E L Murphy

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Increased mortality associated with HTLV-II infection in blood donors: a prospective cohort study
    Jennie R Orland
    University of California San Francisco and Blood Systems Research Institute, San Francisco, CA, USA
    Retrovirology 1:4. 2004
  2. ncbi Highly active antiretroviral therapy decreases mortality and morbidity in patients with advanced HIV disease
    E L Murphy
    Department of Laboratory Medicine, University of California, San Francisco, Box 0884, San Francisco, CA 94143 0884, USA
    Ann Intern Med 135:17-26. 2001
  3. ncbi Risk factors for skin and soft-tissue abscesses among injection drug users: a case-control study
    E L Murphy
    Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143 0884, USA
    Clin Infect Dis 33:35-40. 2001
  4. pmc Respiratory and urinary tract infections, arthritis, and asthma associated with HTLV-I and HTLV-II infection
    Edward L Murphy
    Laboratory Medicine and Epidemiology Biostatistics, University of California San Francisco, California 94118, USA
    Emerg Infect Dis 10:109-16. 2004
  5. ncbi Higher human T lymphotropic virus (HTLV) provirus load is associated with HTLV-I versus HTLV-II, with HTLV-II subtype A versus B, and with male sex and a history of blood transfusion
    Edward L Murphy
    Department of Laboratory Medicine, University of California, San Francisco 94118, USA
    J Infect Dis 190:504-10. 2004
  6. pmc International Retrovirology Association brings together scientists and clinicians to bridge discoveries about human T-lymphotropic viruses from the laboratory to clinical trials
    Edward Murphy
    Laboratory Medicine and Epidemiology Biostatistics, University of California at San Francisco and Blood Systems Research Institute, San Francisco, California, USA
    Retrovirology 2:22. 2005
  7. ncbi Estimating blood donor loss due to the variant CJD travel deferral
    Edward L Murphy
    University of California and Blood Centers of the Pacific, San Francisco, California, USA
    Transfusion 44:645-50. 2004
  8. ncbi Increased incidence of infectious diseases during prospective follow-up of human T-lymphotropic virus type II- and I-infected blood donors. Retrovirus Epidemiology Donor Study
    E L Murphy
    Department of Laboratory Medicine, University of California, San Francisco, 94143 0084, USA
    Arch Intern Med 159:1485-91. 1999
  9. ncbi Long-term variations in human T lymphotropic virus (HTLV)-I and HTLV-II proviral loads and association with clinical data
    Nicholas Kwaan
    University of California, Berkeley, Berkeley, CA, USA
    J Infect Dis 194:1557-64. 2006
  10. ncbi Molecular epidemiology of HTLV-II among United States blood donors and intravenous drug users: an age-cohort effect for HTLV-II RFLP type aO
    E L Murphy
    Department of Laboratory Medicine, University of California San Francisco 94143, USA
    Virology 242:425-34. 1998

Collaborators

Detail Information

Publications56

  1. pmc Increased mortality associated with HTLV-II infection in blood donors: a prospective cohort study
    Jennie R Orland
    University of California San Francisco and Blood Systems Research Institute, San Francisco, CA, USA
    Retrovirology 1:4. 2004
    ..Several published reports suggest that HTLV-I may lead to decreased survival, but HTLV-II has not previously been associated with mortality...
  2. ncbi Highly active antiretroviral therapy decreases mortality and morbidity in patients with advanced HIV disease
    E L Murphy
    Department of Laboratory Medicine, University of California, San Francisco, Box 0884, San Francisco, CA 94143 0884, USA
    Ann Intern Med 135:17-26. 2001
    ..Mortality and morbidity related to AIDS have decreased among HIV-infected patients taking highly active anti-retroviral therapy (HAART), but previous studies may have been confounded by other changes in treatment...
  3. ncbi Risk factors for skin and soft-tissue abscesses among injection drug users: a case-control study
    E L Murphy
    Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143 0884, USA
    Clin Infect Dis 33:35-40. 2001
    ..Cleaning the skin with alcohol before injection was found to have a protective effect. Neither human immunodeficiency virus nor human T-lymphotropic virus type II seropositivity was significantly associated with abscess...
