Cornelis Murre

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent
    Tomokatsu Ikawa
    Division of Biological Sciences, 0377 University of California, San Diego, La Jolla, CA 92093, USA
    Immunity 20:349-60. 2004
  2. doi request reprint Boosting lymphocyte production
    Cornelis Murre
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0377, USA
    Immunity 38:1081-3. 2013
  3. pmc Factors and networks that underpin early hematopoiesis
    Elinore M Mercer
    Department of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, United States
    Semin Immunol 23:317-25. 2011
  4. pmc Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47
    G Bain
    Department of Biology, University of California, San Diego, La Jolla, California 92093, USA
    J Exp Med 190:1605-16. 1999
  5. pmc Early thymocyte development is regulated by modulation of E2A protein activity
    I Engel
    Department of Biology, University of California at San Diego, La Jolla, CA 92093, USA
    J Exp Med 194:733-45. 2001
  6. ncbi request reprint Helix-loop-helix proteins and lymphocyte development
    Cornelis Murre
    Division of Biological Sciences, University of California, San Diego, La Jolla, California 92903, USA
    Nat Immunol 6:1079-86. 2005
  7. pmc Developmental trajectories in early hematopoiesis
    Cornelis Murre
    Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093, USA
    Genes Dev 23:2366-70. 2009
  8. pmc E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment
    Tomokatsu Ikawa
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 203:1329-42. 2006
  9. pmc Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate
    Yin C Lin
    Department of Molecular Biology, University of California San Diego, La Jolla, California, USA
    Nat Immunol 13:1196-204. 2012
  10. pmc Multilineage priming of enhancer repertoires precedes commitment to the B and myeloid cell lineages in hematopoietic progenitors
    Elinore M Mercer
    Department of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA
    Immunity 35:413-25. 2011

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent
    Tomokatsu Ikawa
    Division of Biological Sciences, 0377 University of California, San Diego, La Jolla, CA 92093, USA
    Immunity 20:349-60. 2004
    ..These observations indicate that E2A-deficient hematopoietic progenitor cells remain pluripotent after long-term culture in vitro and that E2A proteins play a critical role in B cell commitment...
  2. doi request reprint Boosting lymphocyte production
    Cornelis Murre
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0377, USA
    Immunity 38:1081-3. 2013
    ..In this issue of Immunity, Satoh et al. (2013) show that the chromatin remodeler Satb1 promotes lymphocyte differentiation in both young and aged stem cells. ..
  3. pmc Factors and networks that underpin early hematopoiesis
    Elinore M Mercer
    Department of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, United States
    Semin Immunol 23:317-25. 2011
    ..Here we describe how distinct families of transcription factors act and are linked together to orchestrate early hematopoiesis...
  4. pmc Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47
    G Bain
    Department of Biology, University of California, San Diego, La Jolla, California 92093, USA
    J Exp Med 190:1605-16. 1999
    ..These results demonstrate that E2A functions as a regulator of thymocyte positive selection...
  5. pmc Early thymocyte development is regulated by modulation of E2A protein activity
    I Engel
    Department of Biology, University of California at San Diego, La Jolla, CA 92093, USA
    J Exp Med 194:733-45. 2001
    ..Mechanistically, these data link pre-TCR mediated signaling and E2A downstream target genes into a common pathway...
  6. ncbi request reprint Helix-loop-helix proteins and lymphocyte development
    Cornelis Murre
    Division of Biological Sciences, University of California, San Diego, La Jolla, California 92903, USA
    Nat Immunol 6:1079-86. 2005
    ..This review discusses HLH proteins in lymphocyte development and homeostasis...
  7. pmc Developmental trajectories in early hematopoiesis
    Cornelis Murre
    Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093, USA
    Genes Dev 23:2366-70. 2009
    ..In this issue of Genes & Development, Inlay and colleagues (pp. 2376-2381) identify novel intermediate stages through which hematopoietic progenitor cells travel...
  8. pmc E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment
    Tomokatsu Ikawa
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 203:1329-42. 2006
    ....
  9. pmc Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate
    Yin C Lin
    Department of Molecular Biology, University of California San Diego, La Jolla, California, USA
    Nat Immunol 13:1196-204. 2012
    ..After development into the pro-B cell stage, Ebf1 and other genes switched compartments to establish new intra- and interdomain interactions associated with a B lineage-specific transcription signature...
