SEAN PADRAIG contact MURPHY

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Glial nitric oxide and ischemia
    Claire L Gibson
    Institute of Cell Signaling, Medical School, University of Nottingham, Nottingham, United Kingdom
    Glia 50:417-26. 2005
  2. ncbi request reprint Nitric oxide, ischaemia and brain inflammation
    S Murphy
    University of Washington School of Medicine, Seattle, WA 98195, U S A
    Biochem Soc Trans 35:1133-7. 2007
  3. doi request reprint Neuregulin signaling in neurons depends on ErbB4 interaction with PSD-95
    Sean P Murphy
    Institute of Cell Signalling, University of Nottingham, Nottingham, UK
    Brain Res 1207:32-5. 2008
  4. ncbi request reprint Progesterone suppresses the inflammatory response and nitric oxide synthase-2 expression following cerebral ischemia
    Claire L Gibson
    Institute of Cell Signalling, Queen s Medical Centre, Clifton Boulevard, Nottingham, NG7 2UH, UK
    Exp Neurol 193:522-30. 2005
  5. ncbi request reprint Progesterone enhances functional recovery after middle cerebral artery occlusion in male mice
    Claire L Gibson
    Institute of Cell Signalling, Queen s Medical Center, University of Nottingham, Nottingham, UK
    J Cereb Blood Flow Metab 24:805-13. 2004
  6. ncbi request reprint G-CSF reduces infarct volume and improves functional outcome after transient focal cerebral ischemia in mice
    Claire L Gibson
    Institute of Cell Signalling, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    J Cereb Blood Flow Metab 25:431-9. 2005
  7. ncbi request reprint G-CSF suppresses edema formation and reduces interleukin-1beta expression after cerebral ischemia in mice
    Claire L Gibson
    Institute of Cell Signalling, University of Nottingham, UK
    J Neuropathol Exp Neurol 64:763-9. 2005
  8. ncbi request reprint Estrogens and experimental ischemic stroke: a systematic review
    Claire L Gibson
    Institute of Cell Signalling, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    J Cereb Blood Flow Metab 26:1103-13. 2006

Research Grants

Collaborators

  • P M Bath
  • Claire L Gibson
  • Malcolm J W Prior
  • Laura J Gray
  • Teresa C Coughlan
  • Despina Constantin
  • Nigel C Jones

Detail Information

Publications8

  1. ncbi request reprint Glial nitric oxide and ischemia
    Claire L Gibson
    Institute of Cell Signaling, Medical School, University of Nottingham, Nottingham, United Kingdom
    Glia 50:417-26. 2005
    ....
  2. ncbi request reprint Nitric oxide, ischaemia and brain inflammation
    S Murphy
    University of Washington School of Medicine, Seattle, WA 98195, U S A
    Biochem Soc Trans 35:1133-7. 2007
    ....
  3. doi request reprint Neuregulin signaling in neurons depends on ErbB4 interaction with PSD-95
    Sean P Murphy
    Institute of Cell Signalling, University of Nottingham, Nottingham, UK
    Brain Res 1207:32-5. 2008
    ..In contrast, granule cell cultures loaded with the decoy peptide were unresponsive to the ligand. We conclude that the association of ErbB4 with PSD-95 is important for neuregulin-induced neuronal differentiation...
  4. ncbi request reprint Progesterone suppresses the inflammatory response and nitric oxide synthase-2 expression following cerebral ischemia
    Claire L Gibson
    Institute of Cell Signalling, Queen s Medical Centre, Clifton Boulevard, Nottingham, NG7 2UH, UK
    Exp Neurol 193:522-30. 2005
    ..Thus, progesterone is neuroprotective in both permanent and transient ischemia, and this effect is related to the suppression of specific aspects of the inflammatory response...
  5. ncbi request reprint Progesterone enhances functional recovery after middle cerebral artery occlusion in male mice
    Claire L Gibson
    Institute of Cell Signalling, Queen s Medical Center, University of Nottingham, Nottingham, UK
    J Cereb Blood Flow Metab 24:805-13. 2004
    ..These results indicate beneficial effects of progesterone administration after cerebral ischemia and illustrate the need to further investigate the mechanisms of progesterone action...
  6. ncbi request reprint G-CSF reduces infarct volume and improves functional outcome after transient focal cerebral ischemia in mice
    Claire L Gibson
    Institute of Cell Signalling, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    J Cereb Blood Flow Metab 25:431-9. 2005
    ..These results indicate long-term beneficial effects of a single dose of G-CSF administered on reperfusion, and illustrate the need to further investigate the mechanisms of G-CSF action...
  7. ncbi request reprint G-CSF suppresses edema formation and reduces interleukin-1beta expression after cerebral ischemia in mice
    Claire L Gibson
    Institute of Cell Signalling, University of Nottingham, UK
    J Neuropathol Exp Neurol 64:763-9. 2005
    ..This suggests that part of the neuroprotection may be attributed to the ability of G-CSF to reduce the inflammatory response...
  8. ncbi request reprint Estrogens and experimental ischemic stroke: a systematic review
    Claire L Gibson
    Institute of Cell Signalling, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    J Cereb Blood Flow Metab 26:1103-13. 2006
    ..On the basis of these data, estrogens are a candidate treatment for ischemic stroke, although further preclinical studies are also warranted...

Research Grants4

  1. ASTROCYTE-DERIVED NITRIC OXIDE IN THE CNS
    Sean Murphy; Fiscal Year: 2003
    ..These studies will not only reveal roles for NO in the onset and recovery from damage following ischemia but may also provide the basis for novel and rational therapeutics. ..
  2. Histone deacetylases - therapeutic targets for functional restoration after strok
    SEAN PADRAIG contact MURPHY; Fiscal Year: 2010
    ..Selected drugs will be tested to reveal what functional benefits they confer on the recovery of mice from stroke injury. ..