  4. pmc Respiratory and urinary tract infections, arthritis, and asthma associated with HTLV-I and HTLV-II infection
    Edward L Murphy
    Laboratory Medicine and Epidemiology Biostatistics, University of California San Francisco, California 94118, USA
    Emerg Infect Dis 10:109-16. 2004
    ..82), and arthritis (IR = 2.84). We conclude that HTLV-II infection may inhibit immunologic responses to respiratory infections and that both HTLV-I and -II may induce inflammatory or autoimmune reactions...
  5. ncbi Higher human T lymphotropic virus (HTLV) provirus load is associated with HTLV-I versus HTLV-II, with HTLV-II subtype A versus B, and with male sex and a history of blood transfusion
    Edward L Murphy
    Department of Laboratory Medicine, University of California, San Francisco 94118, USA
    J Infect Dis 190:504-10. 2004
    ....
  6. pmc International Retrovirology Association brings together scientists and clinicians to bridge discoveries about human T-lymphotropic viruses from the laboratory to clinical trials
    Edward Murphy
    Laboratory Medicine and Epidemiology Biostatistics, University of California at San Francisco and Blood Systems Research Institute, San Francisco, California, USA
    Retrovirology 2:22. 2005
    ....
  7. ncbi Estimating blood donor loss due to the variant CJD travel deferral
    Edward L Murphy
    University of California and Blood Centers of the Pacific, San Francisco, California, USA
    Transfusion 44:645-50. 2004
    ..The FDA recommended new travel deferrals in May 2002 to prevent the potential transmission of variant CJD (vCJD). The predicted impact of such deferrals on the blood supply was controversial...
  8. ncbi Increased incidence of infectious diseases during prospective follow-up of human T-lymphotropic virus type II- and I-infected blood donors. Retrovirus Epidemiology Donor Study
    E L Murphy
    Department of Laboratory Medicine, University of California, San Francisco, 94143 0084, USA
    Arch Intern Med 159:1485-91. 1999
    ....
  9. ncbi Long-term variations in human T lymphotropic virus (HTLV)-I and HTLV-II proviral loads and association with clinical data
    Nicholas Kwaan
    University of California, Berkeley, Berkeley, CA, USA
    J Infect Dis 194:1557-64. 2006
    ..The human T lymphotropic virus (HTLV)-I or -II proviral load (VL) may be linked to viral pathogenesis, but prospective data on VL and disease outcomes are lacking...
  10. ncbi Molecular epidemiology of HTLV-II among United States blood donors and intravenous drug users: an age-cohort effect for HTLV-II RFLP type aO
    E L Murphy
    Department of Laboratory Medicine, University of California San Francisco 94143, USA
    Virology 242:425-34. 1998
    ..This finding could be explained by an epidemic of non-aO HTLV-II RFLP types among younger persons of Hispanic and other race/ethnicity, superimposed upon endemic HTLV-II RFLP type aO among older Black and White persons...
  11. ncbi Evidence among blood donors for a 30-year-old epidemic of human T lymphotropic virus type II infection in the United States
    E L Murphy
    Department of Laboratory Medicine, UCSF Box 0884, San Francisco, CA 94143, USA
    J Infect Dis 180:1777-83. 1999
    ..These data are consistent with a 30-year-old epidemic of HTLV-II in the United States due to injection drug use and secondary sexual transmission and with an apparent West Coast focus...
  12. ncbi Evaluation of screened blood donations for human immunodeficiency virus type 1 infection by culture and DNA amplification of pooled cells
    M P Busch
    Department of Laboratory Medicine, University of California, San Francisco 94143 0134
    N Engl J Med 325:1-5. 1991
    ..Previous estimates of the risk of HIV-1 range from 1 in 38,000 to 1 in 300,000 per unit of blood but are based on either epidemiologic models or the demonstration of seroconversion in recipients...
  13. ncbi Determinants of antimicrobial prophylaxis use and treatment for wasting among patients with advanced human immunodeficiency virus disease in the United States, 1995-1998
    E L Murphy
    Depts of Laboratory Medicine, Medicine and Epidemiology Biostatistics, University of California San Francisco, San Francisco, CA 94143 0884, USA
    Clin Infect Dis 32:116-23. 2001
    ..Treatment of wasting was more common in white than nonwhite patients and in patients with HIV disease who lived in the region west of the Mississippi River of the United States versus those whose lived in the eastern region...
