Research Topics
Genomes and Genes
| Cornelis MurreSummaryAffiliation: University of California Country: USA Publications
| Collaborators
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Detail Information
Publications
Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotentTomokatsu Ikawa
Division of Biological Sciences, 0377 University of California, San Diego, La Jolla, CA 92093, USA
Immunity 20:349-60. 2004..These observations indicate that E2A-deficient hematopoietic progenitor cells remain pluripotent after long-term culture in vitro and that E2A proteins play a critical role in B cell commitment...
Factors and networks that underpin early hematopoiesisElinore M Mercer
Department of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, United States
Semin Immunol 23:317-25. 2011..Here we describe how distinct families of transcription factors act and are linked together to orchestrate early hematopoiesis...- Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47G Bain
Department of Biology, University of California, San Diego, La Jolla, California 92093, USA
J Exp Med 190:1605-16. 1999..These results demonstrate that E2A functions as a regulator of thymocyte positive selection... - Early thymocyte development is regulated by modulation of E2A protein activityI Engel
Department of Biology, University of California at San Diego, La Jolla, CA 92093, USA
J Exp Med 194:733-45. 2001..Mechanistically, these data link pre-TCR mediated signaling and E2A downstream target genes into a common pathway... - Developmental trajectories in early hematopoiesisCornelis Murre
Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093, USA
Genes Dev 23:2366-70. 2009..In this issue of Genes & Development, Inlay and colleagues (pp. 2376-2381) identify novel intermediate stages through which hematopoietic progenitor cells travel... - Helix-loop-helix proteins and lymphocyte developmentCornelis Murre
Division of Biological Sciences, University of California, San Diego, La Jolla, California 92903, USA
Nat Immunol 6:1079-86. 2005..This review discusses HLH proteins in lymphocyte development and homeostasis... - E proteins and Notch signaling cooperate to promote T cell lineage specification and commitmentTomokatsu Ikawa
Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
J Exp Med 203:1329-42. 2006.... - Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fateYin C Lin
Department of Molecular Biology, University of California San Diego, La Jolla, California, USA
Nat Immunol 13:1196-204. 2012..After development into the pro-B cell stage, Ebf1 and other genes switched compartments to establish new intra- and interdomain interactions associated with a B lineage-specific transcription signature... - Multilineage priming of enhancer repertoires precedes commitment to the B and myeloid cell lineages in hematopoietic progenitorsElinore M Mercer
Department of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA
Immunity 35:413-25. 2011..Thus, in hematopoietic progenitors, multilineage priming of enhancer elements precedes commitment to the lymphoid or myeloid cell lineages... - Receptor editing and marginal zone B cell development are regulated by the helix-loop-helix protein, E2AMelanie W Quong
Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
J Exp Med 199:1101-12. 2004..Additionally, we propose a model in which E-proteins enforce the developmental checkpoint at the immature B cell stage... - A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fateYin C Lin
Department of Molecular Biology, University of California, San Diego, La Jolla, California, USA
Nat Immunol 11:635-43. 2010..From this analysis we constructed a global network consisting of transcriptional regulators, signaling and survival factors that we propose orchestrates B cell fate... - Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fateRobert Mansson
Department of Molecular Biology, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 109:21028-33. 2012..This analysis reveals that EBF1 and FOXO1 act in a positive feedback circuitry to promote and stabilize specification to the B-cell lineage... - E2A proteins enforce a proliferation checkpoint in developing thymocytesIsaac Engel
Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA
EMBO J 23:202-11. 2004..In addition, these data provide further insight into how deficiencies in E2A lead to T lymphoma... - Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identitiesSven Heinz
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Mol Cell 38:576-89. 2010.... - E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitorsCraig L Semerad
Division of Biological Sciences, 0377, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 106:1930-5. 2009..Last, the data mechanistically link E2A, cell cycle regulators, and the maintenance of the HSC pool in a common pathway... - Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage developmentRuth Schwartz
Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093 0377, USA
Proc Natl Acad Sci U S A 103:9976-81. 2006..Finally, we suggest that the aberrant activation of Cdk6 in E47-deficient T lineage cells contributes to the development of lymphoid malignancy... - The transcription factors E2A and HEB act in concert to induce the expression of FOXO1 in the common lymphoid progenitorEva Welinder
Department of Molecular Biology, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 108:17402-7. 2011..In summary, the data indicate that the earliest event in B-cell specification involves the induction of FOXO1 expression and requires the combined activities of E2A and HEB... - E protein function in lymphocyte developmentMelanie W Quong
Division of Biology, University of California, San Diego, 9500 Gilman Drive, MC 0366, La Jolla, California 92093 0366, USA
Annu Rev Immunol 20:301-22. 2002..Finally, this review also discusses the role of E47 as a tumor suppressor... 
