arterial pressure... - The role of leptin in the regulation of neuroendocrine function and CNS developmentGwendolyn W Louis
Division of Metabolism, Endocrinology and Diabetes, Department of Medicine, University of Michigan Medical School, 5560 MSRB II 0678, 1150 W Medical Center Dr, Ann Arbor, MI 48109, USA
Rev Endocr Metab Disord 8:85-94. 2007..In this review, we discuss leptin action, the neural circuits on which leptin acts, and our nascent understanding of how early leptin exposure may influence neural development and the predisposition to metabolic diseases... - Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexiaKevin D Niswender
Division of Metabolism, Endocrinology and Nutrition, University of Washington School of Medicine and Harborview Medical Center, Seattle 98104, USA
Diabetes 52:227-31. 2003.... - Leptin receptor signaling and the regulation of mammalian physiologyMartin G Myers
Section on Obesity, Research Division, Joslin Diabetes Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
Recent Prog Horm Res 59:287-304. 2004..Thus, other as-yet-undefined leptin receptor signals are central to these and perhaps other aspects of leptin action... - Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotypeGabriella Segal-Lieberman
Research Division, Joslin Diabetes Center, 1 Joslin Place, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 100:10085-90. 2003..These results highlight the importance of MCH in integration of energy homeostasis downstream of leptin and, in particular, the role of MCH in regulation of energy expenditure... - Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neuronsMerisa L Piper
Diabetes Center, University of California San Francisco, San Francisco, California 94143, USA
Mol Endocrinol 22:751-9. 2008..These results further suggest that leptin's effects on growth and reproduction are mediated by other signaling pathways, and that Stat3-mediated control of these functions is mediated independently of leptin and LepRb neurons... - Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesityJi Yeon Lee
Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
PLoS ONE 3:e1639. 2008..These results demonstrate that STAT5 mediates energy homeostasis in response to endogenous cytokines such as GM-CSF... - Metabolic sensing and regulation by the hypothalamusMartin G Myers
Am J Physiol Endocrinol Metab 294:E809. 2008 - mTOR tells the brain that the body is hungryBarbara B Kahn
Nat Med 12:615-7. 2006 - Hitting the target: leptin and perinatal nutrition in the predisposition to obesityMartin G Myers
Endocrinology 146:4209-10. 2005 - LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptinSarah H Bates
Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
Diabetes 53:3067-73. 2004..Thus, the LRb-->STAT3 signal is central to both the control of energy expenditure by leptin and the neuroendocrine regulation of the SNS and the thyroid axis...
Research Grants
- Mechanisms of Leptin Receptors Signal AttenuationMartin Myers; Fiscal Year: 2007..abstract_text> ..
- MOLECULAR DETERMINANTS OF LEPTIN RECEPTOR/JAK2 SIGNALINGMartin Myers; Fiscal Year: 2007..Each of these aims is crucial to addressing the central hypothesis of this proposal- that Jak2-autonomous signals and Jak2 phosphorylation are critical to the regulation and propagation of physiologic leptin action. ..
- Role of the lateral hypothalamic area in leptin actionMartin G Myers; Fiscal Year: 2010..In this proposal, we will analyze novel neural pathways in the brain that likely contribute to body energy homeostasis in order to define these mechanisms and the potential therapeutic targets that they represent. ..
- Role of the lateral hypothalamic area in leptin actionMartin Myers; Fiscal Year: 2009..These studies will help us to define the function of these neurons and the potential therapeutic targets that they represent. ..
- MOLECULAR DETERMINANTS OF LEPTIN RECEPTOR/JAK2 SIGNALINGMartin Myers; Fiscal Year: 2003....
- LEPTIN RECEPTOR PATHWAYS IN MAMMALIAN PHYSIOLOGYMartin Myers; Fiscal Year: 2004..Furthermore, the understanding gained about the connection between specific cellular signals and physiology will aid in the identification of potential therapeutic targets. ..
- Developmental mechanisms of leptin resistanceRichard B Simerly; Fiscal Year: 2010..We have thus generated a number of novel mouse genetic models with which to analyze the mechanisms and consequences of perinatal hypothalamic programming by leptin and altered nutrition. ..