  14. pmc Hepatitis C virus prevalence and clearance among US blood donors, 2006-2007: associations with birth cohort, multiple pregnancies, and body mass index
    Edward L Murphy
    University of California, San Francisco, CA, USA
    J Infect Dis 202:576-84. 2010
    ..During the period 1992-1993, the prevalence of hepatitis C virus (HCV) antibodies (anti-HCV) among US blood donors was 0.36%, but contemporary data on the prevalence of antibody to HCV and the prevalence of HCV RNA are lacking...
  15. ncbi Quantitation of HTLV-I and II proviral load using real-time quantitative PCR with SYBR Green chemistry
    Tzong Hae Lee
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    J Clin Virol 31:275-82. 2004
    ..Human T-lymphotropic virus type II (HTLV-II) is associated with HAM/TSP and, in HIV coinfected patients only, rare cases of cutaneous T cell lymphoma. Proviral load may be important in the pathogenesis of HTLV-associated disease...
  16. ncbi A prospective study of sexual transmission of human T lymphotropic virus (HTLV)-I and HTLV-II
    Diana F Roucoux
    Blood Systems Research Institute, University of California, San Francisco, San Francisco, California 94118, USA
    J Infect Dis 191:1490-7. 2005
    ..Cross-sectional studies support sexual transmission of human T lymphotropic virus (HTLV)-I/II; however, prospective incidence data, particularly for HTLV-II, are limited...
  17. ncbi A prospective study of the risk of transfusion-acquired viral infections
    E L Murphy
    Department of Laboratory Medicine, University of California San Francisco 94143 0884, USA
    Transfus Med 8:173-8. 1998
    ..04 x 10(3) per allogeneic unit transfused, based upon the upper 95% confidence interval of the zero incidence in this study...
  18. ncbi Risk factors for hepatitis C virus infection in United States blood donors. NHLBI Retrovirus Epidemiology Donor Study (REDS)
    E L Murphy
    University of California San Francisco, San Francisco, CA 94143 0884, USA
    Hepatology 31:756-62. 2000
    ..Weaker associations with incarceration, religious scarification, being stuck or cut with a bloody object, pierced ears or body parts, and immunoglobulin injection must be interpreted with caution...
  19. ncbi Human T-lymphotropic virus type II RFLP subtypes a0 and b4/b5 are associated with different demographic and geographic characteristics in the United States
    H Liu
    University of California San Francisco, San Francisco, California, 94143
    Virology 279:90-6. 2001
    ....
  20. pmc Neurologic abnormalities in HTLV-I- and HTLV-II-infected individuals without overt myelopathy
    H H Biswas
    Blood Systems Research Institute, San Francisco, CA, USA
    Neurology 73:781-9. 2009
    ..However, despite some reports, it is unclear whether HTLV-I or -II infection is associated with other neurologic manifestations...
  21. ncbi Prevalence and clinical features of HTLV neurologic disease in the HTLV Outcomes Study
    J R Orland
    University of California San Francisco, Blood Centers of the Pacific, 94118, USA
    Neurology 61:1588-94. 2003
    ..Whereas the causative association of HTLV-I and HAM/TSP is generally recognized, controversy still surrounds the relationship between HTLV-II and HAM/TSP...
  22. ncbi Laboratory test differences associated with HTLV-I and HTLV-II infection. Retrovirus Epidemiology Donor Study Investigators
    E L Murphy
    University of California San Francisco 94143 0884, USA
    J Acquir Immune Defic Syndr Hum Retrovirol 17:332-8. 1998
    ..Lower eosinophil counts may be related to the increased susceptibility of HTLV-I-infected subjects to parasitic diseases...
  23. pmc Minority and foreign-born representation among US blood donors: demographics and donation frequency for 2006
    Edward L Murphy
    University of California San Francisco, Blood Systems Research Institute, San Francisco, California 94118, USA
    Transfusion 49:2221-8. 2009
    ..Historically, minority populations have represented only a small proportion of US blood donors, but recent trends in immigration and potential blood shortages emphasize the need for recruitment strategies to increase minority donations...
