LEONARD C MURRIN

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. pmc Impairment of brain endothelial glucose transporter by methamphetamine causes blood-brain barrier dysfunction
    P M Abdul Muneer
    Laboratory of Neurovascular Oxidative Injury, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Mol Neurodegener 6:23. 2011
  2. ncbi request reprint Inverse agonism at alpha(2)-adrenoceptors in native tissue
    L C Murrin
    Department of Pharmacology, University of Nebraska College of Medicine, 986260 Nebraska Medical Center, Omaha, NE68198 6260, USA
    Eur J Pharmacol 398:185-91. 2000
  3. ncbi request reprint RanBPM, a scaffolding protein in the immune and nervous systems
    L Charles Murrin
    Department of Pharmacology and Experimental Neuroscience, 985800 Nebraska Medical Center, Omaha, NE 68198 5800, USA
    J Neuroimmune Pharmacol 2:290-5. 2007
  4. pmc Comparison of the maturation of the adrenergic and serotonergic neurotransmitter systems in the brain: implications for differential drug effects on juveniles and adults
    L Charles Murrin
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, 985800 Nebraska Medical Center, Omaha, NE 68198 5800, USA
    Biochem Pharmacol 73:1225-36. 2007
  5. ncbi request reprint Radioligand saturation binding experiments over large concentration ranges
    D B Bylund
    Department of Pharmacology, University of Nebraska Medical Center, Omaha 68198 6260, USA
    Life Sci 67:2897-911. 2000
  6. ncbi request reprint A robust GTP-induced shift in alpha(2)-adrenoceptor agonist affinity in tissue sections from rat brain
    D B Bylund
    Department of Pharmacology, University of Nebraska Medical Center, Omaha, NE 68198 6260, USA
    J Neurosci Methods 105:159-66. 2001
  7. pmc Differential effects of neonatal norepinephrine lesions on immediate early gene expression in developing and adult rat brain
    J D Sanders
    Department of Pharmacology and Experimental Neuroscience, 985800 Nebraska Medical Center, Omaha, NE 68198 5800, USA
    Neuroscience 157:821-32. 2008
  8. ncbi request reprint Alpha-2 adrenergic receptor development in rat CNS: an autoradiographic study
    H K Happe
    Department of Pharmacology, 986260 Nebraska Medical Center, Omaha, NE 68198 6260, USA
    Neuroscience 123:167-78. 2004
  9. ncbi request reprint Development of the norepinephrine transporter in the rat CNS
    J D Sanders
    Department of Pharmacology, 985800 University of Nebraska Medical Center, Omaha, NE 68198 5800, USA
    Neuroscience 130:107-17. 2005
  10. ncbi request reprint Agonist-stimulated [35S]GTPgammaS autoradiography: optimization for high sensitivity
    H K Happe
    Department of Pharmacology, University of Nebraska Medical Center, 986260 Nebraska Medical Center, 600 South 42nd Street, Omaha, NE 68198-6260, USA
    Eur J Pharmacol 422:1-13. 2001

Research Grants

Collaborators

  • David Bylund
  • H K Happe
  • J D Sanders
  • P M Abdul Muneer
  • James Haorah
  • Saleena Alikunju
  • Adam M Szlachetka
  • J W Kable
  • M E Gerety
  • M O'Rourke
  • C L Coulter

