CHARLES MURRY

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Evidence that gene activation and silencing during stem cell differentiation requires a transcriptionally paused intermediate state
    Jonathan L Golob
    Department of Pathology, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e22416. 2011
  2. ncbi request reprint Platelet-derived growth factor-A mRNA expression in fetal, normal adult, and atherosclerotic human aortas. Analysis by competitive polymerase chain reaction
    C E Murry
    Department of Pathology, University of Washington, School of Medicine, Seattle, WA 98195, USA
    Circulation 93:1095-106. 1996
  3. ncbi request reprint Regeneration gaps: observations on stem cells and cardiac repair
    Charles E Murry
    Center for Cardiovascular Biology and Regenerative Medicine, University of Washington, Seattle, Washington 98109, USA
    J Am Coll Cardiol 47:1777-85. 2006
  4. ncbi request reprint Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts
    Charles E Murry
    Department of Pathology, Box 357470, Room D 514 HSB, University of Washington, Seattle, Washington 98195, USA
    Nature 428:664-8. 2004
  5. ncbi request reprint Cell-based cardiac repair: reflections at the 10-year point
    Charles E Murry
    Center for Cardiovascular Biology and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA
    Circulation 112:3174-83. 2005
  6. pmc Monoclonality of smooth muscle cells in human atherosclerosis
    C E Murry
    Department of Pathology, University of Washington, Seattle 98195, USA
    Am J Pathol 151:697-705. 1997
  7. pmc Skeletal myoblast transplantation for repair of myocardial necrosis
    C E Murry
    Department of Pathology, University of Washington School of Medicine, Seattle 98195, USA
    J Clin Invest 98:2512-23. 1996
  8. pmc Muscle differentiation during repair of myocardial necrosis in rats via gene transfer with MyoD
    C E Murry
    Department of Pathology, University of Washington, Seattle 98195, USA
    J Clin Invest 98:2209-17. 1996
  9. ncbi request reprint Myogenic fusion of human bone marrow stromal cells, but not hematopoietic cells
    Daqing Shi
    Fred Hutchinson Cancer Research Center, Division of Clinical Research, and Department of Pathology, University of Washington, Seattle, USA
    Blood 104:290-4. 2004
  10. pmc Ferritin overexpression for noninvasive magnetic resonance imaging-based tracking of stem cells transplanted into the heart
    Anna V Naumova
    Department of Radiology, University of Washington, Seattle, WA 98109, USA
    Mol Imaging 9:201-10. 2010

Research Grants

  1. CARDIAC GRAFTS--SKELETAL MYOBLASTS
    CHARLES MURRY; Fiscal Year: 1999
  2. Cell-Based Cardiac Repair
    CHARLES MURRY; Fiscal Year: 2009
  3. Cell-Based Cardiac Repair
    CHARLES MURRY; Fiscal Year: 2007
  4. CARDIAC GRAFTS--SKELETAL MYOBLASTS
    CHARLES MURRY; Fiscal Year: 2005
  5. CARDIAC GRAFTS-SKELETAL MYOBLASTS - Stem Cell Supplement
    CHARLES MURRY; Fiscal Year: 2003
  6. CARDIAC GRAFTS--SKELETAL MYOBLASTS
    CHARLES MURRY; Fiscal Year: 2004
  7. CARDIAC GRAFTS--SKELETAL MYOBLASTS
    CHARLES MURRY; Fiscal Year: 2003
  8. CARDIAC GRAFTS--SKELETAL MYOBLASTS
    CHARLES MURRY; Fiscal Year: 2002
  9. CARDIAC GRAFTS--SKELETAL MYOBLASTS
    CHARLES MURRY; Fiscal Year: 2001
  10. CARDIAC GRAFTS--SKELETAL MYOBLASTS
    CHARLES MURRY; Fiscal Year: 2000

Collaborators

Detail Information

Publications53

  1. pmc Evidence that gene activation and silencing during stem cell differentiation requires a transcriptionally paused intermediate state
    Jonathan L Golob
    Department of Pathology, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e22416. 2011
    ..These findings indicate that the paused state may be the major transition state for genes changing expression during differentiation, and implicate control of transcriptional elongation as a key checkpoint in lineage specification...
