Research Topics
| E L MurphySummaryAffiliation: University of California Country: USA Publications
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Publications
Increased mortality associated with HTLV-II infection in blood donors: a prospective cohort studyJennie R Orland
University of California San Francisco and Blood Systems Research Institute, San Francisco, CA, USA
Retrovirology 1:4. 2004..Several published reports suggest that HTLV-I may lead to decreased survival, but HTLV-II has not previously been associated with mortality...
Respiratory and urinary tract infections, arthritis, and asthma associated with HTLV-I and HTLV-II infectionEdward L Murphy
Laboratory Medicine and Epidemiology Biostatistics, University of California San Francisco, California 94118, USA
Emerg Infect Dis 10:109-16. 2004..82), and arthritis (IR = 2.84). We conclude that HTLV-II infection may inhibit immunologic responses to respiratory infections and that both HTLV-I and -II may induce inflammatory or autoimmune reactions...
Risk factors for skin and soft-tissue abscesses among injection drug users: a case-control studyE L Murphy
Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143 0884, USA
Clin Infect Dis 33:35-40. 2001..Cleaning the skin with alcohol before injection was found to have a protective effect. Neither human immunodeficiency virus nor human T-lymphotropic virus type II seropositivity was significantly associated with abscess...- Higher human T lymphotropic virus (HTLV) provirus load is associated with HTLV-I versus HTLV-II, with HTLV-II subtype A versus B, and with male sex and a history of blood transfusionEdward L Murphy
Department of Laboratory Medicine, University of California, San Francisco 94118, USA
J Infect Dis 190:504-10. 2004.... - Highly active antiretroviral therapy decreases mortality and morbidity in patients with advanced HIV diseaseE L Murphy
Department of Laboratory Medicine, University of California, San Francisco, Box 0884, San Francisco, CA 94143 0884, USA
Ann Intern Med 135:17-26. 2001..Mortality and morbidity related to AIDS have decreased among HIV-infected patients taking highly active anti-retroviral therapy (HAART), but previous studies may have been confounded by other changes in treatment... - Estimating blood donor loss due to the variant CJD travel deferralEdward L Murphy
University of California and Blood Centers of the Pacific, San Francisco, California, USA
Transfusion 44:645-50. 2004..The FDA recommended new travel deferrals in May 2002 to prevent the potential transmission of variant CJD (vCJD). The predicted impact of such deferrals on the blood supply was controversial... - International Retrovirology Association brings together scientists and clinicians to bridge discoveries about human T-lymphotropic viruses from the laboratory to clinical trialsEdward Murphy
Laboratory Medicine and Epidemiology Biostatistics, University of California at San Francisco and Blood Systems Research Institute, San Francisco, California, USA
Retrovirology 2:22. 2005.... - Increased incidence of infectious diseases during prospective follow-up of human T-lymphotropic virus type II- and I-infected blood donors. Retrovirus Epidemiology Donor StudyE L Murphy
Department of Laboratory Medicine, University of California, San Francisco, 94143 0084, USA
Arch Intern Med 159:1485-91. 1999.... - Long-term variations in human T lymphotropic virus (HTLV)-I and HTLV-II proviral loads and association with clinical dataNicholas Kwaan
University of California, Berkeley, Berkeley, CA, USA
J Infect Dis 194:1557-64. 2006..The association between increasing VLs and bladder/kidney infection may be explained by early HTLV-related neuropathologic progression... - Molecular epidemiology of HTLV-II among United States blood donors and intravenous drug users: an age-cohort effect for HTLV-II RFLP type aOE L Murphy
Department of Laboratory Medicine, University of California San Francisco 94143, USA
