L Myatt

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint Role of fetal membranes in signaling of fetal maturation and parturition
    Leslie Myatt
    Dept of Obstetrics and Gynecology, University of Texas Health Science Center San Antonio, USA
    Int J Dev Biol 54:545-53. 2010
  2. ncbi request reprint Effect of Preeclampsia on Placental Function: Influence of Sexual Dimorphism, microRNA's and Mitochondria
    Leslie Myatt
    Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health Science Center San Antonio, San Antonio, TX, 78229 3900, USA
    Adv Exp Med Biol 814:133-46. 2014
  3. ncbi request reprint Strategy for standardization of preeclampsia research study design
    Leslie Myatt
    Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health Science Center, San Antonio, Mail Code 7836, 7703 Floyd Curl Dr, San Antonio, TX 78229
    Hypertension 63:1293-301. 2014
  4. pmc The utility of uterine artery Doppler velocimetry in prediction of preeclampsia in a low-risk population
    Leslie Myatt
    Department of Obstetrics, University of Cincinnati, Cincinnati, Ohio, USA
    Obstet Gynecol 120:815-22. 2012
  5. pmc First-trimester prediction of preeclampsia in nulliparous women at low risk
    Leslie Myatt
    Department of Obstetrics and Gynecology of the University of Cincinnati, Cincinnati, OH, USA
    Obstet Gynecol 119:1234-42. 2012
  6. doi request reprint A standardized template for clinical studies in preterm birth
    Leslie Myatt
    Department of Obstetrics and Gynecology, University of Texas Health Science Center San Antonio, San Antonio, TX 78229 3900, USA
    Reprod Sci 19:474-82. 2012
  7. pmc Review: Reactive oxygen and nitrogen species and functional adaptation of the placenta
    L Myatt
    Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health Science Center San Antonio, Mail Code 7836, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Placenta 31:S66-9. 2010
  8. ncbi request reprint Nitration of p38 MAPK in the placenta: association of nitration with reduced catalytic activity of p38 MAPK in pre-eclampsia
    R P Webster
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267 0526, USA
    Mol Hum Reprod 12:677-85. 2006
  9. ncbi request reprint Oxidative stress causes vascular dysfunction in the placenta
    L Myatt
    Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Ohio 45267 0526, USA
    J Matern Fetal Med 9:79-82. 2000
  10. pmc Effect of increasing maternal body mass index on oxidative and nitrative stress in the human placenta
    V H J Roberts
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0526, USA
    Placenta 30:169-75. 2009

Research Grants

  1. REGULATION OF PROSTAGLANDIN RECEPTORS IN MYOMETRIUM
    Leslie Myatt; Fiscal Year: 2005
  2. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2005
  3. REGULATION OF PHOSPHOLIPASE A2 IN HUMAN AMNION
    Leslie Myatt; Fiscal Year: 2006
  4. REGULATION OF PROSTAGLANDIN RECEPTORS IN MYOMETRIUM
    Leslie Myatt; Fiscal Year: 2006
  5. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2006
  6. REGULATION OF PHOSPHOLIPASE A2 IN HUMAN AMNION
    Leslie Myatt; Fiscal Year: 2007
  7. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2007
  8. REGULATION OF PHOSPHOLIPASE A2 IN HUMAN AMNION
    Leslie Myatt; Fiscal Year: 2009
  9. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2009
  10. REGULATION OF PHOSPHOLIPASE A2 IN HUMAN AMNION
    Leslie Myatt; Fiscal Year: 2009

Detail Information

Publications26

  1. ncbi request reprint Role of fetal membranes in signaling of fetal maturation and parturition
    Leslie Myatt
    Dept of Obstetrics and Gynecology, University of Texas Health Science Center San Antonio, USA
    Int J Dev Biol 54:545-53. 2010
    ..This positive feedback loop would produce abundant biologically active glucocorticoids and prostaglandins in the fetal membranes or amniotic fluid, which would ultimately promote fetal organ maturation and initiate parturition...