  10. pmc Multilineage priming of enhancer repertoires precedes commitment to the B and myeloid cell lineages in hematopoietic progenitors
    Elinore M Mercer
    Department of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA
    Immunity 35:413-25. 2011
    ..Thus, in hematopoietic progenitors, multilineage priming of enhancer elements precedes commitment to the lymphoid or myeloid cell lineages...
  11. pmc Receptor editing and marginal zone B cell development are regulated by the helix-loop-helix protein, E2A
    Melanie W Quong
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 199:1101-12. 2004
    ..Additionally, we propose a model in which E-proteins enforce the developmental checkpoint at the immature B cell stage...
  12. pmc A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate
    Yin C Lin
    Department of Molecular Biology, University of California, San Diego, La Jolla, California, USA
    Nat Immunol 11:635-43. 2010
    ..From this analysis we constructed a global network consisting of transcriptional regulators, signaling and survival factors that we propose orchestrates B cell fate...
  13. pmc Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fate
    Robert Mansson
    Department of Molecular Biology, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 109:21028-33. 2012
    ..This analysis reveals that EBF1 and FOXO1 act in a positive feedback circuitry to promote and stabilize specification to the B-cell lineage...
  14. pmc E2A proteins enforce a proliferation checkpoint in developing thymocytes
    Isaac Engel
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA
    EMBO J 23:202-11. 2004
    ..In addition, these data provide further insight into how deficiencies in E2A lead to T lymphoma...
  15. pmc Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
    Sven Heinz
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Cell 38:576-89. 2010
    ....
  16. pmc E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors
    Craig L Semerad
    Division of Biological Sciences, 0377, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:1930-5. 2009
    ..Last, the data mechanistically link E2A, cell cycle regulators, and the maintenance of the HSC pool in a common pathway...
  17. pmc Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development
    Ruth Schwartz
    Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093 0377, USA
    Proc Natl Acad Sci U S A 103:9976-81. 2006
    ..Finally, we suggest that the aberrant activation of Cdk6 in E47-deficient T lineage cells contributes to the development of lymphoid malignancy...
  18. pmc The transcription factors E2A and HEB act in concert to induce the expression of FOXO1 in the common lymphoid progenitor
    Eva Welinder
    Department of Molecular Biology, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 108:17402-7. 2011
    ..In summary, the data indicate that the earliest event in B-cell specification involves the induction of FOXO1 expression and requires the combined activities of E2A and HEB...
  19. ncbi request reprint E protein function in lymphocyte development
    Melanie W Quong
    Division of Biology, University of California, San Diego, 9500 Gilman Drive, MC 0366, La Jolla, California 92093 0366, USA
    Annu Rev Immunol 20:301-22. 2002
    ..Finally, this review also discusses the role of E47 as a tumor suppressor...
  20. pmc The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets
    Cliff Y Yang
    Division of Biological Sciences, University of California San Diego, La Jolla, California, USA
    Nat Immunol 12:1221-9. 2011
    ..Furthermore, cytokines altered the expression of Id2 and Id3 differently, which provides insight into how external cues influence gene expression...
  21. pmc Biochemical and phosphoproteomic analysis of the helix-loop-helix protein E47
    Robert Teachenor
    Division of Biological Sciences, University of California, San Diego, La Jolla, California, USA
    Mol Cell Biol 32:1671-82. 2012
    ..In sum, these studies show that the entire ensemble of Id proteins has the ability to interact with E47, identify factors that associate with E47, and reveal a spectrum of phosphorylated residues in E47, including an AKT substrate site...
  22. pmc The 3D structure of the immunoglobulin heavy-chain locus: implications for long-range genomic interactions
    Suchit Jhunjhunwala
    Division of Biological Sciences, 0377, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 133:265-79. 2008
    ..In pro-B cells, the entire repertoire of V(H) regions (2 Mbp) appeared to have merged and juxtaposed to the D(H) elements, mechanistically permitting long-range genomic interactions to occur with relatively high frequency...
  23. pmc The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells
    Masaki Miyazaki
    Department of Molecular Biology, University of California, San Diego, La Jolla, California, USA
    Nat Immunol 12:992-1001. 2011
    ..Collectively, our data show how E2A acted globally to orchestrate development into the T lineage and that Id3 antagonized E2A activity beyond the pre-TCR checkpoint to enforce the naive fate of T cells...