  24. ncbi Triggers for switching from minipool testing by nucleic acid technology to individual-donation nucleic acid testing for West Nile virus: analysis of 2003 data to inform 2004 decision making
    Brian Custer
    Blood Systems Research Institute, San Francisco, California 94118, USA
    Transfusion 44:1547-54. 2004
    ..Strategies were investigated for the application of limited ID-NAT capacity in 2004...
  25. ncbi Correlates of hepatitis C virus (HCV) RNA negativity among HCV-seropositive blood donors
    Michael P Busch
    Blood Systems Research Institute, San Francisco, California 94118, USA
    Transfusion 46:469-75. 2006
    ..Factors associated with resolution of viremia are not well defined. Implementation of routine nucleic acid testing (NAT) of blood donors has yielded a large data set for analysis of demographic correlates of resolved viremia...
  26. ncbi Human T lymphotropic virus type II infection and humoral responses to pneumococcal polysaccharide and tetanus toxoid vaccines
    Gary A Jarvis
    Department of Laboratory Medicine, University of California at San Francisco, San Francisco, California 94121, USA
    J Infect Dis 191:1239-44. 2005
    ..Thus, HTLV-II-infected persons develop robust humoral responses to potentially protective polysaccharide and protein vaccines...
  27. pmc Determinants of subject visit participation in a prospective cohort study of HTLV infection
    Deborah A Devita
    Department of Laboratory Medicine, University of California, San Francisco, California, USA
    BMC Med Res Methodol 9:19. 2009
    ..In 1990-92, following attempted blood donation at five blood centers, we enrolled 155 HTLV-I, 387 HTLV-II and 799 HTLV seronegative persons in a long-term prospective cohort...
  28. pmc Agreement among HLA antibody detection assays is higher in ever-pregnant donors and improved using a consensus cutoff
    Danielle M Carrick
    Blood Systems Research Institute and Blood Centers of the Pacific, San Francisco, California 94118, USA
    Transfusion 51:1105-16. 2011
    ..HLA antibody detection methods include ELISA, flow cytometry, and multiplex bead-based assays, as well as the older lymphocytotoxicity assay, and it is not obvious how to compare results across platforms...
  29. ncbi Modeling red cell procurement with both double-red-cell and whole-blood collection and the impact of European travel deferral on units available for transfusion
    Erin Madden
    School of Public Health, University of California, Berkeley, California, USA
    Transfusion 47:2025-37. 2007
    ..To show the importance of including 2RBCs in predictive models of the blood supply, an existing whole-blood (WB) model was updated to include 2RBC collection and then run to simulate the effect of vCJD deferral on total RBC availability...
  30. pmc A case-control study of factors associated with resolution of hepatitis C viremia in former blood donors (CME)
    Leslie H Tobler
    Blood Systems Research Institute, San Francisco, California, USA
    Transfusion 50:1513-23. 2010
    ..We report a case-control study of factors associated with HCV resolution...
  31. pmc Lower numbers of circulating Natural Killer T (NK T) cells in individuals with human T lymphotropic virus type 1 (HTLV-1) associated neurological disease
    L C Ndhlovu
    Division of Experimental Medicine, Department of Medicine, University of California at San Francisco, San Francisco, CA 94110, USA
    Clin Exp Immunol 158:294-9. 2009
    ..These findings suggest that lower numbers of circulating NK T cells and enrichment of the CD4(+) NK T subset are associated with HTLV-1 disease progression...
  32. ncbi The epidemiology and disease outcomes of human T-lymphotropic virus type II
    Diana F Roucoux
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    AIDS Rev 6:144-54. 2004
    ..HTLV-II and HIV coinfection has not been proven to alter the course of HIV disease, but such patients may have altered levels of CD4+ and CD8+ lymphocytes, and antiretroviral therapy may paradoxically increase HTLV-II proviral load...
  33. doi Associations between West Nile virus infection and symptoms reported by blood donors identified through nucleic acid test screening
    Brian Custer
    Blood Systems Research Institute, University of California, San Francisco, USA
    Transfusion 49:278-88. 2009
    ..Little data are available on subsequent manifestations of WNV-specific disease outcomes in viremic donors...
