Edward Murphy

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Risk factors and outcomes in transfusion-associated circulatory overload
    Edward L Murphy
    Department of Laboratory Medicine, University of California, San Francisco, CA 94118, USA
    Am J Med 126:357.e29-38. 2013
  2. pmc Ten-year incidence of Chagas cardiomyopathy among asymptomatic Trypanosoma cruzi-seropositive former blood donors
    Ester C Sabino
    Department of Infectious Disease and Institute of Tropical Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Circulation 127:1105-15. 2013
  3. pmc BMI and obesity in US blood donors: a potential public health role for the blood centre
    Edward L Murphy
    Laboratory Medicine and Epidemiology Biostatistics, University of California San Francisco, San Francisco, CA, USA
    Public Health Nutr 15:964-71. 2012
  4. pmc Determinants of subject visit participation in a prospective cohort study of HTLV infection
    Deborah A Devita
    Department of Laboratory Medicine, University of California, San Francisco, California, USA
    BMC Med Res Methodol 9:19. 2009
  5. pmc Minority and foreign-born representation among US blood donors: demographics and donation frequency for 2006
    Edward L Murphy
    University of California San Francisco, Blood Systems Research Institute, San Francisco, California 94118, USA
    Transfusion 49:2221-8. 2009
  6. pmc Hepatitis C virus prevalence and clearance among US blood donors, 2006-2007: associations with birth cohort, multiple pregnancies, and body mass index
    Edward L Murphy
    University of California, San Francisco, CA, USA
    J Infect Dis 202:576-84. 2010
  7. ncbi request reprint Long-term variations in human T lymphotropic virus (HTLV)-I and HTLV-II proviral loads and association with clinical data
    Nicholas Kwaan
    University of California, Berkeley, Berkeley, CA, USA
    J Infect Dis 194:1557-64. 2006
  8. ncbi request reprint Quantitation of HTLV-I and II proviral load using real-time quantitative PCR with SYBR Green chemistry
    Tzong Hae Lee
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    J Clin Virol 31:275-82. 2004
  9. ncbi request reprint A prospective study of sexual transmission of human T lymphotropic virus (HTLV)-I and HTLV-II
    Diana F Roucoux
    Blood Systems Research Institute, University of California, San Francisco, San Francisco, California 94118, USA
    J Infect Dis 191:1490-7. 2005
  10. pmc International Retrovirology Association brings together scientists and clinicians to bridge discoveries about human T-lymphotropic viruses from the laboratory to clinical trials
    Edward Murphy
    Laboratory Medicine and Epidemiology Biostatistics, University of California at San Francisco and Blood Systems Research Institute, San Francisco, California, USA
    Retrovirology 2:22. 2005

Research Grants

Collaborators

Detail Information

Publications45

  1. pmc Risk factors and outcomes in transfusion-associated circulatory overload
    Edward L Murphy
    Department of Laboratory Medicine, University of California, San Francisco, CA 94118, USA
    Am J Med 126:357.e29-38. 2013
    ..Transfusion-associated circulatory overload is characterized by new respiratory distress and hydrostatic pulmonary edema within 6 hours after blood transfusion, but its risk factors and outcomes are poorly characterized...
  2. pmc Ten-year incidence of Chagas cardiomyopathy among asymptomatic Trypanosoma cruzi-seropositive former blood donors
    Ester C Sabino
    Department of Infectious Disease and Institute of Tropical Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Circulation 127:1105-15. 2013
    ..Very few studies have measured disease penetrance and prognostic factors of Chagas cardiomyopathy among asymptomatic Trypanosoma cruzi-infected persons...
  3. pmc BMI and obesity in US blood donors: a potential public health role for the blood centre
    Edward L Murphy
    Laboratory Medicine and Epidemiology Biostatistics, University of California San Francisco, San Francisco, CA, USA
    Public Health Nutr 15:964-71. 2012
    ..We asked whether available blood donor data could be used for obesity surveillance...
  4. pmc Determinants of subject visit participation in a prospective cohort study of HTLV infection
    Deborah A Devita
    Department of Laboratory Medicine, University of California, San Francisco, California, USA
    BMC Med Res Methodol 9:19. 2009
    ..In 1990-92, following attempted blood donation at five blood centers, we enrolled 155 HTLV-I, 387 HTLV-II and 799 HTLV seronegative persons in a long-term prospective cohort...
