L Myatt

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi Role of placenta in preeclampsia
    Leslie Myatt
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, PO Box 670526, Cincinnati, OH 45267 0526, USA
    Endocrine 19:103-11. 2002
  2. ncbi Oxidative stress in the placenta
    Leslie Myatt
    Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, PO Box 670526, Cincinnati, OH 45267 0526, USA
    Histochem Cell Biol 122:369-82. 2004
  3. ncbi Nitrotyrosine residues in placenta. Evidence of peroxynitrite formation and action
    L Myatt
    Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, OH 45267 0526, USA
    Hypertension 28:488-93. 1996
  4. ncbi Expression, localization and function of prostaglandin receptors in myometrium
    Leslie Myatt
    Deparment of Obstetrics and Gynecology, College of Medicine, University of Cincinnati, PO Box 670526, Cincinnati, OH 45267, USA
    Prostaglandins Leukot Essent Fatty Acids 70:137-48. 2004
  5. ncbi Oxidative stress causes vascular dysfunction in the placenta
    L Myatt
    Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Ohio 45267 0526, USA
    J Matern Fetal Med 9:79-82. 2000
  6. ncbi Placental adaptive responses and fetal programming
    Leslie Myatt
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, PO Box 670526, Cincinnati, OH 45267, USA
    J Physiol 572:25-30. 2006
  7. ncbi Nitration of p38 MAPK in the placenta: association of nitration with reduced catalytic activity of p38 MAPK in pre-eclampsia
    R P Webster
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267 0526, USA
    Mol Hum Reprod 12:677-85. 2006
  8. ncbi Attenuation of the vasoconstrictor effects of thromboxane and endothelin by nitric oxide in the human fetal-placental circulation
    L Myatt
    Perinatal Research Institute, University of Cincinnati College of Medicine, OH 45267 0526
    Am J Obstet Gynecol 166:224-30. 1992
  9. ncbi Expression and localization of the contractile prostaglandin F receptor in pregnant rat myometrium in late gestation, labor, and postpartum
    H Y Al-Matubsi
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267-0526, USA
    Biol Reprod 65:1029-37. 2001
  10. ncbi The action of nitric oxide in the perfused human fetal-placental circulation
    L Myatt
    Department of Obstetrics and Gynecology, University of Cincinnati, OH 45267
    Am J Obstet Gynecol 164:687-92. 1991

Collaborators

Detail Information

Publications49

  1. ncbi Role of placenta in preeclampsia
    Leslie Myatt
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, PO Box 670526, Cincinnati, OH 45267 0526, USA
    Endocrine 19:103-11. 2002
    ..Current therapies to prevent preeclampsia aim toward preventing the maternal syndrome, not preventing the primary pathophysiology...
  2. ncbi Oxidative stress in the placenta
    Leslie Myatt
    Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, PO Box 670526, Cincinnati, OH 45267 0526, USA
    Histochem Cell Biol 122:369-82. 2004
    ..Nitrative stress, subsequent to oxidative stress is seen in the placenta in preeclampsia and diabetes in association with altered placental function...
  3. ncbi Nitrotyrosine residues in placenta. Evidence of peroxynitrite formation and action
    L Myatt
    Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, OH 45267 0526, USA
    Hypertension 28:488-93. 1996
    ..The presence of nitrotyrosine residues, particularly in the endothelium, may indicate the formation and action of peroxynitrite, resulting in vascular damage that contributes to the increased placental vascular resistance...
  4. ncbi Expression, localization and function of prostaglandin receptors in myometrium
    Leslie Myatt
    Deparment of Obstetrics and Gynecology, College of Medicine, University of Cincinnati, PO Box 670526, Cincinnati, OH 45267, USA
    Prostaglandins Leukot Essent Fatty Acids 70:137-48. 2004
    ..Studies to determine the role of PG receptors in this phenomenon are currently underway...
  5. ncbi Oxidative stress causes vascular dysfunction in the placenta
    L Myatt
    Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Ohio 45267 0526, USA
    J Matern Fetal Med 9:79-82. 2000
    ....
  6. ncbi Placental adaptive responses and fetal programming
    Leslie Myatt
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, PO Box 670526, Cincinnati, OH 45267, USA
    J Physiol 572:25-30. 2006
    ..Hypoxia, oxidative and nitrative stress all alter placenta development and may be a general underlying mechanism that links altered placental function to fetal programming...
