WILLIAM JOSEPH MURPHY

Summary

Affiliation: University of Nevada
Country: USA

Publications

  1. ncbi request reprint Synergistic anti-tumor responses after administration of agonistic antibodies to CD40 and IL-2: coordination of dendritic and CD8+ cell responses
    William J Murphy
    Department of Microbiology, University of Nevada School of Medicine, Reno, NV 89557, USA
    J Immunol 170:2727-33. 2003
  2. ncbi request reprint Natural killer cells: biology and clinical use in cancer therapy
    William H D Hallett
    Department of Microbiology and Immunology, University of Nevada School of Medicine, University of Nevada, Reno, Reno, NV 89557, USA
    Cell Mol Immunol 1:12-21. 2004
  3. ncbi request reprint Tumor regression by anti-CD40 and interleukin-2: role of CD40 in hematopoietic cells and organ-specific effects
    Lisbeth A Welniak
    Department of Microbiology and Immunology, University of Nevada, Reno, Nevada 89557, USA
    Biol Blood Marrow Transplant 10:534-9. 2004
  4. pmc Immunomodulation with CD40 stimulation and interleukin-2 protects mice from disseminated cryptococcosis
    Qing Zhou
    Department of Microbiology and Immunology, University of Nevada, Reno, 1664 N Virginia St, Reno, NV 89557, USA
    Infect Immun 74:2161-8. 2006
  5. ncbi request reprint An absence of CCR5 on donor cells results in acceleration of acute graft-vs-host disease
    Lisbeth A Welniak
    Department of Microbiology and Immunology, University of Nevada, Reno, Nev 89557, USA
    Exp Hematol 32:318-24. 2004
  6. pmc Inhibition of acute graft-versus-host disease with retention of graft-versus-tumor effects by the proteasome inhibitor bortezomib
    Kai Sun
    Department of Microbiology and Immunology, University of Nevada, Reno, NV 89557, USA
    Proc Natl Acad Sci U S A 101:8120-5. 2004
  7. pmc Regulatory and conventional CD4+ T cells show differential effects correlating with PD-1 and B7-H1 expression after immunotherapy
    Kory L Alderson
    Department of Microbiology and Immunology, University of Nevada, Reno, NV 89557, USA
    J Immunol 180:2981-8. 2008
  8. ncbi request reprint NK-cell purging of leukemia: superior antitumor effects of NK cells H2 allogeneic to the tumor and augmentation with inhibitory receptor blockade
    Crystal Y Koh
    Department of Microbiology and Immunology, University of Nevada School of Medicine, Applied Research Facility, Bldg 344 MS 199, Reno, NV 89557, USA
    Blood 102:4067-75. 2003
  9. pmc mAbs to Bacillus anthracis capsular antigen for immunoprotection in anthrax and detection of antigenemia
    Thomas R Kozel
    Department of Microbiology and Immunology, University of Nevada School of Medicine, Reno, NV 89557, USA
    Proc Natl Acad Sci U S A 101:5042-7. 2004
  10. pmc Immunomodulation and pharmacological strategies in the treatment of graft-versus-host disease
    Minghui Li
    University of Nevada, University of Nevada School of Medicine, Department of Microbiology and Immunology, Mail Stop 199, Reno, NV 89557, USA
    Expert Opin Pharmacother 9:2305-16. 2008

