T F Murphy

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. ncbi request reprint Simultaneous respiratory tract colonization by multiple strains of nontypeable haemophilus influenzae in chronic obstructive pulmonary disease: implications for antibiotic therapy
    T F Murphy
    Division of Infectious Diseases, Department of Microbiology, State University of New York at Buffalo, USA
    J Infect Dis 180:404-9. 1999
  2. ncbi request reprint Chronic obstructive pulmonary disease: role of bacteria and guide to antibacterial selection in the older patient
    Timothy F Murphy
    Division of Infectious Diseases, University at Buffalo, State University of New York and Department of Veterans Affairs Western New York Health System, Buffalo, USA
    Drugs Aging 19:761-75. 2002
  3. pmc Biofilm formation by nontypeable Haemophilus influenzae: strain variability, outer membrane antigen expression and role of pili
    Timothy F Murphy
    Division of Infectious Diseases, Department of Medicine, University at Buffalo, State University of New York, USA
    BMC Microbiol 2:7. 2002
  4. ncbi request reprint Persistent colonization by Haemophilus influenzae in chronic obstructive pulmonary disease
    Timothy F Murphy
    Division of Infectious Diseases, Department of Medicine, University at Buffalo, State University of New York and the Veterans Affairs Western New York Healthcare System, Buffalo, New York 14215, USA
    Am J Respir Crit Care Med 170:266-72. 2004
  5. pmc Conservation of outer membrane protein E among strains of Moraxella catarrhalis
    T F Murphy
    Division of Infectious Diseases, Department of Medicine, State University of New York at Buffalo, 14215, USA
    Infect Immun 69:3576-80. 2001
  6. pmc Antigenic structure of outer membrane protein E of Moraxella catarrhalis and construction and characterization of mutants
    T F Murphy
    Division of Infectious Diseases of the Department of Medicine, State University of New York at Buffalo, Buffalo, New York 14215, USA
    Infect Immun 68:6250-6. 2000
  7. ncbi request reprint Bacterial otitis media: pathogenetic considerations
    T F Murphy
    Department of Medicine, State University of New York at Buffalo, Department of Veterans Affairs Western New York Healthcare System, 14215, USA
    Pediatr Infect Dis J 19:S9-15; discussion S15-6. 2000
  8. pmc Analysis of antigenic structure and human immune response to outer membrane protein CD of Moraxella catarrhalis
    T F Murphy
    Divisions of Infectious Diseases, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York 14215, USA
    Infect Immun 67:4578-85. 1999
  9. ncbi request reprint Respiratory infections caused by non-typeable Haemophilus influenzae
    Timothy F Murphy
    Department of Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA
    Curr Opin Infect Dis 16:129-34. 2003
  10. pmc Human immune response to outer membrane protein CD of Moraxella catarrhalis in adults with chronic obstructive pulmonary disease
    Timothy F Murphy
    Division of Infectious Diseases, University at Buffalo, The State University of New York, New York, USA
    Infect Immun 71:1288-94. 2003

Collaborators

Detail Information

Publications80

  1. ncbi request reprint Simultaneous respiratory tract colonization by multiple strains of nontypeable haemophilus influenzae in chronic obstructive pulmonary disease: implications for antibiotic therapy
    T F Murphy
    Division of Infectious Diseases, Department of Microbiology, State University of New York at Buffalo, USA
    J Infect Dis 180:404-9. 1999
    ..Therefore, multiple strains of H. influenzae are frequently present simultaneously in the sputum of adults with COPD, and the antimicrobial susceptibility of different strains in the same sputum sometimes differs...
  2. ncbi request reprint Chronic obstructive pulmonary disease: role of bacteria and guide to antibacterial selection in the older patient
    Timothy F Murphy
    Division of Infectious Diseases, University at Buffalo, State University of New York and Department of Veterans Affairs Western New York Health System, Buffalo, USA
    Drugs Aging 19:761-75. 2002
    ..The major goals of antibacterial therapy for exacerbations of COPD are acceleration of symptom resolution and prevention of the complications of exacerbation...
  3. pmc Biofilm formation by nontypeable Haemophilus influenzae: strain variability, outer membrane antigen expression and role of pili
    Timothy F Murphy
    Division of Infectious Diseases, Department of Medicine, University at Buffalo, State University of New York, USA
    BMC Microbiol 2:7. 2002
    ..Several lines of evidence suggest that the bacterium grows as a biofilm in the human respiratory tract...
