Karen F Murray

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. doi request reprint Randomized, placebo-controlled trial of tenofovir disoproxil fumarate in adolescents with chronic hepatitis B
    Karen F Murray
    Division of Gastroenterology and Hepatology, Seattle Children s and University of Washington School of Medicine, Seattle, WA 98105, USA
    Hepatology 56:2018-26. 2012
  2. pmc An unusual case of an ulcerative colitis flare resulting in disseminated intravascular coagulopathy and a bladder hematoma: a case report
    David L Suskind
    Department of Pediatrics, Seattle Children s Hospital and Regional Medical Center, University of Washington, 4800 Sand Point Way NE, Seattle, Washington, USA
    BMC Gastroenterol 4:26. 2004
  3. doi request reprint Chronic hepatitis
    Karen F Murray
    Hepatobiliary Program, Seattle Children s Hospital and Regional Medical Center, Seattle, WA 98105, USA
    J Pediatr Gastroenterol Nutr 47:225-33. 2008
  4. pmc Design of the PEDS-C trial: pegylated interferon +/- ribavirin for children with chronic hepatitis C viral infection
    Karen F Murray
    Division of Gastroenterology and Nutrition, Department of Pediatrics, University of Washington, Children s Hospital and Regional Medical Center, Seattle, Washington 98105, USA
    Clin Trials 4:661-73. 2007
  5. pmc The combination of ribavirin and peginterferon is superior to peginterferon and placebo for children and adolescents with chronic hepatitis C
    Kathleen B Schwarz
    Department of Pediatrics, Division of Gastroenterology and Nutrition, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Gastroenterology 140:450-458.e1. 2011
  6. pmc Ophthalmologic complications in children with chronic hepatitis C treated with pegylated interferon
    Michael R Narkewicz
    Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Colorado Denver School of Medicine and The Children s Hospital, Aurora, CO 80045, USA
    J Pediatr Gastroenterol Nutr 51:183-6. 2010
  7. doi request reprint Recommendations for screening, monitoring, and referral of pediatric chronic hepatitis B
    Barbara A Haber
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 124:e1007-13. 2009
  8. pmc Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial
    Joel E Lavine
    Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Columbia University, New York, New York, USA
    JAMA 305:1659-68. 2011
  9. doi request reprint Pattern of diagnostic evaluation for the causes of pediatric acute liver failure: an opportunity for quality improvement
    Michael R Narkewicz
    Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado Denver School of Medicine and the Pediatric Liver Center, The Children s Hospital, Aurora, CO, USA
    J Pediatr 155:801-806.e1. 2009
  10. ncbi request reprint Liver histology and alanine aminotransferase levels in children and adults with chronic hepatitis C infection
    Karen F Murray
    Division of Gastroenterology and Nutrition, Department of Pediatrics, Children s Hospital and Regional Medical Center, Seattle, WA 98195 6174, USA
    J Pediatr Gastroenterol Nutr 41:634-8. 2005

Detail Information

Publications23

  1. doi request reprint Randomized, placebo-controlled trial of tenofovir disoproxil fumarate in adolescents with chronic hepatitis B
    Karen F Murray
    Division of Gastroenterology and Hepatology, Seattle Children s and University of Washington School of Medicine, Seattle, WA 98105, USA
    Hepatology 56:2018-26. 2012
    ..001). The rate of grade 3/4 adverse events was higher among patients treated with placebo (24%) than patients treated with tenofovir DF (10%). No patients met the safety endpoint of a 6% decrease in spine bone mineral density at week 72...
  2. pmc An unusual case of an ulcerative colitis flare resulting in disseminated intravascular coagulopathy and a bladder hematoma: a case report
    David L Suskind
    Department of Pediatrics, Seattle Children s Hospital and Regional Medical Center, University of Washington, 4800 Sand Point Way NE, Seattle, Washington, USA
    BMC Gastroenterol 4:26. 2004
    ..Ulcerative colitis has been associated with disseminated intravascular coagulation in conjunction with septicemia, toxic megacolon and surgery...
