E Angela Murphy

Summary

Affiliation: University of South Carolina
Country: USA

Publications

  1. pmc Curcumin's effect on intestinal inflammation and tumorigenesis in the ApcMin/+ mouse
    E Angela Murphy
    Department of Pathology Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina 29209, USA
    J Interferon Cytokine Res 31:219-26. 2011
  2. doi request reprint Immune modulating effects of β-glucan
    E Angela Murphy
    Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC 29209, USA
    Curr Opin Clin Nutr Metab Care 13:656-61. 2010
  3. doi request reprint Benefits of oat beta-glucan and sucrose feedings on infection and macrophage antiviral resistance following exercise stress
    E Angela Murphy
    Division of Applied Physiology, Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1188-94. 2009
  4. doi request reprint Role of brain macrophages on IL-1beta and fatigue following eccentric exercise-induced muscle damage
    Martin D Carmichael
    Division of Applied Physiology, Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA
    Brain Behav Immun 24:564-8. 2010
  5. pmc Quercetin supplementation attenuates the progression of cancer cachexia in ApcMin/+ mice
    Kandy T Velazquez
    Division of Applied Physiology, Department of Exercise Science, and Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC
    J Nutr 144:868-75. 2014
  6. doi request reprint Indomethacin in combination with exercise leads to muscle and brain inflammation in mice
    Reilly T Enos
    Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina 29209, USA
    J Interferon Cytokine Res 33:446-51. 2013
  7. doi request reprint Effects of oat β-glucan on the macrophage cytokine response to herpes simplex virus 1 infection in vitro
    E Angela Murphy
    Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina 29201, USA
    J Interferon Cytokine Res 32:362-7. 2012
  8. doi request reprint Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance
    J Mark Davis
    University of South Carolina, Department of Exercise Science, Columbia, SC 29208, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1071-7. 2009
  9. ncbi request reprint Role of brain IL-1beta on fatigue after exercise-induced muscle damage
    Martin D Carmichael
    Dept of Exercise Science, Arnold School of Public Health, University of South Carolina, 1300 Wheat St, Columbia, SC 29208, USA
    Am J Physiol Regul Integr Comp Physiol 291:R1344-8. 2006
  10. doi request reprint Effect of IL-6 deficiency on susceptibility to HSV-1 respiratory infection and intrinsic macrophage antiviral resistance
    E Angela Murphy
    Division of Applied Physiology, Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina 29208, USA
    J Interferon Cytokine Res 28:589-95. 2008

Collaborators

  • J Mark Davis
  • James A Carson
  • Gregory A Hand
  • Mark R Zielinski
  • Susan E Steck
  • Reilly T Enos
  • Jamie L McClellan
  • Martin D Carmichael
  • Jennifer L Steiner
  • Kandy T Velazquez
  • Melissa J Puppa
  • Udai P Singh
  • Stani D Day
  • Abdul Ghaffar
  • Ibrahim Altamemi
  • Catherine R Guffey
  • Kevin A Carnevale
  • Eugene Mayer
  • Adrienne S Brown
  • Jason J Winnick
  • Mark J Davis
  • Michael D Walla
  • Taryn L Cranford
  • Prakash S Nagarkatti
  • James F Catroppo
  • Raja Fayad
  • Jiajia Zhang
  • Aditi A Narsale
  • Elizabeth E Zumbrun
  • Mitzi Nagarkatti
  • Daping Fan
  • Seung H Jung
  • Franklin G Berger
  • Maria M Pena
  • N van Rooijen
  • Eugene P Mayer
  • Ralph S Welsh
  • Jill A Blackmon