  4. ncbi request reprint Persistent colonization by Haemophilus influenzae in chronic obstructive pulmonary disease
    Timothy F Murphy
    Division of Infectious Diseases, Department of Medicine, University at Buffalo, State University of New York and the Veterans Affairs Western New York Healthcare System, Buffalo, New York 14215, USA
    Am J Respir Crit Care Med 170:266-72. 2004
    ..influenzae and that sputum cultures underestimate the frequency of colonization of the respiratory tract by H. influenzae in COPD. This observation has a significant impact on understanding bacterial colonization in COPD...
  5. pmc Conservation of outer membrane protein E among strains of Moraxella catarrhalis
    T F Murphy
    Division of Infectious Diseases, Department of Medicine, State University of New York at Buffalo, 14215, USA
    Infect Immun 69:3576-80. 2001
    ..These results indicate that OMP E is highly conserved among strains of M. catarrhalis, and preliminary studies indicate that the gene which encodes OMP E remains stable during colonization of the human respiratory tract...
  6. pmc Antigenic structure of outer membrane protein E of Moraxella catarrhalis and construction and characterization of mutants
    T F Murphy
    Division of Infectious Diseases of the Department of Medicine, State University of New York at Buffalo, Buffalo, New York 14215, USA
    Infect Immun 68:6250-6. 2000
    ..In bactericidal assays, the mutants were more readily killed by normal human serum compared to the isogenic parent strains. These results indicate that OMP E is involved in the expression of serum resistance of M. catarrhalis...
  7. ncbi request reprint Bacterial otitis media: pathogenetic considerations
    T F Murphy
    Department of Medicine, State University of New York at Buffalo, Department of Veterans Affairs Western New York Healthcare System, 14215, USA
    Pediatr Infect Dis J 19:S9-15; discussion S15-6. 2000
    ..These areas of investigation have important implications in understanding the pathogenesis of OM. Elucidating mechanisms of pathogenesis will be important in guiding development of novel ways to prevent OM...
  8. pmc Analysis of antigenic structure and human immune response to outer membrane protein CD of Moraxella catarrhalis
    T F Murphy
    Divisions of Infectious Diseases, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York 14215, USA
    Infect Immun 67:4578-85. 1999
    ..While individual adults with COPD show variability in the immune response to OMP CD, a specific region of the OMP CD molecule (amino acids 203 to 260) is important as a target of the human immune response...
  9. ncbi request reprint Respiratory infections caused by non-typeable Haemophilus influenzae
    Timothy F Murphy
    Department of Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA
    Curr Opin Infect Dis 16:129-34. 2003
    ..In addition, newer developments in the areas of mechanisms of pathogenesis, host pathogen interaction, immune responses and efforts toward vaccine development will be reviewed briefly...
  10. pmc Human immune response to outer membrane protein CD of Moraxella catarrhalis in adults with chronic obstructive pulmonary disease
    Timothy F Murphy
    Division of Infectious Diseases, University at Buffalo, The State University of New York, New York, USA
    Infect Immun 71:1288-94. 2003
    ..Three of 28 patients developed new mucosal IgA to OMP CD in sputum supernatants. This study establishes that OMP CD is a target of a systemic and mucosal immune response following infection and colonization in some patients with COPD...
  11. ncbi request reprint Mechanisms of recurrent otitis media: importance of the immune response to bacterial surface antigens
    T F Murphy
    Department of Medicine and Microbiology, State University of New York at Buffalo 14214, USA
    Ann N Y Acad Sci 830:353-60. 1997
    ..The ability of the bacterium to direct the host to make a strain-specific antibody response has important implications in understanding the immune response to otitis media due to NTHI and in designing strategies for vaccine development...
  12. ncbi request reprint Enhancement of pulmonary clearance of Moraxella (Branhamella) catarrhalis following immunization with outer membrane protein CD in a mouse model
    T F Murphy
    Department of Medicine Division of Infectious Diseases, State University of New York at Buffalo, NY, USA
    J Infect Dis 178:1667-75. 1998
    ..On the basis of these results, OMP CD should undergo continued testing to determine whether it will induce a protective immune response in humans...
  13. doi request reprint Mucosal immunization of mice with recombinant OMP P2 induces antibodies that bind to surface epitopes of multiple strains of nontypeable Haemophilus influenzae
    K L Ostberg
    Department of Microbiology and Immunology, University at Buffalo, The State University of New York, Buffalo, New York, USA
    Mucosal Immunol 2:63-73. 2009
    ....
  14. ncbi request reprint Molecular typing of paired bacterial isolates from the adenoid and lateral wall of the nose in children undergoing adenoidectomy: implications in acute rhinosinusitis
    J M Bernstein
    Department of Otolaryngology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, NY, USA
    Otolaryngol Head Neck Surg 125:593-7. 2001
    ..The purpose of this study was to compare the molecular biological profiles of potential pathogens found in the nasopharynx and lateral wall of the nose concomittantly in children undergoing surgery for upper respiratory tract disease...
