T F Murphy
Affiliation: University at Buffalo
- Branhamella catarrhalis: epidemiology, surface antigenic structure, and immune responseT F Murphy
Department of Medicine, State University of New York at Buffalo, USA
Microbiol Rev 60:267-79. 1996..Future studies to understand the mechanisms of infection and to elucidate the human immune response to infection hold promise of developing new methods to treat and prevent infections caused by B. catarrhalis...
- Analysis of antigenic structure and human immune response to outer membrane protein CD of Moraxella catarrhalisT F Murphy
Divisions of Infectious Diseases, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York 14215, USA
Infect Immun 67:4578-85. 1999..While individual adults with COPD show variability in the immune response to OMP CD, a specific region of the OMP CD molecule (amino acids 203 to 260) is important as a target of the human immune response...
- Enhancement of pulmonary clearance of Moraxella (Branhamella) catarrhalis following immunization with outer membrane protein CD in a mouse modelT F Murphy
Department of Medicine Division of Infectious Diseases, State University of New York at Buffalo, NY, USA
J Infect Dis 178:1667-75. 1998..On the basis of these results, OMP CD should undergo continued testing to determine whether it will induce a protective immune response in humans...
- Antigenic structure of outer membrane protein E of Moraxella catarrhalis and construction and characterization of mutantsT F Murphy
Division of Infectious Diseases of the Department of Medicine, State University of New York at Buffalo, Buffalo, New York 14215, USA
Infect Immun 68:6250-6. 2000..In bactericidal assays, the mutants were more readily killed by normal human serum compared to the isogenic parent strains. These results indicate that OMP E is involved in the expression of serum resistance of M. catarrhalis...
- Simultaneous respiratory tract colonization by multiple strains of nontypeable haemophilus influenzae in chronic obstructive pulmonary disease: implications for antibiotic therapyT F Murphy
Division of Infectious Diseases, Department of Microbiology, State University of New York at Buffalo, USA
J Infect Dis 180:404-9. 1999..Therefore, multiple strains of H. influenzae are frequently present simultaneously in the sputum of adults with COPD, and the antimicrobial susceptibility of different strains in the same sputum sometimes differs...
- Conservation of outer membrane protein E among strains of Moraxella catarrhalisT F Murphy
Division of Infectious Diseases, Department of Medicine, State University of New York at Buffalo, 14215, USA
Infect Immun 69:3576-80. 2001..These results indicate that OMP E is highly conserved among strains of M. catarrhalis, and preliminary studies indicate that the gene which encodes OMP E remains stable during colonization of the human respiratory tract...