  2. ncbi request reprint Platelet-derived growth factor-A mRNA expression in fetal, normal adult, and atherosclerotic human aortas. Analysis by competitive polymerase chain reaction
    C E Murry
    Department of Pathology, University of Washington, School of Medicine, Seattle, WA 98195, USA
    Circulation 93:1095-106. 1996
    ..We tested whether platelet-derived growth factor-A (PDGF-A) mRNA levels correlated with cell proliferation in developing aorta, normal adult aorta, and atherosclerotic plaques...
  3. ncbi request reprint Regeneration gaps: observations on stem cells and cardiac repair
    Charles E Murry
    Center for Cardiovascular Biology and Regenerative Medicine, University of Washington, Seattle, Washington 98109, USA
    J Am Coll Cardiol 47:1777-85. 2006
    ..In this commentary, we briefly review the evolution of cell-based cardiac repair, discuss the current state of clinical research, and offer some thoughts on how newcomers can critically evaluate this emerging field...
  4. ncbi request reprint Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts
    Charles E Murry
    Department of Pathology, Box 357470, Room D 514 HSB, University of Washington, Seattle, Washington 98195, USA
    Nature 428:664-8. 2004
    ..These results indicate that haematopoietic stem cells do not readily acquire a cardiac phenotype, and raise a cautionary note for clinical studies of infarct repair...
  5. ncbi request reprint Cell-based cardiac repair: reflections at the 10-year point
    Charles E Murry
    Center for Cardiovascular Biology and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA
    Circulation 112:3174-83. 2005
  6. pmc Monoclonality of smooth muscle cells in human atherosclerosis
    C E Murry
    Department of Pathology, University of Washington, Seattle 98195, USA
    Am J Pathol 151:697-705. 1997
    ..The finding that normal arteries may have large X inactivation patches raises the possibility that plaque monoclonality may arise by expanding a pre-existing clone of cells rather than generating a new clone by mutation or selection...
  7. pmc Skeletal myoblast transplantation for repair of myocardial necrosis
    C E Murry
    Department of Pathology, University of Washington School of Medicine, Seattle 98195, USA
    J Clin Invest 98:2512-23. 1996
    ..Because the grafts convert to fatigue-resistant, slow twitch fibers, this new muscle may be suited to a cardiac work load...
  8. pmc Muscle differentiation during repair of myocardial necrosis in rats via gene transfer with MyoD
    C E Murry
    Department of Pathology, University of Washington, Seattle 98195, USA
    J Clin Invest 98:2209-17. 1996
    ..Thus, MyoD gene transfer can induce skeletal muscle differentiation in healing heart lesions. Modifications of this strategy might eventually provide new contractile tissue to repair myocardial infarcts...
  9. ncbi request reprint Myogenic fusion of human bone marrow stromal cells, but not hematopoietic cells
    Daqing Shi
    Fred Hutchinson Cancer Research Center, Division of Clinical Research, and Department of Pathology, University of Washington, Seattle, USA
    Blood 104:290-4. 2004
    ..These data suggest that marrow-derived cells contribute to myogenesis through fusion and that stromal cells are better fusion partners than hematopoietic cells...
  10. pmc Ferritin overexpression for noninvasive magnetic resonance imaging-based tracking of stem cells transplanted into the heart
    Anna V Naumova
    Department of Radiology, University of Washington, Seattle, WA 98109, USA
    Mol Imaging 9:201-10. 2010
    ..These experiments lay the groundwork for using the MRI gene reporter ferritin to track stem cells transplanted to the heart...
  11. ncbi request reprint Cell grafting for cardiac repair
    Hans Reinecke
    Department of Pathology, University of Washington School of Medicine, Seattle, USA
    Methods Mol Biol 219:97-112. 2003
  12. ncbi request reprint Regenerating the heart
    Michael A Laflamme
    Department of Pathology, Center for Cardiovascular Biology and Regenerative Medicine, University of Washington, 815 Mercer Street, Seattle, Washington 98109, USA
    Nat Biotechnol 23:845-56. 2005
    ....