  15. pmc Mining the Moraxella catarrhalis genome: identification of potential vaccine antigens expressed during human infection
    Elizabeth A Ruckdeschel
    Department of Microbiology, University at Buffalo, State University of New York, Buffalo, New York, USA
    Infect Immun 76:1599-607. 2008
    ..catarrhalis, and represent potential vaccine antigens...
  16. ncbi request reprint Human serum and mucosal antibody responses to outer membrane protein G1b of Moraxella catarrhalis in chronic obstructive pulmonary disease
    Diana G Adlowitz
    Department of Microbiology, University of Buffalo, State University of New York, USA
    FEMS Immunol Med Microbiol 46:139-46. 2006
    ..These observations indicate that outer membrane protein G1b should be evaluated further as a vaccine antigen...
  17. pmc Human antibody response to outer membrane protein G1a, a lipoprotein of Moraxella catarrhalis
    Diana G Adlowitz
    Department of Microbiology and Immunology, University at Buffalo, State University of New York, 14215, USA
    Infect Immun 73:6601-7. 2005
    ..These observations indicate that OMP G1a, a highly conserved surface protein, should be evaluated further as a vaccine candidate...
  18. pmc Use of Moraxella catarrhalis lipooligosaccharide mutants to identify specific oligosaccharide epitopes recognized by human serum antibodies
    Johanna M Schwingel
    Department of Microbiology and Immunology, University at Buffalo, Buffalo, NY 14214, USA
    Infect Immun 77:4548-58. 2009
    ..catarrhalis LOS epitopes developed during natural infection...
  19. pmc Branhamella catarrhalis: epidemiology, surface antigenic structure, and immune response
    T F Murphy
    Department of Medicine, State University of New York at Buffalo, USA
    Microbiol Rev 60:267-79. 1996
    ..Future studies to understand the mechanisms of infection and to elucidate the human immune response to infection hold promise of developing new methods to treat and prevent infections caused by B. catarrhalis...
  20. pmc Characterization of proteins Msp22 and Msp75 as vaccine antigens of Moraxella catarrhalis
    Elizabeth A Ruckdeschel
    Department of Microbiology, University at Buffalo, The State University of New York, Buffalo, NY 14215, United States
    Vaccine 27:7065-72. 2009
    ..Msp22 and Msp75 are antigenically conserved proteins that induce potentially protective immune responses and should be examined further as vaccine antigens for M. catarrhalis...
  21. ncbi request reprint Systemic and mucosal antibody response to Moraxella catarrhalis after exacerbations of chronic obstructive pulmonary disease
    Faris Bakri
    Division of Infectious Diseases, Department of Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA
    J Infect Dis 185:632-40. 2002
    ..Therefore, adults with COPD develop variable humoral immune responses to M. catarrhalis after exacerbations, including new serum IgG and new mucosal IgA to epitopes on the bacterial surface...
  22. ncbi request reprint Sequence stability of the gene encoding outer membrane protein P2 of nontypeable Haemophilus influenzae in the human respiratory tract
    Thomas J Hiltke
    Division of Infectious Diseases, Department of Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA
    J Infect Dis 185:627-31. 2002
    ..Most of these changes occurred within areas of repetitive DNA, suggesting that this type of DNA has a role in antigenic variation of P2. The sequence of ompP2 is relatively stable during persistence of NTHI in the human host...
  23. ncbi request reprint Nontypeable Haemophilus influenzae in the lower respiratory tract of patients with chronic bronchitis
    V Bandi
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Respir Crit Care Med 164:2114-9. 2001
    ..This observation suggests a role for intracellular infection by NTHi in the pathogenesis of exacerbations of CB...
  24. ncbi request reprint Isolation and characterization of the Haemophilus influenzae tolQ, tolR, tolA and tolB genes
    K Sen
    Department of Medicine, State University of New York at Buffalo 14215, USA
    Gene 178:75-81. 1996
    ..Nucleotide sequence (nt) analysis of the entire tolQRABP6 region shows a transcriptional terminator immediately downstream of the P6 gene. The tolQRABP6 gene cluster of H. influenzae may thus constitute an operon...
  25. doi request reprint Moraxella catarrhalis, a human respiratory tract pathogen
    Timothy F Murphy
    Department of Medicine, University at Buffalo, State University of New York, USA
    Clin Infect Dis 49:124-31. 2009
    ..Recent work has elucidated mechanisms of pathogenesis and focused on vaccine development to prevent otitis media in children and respiratory tract infections caused by M. catarrhalis in adults with chronic obstructive pulmonary disease...
