Martin G Myers

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint STAT3 signalling is required for leptin regulation of energy balance but not reproduction
    Sarah H Bates
    Research Division, Joslin Diabetes Center, Harvard Medical School, 1 Joslin Place, Boston, Massachusetts 02215, USA
    Nature 421:856-9. 2003
  2. pmc Insufficiency of Janus kinase 2-autonomous leptin receptor signals for most physiologic leptin actions
    Scott Robertson
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA
    Diabetes 59:782-90. 2010
  3. pmc Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balance
    Rebecca L Leshan
    Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    Nat Med 18:820-3. 2012
  4. pmc How is the hungry brain like a sieve?
    Martin G Myers
    Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, 6317 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105, USA
    Cell Metab 17:467-8. 2013
  5. doi request reprint Central nervous system control of metabolism
    Martin G Myers
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48105, USA
    Nature 491:357-63. 2012
  6. pmc Challenges and opportunities of defining clinical leptin resistance
    Martin G Myers
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA
    Cell Metab 15:150-6. 2012
  7. ncbi request reprint Mechanisms of leptin action and leptin resistance
    Martin G Myers
    Division of Metabolism, Endocrinology and Diabetes, Department of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Annu Rev Physiol 70:537-56. 2008
  8. pmc Outstanding Scientific Achievement Award Lecture 2010: deconstructing leptin: from signals to circuits
    Martin G Myers
    Department of Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Diabetes 59:2708-14. 2010
  9. pmc Obesity and leptin resistance: distinguishing cause from effect
    Martin G Myers
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Trends Endocrinol Metab 21:643-51. 2010
  10. pmc Molecular mapping of the neural pathways linking leptin to the neuroendocrine reproductive axis
    Gwendolyn W Louis
    Division of Metabolism, Endocrinology and Diabetes, Department of Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA
    Endocrinology 152:2302-10. 2011

Detail Information

Publications60

  1. ncbi request reprint STAT3 signalling is required for leptin regulation of energy balance but not reproduction
    Sarah H Bates
    Research Division, Joslin Diabetes Center, Harvard Medical School, 1 Joslin Place, Boston, Massachusetts 02215, USA
    Nature 421:856-9. 2003
    ..LRb-STAT3 signalling thus mediates the effects of leptin on melanocortin production and body energy homeostasis, whereas distinct LRb signals regulate NPY and the control of fertility, growth and glucose homeostasis...
  2. pmc Insufficiency of Janus kinase 2-autonomous leptin receptor signals for most physiologic leptin actions
    Scott Robertson
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA
    Diabetes 59:782-90. 2010
    ..We therefore determined the potential role in leptin action for signals that are activated by Jak2 independently of LepRb phosphorylation (Jak2-autonomous signals)...
  3. pmc Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balance
    Rebecca L Leshan
    Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    Nat Med 18:820-3. 2012
    ..Thus, hypothalamic LepRb(NOS1) neurons are a key site of action of the leptin-mediated control of systemic energy balance...
  4. pmc How is the hungry brain like a sieve?
    Martin G Myers
    Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, 6317 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105, USA
    Cell Metab 17:467-8. 2013
    ..New findings reveal that fasting promotes "leakiness" of some hypothalamic blood vessels, increasing the access of circulating factors to certain hypothalamic neurons that control feeding (Langlet et al., 2013)...
  5. doi request reprint Central nervous system control of metabolism
    Martin G Myers
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48105, USA
    Nature 491:357-63. 2012
    ..The brain's contributions to metabolic control are more readily revealed and play a crucial part in catabolic states or in hormone deficiencies that mimic starvation...
  6. pmc Challenges and opportunities of defining clinical leptin resistance
    Martin G Myers
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA
    Cell Metab 15:150-6. 2012
    ..Further advances require biomarkers that can be used to identify patients who may benefit from leptin therapy and that are useful for understanding the determinants of clinical leptin responsiveness...