Virology 242:425-34. 1998..This finding could be explained by an epidemic of non-aO HTLV-II RFLP types among younger persons of Hispanic and other race/ethnicity, superimposed upon endemic HTLV-II RFLP type aO among older Black and White persons... - Evidence among blood donors for a 30-year-old epidemic of human T lymphotropic virus type II infection in the United StatesE L Murphy
Department of Laboratory Medicine, UCSF Box 0884, San Francisco, CA 94143, USA
J Infect Dis 180:1777-83. 1999..These data are consistent with a 30-year-old epidemic of HTLV-II in the United States due to injection drug use and secondary sexual transmission and with an apparent West Coast focus... - Evaluation of screened blood donations for human immunodeficiency virus type 1 infection by culture and DNA amplification of pooled cellsM P Busch
Department of Laboratory Medicine, University of California, San Francisco 94143 0134
N Engl J Med 325:1-5. 1991..Previous estimates of the risk of HIV-1 range from 1 in 38,000 to 1 in 300,000 per unit of blood but are based on either epidemiologic models or the demonstration of seroconversion in recipients... - Hepatitis C virus prevalence and clearance among US blood donors, 2006-2007: associations with birth cohort, multiple pregnancies, and body mass indexEdward L Murphy
University of California, San Francisco, CA, USA
J Infect Dis 202:576-84. 2010..During the period 1992-1993, the prevalence of hepatitis C virus (HCV) antibodies (anti-HCV) among US blood donors was 0.36%, but contemporary data on the prevalence of antibody to HCV and the prevalence of HCV RNA are lacking... - Determinants of antimicrobial prophylaxis use and treatment for wasting among patients with advanced human immunodeficiency virus disease in the United States, 1995-1998E L Murphy
Depts of Laboratory Medicine, Medicine and Epidemiology Biostatistics, University of California San Francisco, San Francisco, CA 94143 0884, USA
Clin Infect Dis 32:116-23. 2001..Treatment of wasting was more common in white than nonwhite patients and in patients with HIV disease who lived in the region west of the Mississippi River of the United States versus those whose lived in the eastern region... - Quantitation of HTLV-I and II proviral load using real-time quantitative PCR with SYBR Green chemistryTzong-Hae Lee
Blood Systems Research Institute, San Francisco, CA 94118, USA
J Clin Virol 31:275-82. 2004..The sensitivity and high dynamic range allow determination of a broad range of HTLV-I/II proviral load in clinical subjects. This assay will facilitate the study of the relationship between proviral load and pathogenesis... - A prospective study of sexual transmission of human T lymphotropic virus (HTLV)-I and HTLV-IIDiana F Roucoux
Blood Systems Research Institute, University of California, San Francisco, San Francisco, California 94118, USA
J Infect Dis 191:1490-7. 2005..HTLV-I and -II proviral load may be lower in sexually acquired infection, because of a small infectious dose... - A prospective study of the risk of transfusion-acquired viral infectionsE L Murphy
Department of Laboratory Medicine, University of California San Francisco 94143 0884, USA
Transfus Med 8:173-8. 1998..04 x 10(3) per allogeneic unit transfused, based upon the upper 95% confidence interval of the zero incidence in this study... - Neurologic abnormalities in HTLV-I- and HTLV-II-infected individuals without overt myelopathyH H Biswas
Blood Systems Research Institute, San Francisco, CA, USA
Neurology 73:781-9. 2009..However, despite some reports, it is unclear whether HTLV-I or -II infection is associated with other neurologic manifestations... - Human T-lymphotropic virus type II RFLP subtypes a0 and b4/b5 are associated with different demographic and geographic characteristics in the United StatesH Liu
University of California San Francisco, San Francisco, California, 94143
Virology 279:90-6. 2001.... - Risk factors for hepatitis C virus infection in United States blood donors. NHLBI Retrovirus Epidemiology Donor Study (REDS)E L Murphy
University of California San Francisco, San Francisco, CA 94143 0884, USA