  5. pmc Minority and foreign-born representation among US blood donors: demographics and donation frequency for 2006
    Edward L Murphy
    University of California San Francisco, Blood Systems Research Institute, San Francisco, California 94118, USA
    Transfusion 49:2221-8. 2009
    ..Historically, minority populations have represented only a small proportion of US blood donors, but recent trends in immigration and potential blood shortages emphasize the need for recruitment strategies to increase minority donations...
  6. pmc Hepatitis C virus prevalence and clearance among US blood donors, 2006-2007: associations with birth cohort, multiple pregnancies, and body mass index
    Edward L Murphy
    University of California, San Francisco, CA, USA
    J Infect Dis 202:576-84. 2010
    ..During the period 1992-1993, the prevalence of hepatitis C virus (HCV) antibodies (anti-HCV) among US blood donors was 0.36%, but contemporary data on the prevalence of antibody to HCV and the prevalence of HCV RNA are lacking...
  7. ncbi request reprint Long-term variations in human T lymphotropic virus (HTLV)-I and HTLV-II proviral loads and association with clinical data
    Nicholas Kwaan
    University of California, Berkeley, Berkeley, CA, USA
    J Infect Dis 194:1557-64. 2006
    ..The human T lymphotropic virus (HTLV)-I or -II proviral load (VL) may be linked to viral pathogenesis, but prospective data on VL and disease outcomes are lacking...
  8. ncbi request reprint Quantitation of HTLV-I and II proviral load using real-time quantitative PCR with SYBR Green chemistry
    Tzong Hae Lee
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    J Clin Virol 31:275-82. 2004
    ..Human T-lymphotropic virus type II (HTLV-II) is associated with HAM/TSP and, in HIV coinfected patients only, rare cases of cutaneous T cell lymphoma. Proviral load may be important in the pathogenesis of HTLV-associated disease...
  9. ncbi request reprint A prospective study of sexual transmission of human T lymphotropic virus (HTLV)-I and HTLV-II
    Diana F Roucoux
    Blood Systems Research Institute, University of California, San Francisco, San Francisco, California 94118, USA
    J Infect Dis 191:1490-7. 2005
    ..Cross-sectional studies support sexual transmission of human T lymphotropic virus (HTLV)-I/II; however, prospective incidence data, particularly for HTLV-II, are limited...
  10. pmc International Retrovirology Association brings together scientists and clinicians to bridge discoveries about human T-lymphotropic viruses from the laboratory to clinical trials
    Edward Murphy
    Laboratory Medicine and Epidemiology Biostatistics, University of California at San Francisco and Blood Systems Research Institute, San Francisco, California, USA
    Retrovirology 2:22. 2005
    ....
  11. ncbi request reprint Estimating blood donor loss due to the variant CJD travel deferral
    Edward L Murphy
    University of California and Blood Centers of the Pacific, San Francisco, California, USA
    Transfusion 44:645-50. 2004
    ..The FDA recommended new travel deferrals in May 2002 to prevent the potential transmission of variant CJD (vCJD). The predicted impact of such deferrals on the blood supply was controversial...
  12. ncbi request reprint Correlates of hepatitis C virus (HCV) RNA negativity among HCV-seropositive blood donors
    Michael P Busch
    Blood Systems Research Institute, San Francisco, California 94118, USA
    Transfusion 46:469-75. 2006
    ..Factors associated with resolution of viremia are not well defined. Implementation of routine nucleic acid testing (NAT) of blood donors has yielded a large data set for analysis of demographic correlates of resolved viremia...
  13. ncbi request reprint Human T lymphotropic virus type II infection and humoral responses to pneumococcal polysaccharide and tetanus toxoid vaccines
    Gary A Jarvis
    Department of Laboratory Medicine, University of California at San Francisco, San Francisco, California 94121, USA
    J Infect Dis 191:1239-44. 2005
    ..Thus, HTLV-II-infected persons develop robust humoral responses to potentially protective polysaccharide and protein vaccines...
  14. pmc Increased mortality associated with HTLV-II infection in blood donors: a prospective cohort study
    Jennie R Orland
    University of California San Francisco and Blood Systems Research Institute, San Francisco, CA, USA
    Retrovirology 1:4. 2004
    ..Several published reports suggest that HTLV-I may lead to decreased survival, but HTLV-II has not previously been associated with mortality...
