Mark W Murphy

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi Vertebrate DM domain proteins bind similar DNA sequences and can heterodimerize on DNA
    Mark W Murphy
    Dept of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    BMC Mol Biol 8:58. 2007
  2. ncbi Genome-wide analysis of DNA binding and transcriptional regulation by the mammalian Doublesex homolog DMRT1 in the juvenile testis
    Mark W Murphy
    Developmental Biology Center, Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 107:13360-5. 2010
  3. ncbi DMRT1 prevents female reprogramming in the postnatal mammalian testis
    Clinton K Matson
    Developmental Biology Center and Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Nature 476:101-4. 2011
  4. ncbi The mammalian doublesex homolog DMRT1 is a transcriptional gatekeeper that controls the mitosis versus meiosis decision in male germ cells
    Clinton K Matson
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Dev Cell 19:612-24. 2010
  5. ncbi DMRT1 promotes oogenesis by transcriptional activation of Stra8 in the mammalian fetal ovary
    Anthony D Krentz
    Dept of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN, USA
    Dev Biol 356:63-70. 2011
  6. ncbi EGL-5/ABD-B plays an instructive role in male cell fate determination in the C. elegans somatic gonad
    Andrea K Kalis
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Dev Biol 344:827-35. 2010
  7. ncbi The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency
    Anthony D Krentz
    Department of Genetics, Developmental Biology Center, and Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 106:22323-8. 2009
  8. ncbi The DM domain protein MAB-3 promotes sex-specific neurogenesis in C. elegans by regulating bHLH proteins
    Jennifer M Ross
    Department of Genetics, Cell Biology, and Development, Developmental Biology Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Dev Cell 8:881-92. 2005

Collaborators

Detail Information

Publications8

  1. ncbi Vertebrate DM domain proteins bind similar DNA sequences and can heterodimerize on DNA
    Mark W Murphy
    Dept of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    BMC Mol Biol 8:58. 2007
    ..No detailed analysis of DNA binding by the seven vertebrate DM domain proteins, DMRT1-DMRT7 has been reported, and thus it is unknown whether they recognize similar or diverse DNA sequences...
  2. ncbi Genome-wide analysis of DNA binding and transcriptional regulation by the mammalian Doublesex homolog DMRT1 in the juvenile testis
    Mark W Murphy
    Developmental Biology Center, Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 107:13360-5. 2010
    ..Many of the DMRT1 target genes identified here are known to be important for a variety of functions in testicular development; the others are candidates for further investigation...
  3. ncbi DMRT1 prevents female reprogramming in the postnatal mammalian testis
    Clinton K Matson
    Developmental Biology Center and Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Nature 476:101-4. 2011
    ..Reprogramming due to loss of Dmrt1 also may help explain the aetiology of human syndromes linked to DMRT1, including disorders of sexual differentiation and testicular cancer...
  4. ncbi The mammalian doublesex homolog DMRT1 is a transcriptional gatekeeper that controls the mitosis versus meiosis decision in male germ cells
    Clinton K Matson
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Dev Cell 19:612-24. 2010
    ..By coordinating spermatogonial development and mitotic amplification with meiosis, DMRT1 allows abundant, continuous production of sperm...
  5. ncbi DMRT1 promotes oogenesis by transcriptional activation of Stra8 in the mammalian fetal ovary
    Anthony D Krentz
    Dept of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN, USA
    Dev Biol 356:63-70. 2011
    ..Thus DMRT1 controls Stra8 sex-specifically, activating it in the fetal ovary and repressing it in the adult testis...
  6. ncbi EGL-5/ABD-B plays an instructive role in male cell fate determination in the C. elegans somatic gonad
    Andrea K Kalis
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Dev Biol 344:827-35. 2010
    ..We propose that EGL-5 imparts sex-specific function on POP-1 by recruiting it to male-specific gonadal target genes...
  7. ncbi The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency
    Anthony D Krentz
    Department of Genetics, Developmental Biology Center, and Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 106:22323-8. 2009
    ..This work reveals a genetic link between testicular dysgenesis, pluripotency regulation, and teratoma susceptibility that is highly sensitive to genetic background and to gene dosage...
  8. ncbi The DM domain protein MAB-3 promotes sex-specific neurogenesis in C. elegans by regulating bHLH proteins
    Jennifer M Ross
    Department of Genetics, Cell Biology, and Development, Developmental Biology Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Dev Cell 8:881-92. 2005
    ..Proteins related to MAB-3 (DM domain proteins) control sexual differentiation in diverse metazoans. We therefore suggest that regulation of Hes genes by DM domain proteins may be a general mechanism for specifying sex-specific neurons...