The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsetsCliff Y Yang
Division of Biological Sciences, University of California San Diego, La Jolla, California, USA
Nat Immunol 12:1221-9. 2011..Furthermore, cytokines altered the expression of Id2 and Id3 differently, which provides insight into how external cues influence gene expression...- Biochemical and phosphoproteomic analysis of the helix-loop-helix protein E47Robert Teachenor
Division of Biological Sciences, University of California, San Diego, La Jolla, California, USA
Mol Cell Biol 32:1671-82. 2012..In sum, these studies show that the entire ensemble of Id proteins has the ability to interact with E47, identify factors that associate with E47, and reveal a spectrum of phosphorylated residues in E47, including an AKT substrate site... - E-proteins directly regulate expression of activation-induced deaminase in mature B cellsCamil Elie Sayegh
Division of Biological Sciences, University of California San Diego, La Jolla, California 92093, USA
Nat Immunol 4:586-93. 2003..Taken together, our observations link helix-loop-helix activity and Aicda gene expression in a common pathway, in which E-protein activity is required for the efficient induction of Aicda transcription... - The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cellsMasaki Miyazaki
Department of Molecular Biology, University of California, San Diego, La Jolla, California, USA
Nat Immunol 12:992-1001. 2011..Collectively, our data show how E2A acted globally to orchestrate development into the T lineage and that Id3 antagonized E2A activity beyond the pre-TCR checkpoint to enforce the naive fate of T cells... - Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain lociKristina Beck
Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
J Exp Med 206:2271-84. 2009..We propose that in the pre-B and immature B cell compartments, gradients of E12 and E47 activities are established to mechanistically regulate the sequential rearrangement of the Ig light chain genes... - Chromatin architecture and the generation of antigen receptor diversitySuchit Jhunjhunwala
Division of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA
Cell 138:435-48. 2009..Here, we review recently uncovered mechanisms that underpin long-range genomic interactions and the generation of antigen receptor diversity... - The 3D structure of the immunoglobulin heavy-chain locus: implications for long-range genomic interactionsSuchit Jhunjhunwala
Division of Biological Sciences, 0377, University of California, San Diego, La Jolla, CA 92093, USA
Cell 133:265-79. 2008..In pro-B cells, the entire repertoire of V(H) regions (2 Mbp) appeared to have merged and juxtaposed to the D(H) elements, mechanistically permitting long-range genomic interactions to occur with relatively high frequency... - IL-7Ralpha and E47: independent pathways required for development of multipotent lymphoid progenitorsBarbara L Kee
Department of Biology, University of California San Diego, La Jolla, CA 92093, USA
EMBO J 21:103-13. 2002.... - CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cellsStephanie C Degner
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 108:9566-71. 2011..Together, our findings demonstrate that CTCF plays an important role in the 3D structure of the Igh locus and in the regulation of antisense germline transcription and that it contributes to the compaction of the Igh locus... - Suppression of E-protein activity interferes with the development of BCR-ABL-mediated myeloproliferative diseaseJinkyung Ko
Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 105:12967-72. 2008..Collectively, these studies show that suppression of E-protein activity interferes with the development of BCR-ABL-mediated MPD... - Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient miceIsaac Engel
Division of Biology, University of California at San Diego, La Jolla, CA 92093 0366, USA
Proc Natl Acad Sci U S A 99:11322-7. 2002..Specifically, we propose that Notch activation indirectly modulates E2A activity through induction of pre-Talpha expression, ultimately leading to the development of lymphoma... - Defining the pathways of early adult hematopoiesisCornelis Murre
Division of Biological Sciences, 0366, University of California, San Diego, La Jolla, CA 92903, USA
Cell Stem Cell 1:357-8. 2007..In this issue of Cell Stem Cell, Arinobu et al. (2007) and Pronk et al. (2007) provide new insights into the paths traveled by hematopoietic progenitors... - BCR-ABL-transformed GMP as myeloid leukemic stem cellsYosuke Minami
Division of Hematology Oncology, Department of Medicine, University of California at San Diego School of Medicine, La Jolla, CA 92093 0820, USA
Proc Natl Acad Sci U S A 105:17967-72. 2008..These results provide further evidence that BCR-ABL-transformed GMP with abnormal beta-catenin activity can function as leukemic stem cells... - Global approaches to identify novel participants that modulate intestinal epithelial cell developmentCornelis Murre
Department of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
Dev Cell 19:647-8. 2010..In this issue of Developmental Cell, Verzi et al. (2010) use an unbiased global and computational approach to identify distinct partners and functions of CDX2 in intestinal epithelial cell differentiation... - Chromatin topology and the regulation of antigen receptor assemblyClaudia Bossen
Division of Biological Sciences, Department of Molecular Biology, University of California at San Diego, La Jolla, California 92093 0377, USA