  15. ncbi request reprint Triggers for switching from minipool testing by nucleic acid technology to individual-donation nucleic acid testing for West Nile virus: analysis of 2003 data to inform 2004 decision making
    Brian Custer
    Blood Systems Research Institute, San Francisco, California 94118, USA
    Transfusion 44:1547-54. 2004
    ..Strategies were investigated for the application of limited ID-NAT capacity in 2004...
  16. ncbi request reprint Higher human T lymphotropic virus (HTLV) provirus load is associated with HTLV-I versus HTLV-II, with HTLV-II subtype A versus B, and with male sex and a history of blood transfusion
    Edward L Murphy
    Department of Laboratory Medicine, University of California, San Francisco 94118, USA
    J Infect Dis 190:504-10. 2004
    ....
  17. pmc Respiratory and urinary tract infections, arthritis, and asthma associated with HTLV-I and HTLV-II infection
    Edward L Murphy
    Laboratory Medicine and Epidemiology Biostatistics, University of California San Francisco, California 94118, USA
    Emerg Infect Dis 10:109-16. 2004
    ..82), and arthritis (IR = 2.84). We conclude that HTLV-II infection may inhibit immunologic responses to respiratory infections and that both HTLV-I and -II may induce inflammatory or autoimmune reactions...
  18. pmc Vasovagal reactions in whole blood donors at three REDS-II blood centers in Brazil
    Thelma T Goncalez
    Blood Systems Research Institute, 270 Masonic Avenue, San Francisco, CA 94118, USA
    Transfusion 52:1070-8. 2012
    ..Donors are offered snacks and fluids before donating and are required to consume a light meal after donation. For these reasons the frequency of reactions may be different than those observed in other countries...
  19. pmc A case-control study of factors associated with resolution of hepatitis C viremia in former blood donors (CME)
    Leslie H Tobler
    Blood Systems Research Institute, San Francisco, California, USA
    Transfusion 50:1513-23. 2010
    ..We report a case-control study of factors associated with HCV resolution...
  20. ncbi request reprint Modeling red cell procurement with both double-red-cell and whole-blood collection and the impact of European travel deferral on units available for transfusion
    Erin Madden
    School of Public Health, University of California, Berkeley, California, USA
    Transfusion 47:2025-37. 2007
    ..To show the importance of including 2RBCs in predictive models of the blood supply, an existing whole-blood (WB) model was updated to include 2RBC collection and then run to simulate the effect of vCJD deferral on total RBC availability...
  21. ncbi request reprint The consequences of temporary deferral on future whole blood donation
    Brian Custer
    Blood Systems Research Institute, 270 Masonic Avenue, San Francisco, CA 94118, USA
    Transfusion 47:1514-23. 2007
    ..The consequences of temporary deferral are not well understood. This study sought to investigate blood donor return after deferral expiration...
  22. doi request reprint Associations between West Nile virus infection and symptoms reported by blood donors identified through nucleic acid test screening
    Brian Custer
    Blood Systems Research Institute, University of California, San Francisco, USA
    Transfusion 49:278-88. 2009
    ..Little data are available on subsequent manifestations of WNV-specific disease outcomes in viremic donors...
  23. pmc The impact of simple donor education on donor behavioral deferral and infectious disease rates in São Paulo, Brazil
    Thelma T Goncalez
    Blood Systems Research Institute, 270, Masonic Avenue, San Francisco, CA 94118, USA
    Transfusion 50:909-17. 2010
    ..This study assessed the impact of an educational brochure in enhancing blood donors' knowledge about screening test window phase and reducing at-risk individuals from donating...
  24. ncbi request reprint The epidemiology and disease outcomes of human T-lymphotropic virus type II
    Diana F Roucoux
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    AIDS Rev 6:144-54. 2004
    ..HTLV-II and HIV coinfection has not been proven to alter the course of HIV disease, but such patients may have altered levels of CD4+ and CD8+ lymphocytes, and antiretroviral therapy may paradoxically increase HTLV-II proviral load...
  25. pmc Blood transfusion safety in Africa: a literature review of infectious disease and organizational challenges
    Evan M Bloch
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    Transfus Med Rev 26:164-80. 2012
    ..The spectrum of transfusion-transmitted infection include conventional as well as exotic pathogens, many of which are endemic to the region, thereby imparting ongoing challenges to recruitment and testing strategies...