  26. pmc Moraxella catarrhalis in chronic obstructive pulmonary disease: burden of disease and immune response
    Timothy F Murphy
    Buffalo Veterans Affairs Medical Center 151, 3495 Bailey Avenue, Buffalo, NY 14215, USA
    Am J Respir Crit Care Med 172:195-9. 2005
    ..Moraxella catarrhalis is frequently present in the sputum of adults with chronic obstructive pulmonary disease (COPD). Little is known about the role of M. catarrhalis in this common disease...
  27. ncbi request reprint Serum antipneumococcal antibodies and pneumococcal colonization in adults with chronic obstructive pulmonary disease
    Richard Malley
    Division of Infectious Diseases, Department of Medicine, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Infect Dis 196:928-35. 2007
    ..We thus conclude that, in adult patients with COPD, resistance to pneumococcal colonization is unlikely to be determined by higher serum antibody concentrations to pneumococcal antigens...
  28. pmc Outer membrane protein P6 of nontypeable Haemophilus influenzae is a potent and selective inducer of human macrophage proinflammatory cytokines
    Charles S Berenson
    Division of Infectious Diseases 151, VA Western NY Healthcare System, 3495 Bailey Avenue, Buffalo, New York 14215, USA
    Infect Immun 73:2728-35. 2005
    ..OMP P6 of NTHI is a specific trigger of bacteria-induced human macrophage inflammatory events, with IL-8 and TNF-alpha as key effectors of P6-induced macrophage responses...
  29. ncbi request reprint Airway bacterial concentrations and exacerbations of chronic obstructive pulmonary disease
    Sanjay Sethi
    Veterans Affairs Western New York Healthcare System 151, 3495 Bailey Avenue, Buffalo, NY 14215, USA
    Am J Respir Crit Care Med 176:356-61. 2007
    ..Bacterial concentrations are higher during exacerbation than during stable disease; however, these studies are cross sectional and devoid of strain typing...
  30. ncbi request reprint Haemophilus haemolyticus: a human respiratory tract commensal to be distinguished from Haemophilus influenzae
    Timothy F Murphy
    Department of Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA
    J Infect Dis 195:81-9. 2007
    ..In a prospective study, selected isolates of apparent H. influenzae had an altered phenotype. We tested the hypothesis that these variant strains were genetically different from typical H. influenzae...
  31. pmc Identification of surface antigens of Moraxella catarrhalis as targets of human serum antibody responses in chronic obstructive pulmonary disease
    Timothy F Murphy
    VA Western New York Healthcare System, Medical Research 151, 3495 Bailey Avenue, Buffalo, NY 14215, USA
    Infect Immun 73:3471-8. 2005
    ..These results have important implications in understanding human immune responses to M. catarrhalis and in elucidating the elements of a protective immune response...
  32. pmc Construction of a mutant and characterization of the role of the vaccine antigen P6 in outer membrane integrity of nontypeable Haemophilus influenzae
    Timothy F Murphy
    Division of Infectious Diseases, Department of Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA
    Infect Immun 74:5169-76. 2006
    ..The observation that the absence of expression of P6 is detrimental to the cell is a highly desirable feature for a vaccine antigen, supporting further investigation of P6 as a vaccine candidate for H. influenzae...
  33. pmc Antigenic specificity of the mucosal antibody response to Moraxella catarrhalis in chronic obstructive pulmonary disease
    Timothy F Murphy
    VA Western New York Healthcare System, Medical Research 151, 3495 Bailey Avenue, Buffalo, NY 14215, USA
    Infect Immun 73:8161-6. 2005
    ..These results have important implications in understanding the mucosal immune response to M. catarrhalis in the setting of COPD and in elucidating the elements of a protective immune response...
  34. ncbi request reprint Vaccine development for non-typeable Haemophilus influenzae and Moraxella catarrhalis: progress and challenges
    Timothy F Murphy
    University at Buffalo, State University of New York, Medical Research 151, Buffalo VAMC, 3495 Bailey Avenue, Buffalo, NY 14215, USA
    Expert Rev Vaccines 4:843-53. 2005
    ..This paper reviews the key issues in vaccine development for H. influenzae and M. catarrhalis, including areas where progress has been stalled, and proposes areas that deserve investigation in the next 5 years...