  7. ncbi Nitration of p38 MAPK in the placenta: association of nitration with reduced catalytic activity of p38 MAPK in pre-eclampsia
    R P Webster
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267 0526, USA
    Mol Hum Reprod 12:677-85. 2006
    ..Comparison of peptide masses of a 42-kDa protein obtained by mass spectrometry with masses of a theoretical tryptic digest of p38 MAPK that was modified by phosphorylation and nitration identified the protein to be p38 MAPK...
  8. ncbi Attenuation of the vasoconstrictor effects of thromboxane and endothelin by nitric oxide in the human fetal-placental circulation
    L Myatt
    Perinatal Research Institute, University of Cincinnati College of Medicine, OH 45267 0526
    Am J Obstet Gynecol 166:224-30. 1992
    ..Nitric oxide appears to contribute to maintenance of basal vascular tone and to attenuate the actions of vasoconstrictors in this circulation...
  9. ncbi Expression and localization of the contractile prostaglandin F receptor in pregnant rat myometrium in late gestation, labor, and postpartum
    H Y Al-Matubsi
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267-0526, USA
    Biol Reprod 65:1029-37. 2001
    ..Our study suggests an increase in FP-receptor protein in myometrium with advancing gestation and a marked elevation at term. This supports a role for uterine FP receptors in mediation of uterine contractility at term...
  10. ncbi The action of nitric oxide in the perfused human fetal-placental circulation
    L Myatt
    Department of Obstetrics and Gynecology, University of Cincinnati, OH 45267
    Am J Obstet Gynecol 164:687-92. 1991
    ..These compounds had no effect in the absence of the vasoconstrictor. Thus it appears that the placental villus tree has the ability to both generate and respond to nitric oxide...
  11. ncbi Protein nitration in placenta - functional significance
    R P Webster
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, PO Box 670526, Cincinnati, OH 45267, USA
    Placenta 29:985-94. 2008
    ..The targets and extent of nitration of enzymes, receptors, transporters and structural proteins may markedly influence placental cellular function in both physiologic and pathologic settings...
  12. ncbi Review: Reactive oxygen and nitrogen species and functional adaptation of the placenta
    L Myatt
    Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health Science Center San Antonio, Mail Code 7836, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Placenta 31:S66-9. 2010
    ..As protein carbonylation is a covalent modification at Lys, Arg, Pro and Thr residues the switch from carbonylation to nitration at tyrosine residues may alter protein function and hence placental function...
  13. ncbi Expression of NADPH oxidase isoform 1 (Nox1) in human placenta: involvement in preeclampsia
    X L Cui
    Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, PO Box 670526, 231 Albert Sabin Way, Cincinnati, OH 45267 0526, USA
    Placenta 27:422-31. 2006
    ..Western blot analysis of whole placental homogenate confirmed this increase. Our data suggests that increased Nox1 expression is associated with the increased oxidative stress found in these placentas...
  14. ncbi Nitrotyrosine immunostaining correlates with increased extracellular matrix: evidence of postplacental hypoxia
    J Stanek
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0529, USA
    Placenta 22:S56-62. 2001
    ..NT immunostaining may therefore help differentiate those cases of perinatal morbidity/mortality associated with post-placental hypoxia provided that the secondary impact of intrauterine fetal death can be excluded by future studies...
  15. ncbi Effect of increasing maternal body mass index on oxidative and nitrative stress in the human placenta
    V H J Roberts
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0526, USA
    Placenta 30:169-75. 2009
    ..There may be a shift in the balance between nitrative and oxidative stress, which may be a protective mechanism for the placenta...
  16. ncbi Post-Translational Modifications of the P2X(4) purinergic receptor subtype in the human placenta are altered in preeclampsia
    V H J Roberts
    Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0526, USA
    Placenta 28:270-7. 2007
    ..We also propose that the post-translational modifications of nitration and glycosylation are required for the normal functioning of P2X(4)...
