John P Murnane

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Telomeres and chromosome instability
    John P Murnane
    Department of Radiation Oncology, University of California, San Francisco, 1855 Folsom Street, MCB 200, San Francisco, CA 94103, USA
    DNA Repair (Amst) 5:1082-92. 2006
  2. pmc Increased sensitivity of subtelomeric regions to DNA double-strand breaks in a human cancer cell line
    Oliver Zschenker
    Department of Radiation Oncology, University of California, 1855 Folsom St, MCB200, San Francisco, CA 94103, USA
    DNA Repair (Amst) 8:886-900. 2009
  3. pmc The role of ATM in the deficiency in nonhomologous end-joining near telomeres in a human cancer cell line
    Keiko Muraki
    Department of Radiation Oncology, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 9:e1003386. 2013
  4. pmc PIF1 disruption or NBS1 hypomorphism does not affect chromosome healing or fusion resulting from double-strand breaks near telomeres in murine embryonic stem cells
    Gloria E Reynolds
    Department of Radiation Oncology, University of California San Francisco, 2340 Sutter Street, San Francisco, CA 94143 1331, United States
    DNA Repair (Amst) 10:1164-73. 2011
  5. ncbi request reprint Telomeric transgenes are silenced in adult mouse tissues and embryo fibroblasts but are expressed in embryonic stem cells
    Qing Gao
    Department of Radiation Oncology, University of California, 1855 Folsom Street, MCB 200, San Francisco, California 94103, USA
    Stem Cells 25:3085-92. 2007
  6. pmc Effect of telomere proximity on telomere position effect, chromosome healing, and sensitivity to DNA double-strand breaks in a human tumor cell line
    Avanti Kulkarni
    Department of Radiation Oncology, University of California San Francisco, San Francisco, CA 94143 1331, USA
    Mol Cell Biol 30:578-89. 2010
  7. ncbi request reprint Telomere instability in a human tumor cell line expressing NBS1 with mutations at sites phosphorylated by ATM
    Yongli Bai
    Radiation Oncology Research Laboratory, University of California San Francisco, 1855 Folsom Street, San Francisco, CA 94103, USA
    Mol Cancer Res 1:1058-69. 2003
  8. ncbi request reprint Chromosome rearrangements resulting from telomere dysfunction and their role in cancer
    John P Murnane
    Radiation Oncology Research Laboratory, University of California, San Francisco, CA 94103, USA
    Bioessays 26:1164-74. 2004
  9. pmc Telomerase-dependent and -independent chromosome healing in mouse embryonic stem cells
    Qing Gao
    Department of Radiation Oncology, University of California, San Francisco, CA 94103, USA
    DNA Repair (Amst) 7:1233-49. 2008
  10. pmc Telomere dysfunction and chromosome instability
    John P Murnane
    Department of Radiation Oncology, University of California, San Francisco, CA 94143 1331, USA
    Mutat Res 730:28-36. 2012

Collaborators

  • Douglas Miller
  • Oliver Zschenker
  • Elizabeth T Snow
  • Lisa W Chu
  • Carl N Sprung
  • Susan M Bailey
  • Qing Gao
  • Gloria E Reynolds
  • Laure Sabatier
  • Anthony W I Lo
  • Mehrdad Pedram
  • Michelle Ricoul
  • Yongli Bai
  • José F Morales
  • Keiko Muraki
  • Avanti Kulkarni
  • Heinz Ulli G Weier
  • Géraldine Pottier
  • Bijan Fouladi
  • Limei Han
  • Lea A Harrington
  • Bryan E Snow
  • Gloria Reynolds
  • Peggie Cheung
  • Steven E Artandi
  • Andrew Wilcox
  • Benjamin L Franc
  • Henry Van Brocklin
  • Lindsay Innes
  • Ella Jones
  • Dong Wei Gao
  • Mustafa Junabi
  • Jingly F Weier