Annu Rev Immunol 30:337-56. 2012.... - Regulating intertwining proteinsCornelis Murre
Division of Biological Sciences, 0377, University of California, San Diego, La Jolla, CA 92093, USA
Mol Cell 12:1061-2. 2003 - FGF15 promotes neurogenesis and opposes FGF8 function during neocortical developmentUgo Borello
Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, CA 94143, USA
Neural Dev 3:17. 2008..FGF8 and FGF17 signaling have major roles in specification and morphogenesis of the rostroventral telencephalon, whereas the functions of FGF15 and FGF18 in the rostral patterning center have not been established... - Regulation and function of the E2A proteins in B cell developmentCornelis Murre
University of California, San Diego, 9500 Gilman Drive, 0377, La Jolla, CA 92093, USA
Adv Exp Med Biol 596:1-7. 2007 - Reprogramming committed B lineage cellsCornelis Murre
Divison of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
Cell 117:556-8. 2004..A new study in this issue of Cell provides compelling evidence that committed mature B lineage cells can be reprogrammed to become macrophages... - Transcription and recombination factories: common features?Joseph S Lucas
Division of Biological Sciences, 0377 Department of Molecular Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States
Curr Opin Cell Biol 23:318-24. 2011..We suggest that the folding of the chromatin fiber into rosettes underpins a crucial mechanism by which antigen receptor diversity is generated... - Visualization of looping involving the immunoglobulin heavy-chain locus in developing B cellsCamil Sayegh
Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA
Genes Dev 19:322-7. 2005..Based on these observations, we propose that Ig loci are repositioned by a looping mechanism prior to IgH V(D)J rearrangement to facilitate the joining of Ig variable, diversity, and joining segments... - Marking emerging beta- and gammadelta-selected T cellsCornelis Murre
Division of Biological Sciences, 0366, University of California, San Diego, La Jolla, California 92093, USA
Immunity 24:11-3. 2006.... - Ribosomal proteins and the control of alphabeta T lineage developmentCornelis Murre
Division of Biological Sciences, 0366, University of California, San Diego, La Jolla, CA 92093, USA
Immunity 26:751-2. 2007..How do committed alphabeta T lineage cells undergo rapid proliferation and developmental progression during beta selection? A new study shows that a ribosomal protein, RPL22, promotes the survival of expanding alphabeta T cells... - Epigenetics of antigen-receptor gene assemblyCornelis Murre
Division of Biological Sciences, 03777, University of California, San Diego, La Jolla, CA 92093, United States
Curr Opin Genet Dev 17:415-21. 2007..Further studies involving statistical mechanics should provide physical insight into the physical mechanisms that underlie the association of antigen receptor gene segments... - Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcriptionHolly Maier
Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Nat Immunol 5:1069-77. 2004..EBF function was enhanced by interaction with the transcription factor Runx1. These data suggest a molecular basis for the hierarchical dependence of Pax5 function on EBF and E2A in B lymphocyte development... - The cellular Pax-Hox-helix connectionBart A Westerman
Department of Clinical Chemistry, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1081 HV 1007 MB, Amsterdam, The Netherlands
Biochim Biophys Acta 1629:1-7. 2003..These examples indicate that unique combinations of bHLH and Hox proteins, mediated by protein-protein interactions, might be responsible for activating cell-specific sets of target genes... - DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selectionMonica L Friedrich
Department of Molecular Biology and Biochemistry, Center for Immunology, University of California Irvine, Irvine, CA 92697 3900, USA
Int Immunol 17:1379-90. 2005..These findings are consistent with a role for DRAK2 in thymocyte selection and lymphoid maturation, and demonstrate that DRAK2 transduces non-apoptotic signals during thymocyte differentiation... - TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEBJennifer O'Neil
Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Cancer Cell 5:587-96. 2004..These data demonstrate that tal1/scl induces leukemia by repressing E47/HEB and suggest that HDAC inhibitors may prove efficacious in T-ALL patients who express TAL1/SCL... - differential roles for the E2A activation domains in B lymphocytes and macrophagesSavita Bhalla
Department of Pathology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
J Immunol 180:1694-703. 2008..Our findings demonstrate distinct functionalities for the E protein activation domains in B lymphocytes and macrophages... - Interplay between RORgammat, Egr3, and E proteins controls proliferation in response to pre-TCR signalsHongkang Xi
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, Georgia 30322, USA
Immunity 24:813-26. 2006..After Egr3 subsided, the expression and function of RORgammat increased. Thus, transient induction of Egr3 delays the effects of RORgammat and enables pre-TCR signaling to induce both proliferation and gene rearrangement... - Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47Yasutoshi Agata
Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
Immunity 27:871-84. 2007..Thus, the abundance of E47 is rate limiting in locus activation, and feedback signaling downregulates E47 activity to ensure allelic exclusion...