  13. pmc Absence of regeneration in the MRL/MpJ mouse heart following infarction or cryoinjury
    Thomas E Robey
    Department of Bioengineering and Pathology, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA
    Cardiovasc Pathol 17:6-13. 2008
    ..Other groups have reported that permanent and temporary ligation of the coronary artery resulted in scarring without regeneration...
  14. ncbi request reprint Evidence for fusion between cardiac and skeletal muscle cells
    Hans Reinecke
    Department of Pathology, University of Washington, Box 357470, HSB Room D 514 Seattle, Wash 98195 7470, USA
    Circ Res 94:e56-60. 2004
    ..The full text of this article is available online at http://circres.ahajournals.org...
  15. ncbi request reprint Cell-based therapy for myocardial ischemia and infarction: pathophysiological mechanisms
    Michael A Laflamme
    Department of Pathology, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98109, USA
    Annu Rev Pathol 2:307-39. 2007
    ..We review the evidence for potential mechanisms underlying the benefits of cell transplantation in the heart and discuss the clinical contexts in which they may be relevant...
  16. pmc Cell therapy enhances function of remote non-infarcted myocardium
    Alicia Moreno-Gonzalez
    Department of Bioengineering, University of Washington, Seattle, WA 98195 7962, USA
    J Mol Cell Cardiol 47:603-13. 2009
    ..Because the volume of remote myocardium greatly exceeds that of the grafts, this enhanced calcium sensitivity may be a major contributor to global improvements in ventricular function after cell transplantation...
  17. ncbi request reprint Immunohistologic labeling of murine endothelium
    Jitka A Ismail
    Department of Pathology, Box 357470, Room D 514, Health Sciences Building, University of Washington, 1959 Pacific St NE, Seattle, WA 98195, USA
    Cardiovasc Pathol 12:82-90. 2003
    ..With the rising use of mouse models of disease and genetic manipulation, a consistent system to label murine endothelial cells in normal and diseased tissues would be an invaluable tool...
  18. pmc The role of macrophage-derived urokinase plasminogen activator in myocardial infarct repair: urokinase attenuates ventricular remodeling
    Elina Minami
    University of Washington School of Medicine, Division of Cardiology, Seattle, WA 98195, USA
    J Mol Cell Cardiol 49:516-24. 2010
    ..We hypothesize that plasmin generation in the heart in response to injury may induce activation of macrophages to a profibrotic phenotype to allow rapid formation of collagenous scar...
  19. ncbi request reprint Skeletal muscle stem cells do not transdifferentiate into cardiomyocytes after cardiac grafting
    Hans Reinecke
    Department of Pathology, University of Washington, Seattle, Washington 98195 7335, USA
    J Mol Cell Cardiol 34:241-9. 2002
    ..In conclusion, satellite cells differentiate into mature skeletal muscle and do not express cardiac-specific genes after grafting into the heart. Thus, transdifferentiation into cardiomyocytes did not occur...
  20. ncbi request reprint Gene transfer of connexin43 into skeletal muscle
    Hans Reinecke
    Department of Pathology, University of Washington, Seattle, 98195, USA
    Hum Gene Ther 15:627-36. 2004
    ..This strategy may permit electrical coupling of skeletal and cardiac muscle for cardiac repair...
  21. ncbi request reprint Evidence for cardiomyocyte repopulation by extracardiac progenitors in transplanted human hearts
    Michael A Laflamme
    Department of Pathology, University of Washington, Seattle, Washington, USA
    Circ Res 90:634-40. 2002
    ..quot; Thus, adult humans have extracardiac progenitor cells capable of migrating to and repopulating damaged myocardium, but this process occurs at very low levels...
  22. ncbi request reprint Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response
    Jeannette Nussbaum
    Department of Pathology, University of Washington, Seattle, WA, USA
    FASEB J 21:1345-57. 2007
    ..Successful cardiac repair strategies involving ES cells will need to control cardiac differentiation, avoid introducing undifferentiated cells, and will likely require immune modulation to avoid rejection...