  2. ncbi request reprint Effect of Preeclampsia on Placental Function: Influence of Sexual Dimorphism, microRNA's and Mitochondria
    Leslie Myatt
    Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health Science Center San Antonio, San Antonio, TX, 78229 3900, USA
    Adv Exp Med Biol 814:133-46. 2014
    ..This placental dysfunction may lead to a fetal programming effect that results in disease in later life. ..
  3. ncbi request reprint Strategy for standardization of preeclampsia research study design
    Leslie Myatt
    Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health Science Center, San Antonio, Mail Code 7836, 7703 Floyd Curl Dr, San Antonio, TX 78229
    Hypertension 63:1293-301. 2014
    ....
  4. pmc The utility of uterine artery Doppler velocimetry in prediction of preeclampsia in a low-risk population
    Leslie Myatt
    Department of Obstetrics, University of Cincinnati, Cincinnati, Ohio, USA
    Obstet Gynecol 120:815-22. 2012
    ..We estimated whether uterine artery Doppler measurements made in the early second trimester would predict the subsequent development of preeclampsia...
  5. pmc First-trimester prediction of preeclampsia in nulliparous women at low risk
    Leslie Myatt
    Department of Obstetrics and Gynecology of the University of Cincinnati, Cincinnati, OH, USA
    Obstet Gynecol 119:1234-42. 2012
    ..To identify clinical characteristics and biochemical markers in first-trimester samples that would possibly predict the subsequent development of preeclampsia...
  6. doi request reprint A standardized template for clinical studies in preterm birth
    Leslie Myatt
    Department of Obstetrics and Gynecology, University of Texas Health Science Center San Antonio, San Antonio, TX 78229 3900, USA
    Reprod Sci 19:474-82. 2012
    ..This article provides a harmonized open-source template for designing clinical studies addressing preterm birth...
  7. pmc Review: Reactive oxygen and nitrogen species and functional adaptation of the placenta
    L Myatt
    Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health Science Center San Antonio, Mail Code 7836, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Placenta 31:S66-9. 2010
    ..As protein carbonylation is a covalent modification at Lys, Arg, Pro and Thr residues the switch from carbonylation to nitration at tyrosine residues may alter protein function and hence placental function...
  8. ncbi request reprint Nitration of p38 MAPK in the placenta: association of nitration with reduced catalytic activity of p38 MAPK in pre-eclampsia
    R P Webster
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267 0526, USA
    Mol Hum Reprod 12:677-85. 2006
    ..Comparison of peptide masses of a 42-kDa protein obtained by mass spectrometry with masses of a theoretical tryptic digest of p38 MAPK that was modified by phosphorylation and nitration identified the protein to be p38 MAPK...
  9. ncbi request reprint Oxidative stress causes vascular dysfunction in the placenta
    L Myatt
    Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Ohio 45267 0526, USA
    J Matern Fetal Med 9:79-82. 2000
    ....
  10. pmc Effect of increasing maternal body mass index on oxidative and nitrative stress in the human placenta
    V H J Roberts
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0526, USA
    Placenta 30:169-75. 2009
    ..There may be a shift in the balance between nitrative and oxidative stress, which may be a protective mechanism for the placenta...
  11. ncbi request reprint The action of nitric oxide in the perfused human fetal-placental circulation
    L Myatt
    Department of Obstetrics and Gynecology, University of Cincinnati, OH 45267
    Am J Obstet Gynecol 164:687-92. 1991
    ..These compounds had no effect in the absence of the vasoconstrictor. Thus it appears that the placental villus tree has the ability to both generate and respond to nitric oxide...