  26. pmc Blood donor satisfaction and intention of future donation
    Dorothy D Nguyen
    Blood Systems Research Institute, The Department of Laboratory Medicine, California, USA
    Transfusion 48:742-8. 2008
    ..This study evaluated correlations between overall satisfaction with the donation process and donor demographics and the effect of both on a donor's intent to return...
  27. pmc Long-term increases in lymphocytes and platelets in human T-lymphotropic virus type II infection
    Melissa T Bartman
    School of Public Health, University of California, Berkeley, USA
    Blood 112:3995-4002. 2008
    ..The HTLV-II effect on lymphocytes is novel and may be related to viral transactivation or immune response. HTLV-I and HTLV-II associations with higher platelet counts suggest viral effects on hematopoietic growth factors or cytokines...
  28. pmc Increased all-cause and cancer mortality in HTLV-II infection
    Hope H Biswas
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    J Acquir Immune Defic Syndr 54:290-6. 2010
    ..The authors analyzed all-cause and cancer mortality in a prospective cohort of 155 HTLV-I, 387 HTLV-II, and 799 seronegative subjects...
  29. pmc Increased all-cause, liver, and cardiac mortality among hepatitis C virus-seropositive blood donors
    Anne M Guiltinan
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    Am J Epidemiol 167:743-50. 2008
    ..High rates of mortality from drug/alcohol and trauma/suicide causes are likely due to lifestyle factors and may be at least partially preventable...
  30. ncbi request reprint A randomized trial of blood donor recruitment strategies
    Pascale Reich
    Blood Center of the Pacific, San Francisco, California 94118, USA
    Transfusion 46:1090-6. 2006
    ..Improvement in donor return rates, especially among first-time donors, may significantly improve the blood supply. There are few rigorous studies of the effectiveness of various approaches to donor recruitment, however...
  31. ncbi request reprint Global epidemiology of HTLV-I infection and associated diseases
    Fernando A Proietti
    Department of Social and Preventive Medicine, School of Medicine, Federal University of Minas Gerais, Avenida Alfredo Balena, 190, Belo Horizonte, Minas Gerais 30 130 100, Brazil
    Oncogene 24:6058-68. 2005
    ..For this reason, public health interventions aimed at counseling and educating high-risk individuals and populations are of paramount importance...
  32. ncbi request reprint Absence of HBV and HCV, HTLV-I and -II, and human herpes virus-8 activation after allogeneic RBC transfusion in patients with advanced HIV-1 infection
    David M Asmuth
    Department of Internal Medicine, Division of Infectious Diseases and Immunology, University of California Davis Medical Center, 4150 V Street, Suite 6200 PSSB, Sacramento, CA 95817, USA
    Transfusion 43:451-8. 2003
    ....
  33. ncbi request reprint Lapsed donors: an untapped resource
    George B Schreiber
    Westat, Rockville, MD 20850, USA
    Transfusion 43:17-24. 2003
    ..Although prior studies report lower viral prevalence rates in repeat donors than those in first-time donors, it is unknown if this relationship holds after a lapse of several years between donations...
  34. ncbi request reprint Human T lymphotropic virus type I/II infection: prevalence and risk factors in individuals testing for HIV in counseling centers from Southern Brazil
    Nêmora Tregnago Barcellos
    Health State Secretariat, RS, Brasil
    Sex Transm Dis 33:302-6. 2006
    ....
  35. ncbi request reprint Effect of a national disaster on blood supply and safety: the September 11 experience
    Simone A Glynn
    Westat, Rockville, Md 20850 2062, USA
    JAMA 289:2246-53. 2003
    ..An understanding of characteristics of blood donors donating in times of crisis may help predict blood supply safety and donor return patterns...
  36. ncbi request reprint Increased human T-lymphotropic virus type II proviral load following highly active retroviral therapy in HIV-coinfected patients
    Edward L Murphy
    J Acquir Immune Defic Syndr 33:655-6. 2003
  37. ncbi request reprint Relationship between human T lymphotropic virus (HTLV) type 1/2 viral burden and clinical and treatment parameters among patients with HIV type 1 and HTLV-1/2 coinfection
    Mark A Beilke
    Tulane University Health Sciences Center School of Medicine, New Orleans, Louisiana, USA
    Clin Infect Dis 44:1229-34. 2007
    ..The long-term effects of coinfection are unknown, and little information exists regarding how levels of HTLV-1/2 viral burden are affected by antiretroviral medications...