  23. ncbi request reprint Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts
    Michael A Laflamme
    Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 815 Mercer Street, Seattle, WA 98109, USA
    Nat Biotechnol 25:1015-24. 2007
    ..The ability of hES cell-derived cardiomyocytes to partially remuscularize myocardial infarcts and attenuate heart failure encourages their study under conditions that closely match human disease...
  24. pmc Fibroblast growth factor-2 regulates myocardial infarct repair: effects on cell proliferation, scar contraction, and ventricular function
    Jitka A I Virag
    Department of Pathology, University of Washington, Seattle, Washington, USA
    Am J Pathol 171:1431-40. 2007
    ..FGF2 may be more important in healing of infarcts compared with skin wounds because of the mechanical stress under which infarcts heal...
  25. pmc Formation of human myocardium in the rat heart from human embryonic stem cells
    Michael A Laflamme
    Department of Pathology, University of Washington, Seattle, WA 98109, USA
    Am J Pathol 167:663-71. 2005
    ..Thus, hESCs can form human myocardium in the rat heart, permitting studies of human myocardial development and physiology and supporting the feasibility of their use in myocardial repair...
  26. ncbi request reprint Chemical dimerization of fibroblast growth factor receptor-1 induces myoblast proliferation, increases intracardiac graft size, and reduces ventricular dilation in infarcted hearts
    Kelly R Stevens
    Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
    Hum Gene Ther 18:401-12. 2007
    ..Control of intramyocardial graft size by this approach may allow optimization of cell-based therapy to obtain desired cardiac function postinfarction...
  27. ncbi request reprint Muscle cell grafting for the treatment and prevention of heart failure
    Charles E Murry
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Card Fail 8:S532-41. 2002
    ..The review aims to highlight recent advances in cardiac and skeletal muscle cell grafting for myocardial infarct repair...
  28. pmc Proangiogenic scaffolds as functional templates for cardiac tissue engineering
    Lauran R Madden
    Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:15211-6. 2010
    ....
  29. pmc Scaffold-free human cardiac tissue patch created from embryonic stem cells
    Kelly R Stevens
    Department of Bioengineering, University of Washington, Seattle, Washington, USA
    Tissue Eng Part A 15:1211-22. 2009
    ..These novel scaffold-free human myocardial patches address critical challenges related to human cell sourcing and tissue fabrication that previously inhibited progress in cardiac tissue engineering...
  30. pmc Myofibroblast and endothelial cell proliferation during murine myocardial infarct repair
    Jitka Ismail Virag
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    Am J Pathol 163:2433-40. 2003
    ..This provides the basis for identifying the responsible molecules and developing strategies to alter wound repair and improve cardiac function...
  31. ncbi request reprint In vitro generation of differentiated cardiac myofibers on micropatterned laminin surfaces
    Todd C McDevitt
    Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
    J Biomed Mater Res 60:472-9. 2002
    ..Such highly patterned cultures could be used in cell biology and physiology studies, which require accurate reproduction of native myocardial architecture...
  32. ncbi request reprint Extracardiac progenitor cells repopulate most major cell types in the transplanted human heart
    Elina Minami
    Division of Cardiology, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA
    Circulation 112:2951-8. 2005
    ..Here, we explored the extent of endothelial, smooth muscle, and Schwann cell chimerism in patients with sex-mismatched (female-to-male) heart transplants...
  33. pmc Proliferation of cardiomyocytes derived from human embryonic stem cells is mediated via the IGF/PI 3-kinase/Akt signaling pathway
    Todd C McDevitt
    Center for Cardiovascular Biology and Regenerative Medicine, University of Washington, 815 Mercer Street, Seattle, WA 98109, USA
    J Mol Cell Cardiol 39:865-73. 2005
    ..This system should permit identification of regulatory pathways for human cardiomyocyte proliferation and may facilitate expansion of cardiomyocytes from human ES cells for therapeutic purposes...