  17. ncbi The interaction of nitric oxide and superoxide in the human fetal-placental vasculature
    G Holcberg
    Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, OH 45267 0526, USA
    Am J Obstet Gynecol 173:528-33. 1995
    ..CONCLUSION: We conclude that, rather than superoxide inactivating nitric oxide, interaction of the two radicals generates in the placental vasculature a vasodilator, which may be peroxynitrite...
  18. ncbi Determination of non-bilayer phospholipid arrangements and their antibodies in placentae and sera of patients with hypertensive disorders of pregnancy
    B Campos
    Department of Obstetrics and Gynecology, College of Medicine, University of Cincinnati, 231 Albert Sabin, Cincinnati, OH 45267 0526, USA
    Placenta 27:215-24. 2006
    ..This suggests that NPA derived from placenta could be one of multiple factors associated with pregnancy pathologies...
  19. ncbi Vascular biology of preeclampsia
    L Myatt
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267 0526, USA
    J Thromb Haemost 7:375-84. 2009
    ..Preexisting maternal vascular dysfunction intensified by placental factors is possibly responsible for the individual pathologies of preeclampsia...
  20. ncbi Peroxynitrite treatment in vitro disables catalytic activity of recombinant p38 MAPK
    Rose P Webster
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267 0526, USA
    Proteomics 6:4838-44. 2006
    ..Nitration of these specific residues was deduced from the 45.0-Da change in mass that these residues exhibited that was consistent with the loss of a proton and addition of the nitro group...
  21. ncbi The role of trophoblast nutrient and ion transporters in the development of pregnancy complications and adult disease
    Thomas Jansson
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, Cincinnati, OH, USA
    Curr Vasc Pharmacol 7:521-33. 2009
    ....
  22. ncbi Vitamins C and E to prevent complications of pregnancy-associated hypertension
    James M Roberts
    Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, USA
    N Engl J Med 362:1282-91. 2010
    ..We assessed the effects of antioxidant supplementation with vitamins C and E, initiated early in pregnancy, on the risk of serious adverse maternal, fetal, and neonatal outcomes related to pregnancy-associated hypertension...
  23. ncbi Differences in the proteome profile in placenta from normal term and preeclamptic preterm pregnancies
    Rose P Webster
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, Cincinnati, OH, USA
    Proteomics Clin Appl 1:446-56. 2007
    ..Endothelial monocyte-activating polypeptide was shown to be down-regulated in preeclampsia by 2-DE and MS...
  24. ncbi Elucidation of the molecular mechanisms of preeclampsia using proteomic technologies
    Rose P Webster
    Department of Obstetrics and Gynecology, College of Medicine, University of Cincinnati, Cincinnati, OH, USA
    Proteomics Clin Appl 1:1147-55. 2007
    ..Deciphering the placental proteome and studying the differences in protein expression patterns in the normal as against the preeclamptic proteome might possibly in future lead to early detection and therapeutic targeting of preeclampsia...
  25. ncbi Regional expression of prostaglandin E2 and F2alpha receptors in human myometrium, amnion, and choriodecidua with advancing gestation and labor
    Peta L Grigsby
    Department of Obstetrics and Gynecology, University of Cincinnati, Medical College, Cincinnati, Ohio 45267, USA
    Biol Reprod 75:297-305. 2006
    ....
  26. ncbi Expression and distribution of NADPH oxidase isoforms in human myometrium--role in angiotensin II-induced hypertrophy
    Xiao lan Cui
    Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    Biol Reprod 82:305-12. 2010
    ..We conclude that NADPH oxidase mediates angiotensin II-stimulated protein synthesis downstream of AT1 in myometrium smooth muscle cells...
  27. ncbi Heat shock protein-70 and 4-hydroxy-2-nonenal adducts in human placental villous tissue of normotensive, preeclamptic and intrauterine growth restricted pregnancies
    Michael D Hnat
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, Cincinnati, OH, USA
    Am J Obstet Gynecol 193:836-40. 2005
    ..However, these changes were masked when studying tissue homogenates...
  28. ncbi Localization and expression of prostaglandin E2 receptors in human placenta and corresponding fetal membranes with labor
    Peta L Grigsby
    Department of Obstetrics and Gynceology, University of Cincinnati, Medical College, Cincinnati, OH 45267, USA
    Am J Obstet Gynecol 195:260-9. 2006
    ..The aim of this study was to characterize the temporal and tissue specific localization and expression of the PGE2 receptor subtypes (EP1-4) in uteroplacental tissues during human pregnancy...