  7. ncbi request reprint Mechanisms of leptin action and leptin resistance
    Martin G Myers
    Division of Metabolism, Endocrinology and Diabetes, Department of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Annu Rev Physiol 70:537-56. 2008
    ..Other mechanisms that govern feeding behavior and food reward may also underlie the inception of obesity...
  8. pmc Outstanding Scientific Achievement Award Lecture 2010: deconstructing leptin: from signals to circuits
    Martin G Myers
    Department of Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Diabetes 59:2708-14. 2010
    ..In 1998, Dr. Myers received the American Diabetes Association's Career Development Award for his scientific abilities. Dr. Myers' current support includes the National Institute of Diabetes and Digestive and Kidney Diseases MERIT Award...
  9. pmc Obesity and leptin resistance: distinguishing cause from effect
    Martin G Myers
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Trends Endocrinol Metab 21:643-51. 2010
    ..We suggest a framework for approaching these issues and important avenues for future investigation...
  10. pmc Molecular mapping of the neural pathways linking leptin to the neuroendocrine reproductive axis
    Gwendolyn W Louis
    Division of Metabolism, Endocrinology and Diabetes, Department of Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA
    Endocrinology 152:2302-10. 2011
    ..Taken together, these findings suggest that leptin communicates with the neuroendocrine reproductive axis via multiple populations of LepRb neurons that lie afferent to both Kiss1 and GnRH neurons...
  11. pmc The geometry of leptin action in the brain: more complicated than a simple ARC
    Martin G Myers
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Metab 9:117-23. 2009
    ....
  12. pmc Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status
    Eneida C Villanueva
    Division of Metabolism, Department of Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Endocrinology 150:4541-51. 2009
    ..The regulation of mTORC1 in the basomedial hypothalamus thus varies by cell and stimulus type, as opposed to responding in a uniform manner to nutritional and hormonal perturbations...
  13. pmc Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdala
    Rebecca L Leshan
    Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 30:5713-23. 2010
    ..Thus, LepRb VTA neurons represent a subclass of VTA DA neurons that specifically innervates and controls the extCeA; we hypothesize that these neurons primarily modulate CeA-directed behaviors...
  14. pmc Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance
    Gina M Leinninger
    Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Metab 14:313-23. 2011
    ..Thus, LHA LepRb(Nts) neurons mediate physiologic leptin action on OX neurons and the mesolimbic DA system, and contribute importantly to the control of energy balance...
  15. pmc Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neurons
    Gwendolyn W Louis
    Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, and Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 30:11278-87. 2010
    ..These findings thus reveal a major role for LHA leptin action in the modulation of OX neurons, suggesting the importance of LHA LepRb neurons in the regulation of OX signaling that is crucial to leptin action and metabolic control...
  16. pmc Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function
    Marie Björnholm
    Departments of Internal Medicine and Molecular and Integrative Physiology, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    J Clin Invest 117:1354-60. 2007
    ..Thus, leptin activates autoinhibitory signals via LRb Tyr985 to attenuate the anti-adiposity effects of leptin, especially in females, potentially contributing to leptin insensitivity in obesity...
  17. pmc Hyperphagia and obesity in female mice lacking tissue inhibitor of metalloproteinase-1
    Isabelle Gerin
    Department of Molecular and Integrative Physiology, Ann Arbor, Michigan 48109 0622, USA
    Endocrinology 150:1697-704. 2009
    ....
  18. pmc Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding
    Gina M Leinninger
    Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Metab 10:89-98. 2009
    ..Thus, these findings reveal that LHA LepRb neurons link anorexic leptin action to the mesolimbic DA system...
  19. pmc Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus
    Rebecca L Leshan
    Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 29:3138-47. 2009
    ..These results are consistent with a role for LepRb PMv neurons in regulating the reproductive axis in response to metabolic and odorant stimuli...