Detail Information

Publications29

  1. pmc Curcumin's effect on intestinal inflammation and tumorigenesis in the ApcMin/+ mouse
    E Angela Murphy
    Department of Pathology Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina 29209, USA
    J Interferon Cytokine Res 31:219-26. 2011
    ..05). Curcumin also offset the increase in plasma CCL2 (P < 0.05). The benefits of curcumin in colon cancer may be at least in part mediated by its antiinflammatory activity...
  2. doi request reprint Immune modulating effects of β-glucan
    E Angela Murphy
    Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC 29209, USA
    Curr Opin Clin Nutr Metab Care 13:656-61. 2010
    ..To examine the recent scientific literature on the immune modulating effects of β-glucans and subsequent benefits on infection and cancer...
  3. doi request reprint Benefits of oat beta-glucan and sucrose feedings on infection and macrophage antiviral resistance following exercise stress
    E Angela Murphy
    Division of Applied Physiology, Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1188-94. 2009
    ....
  4. doi request reprint Role of brain macrophages on IL-1beta and fatigue following eccentric exercise-induced muscle damage
    Martin D Carmichael
    Division of Applied Physiology, Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA
    Brain Behav Immun 24:564-8. 2010
    ..These results suggest that brain macrophages can contribute to the increase in brain IL-1beta and fatigue that are associated with recovery from exercise-induced muscle damage...
  5. pmc Quercetin supplementation attenuates the progression of cancer cachexia in ApcMin/+ mice
    Kandy T Velazquez
    Division of Applied Physiology, Department of Exercise Science, and Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC
    J Nutr 144:868-75. 2014
    ..Overall, quercetin supplementation positively affected several aspects of cachexia progression in mice and warrants further exploration as a potential anticachectic therapeutic. ..
  6. doi request reprint Indomethacin in combination with exercise leads to muscle and brain inflammation in mice
    Reilly T Enos
    Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina 29209, USA
    J Interferon Cytokine Res 33:446-51. 2013
    ..The combination of IND and exercise can lead to inflammation in both the muscle and brain that is associated with serious side effects and impaired performance in mice. ..
  7. doi request reprint Effects of oat β-glucan on the macrophage cytokine response to herpes simplex virus 1 infection in vitro
    E Angela Murphy
    Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina 29201, USA
    J Interferon Cytokine Res 32:362-7. 2012
    ..This may be a mechanism for the decreased risk for HSV-1 infection following oat β-glucan feedings in mice...
  8. doi request reprint Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance
    J Mark Davis
    University of South Carolina, Department of Exercise Science, Columbia, SC 29208, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1071-7. 2009
    ..05). These benefits of querectin on fitness without exercise training may have important implications for enhancement of athletic and military performance and may also extend to prevention and/or treatment of chronic diseases...
  9. ncbi request reprint Role of brain IL-1beta on fatigue after exercise-induced muscle damage
    Martin D Carmichael
    Dept of Exercise Science, Arnold School of Public Health, University of South Carolina, 1300 Wheat St, Columbia, SC 29208, USA
    Am J Physiol Regul Integr Comp Physiol 291:R1344-8. 2006
    ..01). These results support the hypothesis that increased brain IL-1beta plays an important role in fatigue after muscle-damaging exercise...
  10. doi request reprint Effect of IL-6 deficiency on susceptibility to HSV-1 respiratory infection and intrinsic macrophage antiviral resistance
    E Angela Murphy
    Division of Applied Physiology, Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina 29208, USA
    J Interferon Cytokine Res 28:589-95. 2008
    ..001). Results indicate that IL-6 plays an important role in susceptibility to respiratory infection in mice, which may be mediated at least in part by its effect on macrophage antiviral resistance...
  11. pmc Influence of dietary saturated fat content on adiposity, macrophage behavior, inflammation, and metabolism: composition matters
    Reilly T Enos
    Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, SC, USA
    J Lipid Res 54:152-63. 2013
    ..Macrophage behavior, inflammation, and IR following HFD are heavily influenced by dietary SF content; however, these responses are not necessarily proportional to the SF percentage...
  12. pmc Linking tumor-associated macrophages, inflammation, and intestinal tumorigenesis: role of MCP-1
    Jamie L McClellan
    Dept of Pathology, Microbiology and Immunology, School of Medicine, Univ of South Carolina, Columbia, SC 29209, USA
    Am J Physiol Gastrointest Liver Physiol 303:G1087-95. 2012
    ..05). We demonstrate that MCP-1 is an important mediator of tumor growth and immune regulation that may serve as an important biomarker and/or therapeutic target in colon cancer...
  13. ncbi request reprint The dietary flavonoid quercetin increases VO(2max) and endurance capacity
    J Mark Davis
    Div of Applied Physiology, Dept of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA
    Int J Sport Nutr Exerc Metab 20:56-62. 2010
    ..This apparent increase in fitness without exercise training may have implications beyond that of performance enhancement to health promotion and disease prevention...
  14. ncbi request reprint Oat beta-glucan effects on neutrophil respiratory burst activity following exercise
    E Angela Murphy
    Divison of Applied Physiology, Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA
    Med Sci Sports Exerc 39:639-44. 2007
    ..Consumption of oat beta-glucan (ObetaG), a soluble fiber and mild immune system enhancer, may offset the immunosuppression associated with intense training and perhaps further enhance the benefits of moderate exercise...