  29. ncbi Measurement of mitochondrial respiration in trophoblast culture
    A Maloyan
    Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, University of Texas Health Science Center San Antonio, Mail Code 7836, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Placenta 33:456-8. 2012
    ..However, this does not provide a complete physiological readout of mitochondrial function. This technical note describes a method to measure respiratory function in intact primary syncytiotrophoblast from human term placenta...
  30. ncbi Nitric oxide synthase activity in umbilical and placental vascular tissue of gestational diabetic pregnancies
    S Dollberg
    Department of Pediatrics, University of Cincinnati College of Medicine, Ohio, USA
    Gynecol Obstet Invest 44:177-81. 1997
    ..Nitric oxide (NO) synthase activity in the fetal-placental vasculature of gestational diabetic pregnancies was compared to non-diabetic controls...
  31. ncbi Placental amino acid transport and placental leptin resistance in pregnancies complicated by maternal obesity
    D M Farley
    Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Texas Health Science Center at San Antonio, Texas 78229 3900, USA
    Placenta 31:718-24. 2010
    ..Our objectives were to study placental amino acid transport and the effect of leptin on placental amino acid transport in vitro in the setting of maternal obesity...
  32. ncbi Induction of surfactant protein A expression by cortisol facilitates prostaglandin synthesis in human chorionic trophoblasts
    Kang Sun
    Department of Obstetrics and Gynecology, College of Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, Ohio 45267, USA
    J Clin Endocrinol Metab 91:4988-94. 2006
    ..However, the local expression of SP-A and the effect of SP-A on prostaglandin synthesis in human fetal membranes have not been resolved...
  33. ncbi Expression and localization of prostaglandin E synthase isoforms in human fetal membranes in term and preterm labor
    Juliana W Meadows
    Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, Ohio 45267 0528, USA
    J Clin Endocrinol Metab 88:433-9. 2003
    ..It does not appear that expression of PGES is the rate-limiting step in PGE2 synthesis in fetal membranes at labor...
  34. ncbi Transport of cholesterol across a BeWo cell monolayer: implications for net transport of sterol from maternal to fetal circulation
    Kara E Schmid
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Lipid Res 44:1909-18. 2003
    ..These are the first studies to demonstrate the movement of cholesterol across a placental cell from the maternal circulation (apical side) to the fetal circulation (basolateral side)...
  35. ncbi Enhanced placental cholesterol efflux by fetal HDL in Smith-Lemli-Opitz syndrome
    Katie T Jenkins
    Department of Pathology, Genome Research Institute, University of Cincinnati Medical School, 2180 E Galbraith Road, Cincinnati, OH 45237 0507, USA
    Mol Genet Metab 94:240-7. 2008
    ....
  36. ncbi Transport of maternal cholesterol to the fetus is affected by maternal plasma cholesterol concentrations in the golden Syrian hamster
    Katie T Burke
    Department of Pathology and Laboratory Medicine, University of Cincinnati Medical School, Cincinnati, OH 45237, USA
    J Lipid Res 50:1146-55. 2009
    ....
  37. ncbi Hormonal regulation of prostaglandin E2 receptors: localization and expression in rat cervical tissue
    Andrea C Hinton
    Division of Maternal Fetal Medicine, Good Samaritan Hospital, Cincinnati, Ohio 45220, USA
    Reprod Sci 17:136-46. 2010
    ..Progesterone differentially regulates the expression of PGE2 receptor isoforms in the cervix. Elucidating the regulation of PGE2 receptors may facilitate improved approaches to the prevention and treatment of preterm labor...
  38. ncbi Microsomal prostaglandin E2 synthase-1 is induced by conditional expression of RET/PTC in thyroid PCCL3 cells through the activation of the MEK-ERK pathway
    Efisio Puxeddu
    Division of Endocrinology and Metabolism, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Biol Chem 278:52131-8. 2003
    ..As enzymes involved in prostanoid biosynthesis can be targeted with pharmacological inhibitors, these findings may have therapeutic implications...