  20. ncbi request reprint The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms
    Yusong Gong
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 282:31019-27. 2007
    ..Dissecting the contributions of these individual pathways to leptin action will be important for our ultimate understanding of the processes that regulate energy balance in vivo...
  21. ncbi request reprint Leptin receptor signaling and action in the central nervous system
    Rebecca L Leshan
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Obesity (Silver Spring) 14:208S-212S. 2006
    ..Understanding the regulation and physiological function of these myriad sites of central leptin action will be a crucial next step in the quest to understand mechanisms of leptin action and energy balance...
  22. pmc Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity
    Lawrence S Argetsinger
    Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, Michigan 48109 5622, USA
    Mol Endocrinol 24:1062-76. 2010
    ..g. phosphorylation, binding to a ligand-bound cytokine receptor, and/or binding to Src-homology 2B1, may be essential for JAK2 to assume a maximally active conformation...
  23. ncbi request reprint Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling
    Heike Munzberg
    Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 27:69-74. 2007
    ....
  24. ncbi request reprint Molecular and anatomical determinants of central leptin resistance
    Heike Munzberg
    Division of Metabolism, Endocrinology and Diabetes, Department of Medicine, University of Michigan Medical School, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109, USA
    Nat Neurosci 8:566-70. 2005
    ..We highlight data regarding the expression of SOCS3 (a potential mediator of leptin resistance) in the arcuate nucleus of the hypothalamus...
  25. ncbi request reprint Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis
    Sarah H Bates
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell Metab 1:169-78. 2005
    ..Thus, in addition to LRb/STAT3-mediated adiposity signals, non-LRb/STAT3 leptin signals mediate an important adiposity-independent role in promoting glycemic control...
  26. pmc Critical role of STAT3 in leptin's metabolic actions
    Christoph Buettner
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell Metab 4:49-60. 2006
    ..Our results demonstrate that the activation of the hypothalamic STAT3 pathway is an absolute requirement for the effects of leptin on food intake and hepatic glucose metabolism...
  27. pmc Cooperation between brain and islet in glucose homeostasis and diabetes
    Michael W Schwartz
    Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington 98109, USA
    Nature 503:59-66. 2013
    ..Consequently, therapies that target the BCGS in addition to conventional approaches based on enhancing insulin effects may have the potential to induce diabetes remission, whereas targeting just one typically does not. ..
  28. pmc Ablation of leptin receptor-mediated ERK activation impairs host defense against Gram-negative pneumonia
    Peter Mancuso
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 189:867-75. 2012
    ..These results demonstrate that leptin receptor-mediated ERK activation plays an essential role in host defense against bacterial pneumonia and in leukocyte antibacterial effector functions...
  29. pmc Modulation of the mesolimbic dopamine system by leptin
    Darren M Opland
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Brain Res 1350:65-70. 2010
    ....
  30. pmc Leptin promotes dopamine transporter and tyrosine hydroxylase activity in the nucleus accumbens of Sprague-Dawley rats
    Maura L Perry
    Chemistry Department, University of Michigan, Ann Arbor, MI 48109, USA
    J Neurochem 114:666-74. 2010
    ..Thus, leptin modulates the mesolimbic DA system via multiple acute mechanisms, and increases AMPH-mediated DA efflux in normal animals...
  31. pmc Leptin receptor-induced STAT3-independent signaling pathways are protective against atherosclerosis in a murine model of obesity and hyperlipidemia
    Wei Luo
    University of Michigan, Department of Internal Medicine, Ann Arbor, MI, USA
    Atherosclerosis 214:81-5. 2011
    ..The primary aim of this study was to determine the effects of leptin receptor signaling pathways on atherosclerosis in the setting of obesity and hyperlipidemia...
  32. ncbi request reprint Role reversal: brain insulin and liver STAT3
    Martin G Myers
    Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell Metab 3:231-2. 2006
    ..Inoue et al. (2006) have now identified an IL-6/STAT3-dependent pathway in the liver that mediates a portion of the hepatic metabolic response to CNS insulin...