Detail Information

Publications11

  1. pmc Impairment of brain endothelial glucose transporter by methamphetamine causes blood-brain barrier dysfunction
    P M Abdul Muneer
    Laboratory of Neurovascular Oxidative Injury, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Mol Neurodegener 6:23. 2011
    ..abstract:..
  2. ncbi request reprint Inverse agonism at alpha(2)-adrenoceptors in native tissue
    L C Murrin
    Department of Pharmacology, University of Nebraska College of Medicine, 986260 Nebraska Medical Center, Omaha, NE68198 6260, USA
    Eur J Pharmacol 398:185-91. 2000
    ....
  3. ncbi request reprint RanBPM, a scaffolding protein in the immune and nervous systems
    L Charles Murrin
    Department of Pharmacology and Experimental Neuroscience, 985800 Nebraska Medical Center, Omaha, NE 68198 5800, USA
    J Neuroimmune Pharmacol 2:290-5. 2007
    ..These studies indicate that RanBPM acts as a scaffolding protein and is important in regulating cellular function in both the immune system and the nervous system...
  4. pmc Comparison of the maturation of the adrenergic and serotonergic neurotransmitter systems in the brain: implications for differential drug effects on juveniles and adults
    L Charles Murrin
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, 985800 Nebraska Medical Center, Omaha, NE 68198 5800, USA
    Biochem Pharmacol 73:1225-36. 2007
    ..Consideration of such differences in the development of neurotransmitter systems may be of significance in optimizing treatments for a variety of centrally mediated disorders...
  5. ncbi request reprint Radioligand saturation binding experiments over large concentration ranges
    D B Bylund
    Department of Pharmacology, University of Nebraska Medical Center, Omaha 68198 6260, USA
    Life Sci 67:2897-911. 2000
    ....
  6. ncbi request reprint A robust GTP-induced shift in alpha(2)-adrenoceptor agonist affinity in tissue sections from rat brain
    D B Bylund
    Department of Pharmacology, University of Nebraska Medical Center, Omaha, NE 68198 6260, USA
    J Neurosci Methods 105:159-66. 2001
    ..This method should be especially applicable for determining the extent of coupling of receptors to their G proteins in multiple brain regions using autoradiographic procedures...
  7. pmc Differential effects of neonatal norepinephrine lesions on immediate early gene expression in developing and adult rat brain
    J D Sanders
    Department of Pharmacology and Experimental Neuroscience, 985800 Nebraska Medical Center, Omaha, NE 68198 5800, USA
    Neuroscience 157:821-32. 2008
    ..Our data support the idea that norepinephrine plays an important role during CNS development and that changes in noradrenergic signaling during development may have long lasting effects, potentially on learning and memory...
  8. ncbi request reprint Alpha-2 adrenergic receptor development in rat CNS: an autoradiographic study
    H K Happe
    Department of Pharmacology, 986260 Nebraska Medical Center, Omaha, NE 68198 6260, USA
    Neuroscience 123:167-78. 2004
    ..It demonstrates there is region-specific regulation of alpha-2 receptor development and identifies brain regions where these receptors may play a specific and critical role in the regulation normal development...
  9. ncbi request reprint Development of the norepinephrine transporter in the rat CNS
    J D Sanders
    Department of Pharmacology, 985800 University of Nebraska Medical Center, Omaha, NE 68198 5800, USA
    Neuroscience 130:107-17. 2005
    ..These studies also have important implications for use of drugs targeting the noradrenergic system in children and adolescents, such as antidepressants and drugs of abuse...
  10. ncbi request reprint Agonist-stimulated [35S]GTPgammaS autoradiography: optimization for high sensitivity
    H K Happe
    Department of Pharmacology, University of Nebraska Medical Center, 986260 Nebraska Medical Center, 600 South 42nd Street, Omaha, NE 68198-6260, USA
    Eur J Pharmacol 422:1-13. 2001
    ..The assay conditions described should extend the use of agonist-stimulated [35S]GTPgammaS autoradiography to receptors, which produce low levels of [35S]GTPgammaS binding and to the measurement of changes in receptor-G protein coupling...
  11. ncbi request reprint In vivo gene modification elucidates subtype-specific functions of alpha(2)-adrenergic receptors
    J W Kable
    Department of Pharmacology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
    J Pharmacol Exp Ther 293:1-7. 2000
    ..Although these genetic approaches have limitations, they have significantly increased our understanding of the functions of alpha(2)-adrenergic receptor subtypes...

Research Grants1

  1. Regulation of Mu Opioid Receptor Signal Transduction
    LEONARD MURRIN; Fiscal Year: 2004
    ..Further understanding of the regulation of MOR function is relevant not only to development but to clinical situations involving drugs interacting with MOR, such as pain, diarrhea and drug dependence. ..