  34. pmc The impact of simple donor education on donor behavioral deferral and infectious disease rates in São Paulo, Brazil
    Thelma T Goncalez
    Blood Systems Research Institute, 270, Masonic Avenue, San Francisco, CA 94118, USA
    Transfusion 50:909-17. 2010
    ..This study assessed the impact of an educational brochure in enhancing blood donors' knowledge about screening test window phase and reducing at-risk individuals from donating...
  35. ncbi The consequences of temporary deferral on future whole blood donation
    Brian Custer
    Blood Systems Research Institute, 270 Masonic Avenue, San Francisco, CA 94118, USA
    Transfusion 47:1514-23. 2007
    ..The consequences of temporary deferral are not well understood. This study sought to investigate blood donor return after deferral expiration...
  36. pmc Long-term increases in lymphocytes and platelets in human T-lymphotropic virus type II infection
    Melissa T Bartman
    School of Public Health, University of California, Berkeley, USA
    Blood 112:3995-4002. 2008
    ..The HTLV-II effect on lymphocytes is novel and may be related to viral transactivation or immune response. HTLV-I and HTLV-II associations with higher platelet counts suggest viral effects on hematopoietic growth factors or cytokines...
  37. pmc Increased all-cause, liver, and cardiac mortality among hepatitis C virus-seropositive blood donors
    Anne M Guiltinan
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    Am J Epidemiol 167:743-50. 2008
    ..High rates of mortality from drug/alcohol and trauma/suicide causes are likely due to lifestyle factors and may be at least partially preventable...
  38. pmc Blood donor satisfaction and intention of future donation
    Dorothy D Nguyen
    Blood Systems Research Institute, The Department of Laboratory Medicine, California, USA
    Transfusion 48:742-8. 2008
    ..This study evaluated correlations between overall satisfaction with the donation process and donor demographics and the effect of both on a donor's intent to return...
  39. ncbi A randomized trial of blood donor recruitment strategies
    Pascale Reich
    Blood Center of the Pacific, San Francisco, California 94118, USA
    Transfusion 46:1090-6. 2006
    ..Improvement in donor return rates, especially among first-time donors, may significantly improve the blood supply. There are few rigorous studies of the effectiveness of various approaches to donor recruitment, however...
  40. pmc Increased all-cause and cancer mortality in HTLV-II infection
    Hope H Biswas
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    J Acquir Immune Defic Syndr 54:290-6. 2010
    ..The authors analyzed all-cause and cancer mortality in a prospective cohort of 155 HTLV-I, 387 HTLV-II, and 799 seronegative subjects...
  41. ncbi Relationship between human T lymphotropic virus (HTLV) type 1/2 viral burden and clinical and treatment parameters among patients with HIV type 1 and HTLV-1/2 coinfection
    Mark A Beilke
    Tulane University Health Sciences Center School of Medicine, New Orleans, Louisiana, USA
    Clin Infect Dis 44:1229-34. 2007
    ..The long-term effects of coinfection are unknown, and little information exists regarding how levels of HTLV-1/2 viral burden are affected by antiretroviral medications...
  42. ncbi Absence of HBV and HCV, HTLV-I and -II, and human herpes virus-8 activation after allogeneic RBC transfusion in patients with advanced HIV-1 infection
    David M Asmuth
    Department of Internal Medicine, Division of Infectious Diseases and Immunology, University of California Davis Medical Center, 4150 V Street, Suite 6200 PSSB, Sacramento, CA 95817, USA
    Transfusion 43:451-8. 2003
    ....
  43. ncbi Global epidemiology of HTLV-I infection and associated diseases
    Fernando A Proietti
    Department of Social and Preventive Medicine, School of Medicine, Federal University of Minas Gerais, Avenida Alfredo Balena, 190, Belo Horizonte, Minas Gerais 30 130 100, Brazil
    Oncogene 24:6058-68. 2005
    ..For this reason, public health interventions aimed at counseling and educating high-risk individuals and populations are of paramount importance...