  33. ncbi request reprint Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats
    Gregory J Morton
    Department of Medicine, Harborview Medical Center and University of Washington, Seattle, Washington 98104, USA
    Endocrinology 144:2016-24. 2003
    ..Adenoviral gene therapy is thus a viable strategy with which to study the physiological importance of specific molecules acting in discrete brain areas...
  34. pmc Ectopic expression of Col2.3 and Col3.6 promoters in the brain and association with leptin signaling
    Erica L Scheller
    University of Michigan School of Dentistry, Ann Arbor, Mich, USA
    Cells Tissues Organs 194:268-73. 2011
    ..6(Cre+F/F) mice. Our analysis indicates that neural ObRb deletion, while present, is likely not the sole driver of femoral changes through traditional sympathetic circuits...
  35. doi request reprint Testosterone interacts with the feedback mechanisms engaged by Tyr985 of the leptin receptor and diet-induced obesity
    Joshua A Johnson
    School of Kinesiology, University of Michigan, 3730 Central Campus Recreational Building, 401 Washtenaw Avenue, Ann Arbor, MI 48109, USA
    J Steroid Biochem Mol Biol 132:212-9. 2012
    ....
  36. ncbi request reprint Leptin regulates neointima formation after arterial injury through mechanisms independent of blood pressure and the leptin receptor/STAT3 signaling pathways involved in energy balance
    Peter F Bodary
    Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, USA
    Arterioscler Thromb Vasc Biol 27:70-6. 2007
    ..The relevant cellular leptin receptor pools and signaling pathways involved in leptin-related vascular phenotypes in vivo are unclear...
  37. pmc Critical role for hypothalamic mTOR activity in energy balance
    Hiroyuki Mori
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Metab 9:362-74. 2009
    ..Thus, ongoing mTOR activation in Pomc neurons blocks the catabolic function of these neurons to promote nutrient intake and increased adiposity...
  38. pmc Regulation of Jak2 function by phosphorylation of Tyr317 and Tyr637 during cytokine signaling
    Scott A Robertson
    Department of Internal Medicine, University of Michigan Medical School, 5560 MSRB II, MSP5678, 1150 W Medical Center Dr, Ann Arbor, MI 48109, USA
    Mol Cell Biol 29:3367-78. 2009
    ..The phosphorylation of Tyr(317) and Tyr(637) act in concert with other regulatory events to maintain appropriate control of Jak2 activity and cytokine signaling...
  39. ncbi request reprint Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3
    Sarah L Dunn
    Division of Metabolism, Endocrinology and Diabetes, Department of Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0638, USA
    Mol Endocrinol 19:925-38. 2005
    ....
  40. ncbi request reprint The role of leptin-->STAT3 signaling in neuroendocrine function: an integrative perspective
    Sarah H Bates
    Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
    J Mol Med (Berl) 82:12-20. 2004
    ..We discuss these findings in the context of the hypothalamic neuroendocrine system as it is presently understood...
  41. pmc Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits
    Sebastien G Bouret
    The Saban Research Institute, Developmental Neuroscience Program, Children s Hospital Los Angeles, University of Southern California, Los Angeles, California 90027, USA
    J Neurosci 32:1244-52. 2012
    ..Thus, the developmental actions of leptin on feeding circuits are dependent on LepRb, and distinct signaling pathways are responsible for directing formation of NPY and POMC projections...
  42. ncbi request reprint A simple qPCR-based method to detect correct insertion of homologous targeting vectors in murine ES cells
    Ghada A Soliman
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Transgenic Res 16:665-70. 2007
    ..We have utilized such easily designed and validated qPCR LOH assays to rapidly and accurately identify insertions in multiple target sites (including the Lepr and mTOR loci) in murine ES cells, in order to generate transgenic animals...