  3. doi request reprint Chronic hepatitis
    Karen F Murray
    Hepatobiliary Program, Seattle Children s Hospital and Regional Medical Center, Seattle, WA 98105, USA
    J Pediatr Gastroenterol Nutr 47:225-33. 2008
  4. pmc Design of the PEDS-C trial: pegylated interferon +/- ribavirin for children with chronic hepatitis C viral infection
    Karen F Murray
    Division of Gastroenterology and Nutrition, Department of Pediatrics, University of Washington, Children s Hospital and Regional Medical Center, Seattle, Washington 98105, USA
    Clin Trials 4:661-73. 2007
    ..Establishment of the research team, protocol, administrative infrastructure, and ancillary contributors for the pediatric trial took years of planning...
  5. pmc The combination of ribavirin and peginterferon is superior to peginterferon and placebo for children and adolescents with chronic hepatitis C
    Kathleen B Schwarz
    Department of Pediatrics, Division of Gastroenterology and Nutrition, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Gastroenterology 140:450-458.e1. 2011
    ..We conducted a randomized controlled trial of PEG and ribavirin, compared with PEG and placebo, in children 5 to 17 years old with chronic hepatitis C...
  6. pmc Ophthalmologic complications in children with chronic hepatitis C treated with pegylated interferon
    Michael R Narkewicz
    Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Colorado Denver School of Medicine and The Children s Hospital, Aurora, CO 80045, USA
    J Pediatr Gastroenterol Nutr 51:183-6. 2010
    ..Our purpose is to describe the ophthalmologic complications of pegylated interferon-alpha2a with either placebo or ribavirin in children with chronic HCV (the PEDS-C trial)...
  7. doi request reprint Recommendations for screening, monitoring, and referral of pediatric chronic hepatitis B
    Barbara A Haber
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 124:e1007-13. 2009
    ....
  8. pmc Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial
    Joel E Lavine
    Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Columbia University, New York, New York, USA
    JAMA 305:1659-68. 2011
    ..Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in US children and adolescents and can present with advanced fibrosis or nonalcoholic steatohepatitis (NASH). No treatment has been established...
  9. doi request reprint Pattern of diagnostic evaluation for the causes of pediatric acute liver failure: an opportunity for quality improvement
    Michael R Narkewicz
    Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado Denver School of Medicine and the Pediatric Liver Center, The Children s Hospital, Aurora, CO, USA
    J Pediatr 155:801-806.e1. 2009
    ..To describe the frequency of diagnostic testing for the 4 most common causes of pediatric acute liver failure (PALF) (drugs, metabolic disease, autoimmune process, and infections) in indeterminate PALF within the PALF Study Group Database...
  10. ncbi request reprint Liver histology and alanine aminotransferase levels in children and adults with chronic hepatitis C infection
    Karen F Murray
    Division of Gastroenterology and Nutrition, Department of Pediatrics, Children s Hospital and Regional Medical Center, Seattle, WA 98195 6174, USA
    J Pediatr Gastroenterol Nutr 41:634-8. 2005
    ..Chronic hepatitis C is often a mild disease in children, but whether this is related to younger age or shorter duration of infection is unclear. Histologic severity has been shown to correlate with duration of infection regardless of age...
  11. doi request reprint The pediatric pouch in inflammatory bowel disease: a primer for the gastroenterologist
    Ghassan T Wahbeh
    Inflammatory Bowel Disease Program, Seattle Children s Hospital, University of Washington, W7830, Gastroenterology, 4800 Sand Point Way NE, Seattle, WA 98105, USA
    Expert Rev Gastroenterol Hepatol 7:215-23. 2013
    ..Further study is needed to assess preoperative risk predictors, prevention and treatment of complications...
  12. doi request reprint Drug-related hepatotoxicity and acute liver failure
    Karen F Murray
    Division of Gastroenterology and Nutrition, Seattle Children s Hospital, University of Washington, Seattle, WA, USA
    J Pediatr Gastroenterol Nutr 47:395-405. 2008
    ..Enhanced awareness of the potential hepatotoxicity of commonly prescribed medications may minimize the frequency of serious hepatotoxicity and ALF in pediatric patients...
  13. doi request reprint Infliximab for ulcerative colitis in children and adolescents
    Jean K McGinnis
    Division of Pediatric Gastroenterology, Children s Hospital and Regional Medical Center, University of Washington School of Medicine, Children s Hospital and Regional Medical Center, Seattle, WA, USA
    J Clin Gastroenterol 42:875-9. 2008
    ..To evaluate the efficacy of infliximab treatment in children and adolescents with ulcerative colitis (UC) defined as short and long-term clinical response and surgical avoidance...