  12. ncbi request reprint Nitrotyrosine residues in placenta. Evidence of peroxynitrite formation and action
    L Myatt
    Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, OH 45267 0526, USA
    Hypertension 28:488-93. 1996
    ..The presence of nitrotyrosine residues, particularly in the endothelium, may indicate the formation and action of peroxynitrite, resulting in vascular damage that contributes to the increased placental vascular resistance...
  13. pmc Protein nitration in placenta - functional significance
    R P Webster
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, PO Box 670526, Cincinnati, OH 45267, USA
    Placenta 29:985-94. 2008
    ..The targets and extent of nitration of enzymes, receptors, transporters and structural proteins may markedly influence placental cellular function in both physiologic and pathologic settings...
  14. pmc Evidence of sexual dimorphism in the placental function with severe preeclampsia
    S Muralimanoharan
    Center for Pregnancy and Newborn Research, Dept of Ob Gyn, University of Texas Health Science Center San Antonio, San Antonio, TX 78229, USA
    Placenta 34:1183-9. 2013
    ..We propose that the transcription factor NFκB p65 might, at least partially, be involved in sexual dimorphism during PE. ..
  15. ncbi request reprint The interaction of nitric oxide and superoxide in the human fetal-placental vasculature
    G Holcberg
    Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, OH 45267 0526, USA
    Am J Obstet Gynecol 173:528-33. 1995
    ..CONCLUSION: We conclude that, rather than superoxide inactivating nitric oxide, interaction of the two radicals generates in the placental vasculature a vasodilator, which may be peroxynitrite...
  16. ncbi request reprint Nitrotyrosine immunostaining correlates with increased extracellular matrix: evidence of postplacental hypoxia
    J Stanek
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0529, USA
    Placenta 22:S56-62. 2001
    ..NT immunostaining may therefore help differentiate those cases of perinatal morbidity/mortality associated with post-placental hypoxia provided that the secondary impact of intrauterine fetal death can be excluded by future studies...
  17. pmc Can changes in angiogenic biomarkers between the first and second trimesters of pregnancy predict development of pre-eclampsia in a low-risk nulliparous patient population?
    L Myatt
    Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, OH, USA
    BJOG 120:1183-91. 2013
    ..To determine if change in maternal angiogenic biomarkers between the first and second trimesters predicts pre-eclampsia in low-risk nulliparous women...
  18. pmc MIR-210 modulates mitochondrial respiration in placenta with preeclampsia
    S Muralimanoharan
    Center for Pregnancy and Newborn Research, Dept of Ob Gyn, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Placenta 33:816-23. 2012
    ..These data collectively suggest that miR-210 overexpression during PE could be responsible for placental mitochondria dysfunction...
  19. doi request reprint Placental amino acid transport and placental leptin resistance in pregnancies complicated by maternal obesity
    D M Farley
    Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Texas Health Science Center at San Antonio, Texas 78229 3900, USA
    Placenta 31:718-24. 2010
    ..Our objectives were to study placental amino acid transport and the effect of leptin on placental amino acid transport in vitro in the setting of maternal obesity...
  20. doi request reprint Vascular biology of preeclampsia
    L Myatt
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267 0526, USA
    J Thromb Haemost 7:375-84. 2009
    ..Preexisting maternal vascular dysfunction intensified by placental factors is possibly responsible for the individual pathologies of preeclampsia...
  21. ncbi request reprint Determination of non-bilayer phospholipid arrangements and their antibodies in placentae and sera of patients with hypertensive disorders of pregnancy
    B Campos
    Department of Obstetrics and Gynecology, College of Medicine, University of Cincinnati, 231 Albert Sabin, Cincinnati, OH 45267 0526, USA
    Placenta 27:215-24. 2006
    ..This suggests that NPA derived from placenta could be one of multiple factors associated with pregnancy pathologies...
  22. ncbi request reprint Nitric oxide synthase activity in umbilical and placental vascular tissue of gestational diabetic pregnancies
    S Dollberg
    Department of Pediatrics, University of Cincinnati College of Medicine, Ohio, USA
    Gynecol Obstet Invest 44:177-81. 1997
    ..Nitric oxide (NO) synthase activity in the fetal-placental vasculature of gestational diabetic pregnancies was compared to non-diabetic controls...
