Andrzej Myc

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Nanoemulsion nasal adjuvant W₈₀5EC induces dendritic cell engulfment of antigen-primed epithelial cells
    Andrzej Myc
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan Medical School, Ann Arbor, MI 48109 0648, United States
    Vaccine 31:1072-9. 2013
  2. doi request reprint Preclinical antitumor efficacy evaluation of dendrimer-based methotrexate conjugates
    Andrzej Myc
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan Medical School, BSRB, Ann Arbor, Michigan 48109, USA
    Anticancer Drugs 19:143-9. 2008
  3. pmc Targeting the efficacy of a dendrimer-based nanotherapeutic in heterogeneous xenograft tumors in vivo
    Andrzej Myc
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan Medical School, BSRB, Ann Arbor, MI 48109, USA
    Anticancer Drugs 21:186-92. 2010
  4. ncbi request reprint Dendrimer-based BH3 conjugate that targets human carcinoma cells
    Andrzej Myc
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan Medical School, BSRB, Ann Arbor, MI 48109 0648, USA
    Biomacromolecules 8:2986-9. 2007
  5. ncbi request reprint PAMAM dendrimer-based multifunctional conjugate for cancer therapy: synthesis, characterization, and functionality
    Istvan J Majoros
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, 200 Zina Pitcher Place, 4027 Kresge II, Ann Arbor, 48109 0533, USA
    Biomacromolecules 7:572-9. 2006
  6. ncbi request reprint Targeting and inhibition of cell growth by an engineered dendritic nanodevice
    Thommey P Thomas
    Center for Biologic Nanotechnology, University of Michigan Medical School, 9220 MSRB III, Ann Arbor, Michigan 48109 0648, USA
    J Med Chem 48:3729-35. 2005
  7. ncbi request reprint In vitro targeting of synthesized antibody-conjugated dendrimer nanoparticles
    Thommey P Thomas
    Center for Biologic Nanotechnology, 9220 MSRB III, University of Michigan Medical School, Ann Arbor, Michigan 48109 0648, USA
    Biomacromolecules 5:2269-74. 2004
  8. ncbi request reprint Development of immune response that protects mice from viral pneumonitis after a single intranasal immunization with influenza A virus and nanoemulsion
    Andrzej Myc
    Department of Internal Medicine, Division of Allergy, Center of Biologic Nanotechnology, University of Michigan, 9240 MSRB III, Ann Arbor, MI 48109 0666, USA
    Vaccine 21:3801-14. 2003
  9. doi request reprint Extended cavity laser enhanced two-photon flow cytometry
    Eric R Tkaczyk
    University of Michigan, Center for Ultrafast Optical Science, Electrical Engineering and Computer Science Department, Ann Arbor, Michigan 48109 2099, USA
    J Biomed Opt 13:041319. 2008
  10. doi request reprint Synthesis, characterization, and in vitro testing of superparamagnetic iron oxide nanoparticles targeted using folic Acid-conjugated dendrimers
    Kevin J Landmark
    Programs in Applied Physics, University of Michigan, Ann Arbor, Michigan 48109, USA
    ACS Nano 2:773-83. 2008