  43. pmc Leptin acts independently of food intake to modulate gut microbial composition in male mice
    Michael W Rajala
    Department of Internal Medicine, Division of Gastroenterology M W R, Division of Metabolism, Endocrinology and Diabetes C M P, M G M and Division of Infectious Disease J S O, S K F, V B Y Department of Microbiology and Immunology V B Y, Department of Molecular and Integrative Physiology M G M, and Neuroscience Program M G M, University of Michigan, Ann Arbor, Michigan
    Endocrinology 155:748-57. 2014
    ..Overall, our data reveal a role for LepRb signaling extrinsic to the intestinal epithelium and independent of food intake in the control of the gut microbiome. ..
  44. pmc Disruption of leptin receptor-STAT3 signaling enhances leukotriene production and pulmonary host defense against pneumococcal pneumonia
    Peter Mancuso
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 186:1081-90. 2011
    ..These data provide novel insights into the intracellular signaling events by which leptin contributes to host defense against bacterial pneumonia...
  45. ncbi request reprint SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation-dependent and -independent mechanisms
    Zhiqin Li
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0622, USA
    Mol Endocrinol 21:2270-81. 2007
    ..SH2B1-IRS1 interaction facilitates IRS1 phosphorylation by recruiting IRS1 to JAK2 and/or by protecting IRS1 from dephosphorylation, thus specifically enhancing leptin stimulation of the phosphatidylinositol 3-kinase pathway...
  46. pmc Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain
    Barton Wicksteed
    Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Chicago, Chicago, llinois, USA
    Diabetes 59:3090-8. 2010
    ..The objective of this study was to examine whether mouse transgenic Cre lines, used to mediate β-cell- or pancreas-specific recombination, also drive Cre expression in the brain...
  47. pmc Molecular and neural mediators of leptin action
    Scott A Robertson
    Division of Metabolism, Endocrinology and Diabetes, Department of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0678, USA
    Physiol Behav 94:637-42. 2008
    ..Here, we review the status of knowledge regarding the molecular mediators of leptin action and the neural substrate via which leptin acts to regulate physiologic processes...
  48. pmc Cardiovascular and sympathetic effects of disrupting tyrosine 985 of the leptin receptor
    Shannon M Harlan
    Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Hypertension 57:627-32. 2011
    ..These findings provide important insight into the molecular mechanisms underlying leptin's effects on the sympathetic cardiovascular function and arterial pressure...
  49. pmc Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cells
    Christa M Patterson
    Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, 1000 Wall St, Brehm Tower, Ann Arbor, MI 48105, USA
    Brain Res 1378:18-28. 2011
    ..In some nuclei that contained both soma and projections, the distribution of soma and projections differed, suggesting that these areas transmit leptin-encoded information in a neuroanatomically directional manner...
  50. ncbi request reprint The role of leptin in the regulation of neuroendocrine function and CNS development
    Gwendolyn W Louis
    Division of Metabolism, Endocrinology and Diabetes, Department of Medicine, University of Michigan Medical School, 5560 MSRB II 0678, 1150 W Medical Center Dr, Ann Arbor, MI 48109, USA
    Rev Endocr Metab Disord 8:85-94. 2007
    ..In this review, we discuss leptin action, the neural circuits on which leptin acts, and our nascent understanding of how early leptin exposure may influence neural development and the predisposition to metabolic diseases...
  51. ncbi request reprint Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia
    Kevin D Niswender
    Division of Metabolism, Endocrinology and Nutrition, University of Washington School of Medicine and Harborview Medical Center, Seattle 98104, USA
    Diabetes 52:227-31. 2003
    ....
  52. doi request reprint SnapShot: Neural Pathways that Control Feeding
    Martin G Myers
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Metab 19:732-732.e1. 2014
    ..This SnapShot provides an overview of brain systems such as the hypothalamus and brainstem that sense and integrate nutritional signals controlling eating. ..