  24. ncbi request reprint E-proteins directly regulate expression of activation-induced deaminase in mature B cells
    Camil Elie Sayegh
    Division of Biological Sciences, University of California San Diego, La Jolla, California 92093, USA
    Nat Immunol 4:586-93. 2003
    ..Taken together, our observations link helix-loop-helix activity and Aicda gene expression in a common pathway, in which E-protein activity is required for the efficient induction of Aicda transcription...
  25. pmc Chromatin architecture and the generation of antigen receptor diversity
    Suchit Jhunjhunwala
    Division of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 138:435-48. 2009
    ..Here, we review recently uncovered mechanisms that underpin long-range genomic interactions and the generation of antigen receptor diversity...
  26. pmc Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci
    Kristina Beck
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 206:2271-84. 2009
    ..We propose that in the pre-B and immature B cell compartments, gradients of E12 and E47 activities are established to mechanistically regulate the sequential rearrangement of the Ig light chain genes...
  27. pmc IL-7Ralpha and E47: independent pathways required for development of multipotent lymphoid progenitors
    Barbara L Kee
    Department of Biology, University of California San Diego, La Jolla, CA 92093, USA
    EMBO J 21:103-13. 2002
    ....
  28. doi request reprint Defining the pathways of early adult hematopoiesis
    Cornelis Murre
    Division of Biological Sciences, 0366, University of California, San Diego, La Jolla, CA 92903, USA
    Cell Stem Cell 1:357-8. 2007
    ..In this issue of Cell Stem Cell, Arinobu et al. (2007) and Pronk et al. (2007) provide new insights into the paths traveled by hematopoietic progenitors...
  29. pmc CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells
    Stephanie C Degner
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:9566-71. 2011
    ..Together, our findings demonstrate that CTCF plays an important role in the 3D structure of the Igh locus and in the regulation of antisense germline transcription and that it contributes to the compaction of the Igh locus...
  30. pmc Suppression of E-protein activity interferes with the development of BCR-ABL-mediated myeloproliferative disease
    Jinkyung Ko
    Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 105:12967-72. 2008
    ..Collectively, these studies show that suppression of E-protein activity interferes with the development of BCR-ABL-mediated MPD...
  31. pmc BCR-ABL-transformed GMP as myeloid leukemic stem cells
    Yosuke Minami
    Division of Hematology Oncology, Department of Medicine, University of California at San Diego School of Medicine, La Jolla, CA 92093 0820, USA
    Proc Natl Acad Sci U S A 105:17967-72. 2008
    ..These results provide further evidence that BCR-ABL-transformed GMP with abnormal beta-catenin activity can function as leukemic stem cells...
  32. pmc Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice
    Isaac Engel
    Division of Biology, University of California at San Diego, La Jolla, CA 92093 0366, USA
    Proc Natl Acad Sci U S A 99:11322-7. 2002
    ..Specifically, we propose that Notch activation indirectly modulates E2A activity through induction of pre-Talpha expression, ultimately leading to the development of lymphoma...
  33. ncbi request reprint Global approaches to identify novel participants that modulate intestinal epithelial cell development
    Cornelis Murre
    Department of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Dev Cell 19:647-8. 2010
    ..In this issue of Developmental Cell, Verzi et al. (2010) use an unbiased global and computational approach to identify distinct partners and functions of CDX2 in intestinal epithelial cell differentiation...
  34. doi request reprint Chromatin topology and the regulation of antigen receptor assembly
    Claudia Bossen
    Division of Biological Sciences, Department of Molecular Biology, University of California at San Diego, La Jolla, California 92093 0377, USA
    Annu Rev Immunol 30:337-56. 2012
    ....
  35. ncbi request reprint Regulating intertwining proteins
    Cornelis Murre
    Division of Biological Sciences, 0377, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Cell 12:1061-2. 2003
  36. pmc FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development
    Ugo Borello
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, CA 94143, USA
    Neural Dev 3:17. 2008
    ..FGF8 and FGF17 signaling have major roles in specification and morphogenesis of the rostroventral telencephalon, whereas the functions of FGF15 and FGF18 in the rostral patterning center have not been established...
  37. pmc Nuclear location and the control of developmental progression
    Yin C Lin
    Division of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, United States
    Curr Opin Genet Dev 23:104-8. 2013
    ..Here we discuss the implications of a dynamic genome and how it relates to the control of developmental progression...
  38. ncbi request reprint Reprogramming committed B lineage cells
    Cornelis Murre
    Divison of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 117:556-8. 2004
    ..A new study in this issue of Cell provides compelling evidence that committed mature B lineage cells can be reprogrammed to become macrophages...