  35. ncbi request reprint Vaccines for otitis media: proposals for overcoming obstacles to progress
    Timothy F Murphy
    Division of Infectious Diseases, Department of Medicine, University at Buffalo, SUNY, USA
    Vaccine 23:2696-702. 2005
    ..This review outlines a series of specific proposals intended to advance vaccine development for otitis media...
  36. doi request reprint Microbial interactions in the respiratory tract
    Timothy F Murphy
    Division of Infectious Diseases, The State University of New York, Buffalo, NY, USA
    Pediatr Infect Dis J 28:S121-6. 2009
    ....
  37. ncbi request reprint Inflammatory profile of new bacterial strain exacerbations of chronic obstructive pulmonary disease
    Sanjay Sethi
    Division of Pulmonary and Critical Care and Sleep Medicine, Department of Medicine, University at Buffalo, State University of New York, USA
    Am J Respir Crit Care Med 177:491-7. 2008
    ..The relationship between clinical severity and course of exacerbation and inflammation is also not fully understood...
  38. doi request reprint Pseudomonas aeruginosa in adults with chronic obstructive pulmonary disease
    Timothy F Murphy
    Division of Infectious Disease, Department of Medicine, University at Buffalo, State University of New York, Veterans Affairs Western New York Healthcare System, Medical Research 151, 3495 Bailey Avenue, Buffalo, NY 14215, USA
    Curr Opin Pulm Med 15:138-42. 2009
    ..The purpose of this review is to critically review the literature in an effort to understand the role of P. aeruginosa in the course and pathogenesis of COPD...
  39. ncbi request reprint Current and Future Prospects for a Vaccine for Nontypeable Haemophilus influenzae
    Timothy F Murphy
    Veterans Affairs Western New York Healthcare System, Buffalo VA Medical Center, Medical Research 151, 3495 Bailey Avenue, Buffalo, NY 14215, USA
    Curr Infect Dis Rep 11:177-82. 2009
    ..influenzae otitis media. This important result provides a proof of principle for developing a vaccine to prevent otitis media caused by nontypeable H. influenzae. Several vaccine antigens for nontypeable H. influenzae are in development...
  40. pmc Moraxella catarrhalis acquisition, airway inflammation and protease-antiprotease balance in chronic obstructive pulmonary disease
    Ganapathi I Parameswaran
    Division of Infectious Diseases, University at Buffalo, State University of New York, 701 Ellicott Street, Buffalo, NY 14203, USA
    BMC Infect Dis 9:178. 2009
    ..catarrhalis as compared to colonization...
  41. ncbi request reprint Strain-specific immune response to Haemophilus influenzae in chronic obstructive pulmonary disease
    Sanjay Sethi
    Department of Medicine, University of Buffalo SUNY and the Veterans Affairs Western New York Healthcare System, Buffalo, NY 14215, USA
    Am J Respir Crit Care Med 169:448-53. 2004
    ..2%) heterologous strains. Development of an immune response to H. influenzae supports its role in causing exacerbations. The strain specificity of the immune response likely represents a mechanism of recurrent exacerbations...
  42. ncbi request reprint New strains of bacteria and exacerbations of chronic obstructive pulmonary disease
    Sanjay Sethi
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, State University of New York, Buffalo, NY, USA
    N Engl J Med 347:465-71. 2002
    ..We hypothesized that the acquisition of a new strain of a pathogenic bacterial species is associated with exacerbation of chronic obstructive pulmonary disease...
  43. doi request reprint Placebo-controlled trials of treatments for community-acquired pneumonia: review of the literature and discussion of feasibility and potential value
    Timothy F Murphy
    Department of Medicine, Division of Infectious Diseases, State University of New York at Buffalo, Buffalo, New York, USA
    Clin Infect Dis 47:S145-9. 2008
    ..On the basis of the data reviewed, there is no justification for placebo-controlled trials involving patients with CAP of any degree of severity...
  44. ncbi request reprint The role of bacteria in airway inflammation in exacerbations of chronic obstructive pulmonary disease
    Timothy F Murphy
    Division of Infectious Diseases, University at Buffalo, State University of New York and Veterans Affairs Western New York Healthcare System, Buffalo, New York, USA
    Curr Opin Infect Dis 19:225-30. 2006
    ..The purpose of this review is to evaluate the status of research on the role of bacteria in airway inflammation during exacerbations and the mechanisms by which bacterial antigens induce inflammation...
  45. doi request reprint Nontypeable Haemophilus influenzae as a pathogen in children
    Timothy F Murphy
    University at Buffalo, The State University of New York, Buffalo, NY
    Pediatr Infect Dis J 28:43-8. 2009
    ..influenzae. Feasibility of vaccination for prevention of otitis media due to nontypeable H. influenzae was recently demonstrated in a clinical trial with a vaccine that included the surface virulence factor, protein D...