  15. ncbi request reprint Exercise training increases mitochondrial biogenesis in the brain
    Jennifer L Steiner
    Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA
    J Appl Physiol (1985) 111:1066-71. 2011
    ....
  16. doi request reprint Susceptibility to infection and inflammatory response following influenza virus (H1N1, A/PR/8/34) challenge: role of macrophages
    E Angela Murphy
    Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC 29209 USA
    J Interferon Cytokine Res 31:501-8. 2011
    ..05). These data suggest that macrophages play a necessary role in controlling susceptibility to influenza virus and the host's cytokine-mediated response to influenza infection...
  17. pmc Quercetin's effects on intestinal polyp multiplicity and macrophage number in the Apc(Min/+) mouse
    E Angela Murphy
    Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina 29209, USA
    Nutr Cancer 63:421-6. 2011
    ..05). These data suggest that quercetin can reduce polyp number and size distribution in the Apc(Min/+) mouse and that these effects may be related to a reduction in macrophage infiltration...
  18. pmc Intestinal inflammatory cytokine response in relation to tumorigenesis in the Apc(Min/+) mouse
    Jamie L McClellan
    Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, SC 29209, USA
    Cytokine 57:113-9. 2012
    ..Further, these data may be relevant in the design of future investigations of therapeutic interventions to effectively target inflammatory processes in rodent models...
  19. ncbi request reprint Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage
    J Mark Davis
    Division of Applied Physiology, Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA
    Am J Physiol Regul Integr Comp Physiol 292:R2168-73. 2007
    ..05) that were blunted by curcumin feedings. These results support the hypothesis that curcumin can reduce inflammation and offset some of the performance deficits associated with eccentric exercise-induced muscle damage...
  20. ncbi request reprint Exercise effects on polyp burden and immune markers in the ApcMin/+ mouse model of intestinal tumorigenesis
    Jamie L McClellan
    Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, SC 29209, USA
    Int J Oncol 45:861-8. 2014
    ..05). Overall the data provide important new information on immune regulation as a possible mechanism for the documented benefits of exercise training on reducing colon cancer progression. ..
  21. doi request reprint Linking obesity to colorectal cancer: recent insights into plausible biological mechanisms
    Catherine R Guffey
    Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC 29209, USA
    Curr Opin Clin Nutr Metab Care 16:595-600. 2013
    ..This review will examine the recent scientific literature on the mechanisms that are thought to link obesity to colorectal cancer (CRC) risk...
  22. pmc Reducing the Dietary Omega-6:Omega-3 Utilizing α-Linolenic Acid; Not a Sufficient Therapy for Attenuating High-Fat-Diet-Induced Obesity Development Nor Related Detrimental Metabolic and Adipose Tissue Inflammatory Outcomes
    Reilly T Enos
    Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, United States of America
    PLoS ONE 9:e94897. 2014
    ....
  23. ncbi request reprint Recovery of running performance following muscle-damaging exercise: relationship to brain IL-1beta
    Martin D Carmichael
    Division of Applied Physiology, Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, 29205, USA
    Brain Behav Immun 19:445-52. 2005
    ....
  24. pmc Role of microRNAs in resveratrol-mediated mitigation of colitis-associated tumorigenesis in Apc(Min/+) mice
    Ibrahim Altamemi
    Department of Pathology, Microbiology, and Immunology, School of Medicine I A, E A M, J F C, E E Z, J L M, U P S, P S N, M N and Arnold School of Public Health J Z, University of South Carolina, Columbia, South Carolina
    J Pharmacol Exp Ther 350:99-109. 2014
    ..These results suggest that resveratrol mediates anti-inflammatory properties and suppresses intestinal tumorigenesis through miRNA modulation. ..
  25. ncbi request reprint Insight into the impact of dietary saturated fat on tissue-specific cellular processes underlying obesity-related diseases
    Reilly T Enos
    Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, SC 29209, USA Division of Applied Physiology, Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA
    J Nutr Biochem 25:600-12. 2014
    ....
  26. doi request reprint Effects of the dietary flavonoid quercetin upon performance and health
    J Mark Davis
    Division of Applied Physiology, Department of Exercise Science Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA
    Curr Sports Med Rep 8:206-13. 2009
    ..This article will examine the recent scientific literature concerning the role of quercetin in mental and physical performance and health...
  27. pmc Cachectic skeletal muscle response to a novel bout of low-frequency stimulation
    Melissa J Puppa
    Department of Exercise Science, University of South Carolina, Columbia, South Carolina
    J Appl Physiol (1985) 116:1078-87. 2014
    ..These data demonstrate that cachexia alters the muscle metabolic response to acute LoFS, and combination therapies in concert with muscle contraction may be beneficial for improving muscle mass and function during cachexia. ..
  28. doi request reprint Importance of chemokine (CC-motif) ligand 2 in breast cancer
    Jennifer L Steiner
    Department of Exercise Science, University of South Carolina, Columbia, SC 29209, USA
    Int J Biol Markers 27:e179-85. 2012
    ..While there is emerging support for a tumor promoting role of CCL2 in breast cancer, additional research is required before CCL2 can be decisively established as a prognostic factor and/or treatment target in breast cancer...
  29. ncbi request reprint Carbohydrate feedings during team sport exercise preserve physical and CNS function
    Jason J Winnick
    Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA
    Med Sci Sports Exerc 37:306-15. 2005
    ....