Collaborators

Detail Information

Publications22

  1. pmc Nanoemulsion nasal adjuvant W₈₀5EC induces dendritic cell engulfment of antigen-primed epithelial cells
    Andrzej Myc
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan Medical School, Ann Arbor, MI 48109 0648, United States
    Vaccine 31:1072-9. 2013
    ....
  2. doi request reprint Preclinical antitumor efficacy evaluation of dendrimer-based methotrexate conjugates
    Andrzej Myc
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan Medical School, BSRB, Ann Arbor, Michigan 48109, USA
    Anticancer Drugs 19:143-9. 2008
    ..Further in-vivo studies are, however, necessary to prove the clinical potential of this targeted therapeutic nanodevice...
  3. pmc Targeting the efficacy of a dendrimer-based nanotherapeutic in heterogeneous xenograft tumors in vivo
    Andrzej Myc
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan Medical School, BSRB, Ann Arbor, MI 48109, USA
    Anticancer Drugs 21:186-92. 2010
    ..The animal model of the artificial heterogeneous xenograft tumor showed that the nanotherapeutic was preferentially cytotoxic to KB cells...
  4. ncbi request reprint Dendrimer-based BH3 conjugate that targets human carcinoma cells
    Andrzej Myc
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan Medical School, BSRB, Ann Arbor, MI 48109 0648, USA
    Biomacromolecules 8:2986-9. 2007
    ..The results show, for the first time, the therapeutic potential of targeted BH3 peptides as a means of inducing apoptosis by interfering with anti-apoptotic proteins within specific cells...
  5. ncbi request reprint PAMAM dendrimer-based multifunctional conjugate for cancer therapy: synthesis, characterization, and functionality
    Istvan J Majoros
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, 200 Zina Pitcher Place, 4027 Kresge II, Ann Arbor, 48109 0533, USA
    Biomacromolecules 7:572-9. 2006
    ..We present here the synthesis, characterization, and functionality of these dendrimer conjugates...
  6. ncbi request reprint Targeting and inhibition of cell growth by an engineered dendritic nanodevice
    Thommey P Thomas
    Center for Biologic Nanotechnology, University of Michigan Medical School, 9220 MSRB III, Ann Arbor, Michigan 48109 0648, USA
    J Med Chem 48:3729-35. 2005
    ..These studies show the potential of G5-FI-FA-MTX or G5-FA-MTX for targeting and growth suppression of tumor cells that overexpress FA-receptors...
  7. ncbi request reprint In vitro targeting of synthesized antibody-conjugated dendrimer nanoparticles
    Thommey P Thomas
    Center for Biologic Nanotechnology, 9220 MSRB III, University of Michigan Medical School, Ann Arbor, Michigan 48109 0648, USA
    Biomacromolecules 5:2269-74. 2004
    ..Confocal microscopic analysis suggested at least some cellular internalization of the dendrimer conjugate. Dendrimer-antibody conjugates are a suitable platform for targeted molecule delivery into antigen-expressing cells...
  8. ncbi request reprint Development of immune response that protects mice from viral pneumonitis after a single intranasal immunization with influenza A virus and nanoemulsion
    Andrzej Myc
    Department of Internal Medicine, Division of Allergy, Center of Biologic Nanotechnology, University of Michigan, 9240 MSRB III, Ann Arbor, MI 48109 0666, USA
    Vaccine 21:3801-14. 2003
    ..This paper demonstrates that nanoemulsion can be employed as a non-toxic mucosal adjuvant for influenza virus vaccine...
  9. doi request reprint Extended cavity laser enhanced two-photon flow cytometry
    Eric R Tkaczyk
    University of Michigan, Center for Ultrafast Optical Science, Electrical Engineering and Computer Science Department, Ann Arbor, Michigan 48109 2099, USA
    J Biomed Opt 13:041319. 2008
    ....
  10. doi request reprint Synthesis, characterization, and in vitro testing of superparamagnetic iron oxide nanoparticles targeted using folic Acid-conjugated dendrimers
    Kevin J Landmark
    Programs in Applied Physics, University of Michigan, Ann Arbor, Michigan 48109, USA
    ACS Nano 2:773-83. 2008
    ..The results were consistent between the uptake distribution quantified by flow cytometry using 6-TAMRA UV-visible fluorescence intensity and the cellular iron content determined using X-ray fluorescence microscopy...
  11. doi request reprint Quantitative two-photon flow cytometry--in vitro and in vivo
    Cheng Frank Zhong
    University of Michigan, Electrical Engineering and Computer Science Department, Center for Ultrafast Optical Science, 2200 Bonisteel Boulevard, Ann Arbor, Michigan 48109 2099, USA
    J Biomed Opt 13:034008. 2008
    ..The technique also enables us to monitor the fluorescent dye labeling dynamics in vivo. In addition, we present a unique two-beam scanning method to conduct cell size measurement in nonuniform flow...