  46. ncbi request reprint Acute exacerbations of chronic bronchitis: new developments concerning microbiology and pathophysiology--impact on approaches to risk stratification and therapy
    Sanjay Sethi
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University at Buffalo SUNY, Buffalo, NY 14260, USA
    Infect Dis Clin North Am 18:861-82, ix. 2004
    ..This article discusses a rational, stratified approach to the use of antibiotics for this condition based on these recent studies...
  47. doi request reprint Pseudomonas aeruginosa in chronic obstructive pulmonary disease
    Timothy F Murphy
    Medical Research 151, Buffalo Veterans Affairs Medical Center, 3495 Bailey Avenue, Buffalo, NY 14215, USA
    Am J Respir Crit Care Med 177:853-60. 2008
    ..Pseudomonas aeruginosa is isolated from adults with chronic obstructive pulmonary disease (COPD) in cross-sectional studies. However, patterns of carriage and the role of P. aeruginosa in COPD are unknown...
  48. ncbi request reprint Expression of a peroxiredoxin-glutaredoxin by Haemophilus influenzae in biofilms and during human respiratory tract infection
    Timothy F Murphy
    Division of Infectious Diseases, University at Buffalo, State University of New York, Buffalo, NY, USA
    FEMS Immunol Med Microbiol 44:81-9. 2005
    ..influenzae and the degree of involvement varies among strains; and (3) peroxiredoxin-glutaredoxin is expressed by H. influenzae during infection of the human respiratory tract and is recognized by the human immune system...
  49. pmc Molecular analysis of the P2 porin protein of nontypeable Haemophilus influenzae
    D J Sikkema
    Department of Medicine, State University of New York, Buffalo
    Infect Immun 60:5204-11. 1992
    ..influenzae type b strains. We conclude that the molecular mass and antigenic heterogeneity of the P2 molecule of NTHI is due to variations in gene sequence that are clustered primarily in four large hypervariable regions of the gene...
  50. pmc Bacterial infection in chronic obstructive pulmonary disease in 2000: a state-of-the-art review
    S Sethi
    Division of Pulmonary and Critical Medicine, State University of New York at Buffalo, Buffalo, New York, USA
    Clin Microbiol Rev 14:336-63. 2001
    ....
  51. ncbi request reprint Antibodies directed at a conserved motif in loop 6 of outer membrane protein P2 of nontypeable Haemophilus influenzae recognize multiple strains in immunoassays
    John M Neary
    Department of Microbiology, University of Buffalo, State University of New York, Buffalo, NY, USA
    FEMS Immunol Med Microbiol 46:251-61. 2006
    ..These results support the concept of using conserved regions of the P2 protein as a vaccine antigen...
  52. doi request reprint Chronic obstructive pulmonary disease: role of bacteria and updated guide to antibacterial selection in the older patient
    G Iyer Parameswaran
    Division of Infectious Diseases, Department of Medicine, University at Buffalo, State University of New York, Buffalo, New York 14215, USA
    Drugs Aging 26:985-95. 2009
    ..Use of antibacterials, based on current susceptibility patterns, is beneficial in patients with severe COPD experiencing exacerbations and in patients with severe exacerbations...
  53. ncbi request reprint Lymphocyte proliferative response to P6 of Haemophilus influenzae is associated with relative protection from exacerbations of chronic obstructive pulmonary disease
    Yusuke Abe
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Am J Respir Crit Care Med 165:967-71. 2002
    ..These results indicate that decreased proliferation of T cells to P6 is associated with exacerbations of COPD and suggest that the ability of T cells to recognize P6 is associated with relative protection from exacerbations due to NTHI...
  54. ncbi request reprint Horizontal transfer of the gene encoding outer membrane protein P2 of nontypeable Haemophilus influenzae, in a patient with chronic obstructive pulmonary disease
    Thomas J Hiltke
    Division of Infectious Diseases, Department of Medicine, University at Buffalo, Buffalo, New York 14215, USA
    J Infect Dis 188:114-7. 2003
    ..Observation of ompP2 horizontal transfer in the human respiratory tract has important implications for both the understanding of ompP2 diversity among strains and the future design of OMP P2-based vaccines...
  55. ncbi request reprint Role of an immunodominant T cell epitope of the P6 protein of nontypeable Haemophilus influenzae in murine protective immunity
    Michelle McMahon
    Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Street, Buffalo, NY 14263, USA
    Vaccine 23:3590-6. 2005
    ..Collectively, these results establish that, in a mouse model, P6 contains a single immunodominant T cell epitope and this epitope plays an important role in protective immune responses induced by immunization with P6...