Research Grants

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Synergistic anti-tumor responses after administration of agonistic antibodies to CD40 and IL-2: coordination of dendritic and CD8+ cell responses
    William J Murphy
    Department of Microbiology, University of Nevada School of Medicine, Reno, NV 89557, USA
    J Immunol 170:2727-33. 2003
    ..CD40 stimulation and IL-2 may therefore be of use to promote antitumor responses in advanced metastatic cancer...
  2. ncbi request reprint Natural killer cells: biology and clinical use in cancer therapy
    William H D Hallett
    Department of Microbiology and Immunology, University of Nevada School of Medicine, University of Nevada, Reno, Reno, NV 89557, USA
    Cell Mol Immunol 1:12-21. 2004
    ..This review will attempt to be a synthesis of current knowledge concerning NK cells, their involvement in BMT, and their use as an immunotherapy for cancer and other hematologic malignancies...
  3. ncbi request reprint Tumor regression by anti-CD40 and interleukin-2: role of CD40 in hematopoietic cells and organ-specific effects
    Lisbeth A Welniak
    Department of Microbiology and Immunology, University of Nevada, Reno, Nevada 89557, USA
    Biol Blood Marrow Transplant 10:534-9. 2004
    ..The results also suggest that the immunologic events in the liver may be more revealing that those in lymphoid organs with regard to critical events related to responses after therapy...
  4. pmc Immunomodulation with CD40 stimulation and interleukin-2 protects mice from disseminated cryptococcosis
    Qing Zhou
    Department of Microbiology and Immunology, University of Nevada, Reno, 1664 N Virginia St, Reno, NV 89557, USA
    Infect Immun 74:2161-8. 2006
    ..These studies indicate that immunotherapy using anti-CD40 and IL-2 has therapeutic potential in augmenting host resistance to disseminated cryptococcosis and that IFN-gamma is essential for efficacy...
  5. ncbi request reprint An absence of CCR5 on donor cells results in acceleration of acute graft-vs-host disease
    Lisbeth A Welniak
    Department of Microbiology and Immunology, University of Nevada, Reno, Nev 89557, USA
    Exp Hematol 32:318-24. 2004
    ..We therefore assessed the role of CCR5 on donor cells in models where intensive conditioning of the recipient occurs, thus more appropriately mirroring the clinical experience...
  6. pmc Inhibition of acute graft-versus-host disease with retention of graft-versus-tumor effects by the proteasome inhibitor bortezomib
    Kai Sun
    Department of Microbiology and Immunology, University of Nevada, Reno, NV 89557, USA
    Proc Natl Acad Sci U S A 101:8120-5. 2004
    ..Increased cytotoxic T cell killing of the tumor was also observed. Thus, the combination of proteasome inhibition with selective immune attack can markedly increase the efficacy of BMT in cancer...
  7. pmc Regulatory and conventional CD4+ T cells show differential effects correlating with PD-1 and B7-H1 expression after immunotherapy
    Kory L Alderson
    Department of Microbiology and Immunology, University of Nevada, Reno, NV 89557, USA
    J Immunol 180:2981-8. 2008
    ..These results suggest that subset-specific expansion may contribute to marked shifts in the composition of the T cell compartment, potentially influencing the effectiveness of some immunotherapeutic approaches that rely on IFN-gamma...
  8. ncbi request reprint NK-cell purging of leukemia: superior antitumor effects of NK cells H2 allogeneic to the tumor and augmentation with inhibitory receptor blockade
    Crystal Y Koh
    Department of Microbiology and Immunology, University of Nevada School of Medicine, Applied Research Facility, Bldg 344 MS 199, Reno, NV 89557, USA
    Blood 102:4067-75. 2003
    ..These results demonstrate that H2-allogeneic NK cells mediate more potent antitumor effects than syngeneic NK cells without adverse hematologic effects and thus may be useful in cancer therapy...
  9. pmc mAbs to Bacillus anthracis capsular antigen for immunoprotection in anthrax and detection of antigenemia
    Thomas R Kozel
    Department of Microbiology and Immunology, University of Nevada School of Medicine, Reno, NV 89557, USA
    Proc Natl Acad Sci U S A 101:5042-7. 2004
    ....
  10. pmc Immunomodulation and pharmacological strategies in the treatment of graft-versus-host disease
    Minghui Li
    University of Nevada, University of Nevada School of Medicine, Department of Microbiology and Immunology, Mail Stop 199, Reno, NV 89557, USA
    Expert Opin Pharmacother 9:2305-16. 2008
    ..However, morbidity and mortality due to graft-versus-host disease (GVHD) remain a major barrier to its application...
  11. ncbi request reprint The synthetic triterpenoid, CDDO, suppresses alloreactive T cell responses and reduces murine early acute graft-versus-host disease mortality
    Kai Sun
    Department of Microbiology and Immunology, University of Nevada, Reno, Nevada, USA
    Biol Blood Marrow Transplant 13:521-9. 2007
    ..These findings indicate that CDDO has a significant immunomodulatory effects in vitro and on early lethal aGVHD development, particularly affecting the liver, in a murine allo-HSCT model...
  12. pmc Combination therapy using IL-2 and anti-CD25 results in augmented natural killer cell-mediated antitumor responses
    William H D Hallett
    Department of Microbiology and Immunology, University of Nevada School of Medicine, University of Nevada, Reno, NV 89557, USA
    Biol Blood Marrow Transplant 14:1088-99. 2008
    ..These findings demonstrate that superior NK cell-mediated antileukemic effects can be achieved with IL-2 administration and concurrent depletion of CD25(+) cells...
  13. ncbi request reprint Immunobiology of allogeneic hematopoietic stem cell transplantation
    Lisbeth A Welniak
    Department of Microbiology and Immunology, University of Nevada, Reno, Nevada 89557, USA
    Annu Rev Immunol 25:139-70. 2007
    ..We also review new strategies to optimize the GVT and improve overall immune function while reducing GVHD and graft rejection...