  23. pmc Measurement of mitochondrial respiration in trophoblast culture
    A Maloyan
    Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, University of Texas Health Science Center San Antonio, Mail Code 7836, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Placenta 33:456-8. 2012
    ..However, this does not provide a complete physiological readout of mitochondrial function. This technical note describes a method to measure respiratory function in intact primary syncytiotrophoblast from human term placenta...
  24. pmc Expression of NADPH oxidase isoform 1 (Nox1) in human placenta: involvement in preeclampsia
    X L Cui
    Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, PO Box 670526, 231 Albert Sabin Way, Cincinnati, OH 45267 0526, USA
    Placenta 27:422-31. 2006
    ..Western blot analysis of whole placental homogenate confirmed this increase. Our data suggests that increased Nox1 expression is associated with the increased oxidative stress found in these placentas...
  25. ncbi request reprint Expression and localization of the contractile prostaglandin F receptor in pregnant rat myometrium in late gestation, labor, and postpartum
    H Y Al-Matubsi
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267-0526, USA
    Biol Reprod 65:1029-37. 2001
    ..Our study suggests an increase in FP-receptor protein in myometrium with advancing gestation and a marked elevation at term. This supports a role for uterine FP receptors in mediation of uterine contractility at term...
  26. ncbi request reprint Post-Translational Modifications of the P2X(4) purinergic receptor subtype in the human placenta are altered in preeclampsia
    V H J Roberts
    Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0526, USA
    Placenta 28:270-7. 2007
    ..We also propose that the post-translational modifications of nitration and glycosylation are required for the normal functioning of P2X(4)...

Research Grants29

  1. REGULATION OF PROSTAGLANDIN RECEPTORS IN MYOMETRIUM
    Leslie Myatt; Fiscal Year: 2005
    ..The confocal microscopy will provide information on cellular localization of receptors and the promoter analyses will reveal potential regulatory sites for control of expression of uterine receptors at parturition. ..
  2. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2005
    ..We will use site-directed mutagenesis to identify the tyrosine residues that are nitrated in p38 MAP kinase and the functional significance of this. ..
  3. REGULATION OF PHOSPHOLIPASE A2 IN HUMAN AMNION
    Leslie Myatt; Fiscal Year: 2006
    ..abstract_text> ..
  4. REGULATION OF PROSTAGLANDIN RECEPTORS IN MYOMETRIUM
    Leslie Myatt; Fiscal Year: 2006
    ..The confocal microscopy will provide information on cellular localization of receptors and the promoter analyses will reveal potential regulatory sites for control of expression of uterine receptors at parturition. ..
  5. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2006
    ..We will use site-directed mutagenesis to identify the tyrosine residues that are nitrated in p38 MAP kinase and the functional significance of this. ..
  6. REGULATION OF PHOSPHOLIPASE A2 IN HUMAN AMNION
    Leslie Myatt; Fiscal Year: 2007
    ..abstract_text> ..
  7. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2007
    ..We will use site-directed mutagenesis to identify the tyrosine residues that are nitrated in p38 MAP kinase and the functional significance of this. ..
  8. REGULATION OF PHOSPHOLIPASE A2 IN HUMAN AMNION
    Leslie Myatt; Fiscal Year: 2009
    ..abstract_text> ..
  9. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2009
    ....
  10. REGULATION OF PHOSPHOLIPASE A2 IN HUMAN AMNION
    Leslie Myatt; Fiscal Year: 2009
    ..abstract_text> ..
  11. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2004
    ..We will use site-directed mutagenesis to identify the tyrosine residues that are nitrated in p38 MAP kinase and the functional significance of this. ..