  56. pmc Proteomic expression profiling of Haemophilus influenzae grown in pooled human sputum from adults with chronic obstructive pulmonary disease reveal antioxidant and stress responses
    Jun Qu
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14260, USA
    BMC Microbiol 10:162. 2010
    ..Proteomic profiling was accomplished by Nano-flow liquid chromatography/mass spectroscopy with low void volume and high separation efficiency with a shallow, long gradient...
  57. pmc Characterization of igaB, a second immunoglobulin A1 protease gene in nontypeable Haemophilus influenzae
    Matthew M Fernaays
    Department of Microbiology, University at Buffalo, State University of New York, Buffalo, NY 14215, USA
    Infect Immun 74:5860-70. 2006
    ..These data support the hypothesis that the newly discovered igaB gene is a potential virulence factor in nontypeable H. influenzae...
  58. pmc Human milk lactoferrin inactivates two putative colonization factors expressed by Haemophilus influenzae
    J Qiu
    Department of Medicine, Division of Gastroenterology, Tufts New England Medical Center, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 95:12641-6. 1998
    ..influenzae by selectively inactivating IgA1 protease and Hap, thereby interfering with colonization. Future studies should examine the therapeutic potential of lactoferrin, perhaps as a supplement in infant formulas...
  59. pmc Differential genome contents of nontypeable Haemophilus influenzae strains from adults with chronic obstructive pulmonary disease
    Matthew M Fernaays
    Department of Microbiology, VA Western New York Healthcare System, Medical Research 151, 3495 Bailey Avenue, Buffalo, NY 14215, USA
    Infect Immun 74:3366-74. 2006
    ..influenzae to cause exacerbations of COPD, supporting the concept that differences in pathogenic potential are based in part on genomic differences among infecting strains, not merely host factors...
  60. ncbi request reprint Infections in chronic lung diseases
    G Iyer Parameswaran
    Division of Infectious Diseases, Department of Medicine, 3495 Bailey Avenue, University at Buffalo, State University of New York, Buffalo, NY 14215, USA
    Infect Dis Clin North Am 21:673-95, viii. 2007
    ..Rather than discussing the role of infections as etiology of these diseases, this article focuses on infections that occur in the background of established chronic lung disease...
  61. ncbi request reprint Identification and characterization of outer membrane proteins G1a and G1b of Moraxella catarrhalis
    Diana G Adlowitz
    Department of Medicine, University at Buffalo, State University of New York, Buffalo, NY 14215, USA
    Vaccine 22:2533-40. 2004
    ..catarrhalis...
  62. pmc Whipple's disease: neurological relapse presenting as headache for two years
    Anuritha R Marumganti
    Internal Medicine Residency Program, State University of New York, University at Buffalo, Buffalo, NY, USA
    J Gen Intern Med 23:2131-3. 2008
    ..Failure to recognize this presentation can lead to misdiagnosis or a significant delay in diagnosis and treatment...
  63. ncbi request reprint Inflammatory markers in bacterial exacerbations of COPD
    Timothy F Murphy
    Am J Respir Crit Care Med 165:132. 2002
  64. ncbi request reprint Otitis media, bacterial colonization, and the smoking parent
    Timothy F Murphy
    Clin Infect Dis 42:904-6. 2006
  65. ncbi request reprint Immunity to nontypeable Haemophilus influenzae: elucidating protective responses
    Timothy F Murphy
    Am J Respir Crit Care Med 167:486-7. 2003
  66. ncbi request reprint Infectious exacerbations of chronic obstructive pulmonary disease associated with respiratory viruses and non-typeable Haemophilus influenzae
    Venkata Bandi
    Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX, USA
    FEMS Immunol Med Microbiol 37:69-75. 2003
    ..The results show that exacerbations in adults with COPD were associated with infection caused by virus alone, non-typeable H. influenzae alone, or virus and non-typeable H. influenzae simultaneously...
  67. ncbi request reprint Dynamics of dendritic cell migration and the subsequent induction of protective immunity in the lung after repeated airway challenges by nontypeable Haemophilus influenzae outer membrane protein
    Shin ichi Kurita
    Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
    Vaccine 24:5896-903. 2006
    ....