  53. ncbi request reprint Leptin receptor signaling and the regulation of mammalian physiology
    Martin G Myers
    Section on Obesity, Research Division, Joslin Diabetes Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
    Recent Prog Horm Res 59:287-304. 2004
    ..Thus, other as-yet-undefined leptin receptor signals are central to these and perhaps other aspects of leptin action...
  54. pmc Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity
    Ji Yeon Lee
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 3:e1639. 2008
    ..These results demonstrate that STAT5 mediates energy homeostasis in response to endogenous cytokines such as GM-CSF...
  55. ncbi request reprint LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin
    Sarah H Bates
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 53:3067-73. 2004
    ..Thus, the LRb-->STAT3 signal is central to both the control of energy expenditure by leptin and the neuroendocrine regulation of the SNS and the thyroid axis...
  56. ncbi request reprint Hitting the target: leptin and perinatal nutrition in the predisposition to obesity
    Martin G Myers
    Endocrinology 146:4209-10. 2005
  57. doi request reprint Metabolic sensing and regulation by the hypothalamus
    Martin G Myers
    Am J Physiol Endocrinol Metab 294:E809. 2008
  58. pmc Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype
    Gabriella Segal-Lieberman
    Research Division, Joslin Diabetes Center, 1 Joslin Place, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 100:10085-90. 2003
    ..These results highlight the importance of MCH in integration of energy homeostasis downstream of leptin and, in particular, the role of MCH in regulation of energy expenditure...
  59. pmc Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons
    Merisa L Piper
    Diabetes Center, University of California San Francisco, San Francisco, California 94143, USA
    Mol Endocrinol 22:751-9. 2008
    ..These results further suggest that leptin's effects on growth and reproduction are mediated by other signaling pathways, and that Stat3-mediated control of these functions is mediated independently of leptin and LepRb neurons...
  60. ncbi request reprint mTOR tells the brain that the body is hungry
    Barbara B Kahn
    Nat Med 12:615-7. 2006

Research Grants27

  1. MOLECULAR DETERMINANTS OF LEPTIN RECEPTOR/JAK2 SIGNALING
    Martin Myers; Fiscal Year: 2003
    ....
  2. LEPTIN RECEPTOR PATHWAYS IN MAMMALIAN PHYSIOLOGY
    Martin Myers; Fiscal Year: 2002
    ..Furthermore, the understanding gained about the connection between specific cellular signals and physiology will aid in the identification of potential therapeutic targets. ..
  3. Mechanisms of Leptin Receptors Signal Attenuation
    Martin Myers; Fiscal Year: 2005
    ..abstract_text> ..
  4. MOLECULAR DETERMINANTS OF LEPTIN RECEPTOR/JAK2 SIGNALING
    Martin Myers; Fiscal Year: 2001
    ....
  5. MOLECULAR DETERMINANTS OF LEPTIN RECEPTOR/JAK2 SIGNALING
    Martin Myers; Fiscal Year: 2006
    ..Each of these aims is crucial to addressing the central hypothesis of this proposal- that Jak2-autonomous signals and Jak2 phosphorylation are critical to the regulation and propagation of physiologic leptin action. ..
  6. MOLECULAR DETERMINANTS OF LEPTIN RECEPTOR/JAK2 SIGNALING
    Martin Myers; Fiscal Year: 2007
    ..Each of these aims is crucial to addressing the central hypothesis of this proposal- that Jak2-autonomous signals and Jak2 phosphorylation are critical to the regulation and propagation of physiologic leptin action. ..
  7. Developmental mechanisms of leptin resistance
    Martin Myers; Fiscal Year: 2009
    ..We have thus generated a number of novel mouse genetic models with which to analyze the mechanisms and consequences of perinatal hypothalamic programming by leptin and altered nutrition. ..
  8. Role of the lateral hypothalamic area in leptin action
    Martin G Myers; Fiscal Year: 2010
    ..In this proposal, we will analyze novel neural pathways in the brain that likely contribute to body energy homeostasis in order to define these mechanisms and the potential therapeutic targets that they represent. ..