  12. REGULATION OF PROSTAGLANDIN RECEPTORS IN MYOMETRIUM
    Leslie Myatt; Fiscal Year: 2004
    ..The confocal microscopy will provide information on cellular localization of receptors and the promoter analyses will reveal potential regulatory sites for control of expression of uterine receptors at parturition. ..
  13. REGULATION OF PHOSPHOLIPASE A2 IN HUMAN AMNION
    Leslie Myatt; Fiscal Year: 2003
    ..This study will provide novel data on phosphorylation and activation of cPLA2 in human amnion tissue and further define the role of this crucial regulatory step in eicosanoid synthesis in the fetal membranes at parturition. ..
  14. NITRIC OXIDE AND SUPEROXIDE INTERACTIONS IN THE PLACENTA
    Leslie Myatt; Fiscal Year: 1999
    ..5. Expression of mRNA and protein for SOD isoforms, xanthine oxidase and the cytochrome b558 subunit of NADPH oxidase in normal and pathologic placental tissues using RT-PCR and immunohistochemistry. ..
  15. NITRIC OXIDE AND SUPEROXIDE INTERACTIONS IN THE PLACENTA
    Leslie Myatt; Fiscal Year: 2000
    ..5. Expression of mRNA and protein for SOD isoforms, xanthine oxidase and the cytochrome b558 subunit of NADPH oxidase in normal and pathologic placental tissues using RT-PCR and immunohistochemistry. ..
  16. REGULATION OF PHOSPHOLIPASE A2 IN HUMAN AMNION
    Leslie Myatt; Fiscal Year: 2000
    ..This study will provide novel data on phosphorylation and activation of cPLA2 in human amnion tissue and further define the role of this crucial regulatory step in eicosanoid synthesis in the fetal membranes at parturition. ..
  17. NITRIC OXIDE AND SUPEROXIDE INTERACTIONS IN THE PLACENTA
    Leslie Myatt; Fiscal Year: 2001
    ..5. Expression of mRNA and protein for SOD isoforms, xanthine oxidase and the cytochrome b558 subunit of NADPH oxidase in normal and pathologic placental tissues using RT-PCR and immunohistochemistry. ..
  18. REGULATION OF PHOSPHOLIPASE A2 IN HUMAN AMNION
    Leslie Myatt; Fiscal Year: 2001
    ..This study will provide novel data on phosphorylation and activation of cPLA2 in human amnion tissue and further define the role of this crucial regulatory step in eicosanoid synthesis in the fetal membranes at parturition. ..
  19. REGULATION OF PROSTAGLANDIN RECEPTORS IN MYOMETRIUM
    Leslie Myatt; Fiscal Year: 2002
    ..The confocal microscopy will provide information on cellular localization of receptors and the promoter analyses will reveal potential regulatory sites for control of expression of uterine receptors at parturition. ..
  20. NITRIC OXIDE AND SUPEROXIDE INTERACTIONS IN THE PLACENTA
    Leslie Myatt; Fiscal Year: 2002
    ..5. Expression of mRNA and protein for SOD isoforms, xanthine oxidase and the cytochrome b558 subunit of NADPH oxidase in normal and pathologic placental tissues using RT-PCR and immunohistochemistry. ..
  21. REGULATION OF PHOSPHOLIPASE A2 IN HUMAN AMNION
    Leslie Myatt; Fiscal Year: 2002
    ..This study will provide novel data on phosphorylation and activation of cPLA2 in human amnion tissue and further define the role of this crucial regulatory step in eicosanoid synthesis in the fetal membranes at parturition. ..
  22. REGULATION OF PROSTAGLANDIN RECEPTORS IN MYOMETRIUM
    Leslie Myatt; Fiscal Year: 2003
    ..The confocal microscopy will provide information on cellular localization of receptors and the promoter analyses will reveal potential regulatory sites for control of expression of uterine receptors at parturition. ..
  23. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2010
    ....