  34. ncbi request reprint NFATc3-induced reductions in voltage-gated K+ currents after myocardial infarction
    Charles F Rossow
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    Circ Res 94:1340-50. 2004
    ..We propose that increased beta-adrenergic signaling after MI activates calcineurin and NFATc3, which decreases I(to), I(Kslow1), and I(Kslow2) via a reduction in Kv1.5, Kv2.1, Kv4.2, and Kv4.3 expression...
  35. pmc Chromatin remodeling during mouse and human embryonic stem cell differentiation
    Jonathan L Golob
    Department of Pathology, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98109, USA
    Dev Dyn 237:1389-98. 2008
    ....
  36. pmc Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells
    Sharon L Paige
    Department of Pathology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 5:e11134. 2010
    ..Our group has developed an efficient protocol to generate cardiomyocytes from human embryonic stem (ES) cells via induction with activin A and BMP4...
  37. doi request reprint Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development
    Charles E Murry
    Departments of Pathology and Bioengineering, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA
    Cell 132:661-80. 2008
    ..The next challenge will be to demonstrate the functional utility of these cells, both in vitro and in preclinical models of human disease...
  38. ncbi request reprint rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice
    Paul Gregorevic
    Department of Neurology, Senator Paul D Wellstone Muscular Dystrophy Cooperative Research Center, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA
    Nat Med 12:787-9. 2006
    ..These findings suggest rAAV vector-mediated systemic gene transfer may be useful for treatment of serious neuromuscular disorders such as Duchenne muscular dystrophy...
  39. ncbi request reprint Intracoronary E-/L-selectin blockade reduces neutrophil infiltration in heart transplantation
    Yvonne M Carter
    Department of Surgery, University of Washington, Seattle, Washington, USA
    Ann Thorac Surg 74:2064-70; discussion 2070-1. 2002
    ..This study examined the effect of local intracoronary delivery of a unique monoclonal antibody (mAb) to both E- and L-selectin (EL-246) on neutrophil infiltration after global ischemia during cardiac transplantation...
  40. pmc Biphasic role for Wnt/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cells
    Shuichi Ueno
    Department of Pathology, Center for Cardiovascular Biology, University of Washington School of Medicine, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 104:9685-90. 2007
    ..Thus, Wnt/beta-catenin signaling promotes cardiac differentiation at early developmental stages and inhibits it later. Control of this pathway may promote derivation of cardiomyocytes for basic research and cell therapy applications...
  41. pmc Growth of engineered human myocardium with mechanical loading and vascular coculture
    Nathaniel L Tulloch
    Molecular and Cellular Biology Program, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 815 Mercer St, Seattle, WA 98109, USA
    Circ Res 109:47-59. 2011
    ..The developing heart requires both mechanical load and vascularization to reach its proper size, yet the regulation of human heart growth by these processes is poorly understood...
  42. pmc VEGF induces differentiation of functional endothelium from human embryonic stem cells: implications for tissue engineering
    Marilyn B Nourse
    Arra and Eva Woods Professor of Pathology and Bioengineering, Director, Center for Cardiovascular Biology, Codirector, Institute for Stem Cell and Regenerative Medicine, University of Washington, 815 Mercer Street, Room 453 Brotman Building, Seattle, WA 98109, USA
    Arterioscler Thromb Vasc Biol 30:80-9. 2010
    ..We endeavored to induce and isolate functional endothelial cells from differentiating hESCs...
  43. ncbi request reprint Spatially organized layers of cardiomyocytes on biodegradable polyurethane films for myocardial repair
    Todd C McDevitt
    Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
    J Biomed Mater Res A 66:586-95. 2003
    ..This approach may serve as a novel method for transplantation of organized cardiac tissue constructs to the heart for myocardial repair...
  44. pmc Systems approaches to preventing transplanted cell death in cardiac repair
    Thomas E Robey
    Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
    J Mol Cell Cardiol 45:567-81. 2008
    ..CEPO's effects were additive to heat shock, implying independent survival pathways. This system should permit combinatorial approaches to enhance graft viability in a fraction of the time required for conventional histology...
