Research Topics
Species | WILLIAM JOSEPH MURPHYSummaryAffiliation: University of Nevada Country: USA Publications
Research Grants
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Detail Information
Publications
Synergistic anti-tumor responses after administration of agonistic antibodies to CD40 and IL-2: coordination of dendritic and CD8+ cell responsesWilliam J Murphy
Department of Microbiology, University of Nevada School of Medicine, Reno, NV 89557, USA
J Immunol 170:2727-33. 2003..CD40 stimulation and IL-2 may therefore be of use to promote antitumor responses in advanced metastatic cancer...- Natural killer cells: biology and clinical use in cancer therapyWilliam H D Hallett
Department of Microbiology and Immunology, University of Nevada School of Medicine, University of Nevada, Reno, Reno, NV 89557, USA
Cell Mol Immunol 1:12-21. 2004..This review will attempt to be a synthesis of current knowledge concerning NK cells, their involvement in BMT, and their use as an immunotherapy for cancer and other hematologic malignancies... - Tumor regression by anti-CD40 and interleukin-2: role of CD40 in hematopoietic cells and organ-specific effectsLisbeth A Welniak
Department of Microbiology and Immunology, University of Nevada, Reno, Nevada 89557, USA
Biol Blood Marrow Transplant 10:534-9. 2004..The results also suggest that the immunologic events in the liver may be more revealing that those in lymphoid organs with regard to critical events related to responses after therapy... 
Immunomodulation with CD40 stimulation and interleukin-2 protects mice from disseminated cryptococcosisQing Zhou
Department of Microbiology and Immunology, University of Nevada, Reno, 1664 N Virginia St, Reno, NV 89557, USA
Infect Immun 74:2161-8. 2006..These studies indicate that immunotherapy using anti-CD40 and IL-2 has therapeutic potential in augmenting host resistance to disseminated cryptococcosis and that IFN-gamma is essential for efficacy...- An absence of CCR5 on donor cells results in acceleration of acute graft-vs-host diseaseLisbeth A Welniak
Department of Microbiology and Immunology, University of Nevada, Reno, Nev 89557, USA
Exp Hematol 32:318-24. 2004..We therefore assessed the role of CCR5 on donor cells in models where intensive conditioning of the recipient occurs, thus more appropriately mirroring the clinical experience... - Inhibition of acute graft-versus-host disease with retention of graft-versus-tumor effects by the proteasome inhibitor bortezomibKai Sun
Department of Microbiology and Immunology, University of Nevada, Reno, NV 89557, USA
Proc Natl Acad Sci U S A 101:8120-5. 2004..Increased cytotoxic T cell killing of the tumor was also observed. Thus, the combination of proteasome inhibition with selective immune attack can markedly increase the efficacy of BMT in cancer... - Regulatory and conventional CD4+ T cells show differential effects correlating with PD-1 and B7-H1 expression after immunotherapyKory L Alderson
Department of Microbiology and Immunology, University of Nevada, Reno, NV 89557, USA
J Immunol 180:2981-8. 2008..These results suggest that subset-specific expansion may contribute to marked shifts in the composition of the T cell compartment, potentially influencing the effectiveness of some immunotherapeutic approaches that rely on IFN-gamma... - NK-cell purging of leukemia: superior antitumor effects of NK cells H2 allogeneic to the tumor and augmentation with inhibitory receptor blockadeCrystal Y Koh
Department of Microbiology and Immunology, University of Nevada School of Medicine, Applied Research Facility, Bldg 344/MS 199, Reno, NV 89557, USA
Blood 102:4067-75. 2003..These results demonstrate that H2-allogeneic NK cells mediate more potent antitumor effects than syngeneic NK cells without adverse hematologic effects and thus may be useful in cancer therapy... - mAbs to Bacillus anthracis capsular antigen for immunoprotection in anthrax and detection of antigenemiaThomas R Kozel
Department of Microbiology and Immunology, University of Nevada School of Medicine, Reno, NV 89557, USA
Proc Natl Acad Sci U S A 101:5042-7. 2004.... - Immunomodulation and pharmacological strategies in the treatment of graft-versus-host diseaseMinghui Li
University of Nevada, University of Nevada School of Medicine, Department of Microbiology and Immunology, Mail Stop 199, Reno, NV 89557, USA
Expert Opin Pharmacother 9:2305-16. 2008..However, morbidity and mortality due to graft-versus-host disease (GVHD) remain a major barrier to its application... - The synthetic triterpenoid, CDDO, suppresses alloreactive T cell responses and reduces murine early acute graft-versus-host disease mortalityKai Sun
Department of Microbiology and Immunology, University of Nevada, Reno, Nevada, USA
Biol Blood Marrow Transplant 13:521-9. 2007..These findings indicate that CDDO has a significant immunomodulatory effects in vitro and on early lethal aGVHD development, particularly affecting the liver, in a murine allo-HSCT model... - Combination therapy using IL-2 and anti-CD25 results in augmented natural killer cell-mediated antitumor responsesWilliam H D Hallett
Department of Microbiology and Immunology, University of Nevada School of Medicine, University of Nevada, Reno, NV 89557, USA
Biol Blood Marrow Transplant 14:1088-99. 2008..These findings demonstrate that superior NK cell-mediated antileukemic effects can be achieved with IL-2 administration and concurrent depletion of CD25(+) cells... - Immunobiology of allogeneic hematopoietic stem cell transplantationLisbeth A Welniak
Department of Microbiology and Immunology, University of Nevada, Reno, Nevada 89557, USA