  9. Developmental mechanisms of leptin resistance
    Richard B Simerly; Fiscal Year: 2010
    ..We have thus generated a number of novel mouse genetic models with which to analyze the mechanisms and consequences of perinatal hypothalamic programming by leptin and altered nutrition. ..
  10. MOLECULAR DETERMINANTS OF LEPTIN RECEPTOR/JAK2 SIGNALING
    Martin Myers; Fiscal Year: 2005
    ..Each of these aims is crucial to addressing the central hypothesis of this proposal- that Jak2-autonomous signals and Jak2 phosphorylation are critical to the regulation and propagation of physiologic leptin action. ..
  11. LEPTIN RECEPTOR PATHWAYS IN MAMMALIAN PHYSIOLOGY
    Martin Myers; Fiscal Year: 2004
    ..Furthermore, the understanding gained about the connection between specific cellular signals and physiology will aid in the identification of potential therapeutic targets. ..
  12. MOLECULAR DETERMINANTS OF LEPTIN RECEPTOR/JAK2 SIGNALING
    Martin Myers; Fiscal Year: 2000
    ....
  13. LEPTIN RECEPTOR PATHWAYS IN MAMMALIAN PHYSIOLOGY
    Martin Myers; Fiscal Year: 2001
    ..Furthermore, the understanding gained about the connection between specific cellular signals and physiology will aid in the identification of potential therapeutic targets. ..
  14. MOLECULAR DETERMINANTS OF LEPTIN RECEPTOR/JAK2 SIGNALING
    Martin Myers; Fiscal Year: 1999
    ....
  15. LEPTIN RECEPTOR PATHWAYS IN MAMMALIAN PHYSIOLOGY
    Martin Myers; Fiscal Year: 2000
    ..Furthermore, the understanding gained about the connection between specific cellular signals and physiology will aid in the identification of potential therapeutic targets. ..
  16. Role of the lateral hypothalamic area in leptin action
    Martin Myers; Fiscal Year: 2009
    ..In this proposal, we will analyze novel neural pathways in the brain that likely contribute to body energy homeostasis in order to define these mechanisms and the potential therapeutic targets that they represent. ..
  17. MOLECULAR DETERMINANTS OF LEPTIN RECEPTOR/JAK2 SIGNALING
    Martin Myers; Fiscal Year: 2001
    ....
  18. Mechanisms of Leptin Receptors Signal Attenuation
    Martin Myers; Fiscal Year: 2006
    ..abstract_text> ..
  19. Mechanisms of Leptin Receptors Signal Attenuation
    Martin Myers; Fiscal Year: 2007
    ..abstract_text> ..
  20. MOLECULAR DETERMINANTS OF LEPTIN RECEPTOR/JAK2 SIGNALING
    Martin Myers; Fiscal Year: 2002
    ....
  21. Mechanisms of Leptin Receptors Signal Attenuation
    Martin Myers; Fiscal Year: 2006
    ..abstract_text> ..
  22. LEPTIN RECEPTOR PATHWAYS IN MAMMALIAN PHYSIOLOGY
    Martin Myers; Fiscal Year: 2003
    ..Furthermore, the understanding gained about the connection between specific cellular signals and physiology will aid in the identification of potential therapeutic targets. ..
  23. Role of the lateral hypothalamic area in leptin action
    Martin Myers; Fiscal Year: 2009
    ..These studies will help us to define the function of these neurons and the potential therapeutic targets that they represent. ..
  24. MOLECULAR DETERMINANTS OF LEPTIN RECEPTOR/JAK2 SIGNALING
    Martin Myers; Fiscal Year: 2004
    ..Each of these aims is crucial to addressing the central hypothesis of this proposal- that Jak2-autonomous signals and Jak2 phosphorylation are critical to the regulation and propagation of physiologic leptin action. ..