  45. doi request reprint A hierarchical network controls protein translation during murine embryonic stem cell self-renewal and differentiation
    Prabha Sampath
    Department of Pathology, Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA
    Cell Stem Cell 2:448-60. 2008
    ..Parsimonious translation in pluripotent state and hierarchical translational regulation during differentiation may be important quality controls for self-renewal and choice of fate in ESCs...
  46. doi request reprint Retention and biodistribution of microspheres injected into ischemic myocardium
    Jeff N Anderl
    Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
    J Biomed Mater Res A 88:704-10. 2009
    ..Gelling agents reduced short-term leakage, but failed to enhance longer-term retention. Hydrogels with stiffer mechanical properties might enhance retention and reduce variability...
  47. ncbi request reprint Selective control of endothelial cell proliferation with a synthetic dimerizer of FGF receptor-1
    Marilyn B Nourse
    Department of Bioengineering, University of Washington, Seattle, WA 98109, USA
    Lab Invest 87:828-35. 2007
    ....
  48. ncbi request reprint Taking the death toll after cardiomyocyte grafting: a reminder of the importance of quantitative biology
    Hans Reinecke
    J Mol Cell Cardiol 34:251-3. 2002
  49. pmc Bones of contention: marrow-derived cells in myocardial regeneration
    Mark A Sussman
    SDSU Heart Institute and Department of Biology, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182, USA
    J Mol Cell Cardiol 44:950-3. 2008
    ....
  50. doi request reprint Get with the (re)program: cardiovascular potential of skin-derived induced pluripotent stem cells
    Nathaniel L Tulloch
    Circulation 118:472-5. 2008
  51. ncbi request reprint Skeletal muscle meets cardiac muscle. Friends or foes?
    Elina Minami
    J Am Coll Cardiol 41:1084-6. 2003
  52. ncbi request reprint Cardiac aid to the injured but not the elderly?
    Charles E Murry
    Nat Med 13:901-2. 2007

Research Grants13

  1. CARDIAC GRAFTS--SKELETAL MYOBLASTS
    CHARLES MURRY; Fiscal Year: 1999
    ....
  2. Cell-Based Cardiac Repair
    CHARLES MURRY; Fiscal Year: 2009
    ..In addition to potential therapeutic applications, these studies will provide the first systematic analysis of pathways regulating death and proliferation in human cardiomyocytes. ..
  3. Cell-Based Cardiac Repair
    CHARLES MURRY; Fiscal Year: 2007
    ..In addition to potential therapeutic applications, these studies will provide the first systematic analysis of pathways regulating death and proliferation in human cardiomyocytes. ..
  4. CARDIAC GRAFTS--SKELETAL MYOBLASTS
    CHARLES MURRY; Fiscal Year: 2005
    ....
  5. CARDIAC GRAFTS-SKELETAL MYOBLASTS - Stem Cell Supplement
    CHARLES MURRY; Fiscal Year: 2003
    ..If such pathways can be understood, it could provide a rational basis to control cardiomyocyte proliferation for cardiac repair applications. ..
  6. CARDIAC GRAFTS--SKELETAL MYOBLASTS
    CHARLES MURRY; Fiscal Year: 2004
    ....
  7. CARDIAC GRAFTS--SKELETAL MYOBLASTS
    CHARLES MURRY; Fiscal Year: 2003
    ....
  8. CARDIAC GRAFTS--SKELETAL MYOBLASTS
    CHARLES MURRY; Fiscal Year: 2002
    ....
  9. CARDIAC GRAFTS--SKELETAL MYOBLASTS
    CHARLES MURRY; Fiscal Year: 2001
    ....
  10. CARDIAC GRAFTS--SKELETAL MYOBLASTS
    CHARLES MURRY; Fiscal Year: 2000
    ....
  11. Cell-Based Cardiac Repair
    Charles E Murry; Fiscal Year: 2010
    ..In addition to potential therapeutic applications, these studies will provide the first systematic analysis of pathways regulating death and proliferation in human cardiomyocytes. ..