  38. pmc Knowledge, attitudes and motivations among blood donors in São Paulo, Brazil
    Thelma T Goncalez
    Fundação Pró Sangue Hemocentro de São Paulo, Sao Paulo, Brazil
    AIDS Behav 12:S39-47. 2008
    ..Altruism is the main motivator for blood donation in Brazil; other motivators were associated with specific demographic subgroups. HIV test-seeking might be reduced by educational interventions...
  39. ncbi request reprint HTLV in the Americas: challenges and perspectives
    Anna Bárbara F Carneiro-Proietti
    Fundação Hemominas, Belo Horizonte, Minas Gerais, Brazil
    Rev Panam Salud Publica 19:44-53. 2006
    ..For this reason, public health interventions aimed at counseling and educating high-risk individuals and populations are of vital importance. In the Americas this is especially important in the areas of high prevalence...
  40. ncbi request reprint Endemic versus epidemic viral spreads display distinct patterns of HTLV-2b replication
    Anne Sophie Gabet
    Oncovirologie et Biothérapies, UMR5537 CNRS Université Claude Bernard, Centre Leon Berard, Lyon, France
    Virology 345:13-21. 2006
    ....
  41. ncbi request reprint Factors influencing the decision to donate: racial and ethnic comparisons
    Simone A Glynn
    Westat, Rockville, Maryland 20850, USA
    Transfusion 46:980-90. 2006
    ..Understanding factors that encourage different racial and ethnic groups to donate is crucial for donor recruitment and retention...
  42. ncbi request reprint Factors influencing donor return
    Karen S Schlumpf
    Westat, Rockville, MD 20850, USA
    Transfusion 48:264-72. 2008
    ..To predict future blood donation behavior and improve donor retention, it is important to understand the determinants of donor return...
  43. ncbi request reprint Community blood supply model: development of a new model to assess the safety, sufficiency, and cost of the blood supply
    Brian Custer
    Pharmaceutical Outcomes Research and Policy Program, University of Washington, Seattle, USA
    Med Decis Making 25:571-82. 2005
    ..However, as a result of increasingly stringent screening measures, one of the greatest threats may be an insufficient supply. The balance between safety and adequacy of the blood supply has not received enough attention...
  44. ncbi request reprint Quantifying losses to the donated blood supply due to donor deferral and miscollection
    Brian Custer
    Pharmaceutical Outcomes Research and Policy Program, University of Washington, Seattle, Washington, USA
    Transfusion 44:1417-26. 2004
    ..Donors are deferred for multiple reasons. Losses related to disease marker rates are well established. Donor and donation losses for other reasons, however, have not been extensively quantified...
  45. ncbi request reprint Risk factors for human immunodeficiency virus infection among blood donors in Sao Paulo, Brazil, and their relevance to current donor deferral criteria
    Cesar de Almeida Neto
    Pro Blood Foundation, Blood Center of Sao Paulo, Brazil
    Transfusion 47:608-14. 2007
    ..The objective of this study was to investigate risk factors of human immunodeficiency virus (HIV)-seropositive blood donors in Brazil and to determine if current donor deferral criteria are appropriate...

Research Grants13

  1. Pathophysiology of HTLV-I and HTLV-II Infection
    Edward Murphy; Fiscal Year: 2007
    ..Blood will be collected from all subjects, and bronchoalveolar lavage fluid and cerebrospinal fluid from subsets with disease, for studies of HTLV virology and immunology. ..
  2. Clinical Epidemiology of HTLV-I and HTLV-II Infection
    Edward Murphy; Fiscal Year: 2007
    ..This program brings blood bankers from less developed countries for an intensive summer training program in research methods related to blood safety. ..
  3. XI International Conference on Human Retrovirology: HTLV
    Edward Murphy; Fiscal Year: 2007
    ....
  4. PATHOPHYSIOLOGY OF HTLV1 AND HTLVII INFECTION
    Edward Murphy; Fiscal Year: 2003
    ..Blood will be collected from all subjects at each visit for complete blood counts, measurement of HTLV viral load, and for an extensive specimen repository. ..