Hepatology 31:756-62. 2000..Weaker associations with incarceration, religious scarification, being stuck or cut with a bloody object, pierced ears or body parts, and immunoglobulin injection must be interpreted with caution... - Laboratory test differences associated with HTLV-I and HTLV-II infection. Retrovirus Epidemiology Donor Study InvestigatorsE L Murphy
University of California San Francisco 94143 0884, USA
J Acquir Immune Defic Syndr Hum Retrovirol 17:332-8. 1998..Lower eosinophil counts may be related to the increased susceptibility of HTLV-I-infected subjects to parasitic diseases... - Prevalence and clinical features of HTLV neurologic disease in the HTLV Outcomes StudyJ R Orland
University of California San Francisco, Blood Centers of the Pacific, 94118, USA
Neurology 61:1588-94. 2003..Whereas the causative association of HTLV-I and HAM/TSP is generally recognized, controversy still surrounds the relationship between HTLV-II and HAM/TSP... - Triggers for switching from minipool testing by nucleic acid technology to individual-donation nucleic acid testing for West Nile virus: analysis of 2003 data to inform 2004 decision makingBrian Custer
Blood Systems Research Institute, San Francisco, California 94118, USA
Transfusion 44:1547-54. 2004..Strategies were investigated for the application of limited ID-NAT capacity in 2004... - Correlates of hepatitis C virus (HCV) RNA negativity among HCV-seropositive blood donorsMichael P Busch
Blood Systems Research Institute, San Francisco, California 94118, USA
Transfusion 46:469-75. 2006..Factors associated with resolution of viremia are not well defined. Implementation of routine nucleic acid testing (NAT) of blood donors has yielded a large data set for analysis of demographic correlates of resolved viremia... - Human T lymphotropic virus type II infection and humoral responses to pneumococcal polysaccharide and tetanus toxoid vaccinesGary A Jarvis
Department of Laboratory Medicine, University of California at San Francisco, San Francisco, California 94121, USA
J Infect Dis 191:1239-44. 2005..Thus, HTLV-II-infected persons develop robust humoral responses to potentially protective polysaccharide and protein vaccines... - Minority and foreign-born representation among US blood donors: demographics and donation frequency for 2006Edward L Murphy
University of California San Francisco, Blood Systems Research Institute, San Francisco, California 94118, USA
Transfusion 49:2221-8. 2009..Historically, minority populations have represented only a small proportion of US blood donors, but recent trends in immigration and potential blood shortages emphasize the need for recruitment strategies to increase minority donations... - Determinants of subject visit participation in a prospective cohort study of HTLV infectionDeborah A Devita
Department of Laboratory Medicine, University of California, San Francisco, California, USA
BMC Med Res Methodol 9:19. 2009..In 1990-92, following attempted blood donation at five blood centers, we enrolled 155 HTLV-I, 387 HTLV-II and 799 HTLV seronegative persons in a long-term prospective cohort... - Agreement among HLA antibody detection assays is higher in ever-pregnant donors and improved using a consensus cutoffDanielle M Carrick
Blood Systems Research Institute and Blood Centers of the Pacific, San Francisco, California 94118, USA
Transfusion 51:1105-16. 2011..HLA antibody detection methods include ELISA, flow cytometry, and multiplex bead-based assays, as well as the older lymphocytotoxicity assay, and it is not obvious how to compare results across platforms... - Modeling red cell procurement with both double-red-cell and whole-blood collection and the impact of European travel deferral on units available for transfusionErin Madden
School of Public Health, University of California, Berkeley, California, USA
Transfusion 47:2025-37. 2007..To show the importance of including 2RBCs in predictive models of the blood supply, an existing whole-blood (WB) model was updated to include 2RBC collection and then run to simulate the effect of vCJD deferral on total RBC availability... 