  39. ncbi Differential localization of prostaglandin E synthase isoforms in human placental cell types
    J W Meadows
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, MSB 5454, Cincinnati, OH 45267, USA
    Placenta 25:259-65. 2004
    ..Our results suggest that mPGES could play a role in trophoblast invasion via its association with EVTs in the basal plate, whereas cPGES could be involved in apoptosis or repair mechanisms...
  40. ncbi Loss of proliferative capacity in a retroviral immortalized human uterine smooth muscle cell line derived from leiomyoma is restored by hTERT overexpression
    BaoJun Chang
    Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Reprod Sci 16:1062-71. 2009
    ..Our finding suggests that ULTR-hT cells can be a useful in vitro model for studying human myometrium differentiation both in pregnancy and pathological growth...
  41. ncbi Expression and localization of adipophilin and perilipin in human fetal membranes: association with lipid bodies and enzymes involved in prostaglandin synthesis
    Juliana W Meadows
    Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, Ohio 45267-0526, USA
    J Clin Endocrinol Metab 90:2344-50. 2005
    ..The structural and functional roles of adipophilin and perilipin in gestation and labor remain to be determined...
  42. ncbi Enhancement of glucocorticoid-induced 11beta-hydroxysteroid dehydrogenase type 1 expression by proinflammatory cytokines in cultured human amnion fibroblasts
    Kang Sun
    Department of Obtetrics and Gynecology, University of Cincinnaty, College of Medicine, Cincinnati, Ohio 45267, USA and Department of Physiology, Second Military Medical University, Shanghai 20004333, China
    Endocrinology 144:5568-77. 2003
    ..This study suggests that glucocorticoids can positively induce 11beta-HSD1 expression in amnion fibroblasts, an effect further strengthened by proinflammatory cytokines...
  43. ncbi The role of the placenta in pre-eclampsia--a workshop report
    Fiona Lyall
    Maternal and Fetal Medicine Section, Institute of Medical Genetics, Yorkhill, Glasgow, G3 8SJ, UK
    Placenta 23:S142-5. 2002
  44. ncbi Role of glucocorticoid receptor and CCAAT/enhancer-binding protein alpha in the feed-forward induction of 11beta-hydroxysteroid dehydrogenase type 1 expression by cortisol in human amnion fibroblasts
    Zhen Yang
    School of Life Sciences, Fudan University, 220 Handan Road, Shanghai 200433, People s Republic of China
    J Endocrinol 195:241-53. 2007
    ....
  45. ncbi The expression of interleukin-15 and interleukin-18 by human term placenta is not affected by lipopolysaccharide
    Alaa Amash
    Shraga Segal Department of Microbiology and Immunology and BGU Cancer Research Center, Beer Sheva, Israel
    Eur Cytokine Netw 18:188-94. 2007
    ..Moreover, our results indicate that IL-15 and IL-18 are not part of the mechanism of the response of human placenta to LPS...
  46. ncbi Paradox of glucocorticoid-induced cytosolic phospholipase A2 group IVA messenger RNA expression involves glucocorticoid receptor binding to the promoter in human amnion fibroblasts
    Chunming Guo
    School of Life Sciences, Fudan University, Shanghai, PR China
    Biol Reprod 78:193-7. 2008
    ....
  47. ncbi Glucocorticoids induce cytosolic phospholipase A2 and prostaglandin H synthase type 2 but not microsomal prostaglandin E synthase (PGES) and cytosolic PGES expression in cultured primary human amnion cells
    Kang Sun
    Department of Physiology, Second Military Medical University, Shanghai 200433, China
    J Clin Endocrinol Metab 88:5564-71. 2003
    ..Glucocorticoids increase PGE(2) production only in the amnion fibroblasts mainly through induction of cPLA(2) and PGHS-2 expression...
  48. ncbi Kaposi's sarcoma associated herpesvirus G-protein coupled receptor activation of cyclooxygenase-2 in vascular endothelial cells
    Bryan D Shelby
    Department of Microbiology and Immunology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Virol J 4:87. 2007
    ....
  49. ncbi Enhancement of cortisol-induced 11beta-hydroxysteroid dehydrogenase type 1 expression by interleukin 1beta in cultured human chorionic trophoblast cells
    Wenjiao Li
    School of Life Sciences, The First Maternal and Fetal Care Hospital, Fudan University, Shanghai, China
    Endocrinology 147:2490-5. 2006
    ....