  12. ncbi request reprint Design and function of a dendrimer-based therapeutic nanodevice targeted to tumor cells through the folate receptor
    Antonio Quintana
    Center for Biologic Nanotechnology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109 0648, USA
    Pharm Res 19:1310-6. 2002
    ..A complex nanodevice was designed and synthesized that targets tumor cell through the folate receptor...
  13. ncbi request reprint Efficacy, immunogenicity and stability of a novel intranasal nanoemulsion-adjuvanted influenza vaccine in a murine model
    Tarek Hamouda
    NanoBio Corp, Ann Arbor, MI, USA
    Hum Vaccin 6:585-94. 2010
    ..The nanoemulsion adjuvant can result in antigen sparing and cross-protection. The potential exists for a nasally administered influenza vaccine that may require little or no refrigerated storage...
  14. ncbi request reprint Dendrimer-based targeted delivery of an apoptotic sensor in cancer cells
    Andrzej Myc
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA
    Biomacromolecules 8:13-8. 2007
    ..These results show, for the first time, the potential applicability of a targeted apoptosis-measuring nanodevice, which could be used for simultaneously monitoring the apoptotic potential of a delivered drug...
  15. pmc Sensitive molecular binding assay using a photonic crystal structure in total internal reflection
    Yunbo Guo
    Center for Ultrafast Optical Science, University of Michigan, Ann Arbor, MI 48109 2099, USA
    Opt Express 16:11741-9. 2008
    ..06 pg/mm(2) or a refractive index resolution of 3 x 10(-8) RIU; this represents a significant improvement relative to state-of-the-art surface-plasmon-resonance-based systems...
  16. ncbi request reprint Synthesis and in vitro testing of J591 antibody-dendrimer conjugates for targeted prostate cancer therapy
    Anil K Patri
    Center for Biologic Nanotechnology, Department of Internal Medicine, Division of Allergy, University of Michigan, 9220 MSRB III, Box 0648, Ann Arbor, Michigan 48109, USA
    Bioconjug Chem 15:1174-81. 2004
    ..Confocal microscopy experiments document the binding and internalization of these conjugates. This research encourages the further study of antibody-dendrimer-drug conjugates for use in targeted therapeutics...
  17. pmc Characterization of stability and nasal delivery systems for immunization with nanoemulsion-based vaccines
    Paul E Makidon
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan 48109 5648, USA
    J Aerosol Med Pulm Drug Deliv 23:77-89. 2010
    ....
  18. doi request reprint OT-II TCR transgenic mice fail to produce anti-ovalbumin antibodies upon vaccination
    Shelly Leung
    Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cell Immunol 282:79-84. 2013
    ..These data suggest that OT-II B-cells are not defective as APCs, however, downstream antibody responses are abrogated in this transgenic strain. ..
  19. ncbi request reprint The fungicidal activity of novel nanoemulsion (X8W60PC) against clinically important yeast and filamentous fungi
    Andrzej Myc
    Department of Internal Medicine, Division of Allergy, Center for Biologic Nanotechnology, University of Michigan, Ann Arbor, MI, USA
    Mycopathologia 155:195-201. 2002
    ..This shows that the nanoemulsion structure is an important factor in the anti-fungal activity. The X8W60PC has great potential as a topical anti-fungal agent and further investigation into the mechanism of fungicidal action is warranted...
  20. ncbi request reprint Activation of human and mouse Kupffer cells by lipopolysaccharide is mediated by CD14
    Grace L Su
    Department of Veterans Affairs Medical Center, Ann Arbor, Michigan 48109, USA
    Am J Physiol Gastrointest Liver Physiol 283:G640-5. 2002
    ..Kupffer cells from CD14 knockout mice produced significantly less TNF-alpha in response to the same amount of LPS. Together, these data strongly support a critical role for CD14 in Kupffer cell responses to LPS...
  21. doi request reprint Dendrimer-based multivalent vancomycin nanoplatform for targeting the drug-resistant bacterial surface
    Seok Ki Choi
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    ACS Nano 7:214-28. 2013
    ....
  22. ncbi request reprint Prevention of influenza pneumonitis by sialic Acid-conjugated dendritic polymers
    Jeffrey J Landers
    Center for Biologic Nanotechnology, Department of Internal Medicine, Division of Allergy, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Infect Dis 186:1222-30. 2002
    ..Polyvalent binding inhibitors have potential as antiviral therapeutics, but issues related to strain specificity must be resolved...