  14. pmc Differential effects of donor T-cell cytokines on outcome with continuous bortezomib administration after allogeneic bone marrow transplantation
    Kai Sun
    Department of Microbiology and Immunology, University of Nevada, School of Medicine, Reno, NV 89557, USA
    Blood 112:1522-9. 2008
    ..These results indicate that decreased toxicity and increased efficacy of bortezomib in murine allo-BMT can be achieved by removal of CD4(+) T cells from the graft or by inhibiting TNFalpha...
  15. ncbi request reprint The immunobiology of natural killer cells and bone marrow allograft rejection
    Isabel Barao
    Department of Microbiology and Immunology, University of Nevada School of Medicine, University of Nevada, Reno, Nevda 89557, USA
    Biol Blood Marrow Transplant 9:727-41. 2003
    ....
  16. pmc Peyer patches are not required for acute graft-versus-host disease after myeloablative conditioning and murine allogeneic bone marrow transplantation
    Lisbeth A Welniak
    Department of Microbiology and Immunology, University of Nevada School of Medicine, Mail Stop 199, Reno, NV 89557, USA
    Blood 107:410-2. 2006
    ..We conclude that neither PPs nor host TNF-alpha is required for the development of acute lethal GVHD in mice that undergo myeloablative conditioning and allogeneic BMT...
  17. pmc Suppression of natural killer cell-mediated bone marrow cell rejection by CD4+CD25+ regulatory T cells
    Isabel Barao
    Department of Microbiology and Immunology, University of Nevada School of Medicine, Reno, NV 89557, USA
    Proc Natl Acad Sci U S A 103:5460-5. 2006
    ..Thus, CD4(+)CD25(+) Treg cells can potently inhibit NK cell function in vivo, and their depletion may have therapeutic ramifications for NK cell function in BM transplantation and cancer therapy...
  18. ncbi request reprint IFN-gamma mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy
    Vanessa Berner
    Department of Microbiology and Immunology, University of Nevada at Reno, Reno, Nevada 89557, USA
    Nat Med 13:354-60. 2007
    ..Thus, although immunotherapeutic regimens inducing strong IFN-gamma responses can lead to successful early antitumor efficacy, they may also impair the development of durable antitumor responses...
  19. pmc Immunotherapy following hematopoietic stem cell transplantation: potential for synergistic effects
    Myriam N Bouchlaka
    Department of Microbiology and Immunology, University of Nevada, Reno, NV, USA
    Immunotherapy 2:399-418. 2010
    ....
  20. pmc Hematopoietic progenitor cell regulation by CD4+CD25+ T cells
    Maite Urbieta
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Blood 115:4934-43. 2010
    ..Together, these findings illustrate that both recipient and donor Tregs can influence hematopoietic progenitor cell activity after transplantation and that these cells can alter responses outside the adaptive and innate immune systems...
  21. ncbi request reprint Sensitization of tumor cells to NK cell-mediated killing by proteasome inhibition
    William H D Hallett
    Department of Microbiology and Immunology, University of Nevada School of Medicine, University of Nevada, Reno, NV 89557, USA
    J Immunol 180:163-70. 2008
    ..These results suggest that the combination of proteasome inhibition with immune therapy may result in increased antitumor efficacy...
  22. pmc Differential effects of proteasome inhibition by bortezomib on murine acute graft-versus-host disease (GVHD): delayed administration of bortezomib results in increased GVHD-dependent gastrointestinal toxicity
    Kai Sun
    Department of Microbiology and Immunology, University of Nevada, Reno, NV 89557, USA
    Blood 106:3293-9. 2005
    ..These results indicate that the differential effects of proteasome inhibition with bortezomib on GVHD are critically dependent on the timing of bortezomib administration...
  23. ncbi request reprint Positive and negative regulation of Natural Killer cells: therapeutic implications
    William H D Hallett
    Department of Microbiology and Immunology, MS 199, University of Nevada School of Medicine, University of Nevada Reno, Reno, NV 89557, USA
    Semin Cancer Biol 16:367-82. 2006
    ....
  24. ncbi request reprint Immune response and immunotherapy to Cryptococcus infections
    Qing Zhou
    Department of Microbiology and Immunology, University of Nevada, Reno, NV 89557, USA
    Immunol Res 35:191-208. 2006
    ..neoformans to the brain. In this review, we analyze the current understanding of the interaction between host immune response and C. neoformans as well as the current state of immunotherapeutic strategies for treating cryptococcosis...
  25. ncbi request reprint Effects of organ-specific loss of insulin-like growth factor-I production on murine hematopoiesis
    Lisbeth A Welniak
    Department of Microbiology and Immunology, University of Nevada School of Medicine, Reno 89557, USA
    Biol Blood Marrow Transplant 10:32-9. 2004
    ..Liver production of IGF-I and, therefore, normal serum levels of this hormone, although not necessary for general organ growth and development, seems necessary for survival or transition of myeloid progenitors into the spleen...
  26. ncbi request reprint Antigen specific memory T cells and their putative need for the generation of sustained anti-tumor responses
    Kory L Alderson
    University of Neveda, Reno, Neveda, USA
    Adv Exp Med Biol 684:155-65. 2010
    ....
  27. pmc Treating metastatic solid tumors with bortezomib and a tumor necrosis factor-related apoptosis-inducing ligand receptor agonist antibody
    Anil Shanker
    Laboratory of Experimental Immunology, Cancer and Inflammation Program, SAIC Frederick, Inc, National Cancer Institute Frederick, Frederick, MD 21702, USA
    J Natl Cancer Inst 100:649-62. 2008
    ..All statistical tests were two-sided...

Research Grants1

  1. Positive and Negative Regulation of Natural Killer Cells After BMT
    William Murphy; Fiscal Year: 2007
    ..The data obtained from this proposal should yield significant insights into NK cell biology as well as allowing the development of approaches that result in superior anti-tumor effects. ..