A case-control study of factors associated with resolution of hepatitis C viremia in former blood donors (CME)Leslie H Tobler
Blood Systems Research Institute, San Francisco, California, USA
Transfusion 50:1513-23. 2010..We report a case-control study of factors associated with HCV resolution...- Lower numbers of circulating Natural Killer T (NK T) cells in individuals with human T lymphotropic virus type 1 (HTLV-1) associated neurological diseaseL C Ndhlovu
Division of Experimental Medicine, Department of Medicine, University of California at San Francisco, San Francisco, CA 94110, USA
Clin Exp Immunol 158:294-9. 2009..These findings suggest that lower numbers of circulating NK T cells and enrichment of the CD4(+) NK T subset are associated with HTLV-1 disease progression... - Associations between West Nile virus infection and symptoms reported by blood donors identified through nucleic acid test screeningBrian Custer
Blood Systems Research Institute, University of California, San Francisco, USA
Transfusion 49:278-88. 2009..Little data are available on subsequent manifestations of WNV-specific disease outcomes in viremic donors... - The consequences of temporary deferral on future whole blood donationBrian Custer
Blood Systems Research Institute, 270 Masonic Avenue, San Francisco, CA 94118, USA
Transfusion 47:1514-23. 2007..The consequences of temporary deferral are not well understood. This study sought to investigate blood donor return after deferral expiration... - The impact of simple donor education on donor behavioral deferral and infectious disease rates in São Paulo, BrazilThelma T Goncalez
Blood Systems Research Institute, 270, Masonic Avenue, San Francisco, CA 94118, USA
Transfusion 50:909-17. 2010..This study assessed the impact of an educational brochure in enhancing blood donors' knowledge about screening test window phase and reducing at-risk individuals from donating... - The epidemiology and disease outcomes of human T-lymphotropic virus type IIDiana F Roucoux
Blood Systems Research Institute, San Francisco, CA 94118, USA
AIDS Rev 6:144-54. 2004..HTLV-II and HIV coinfection has not been proven to alter the course of HIV disease, but such patients may have altered levels of CD4+ and CD8+ lymphocytes, and antiretroviral therapy may paradoxically increase HTLV-II proviral load... - Long-term increases in lymphocytes and platelets in human T-lymphotropic virus type II infectionMelissa T Bartman
School of Public Health, University of California, Berkeley, USA
Blood 112:3995-4002. 2008..The HTLV-II effect on lymphocytes is novel and may be related to viral transactivation or immune response. HTLV-I and HTLV-II associations with higher platelet counts suggest viral effects on hematopoietic growth factors or cytokines... - Blood donor satisfaction and intention of future donationDorothy D Nguyen
Blood Systems Research Institute, The Department of Laboratory Medicine, California, USA
Transfusion 48:742-8. 2008..This study evaluated correlations between overall satisfaction with the donation process and donor demographics and the effect of both on a donor's intent to return... - Increased all-cause and cancer mortality in HTLV-II infectionHope H Biswas
Blood Systems Research Institute, San Francisco, CA 94118, USA
J Acquir Immune Defic Syndr 54:290-6. 2010..The authors analyzed all-cause and cancer mortality in a prospective cohort of 155 HTLV-I, 387 HTLV-II, and 799 seronegative subjects... - Increased all-cause, liver, and cardiac mortality among hepatitis C virus-seropositive blood donorsAnne M Guiltinan
Blood Systems Research Institute, San Francisco, CA 94118, USA
Am J Epidemiol 167:743-50. 2008..High rates of mortality from drug/alcohol and trauma/suicide causes are likely due to lifestyle factors and may be at least partially preventable... - A randomized trial of blood donor recruitment strategiesPascale Reich
Blood Center of the Pacific, San Francisco, California 94118, USA
Transfusion 46:1090-6. 2006..E-mail recruitment was substantially less effective than telephone recruitment, perhaps due to technical problems. The study illustrates the utility of the randomized clinical trial study design for testing donor recruitment strategies... - Relationship between human T lymphotropic virus (HTLV) type 1/2 viral burden and clinical and treatment parameters among patients with HIV type 1 and HTLV-1/2 coinfectionMark A Beilke
Tulane University Health Sciences Center School of Medicine, New Orleans, Louisiana, USA
Clin Infect Dis 44:1229-34. 2007..The long-term effects of coinfection are unknown, and little information exists regarding how levels of HTLV-1/2 viral burden are affected by antiretroviral medications... - Lapsed donors: an untapped resourceGeorge B Schreiber