  68. pmc Modulation of airway inflammation by Haemophilus influenzae isolates associated with chronic obstructive pulmonary disease exacerbation
    Dwight C Look
    Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Drive, C33 GH, Iowa City, 52242, USA
    Proc Am Thorac Soc 3:482-3. 2006
  69. ncbi request reprint Recent advances in otitis media. 5. Microbiology and immunology
    Stephen J Barenkamp
    Department of Pediatrics, St Louis University School of Medicine, Missouri, USA
    Ann Otol Rhinol Laryngol Suppl 194:60-85. 2005
  70. pmc Serial isolates of persistent Haemophilus influenzae in patients with chronic obstructive pulmonary disease express diminishing quantities of the HMW1 and HMW2 adhesins
    Deborah M Cholon
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Infect Immun 76:4463-8. 2008
    ....
  71. ncbi request reprint Nontypeable Haemophilus influenzae lipoprotein P6 induces MUC5AC mucin transcription via TLR2-TAK1-dependent p38 MAPK-AP1 and IKKbeta-IkappaBalpha-NF-kappaB signaling pathways
    Ran Chen
    Gonda Department of Cell and Molecular Biology, House Ear Institute, University of Southern California, Los Angeles, CA 90057, USA
    Biochem Biophys Res Commun 324:1087-94. 2004
    ..This study may bring new insights into the molecular pathogenesis of NTHi-induced infections and lead to novel therapeutic intervention for inhibiting mucin overproduction in patients with NTHi infections...
  72. ncbi request reprint Investigation of non-typeable Haemophilus influenzae outer membrane protein P6 as a new carrier for lipooligosaccharide conjugate vaccines
    Tinghuai Wu
    Vaccine Research Section, National Institute on Deafness and Other Communication Disorders, Rockville, MD, USA
    Vaccine 23:5177-85. 2005
    ..These data indicate that P6 could serve as an effective carrier for dLOS or other carbohydrate conjugates and that the ratio of carbohydrate to P6 might contribute to immune responses in vivo...
  73. ncbi request reprint Recent advances in otitis media. 6. Vaccine
    G Scott Giebink
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, USA
    Ann Otol Rhinol Laryngol Suppl 194:86-103. 2005
  74. pmc Relationships of nontypeable Haemophilus influenzae strains to hemolytic and nonhemolytic Haemophilus haemolyticus strains
    Kirk W McCrea
    Department of Epidemiology, University of Michigan School of Public Health Tower, 109 Observatory, Ann Arbor, MI 48109 2029, USA
    J Clin Microbiol 46:406-16. 2008
    ..Future comparative genomic studies identifying common and distinctive genes could be useful in evaluating their role in the commensal or virulent growth, respectively, of H. influenzae...
  75. pmc Haemophilus influenzae from patients with chronic obstructive pulmonary disease exacerbation induce more inflammation than colonizers
    Cecilia L Chin
    Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Drive, C33 GH, Iowa City, IA 52242, USA
    Am J Respir Crit Care Med 172:85-91. 2005
    ..Airway infection with Haemophilus influenzae causes airway inflammation, and isolation of new strains of this bacteria is associated with increased risk of exacerbations in patients with chronic obstructive pulmonary disease (COPD)...
  76. ncbi request reprint Informed consent, capitation, and conflicts of interest in clinical trials: views from the field
    Peter Angelos
    Department of Surgery and MacLean Center for Clinical Medical Ethics, University of Chicago Medical Center, Chicago, IL 60637, USA, and Critical Care Medicine, St Michael s Hospital, Toronto, Canada
    Surgery 140:740-8. 2006
    ..There is no clear consensus about whether this financial aspect of trials should be part of the informed consent process or whether it represents a potential conflict of interest...
  77. ncbi request reprint RSV infection--not for kids only
    Sanjay Sethi
    N Engl J Med 352:1810-2. 2005
  78. pmc Presence of copper- and zinc-containing superoxide dismutase in commensal Haemophilus haemolyticus isolates can be used as a marker to discriminate them from nontypeable H. influenzae isolates
    W W Mary Fung
    Department of Paediatrics, Division of Medicine, Imperial College, St Mary s Campus, London W2 1PG, United Kingdom
    J Clin Microbiol 44:4222-6. 2006
    ..The presence of sodC or its cognate protein, copper-zinc superoxide dismutase, can distinguish respiratory isolates of H. haemolyticus from NT H. influenzae with 100% accuracy...
  79. ncbi request reprint Recent advances in otitis media. 7. Vaccine
    Lauren O Bakaletz
    Ann Otol Rhinol Laryngol Suppl 188:82-94. 2002
  80. ncbi request reprint Ethical concerns about federal approval of risky pediatric studies
    Loretta M Kopelman
    Department of Medical Humanities, Brody School of Medicine at East Carolina University, Greenville, North Carolina 27858 4354, USA
    Pediatrics 113:1783-9. 2004
    ....