Annu Rev Immunol 25:139-70. 2007..We also review new strategies to optimize the GVT and improve overall immune function while reducing GVHD and graft rejection... - Differential effects of donor T-cell cytokines on outcome with continuous bortezomib administration after allogeneic bone marrow transplantationKai Sun
Department of Microbiology and Immunology, University of Nevada, School of Medicine, Reno, NV 89557, USA
Blood 112:1522-9. 2008..These results indicate that decreased toxicity and increased efficacy of bortezomib in murine allo-BMT can be achieved by removal of CD4(+) T cells from the graft or by inhibiting TNFalpha... - The immunobiology of natural killer cells and bone marrow allograft rejectionIsabel Barao
Department of Microbiology and Immunology, University of Nevada School of Medicine, University of Nevada, Reno, Nevda 89557, USA
Biol Blood Marrow Transplant 9:727-41. 2003.... - Peyer patches are not required for acute graft-versus-host disease after myeloablative conditioning and murine allogeneic bone marrow transplantationLisbeth A Welniak
Department of Microbiology and Immunology, University of Nevada School of Medicine, Mail Stop 199, Reno, NV 89557, USA
Blood 107:410-2. 2006..We conclude that neither PPs nor host TNF-alpha is required for the development of acute lethal GVHD in mice that undergo myeloablative conditioning and allogeneic BMT... - Suppression of natural killer cell-mediated bone marrow cell rejection by CD4+CD25+ regulatory T cellsIsabel Barao
Department of Microbiology and Immunology, University of Nevada School of Medicine, Reno, NV 89557, USA
Proc Natl Acad Sci U S A 103:5460-5. 2006..Thus, CD4(+)CD25(+) Treg cells can potently inhibit NK cell function in vivo, and their depletion may have therapeutic ramifications for NK cell function in BM transplantation and cancer therapy... - IFN-gamma mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapyVanessa Berner
Department of Microbiology and Immunology, University of Nevada at Reno, Reno, Nevada 89557, USA
Nat Med 13:354-60. 2007..Thus, although immunotherapeutic regimens inducing strong IFN-gamma responses can lead to successful early antitumor efficacy, they may also impair the development of durable antitumor responses... - Immunotherapy following hematopoietic stem cell transplantation: potential for synergistic effectsMyriam N Bouchlaka
Department of Microbiology and Immunology, University of Nevada, Reno, NV, USA
Immunotherapy 2:399-418. 2010.... - Hematopoietic progenitor cell regulation by CD4+CD25+ T cellsMaite Urbieta
Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33101, USA
Blood 115:4934-43. 2010..Together, these findings illustrate that both recipient and donor Tregs can influence hematopoietic progenitor cell activity after transplantation and that these cells can alter responses outside the adaptive and innate immune systems... - Sensitization of tumor cells to NK cell-mediated killing by proteasome inhibitionWilliam H D Hallett
Department of Microbiology and Immunology, University of Nevada School of Medicine, University of Nevada, Reno, NV 89557, USA
J Immunol 180:163-70. 2008..These results suggest that the combination of proteasome inhibition with immune therapy may result in increased antitumor efficacy... - Differential effects of proteasome inhibition by bortezomib on murine acute graft-versus-host disease (GVHD): delayed administration of bortezomib results in increased GVHD-dependent gastrointestinal toxicityKai Sun
Department of Microbiology and Immunology, University of Nevada, Reno, NV 89557, USA
Blood 106:3293-9. 2005..These results indicate that the differential effects of proteasome inhibition with bortezomib on GVHD are critically dependent on the timing of bortezomib administration... - Positive and negative regulation of Natural Killer cells: therapeutic implicationsWilliam H D Hallett
Department of Microbiology and Immunology, MS 199, University of Nevada School of Medicine, University of Nevada Reno, Reno, NV 89557, USA
Semin Cancer Biol 16:367-82. 2006.... - Immune response and immunotherapy to Cryptococcus infectionsQing Zhou
Department of Microbiology and Immunology, University of Nevada, Reno, NV 89557, USA
Immunol Res 35:191-208. 2006..neoformans to the brain. In this review, we analyze the current understanding of the interaction between host immune response and C. neoformans as well as the current state of immunotherapeutic strategies for treating cryptococcosis... - Effects of organ-specific loss of insulin-like growth factor-I production on murine hematopoiesisLisbeth A Welniak
Department of Microbiology and Immunology, University of Nevada School of Medicine, Reno 89557, USA
Biol Blood Marrow Transplant 10:32-9. 2004..Liver production of IGF-I and, therefore, normal serum levels of this hormone, although not necessary for general organ growth and development, seems necessary for survival or transition of myeloid progenitors into the spleen... - Antigen specific memory T cells and their putative need for the generation of sustained anti-tumor responsesKory L Alderson
University of Neveda, Reno, Neveda, USA
Adv Exp Med Biol 684:155-65. 2010.... - Treating metastatic solid tumors with bortezomib and a tumor necrosis factor-related apoptosis-inducing ligand receptor agonist antibodyAnil Shanker
Laboratory of Experimental Immunology, Cancer and Inflammation Program, SAIC Frederick, Inc, National Cancer Institute Frederick, Frederick, MD 21702, USA
J Natl Cancer Inst 100:649-62. 2008..All statistical tests were two-sided...
Research Grants
- Positive and Negative Regulation of Natural Killer Cells After BMTWilliam Murphy; Fiscal Year: 2007..The data obtained from this proposal should yield significant insights into NK cell biology as well as allowing the development of approaches that result in superior anti-tumor effects. ..