Westat, Rockville, MD 20850, USA
Transfusion 43:17-24. 2003..Although prior studies report lower viral prevalence rates in repeat donors than those in first-time donors, it is unknown if this relationship holds after a lapse of several years between donations... - Endemic versus epidemic viral spreads display distinct patterns of HTLV-2b replicationAnne-Sophie Gabet
, , , Lyon, France
Virology 345:13-21. 2006.... - Human T lymphotropic virus type I/II infection: prevalence and risk factors in individuals testing for HIV in counseling centers from Southern BrazilNêmora Tregnago Barcellos
Health State Secretariat, RS, Brasil
Sex Transm Dis 33:302-6. 2006.... - HTLV in the Americas: challenges and perspectivesAnna Bárbara F Carneiro-Proietti
Fundação Hemominas, Belo Horizonte, Minas Gerais, Brazil
Rev Panam Salud Publica 19:44-53. 2006..For this reason, public health interventions aimed at counseling and educating high-risk individuals and populations are of vital importance. In the Americas this is especially important in the areas of high prevalence... - Global epidemiology of HTLV-I infection and associated diseasesFernando A Proietti
Department of Social and Preventive Medicine, School of Medicine, Federal University of Minas Gerais, Avenida Alfredo Balena, 190, Belo Horizonte, Minas Gerais 30 130 100, Brazil
Oncogene 24:6058-68. 2005..For this reason, public health interventions aimed at counseling and educating high-risk individuals and populations are of paramount importance... - Absence of HBV and HCV, HTLV-I and -II, and human herpes virus-8 activation after allogeneic RBC transfusion in patients with advanced HIV-1 infectionDavid M Asmuth
Department of Internal Medicine, Division of Infectious Diseases and Immunology, University of California Davis Medical Center, 4150 V Street, Suite 6200 PSSB, Sacramento, CA 95817, USA
Transfusion 43:451-8. 2003.... - Effect of a national disaster on blood supply and safety: the September 11 experienceSimone A Glynn
Westat, Rockville, Md 20850 2062, USA
JAMA 289:2246-53. 2003..An understanding of characteristics of blood donors donating in times of crisis may help predict blood supply safety and donor return patterns... - Knowledge, attitudes and motivations among blood donors in São Paulo, BrazilThelma T Goncalez
Fundação Pró Sangue Hemocentro de São Paulo, Sao Paulo, Brazil
AIDS Behav 12:S39-47. 2008..Altruism is the main motivator for blood donation in Brazil; other motivators were associated with specific demographic subgroups. HIV test-seeking might be reduced by educational interventions... - Increased human T-lymphotropic virus type II proviral load following highly active retroviral therapy in HIV-coinfected patientsEdward L Murphy
J Acquir Immune Defic Syndr 33:655-6. 2003 - Quantifying losses to the donated blood supply due to donor deferral and miscollectionBrian Custer
Pharmaceutical Outcomes Research and Policy Program, University of Washington, Seattle, Washington, USA
Transfusion 44:1417-26. 2004..Donors are deferred for multiple reasons. Losses related to disease marker rates are well established. Donor and donation losses for other reasons, however, have not been extensively quantified... - Factors influencing the decision to donate: racial and ethnic comparisonsSimone A Glynn
Westat, Rockville, Maryland 20850, USA
Transfusion 46:980-90. 2006..Understanding factors that encourage different racial and ethnic groups to donate is crucial for donor recruitment and retention... - Risk factors for human immunodeficiency virus infection among blood donors in Sao Paulo, Brazil, and their relevance to current donor deferral criteriaCesar de Almeida Neto
Pro Blood Foundation, Blood Center of Sao Paulo, Brazil
Transfusion 47:608-14. 2007..The objective of this study was to investigate risk factors of human immunodeficiency virus (HIV)-seropositive blood donors in Brazil and to determine if current donor deferral criteria are appropriate... - Factors influencing donor returnKaren S Schlumpf
Westat, Rockville, MD 20850, USA
Transfusion 48:264-72. 2008..To predict future blood donation behavior and improve donor retention, it is important to understand the determinants of donor return... - Community blood supply model: development of a new model to assess the safety, sufficiency, and cost of the blood supplyBrian Custer
Pharmaceutical Outcomes Research and Policy Program, University of Washington, Seattle, USA
Med Decis Making 25:571-82. 2005..However, as a result of increasingly stringent screening measures, one of the greatest threats may be an insufficient supply. The balance between safety and adequacy of the blood supply has not received enough attention...