  39. ncbi request reprint Ribosomal proteins and the control of alphabeta T lineage development
    Cornelis Murre
    Division of Biological Sciences, 0366, University of California, San Diego, La Jolla, CA 92093, USA
    Immunity 26:751-2. 2007
    ..How do committed alphabeta T lineage cells undergo rapid proliferation and developmental progression during beta selection? A new study shows that a ribosomal protein, RPL22, promotes the survival of expanding alphabeta T cells...
  40. pmc Transcription and recombination factories: common features?
    Joseph S Lucas
    Division of Biological Sciences, 0377 Department of Molecular Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States
    Curr Opin Cell Biol 23:318-24. 2011
    ..We suggest that the folding of the chromatin fiber into rosettes underpins a crucial mechanism by which antigen receptor diversity is generated...
  41. pmc Visualization of looping involving the immunoglobulin heavy-chain locus in developing B cells
    Camil E Sayegh
    Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA
    Genes Dev 19:322-7. 2005
    ..Based on these observations, we propose that Ig loci are repositioned by a looping mechanism prior to IgH V(D)J rearrangement to facilitate the joining of Ig variable, diversity, and joining segments...
  42. ncbi request reprint Marking emerging beta- and gammadelta-selected T cells
    Cornelis Murre
    Division of Biological Sciences, 0366, University of California, San Diego, La Jolla, California 92093, USA
    Immunity 24:11-3. 2006
    ....
  43. ncbi request reprint Regulation and function of the E2A proteins in B cell development
    Cornelis Murre
    University of California, San Diego, 9500 Gilman Drive, 0377, La Jolla, CA 92093, USA
    Adv Exp Med Biol 596:1-7. 2007
  44. pmc Epigenetics of antigen-receptor gene assembly
    Cornelis Murre
    Division of Biological Sciences, 03777, University of California, San Diego, La Jolla, CA 92093, United States
    Curr Opin Genet Dev 17:415-21. 2007
    ..Further studies involving statistical mechanics should provide physical insight into the physical mechanisms that underlie the association of antigen receptor gene segments...
  45. ncbi request reprint The cellular Pax-Hox-helix connection
    Bart A Westerman
    Department of Clinical Chemistry, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1081 HV 1007 MB, Amsterdam, The Netherlands
    Biochim Biophys Acta 1629:1-7. 2003
    ..These examples indicate that unique combinations of bHLH and Hox proteins, mediated by protein-protein interactions, might be responsible for activating cell-specific sets of target genes...
  46. ncbi request reprint Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription
    Holly Maier
    Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Nat Immunol 5:1069-77. 2004
    ..EBF function was enhanced by interaction with the transcription factor Runx1. These data suggest a molecular basis for the hierarchical dependence of Pax5 function on EBF and E2A in B lymphocyte development...
  47. ncbi request reprint differential roles for the E2A activation domains in B lymphocytes and macrophages
    Savita Bhalla
    Department of Pathology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Immunol 180:1694-703. 2008
    ..Our findings demonstrate distinct functionalities for the E protein activation domains in B lymphocytes and macrophages...
  48. ncbi request reprint Interplay between RORgammat, Egr3, and E proteins controls proliferation in response to pre-TCR signals
    Hongkang Xi
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, Georgia 30322, USA
    Immunity 24:813-26. 2006
    ..After Egr3 subsided, the expression and function of RORgammat increased. Thus, transient induction of Egr3 delays the effects of RORgammat and enables pre-TCR signaling to induce both proliferation and gene rearrangement...
  49. ncbi request reprint Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47
    Yasutoshi Agata
    Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Immunity 27:871-84. 2007
    ..Thus, the abundance of E47 is rate limiting in locus activation, and feedback signaling downregulates E47 activity to ensure allelic exclusion...
  50. ncbi request reprint DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selection
    Monica L Friedrich
    Department of Molecular Biology and Biochemistry, Center for Immunology, University of California Irvine, Irvine, CA 92697 3900, USA
    Int Immunol 17:1379-90. 2005
    ..These findings are consistent with a role for DRAK2 in thymocyte selection and lymphoid maturation, and demonstrate that DRAK2 transduces non-apoptotic signals during thymocyte differentiation...
  51. ncbi request reprint TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB
    Jennifer O'Neil
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cancer Cell 5:587-96. 2004
    ..These data demonstrate that tal1/scl induces leukemia by repressing E47/HEB and suggest that HDAC inhibitors may prove efficacious in T-ALL patients who express TAL1/SCL...