  14. doi request reprint Biliary atresia: recent progress
    Mikelle D Bassett
    Department of Pediatrics, Seattle Children s Hospital, University of Washington School of Medicine, Seattle, WA, USA
    J Clin Gastroenterol 42:720-9. 2008
    ..The goals of this article are to review the important clinical aspects of EHBA and to highlight some of the more recent scientific and clinical developments contributing to our understanding of this condition...
  15. doi request reprint Hepatobiliary associations with inflammatory bowel disease
    Crystal Knight
    Seattle Children s and University of Washington School of Medicine, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, 4800 Sand Point Way, NE, PO Box 5371 W 7830, Seattle, WA 98105, USA
    Expert Rev Gastroenterol Hepatol 3:681-91. 2009
    ..This review will discuss the most common liver disease associations seen in patients with IBD: PSC, AIH and overlap syndrome. Additionally, the most common drug-related hepatotoxicities encountered when treating IBD will be reviewed...
  16. doi request reprint Detection of polyethylene glycol-based laxatives in stool
    Martin Sadilek
    Department of Chemistry, Seattle Children s and University of Washington School of Medicine, Seattle, USA
    J Pediatr Gastroenterol Nutr 50:276-9. 2010
    ..This new MS methodology to test stool for PEG is described. It is likely to prove useful in the documentation of surreptitious PEG administration and in evaluation of PEG treatment failure...
  17. doi request reprint Hidden attraction: a menacing meal of magnets and batteries
    Julie C Brown
    Seattle Children s Hospital and University of Washington, Seattle, Washington 98105, USA
    J Emerg Med 43:266-9. 2012
    ..Magnet and button battery ingestions are increasingly common, and can result in significant morbidity. Timely identification of hazardous foreign body ingestions can be difficult in non-verbal and non-disclosing children...
  18. ncbi request reprint Interferon alfa-2b in combination with ribavirin for the treatment of chronic hepatitis C in children: efficacy, safety, and pharmacokinetics
    Regino P Gonzalez-Peralta
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, FL 32610, USA
    Hepatology 42:1010-8. 2005
    ..In conclusion, interferon alfa-2b in combination with ribavirin is effective and safe in children with chronic hepatitis C virus...
  19. pmc Pathology of chronic hepatitis C in children: liver biopsy findings in the Peds-C Trial
    Zachary D Goodman
    Armed Forces Institute of Pathology and Veterans Administration Special Reference Laboratory for Pathology, Washington, DC, USA
    Hepatology 47:836-43. 2008
    ....
  20. doi request reprint Hepatitis B and C in children
    Evelyn K Hsu
    Pediatric Gastroenterology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Nat Clin Pract Gastroenterol Hepatol 5:311-20. 2008
    ..Interferon alpha and ribavirin, used in combination, are currently approved in the US for the treatment of children older than 3 years of age with chronic HCV infection...
  21. ncbi request reprint Autoimmune hepatitis: are we using the right therapy?
    Karen F Murray
    J Pediatr Gastroenterol Nutr 44:18-9. 2007
  22. ncbi request reprint A randomized, double-blind trial of Lactobacillus GG versus placebo in addition to standard maintenance therapy for children with Crohn's disease
    Athos Bousvaros
    Division of Pediatric Gastroenterology, Children s Hospital, Boston, Massachusetts 02115, USA
    Inflamm Bowel Dis 11:833-9. 2005
    ..18). The LGG was well tolerated, with a side effect profile comparable with placebo. This study suggests that LGG does not prolong time to relapse in children with CD when given as an adjunct to standard therapy...
  23. ncbi request reprint Infantile Crohn disease presenting with diarrhea and pyoderma gangrenosum
    James G H Dinulos
    Department of Medicine and Pediatrics Dermatology, Dartmouth Hitchcock Clinic, Dartmouth Medical School, Lebanon, New Hampshire, USA
    Pediatr Dermatol 23:43-8. 2006
    ..This article reports a rare instance of an infant who developed pyoderma gangrenosum due to Crohn disease and reviews cutaneous signs of systemic disease in infants presenting with chronic diarrhea and rash...