  44. ncbi HTLV in the Americas: challenges and perspectives
    Anna Bárbara F Carneiro-Proietti
    Fundação Hemominas, Belo Horizonte, Minas Gerais, Brazil
    Rev Panam Salud Publica 19:44-53. 2006
    ..For this reason, public health interventions aimed at counseling and educating high-risk individuals and populations are of vital importance. In the Americas this is especially important in the areas of high prevalence...
  45. ncbi Effect of a national disaster on blood supply and safety: the September 11 experience
    Simone A Glynn
    Westat, Rockville, Md 20850 2062, USA
    JAMA 289:2246-53. 2003
    ..An understanding of characteristics of blood donors donating in times of crisis may help predict blood supply safety and donor return patterns...
  46. ncbi Lapsed donors: an untapped resource
    George B Schreiber
    Westat, Rockville, MD 20850, USA
    Transfusion 43:17-24. 2003
    ..Although prior studies report lower viral prevalence rates in repeat donors than those in first-time donors, it is unknown if this relationship holds after a lapse of several years between donations...
  47. pmc Knowledge, attitudes and motivations among blood donors in São Paulo, Brazil
    Thelma T Goncalez
    Fundação Pró Sangue Hemocentro de São Paulo, Sao Paulo, Brazil
    AIDS Behav 12:S39-47. 2008
    ..Altruism is the main motivator for blood donation in Brazil; other motivators were associated with specific demographic subgroups. HIV test-seeking might be reduced by educational interventions...
  48. ncbi Human T lymphotropic virus type I/II infection: prevalence and risk factors in individuals testing for HIV in counseling centers from Southern Brazil
    Nêmora Tregnago Barcellos
    Health State Secretariat, RS, Brasil
    Sex Transm Dis 33:302-6. 2006
    ....
  49. ncbi Endemic versus epidemic viral spreads display distinct patterns of HTLV-2b replication
    Anne Sophie Gabet
    Oncovirologie et Biothérapies, UMR5537 CNRS Université Claude Bernard, Centre Leon Berard, Lyon, France
    Virology 345:13-21. 2006
    ....
  50. ncbi Increased human T-lymphotropic virus type II proviral load following highly active retroviral therapy in HIV-coinfected patients
    Edward L Murphy
    J Acquir Immune Defic Syndr 33:655-6. 2003
  51. ncbi Community blood supply model: development of a new model to assess the safety, sufficiency, and cost of the blood supply
    Brian Custer
    Pharmaceutical Outcomes Research and Policy Program, University of Washington, Seattle, USA
    Med Decis Making 25:571-82. 2005
    ..However, as a result of increasingly stringent screening measures, one of the greatest threats may be an insufficient supply. The balance between safety and adequacy of the blood supply has not received enough attention...
  52. ncbi Risk factors for human immunodeficiency virus infection among blood donors in Sao Paulo, Brazil, and their relevance to current donor deferral criteria
    Cesar de Almeida Neto
    Pro Blood Foundation, Blood Center of Sao Paulo, Brazil
    Transfusion 47:608-14. 2007
    ..The objective of this study was to investigate risk factors of human immunodeficiency virus (HIV)-seropositive blood donors in Brazil and to determine if current donor deferral criteria are appropriate...
  53. ncbi Quantifying losses to the donated blood supply due to donor deferral and miscollection
    Brian Custer
    Pharmaceutical Outcomes Research and Policy Program, University of Washington, Seattle, Washington, USA
    Transfusion 44:1417-26. 2004
    ..Donors are deferred for multiple reasons. Losses related to disease marker rates are well established. Donor and donation losses for other reasons, however, have not been extensively quantified...
  54. ncbi Factors influencing the decision to donate: racial and ethnic comparisons
    Simone A Glynn
    Westat, Rockville, Maryland 20850, USA
    Transfusion 46:980-90. 2006
    ..Understanding factors that encourage different racial and ethnic groups to donate is crucial for donor recruitment and retention...
  55. ncbi Factors influencing donor return
    Karen S Schlumpf
    Westat, Rockville, MD 20850, USA
    Transfusion 48:264-72. 2008
    ..To predict future blood donation behavior and improve donor retention, it is important to understand the determinants of donor return...