Detail Information

Publications20

  1. ncbi request reprint Telomeres and chromosome instability
    John P Murnane
    Department of Radiation Oncology, University of California, San Francisco, 1855 Folsom Street, MCB 200, San Francisco, CA 94103, USA
    DNA Repair (Amst) 5:1082-92. 2006
    ..Factors promoting spontaneous telomere loss and the resulting B/F/B cycles are therefore likely to be important in generating the karyotypic changes associated with human cancer...
  2. pmc Increased sensitivity of subtelomeric regions to DNA double-strand breaks in a human cancer cell line
    Oliver Zschenker
    Department of Radiation Oncology, University of California, 1855 Folsom St, MCB200, San Francisco, CA 94103, USA
    DNA Repair (Amst) 8:886-900. 2009
    ....
  3. pmc The role of ATM in the deficiency in nonhomologous end-joining near telomeres in a human cancer cell line
    Keiko Muraki
    Department of Radiation Oncology, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 9:e1003386. 2013
    ....
  4. pmc PIF1 disruption or NBS1 hypomorphism does not affect chromosome healing or fusion resulting from double-strand breaks near telomeres in murine embryonic stem cells
    Gloria E Reynolds
    Department of Radiation Oncology, University of California San Francisco, 2340 Sutter Street, San Francisco, CA 94143 1331, United States
    DNA Repair (Amst) 10:1164-73. 2011
    ....
  5. ncbi request reprint Telomeric transgenes are silenced in adult mouse tissues and embryo fibroblasts but are expressed in embryonic stem cells
    Qing Gao
    Department of Radiation Oncology, University of California, 1855 Folsom Street, MCB 200, San Francisco, California 94103, USA
    Stem Cells 25:3085-92. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  6. pmc Effect of telomere proximity on telomere position effect, chromosome healing, and sensitivity to DNA double-strand breaks in a human tumor cell line
    Avanti Kulkarni
    Department of Radiation Oncology, University of California San Francisco, San Francisco, CA 94143 1331, USA
    Mol Cell Biol 30:578-89. 2010
    ..Conversely, the region 100 kb from the telomere was highly sensitive to double-strand breaks, demonstrating that the sensitive region is a relatively large target for ionizing radiation-induced chromosome instability...
  7. ncbi request reprint Telomere instability in a human tumor cell line expressing NBS1 with mutations at sites phosphorylated by ATM
    Yongli Bai
    Radiation Oncology Research Laboratory, University of California San Francisco, 1855 Folsom Street, San Francisco, CA 94103, USA
    Mol Cancer Res 1:1058-69. 2003
    ..Telomere loss showed no correlation with radiosensitivity or radioresistant DNA synthesis, demonstrating that NBS1(S278A/S343A) promotes telomere loss through a separate pathway from these other phenotypes associated with NBS...
  8. ncbi request reprint Chromosome rearrangements resulting from telomere dysfunction and their role in cancer
    John P Murnane
    Radiation Oncology Research Laboratory, University of California, San Francisco, CA 94103, USA
    Bioessays 26:1164-74. 2004
    ..Thus, the loss of a single telomere can result in instability in multiple chromosomes, and generate many of the types of rearrangements commonly associated with human cancer...
  9. pmc Telomerase-dependent and -independent chromosome healing in mouse embryonic stem cells
    Qing Gao
    Department of Radiation Oncology, University of California, San Francisco, CA 94103, USA
    DNA Repair (Amst) 7:1233-49. 2008
    ....
  10. pmc Telomere dysfunction and chromosome instability
    John P Murnane
    Department of Radiation Oncology, University of California, San Francisco, CA 94143 1331, USA
    Mutat Res 730:28-36. 2012
    ..Knowledge concerning the factors promoting telomere loss and its consequences is therefore important for understanding chromosome instability in human cancer...
  11. pmc Telomere loss as a mechanism for chromosome instability in human cancer
    John P Murnane
    Department of Radiation Oncology, University of California San Francisco, San Francisco, CA 94143 1331, USA
    Cancer Res 70:4255-9. 2010
    ..Cancer Res; 70(11); 4255-9. (c)2010 AACR...
  12. pmc Telomere position effect and silencing of transgenes near telomeres in the mouse
    Mehrdad Pedram
    Department of Radiation Oncology, University of California, 1855 Folsom St, MCB 200, San Francisco, CA 94103, USA
    Mol Cell Biol 26:1865-78. 2006
    ..In contrast, telomeric transgenes were not silenced in ES cell lines isolated from 3-day-old preimplantation embryos, consistent with the hypothesis that TPE plays a role in the development of the embryo...
  13. ncbi request reprint Environmental factors affecting transcription of the human L1 retrotransposon. II. Stressors
    José F Morales
    Radiation Oncology Research Laboratory, University of California San Francisco, 1855 Folsom Street, MCB 200, San Francisco, CA 94103, USA
    Mutagenesis 18:151-8. 2003
    ..No increase in beta-galactosidase activity was observed after exposure to X-rays or hydrogen peroxide...
  14. ncbi request reprint Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein
    Yongli Bai
    Radiation Oncology Research Laboratory, University of California San Francisco, 1855 Folsom Street, MCB 200, San Francisco, CA 94103, USA
    Hum Genet 113:337-47. 2003
    ..Thus, telomere loss can contribute to chromosome instability in cells deficient in WRN regardless of the expression of telomerase activity...
  15. pmc DNA amplification by breakage/fusion/bridge cycles initiated by spontaneous telomere loss in a human cancer cell line
    Anthony W I Lo
    Radiation Oncology Research Laboratory, University of California, 1855 Folsom Street, MCB 200, San Francisco, CA 94103, USA
    Neoplasia 4:531-8. 2002
    ..The amplification of subtelomeric DNA on the marker chromosome provides conclusive evidence that B/F/B cycles initiated by spontaneous telomere loss are a mechanism for gene amplification in human cancer cells...
  16. ncbi request reprint Applications and technical challenges of fluorescence in situ hybridization in stem cell research
    Heinz Ulli G Weier
    Life Sciences Division 74 157, University of California, E O Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Blood Cells Mol Dis 32:68-76. 2004
    ..This report summarizes our technical achievements relevant to stem cell research and outlines plans for future research and developments...
  17. pmc Chromosome instability as a result of double-strand breaks near telomeres in mouse embryonic stem cells
    Anthony W I Lo
    Radiation Oncology Research Laboratory, University of California, San Francisco, California 94103, USA
    Mol Cell Biol 22:4836-50. 2002
    ....
  18. ncbi request reprint Environmental factors affecting transcription of the human L1 retrotransposon. I. Steroid hormone-like agents
    José F Morales
    Radiation Oncology Research Laboratory, University of California San Francisco, 1855 Folsom Street, MCB 200, San Francisco, CA 94103, USA
    Mutagenesis 17:193-200. 2002
    ....
  19. ncbi request reprint The loss of a single telomere can result in instability of multiple chromosomes in a human tumor cell line
    Laure Sabatier
    Laboratoire de Radiologie et Oncologie, Commissariat a l Energie Atomique, Fontenay aux Roses, France
    Mol Cancer Res 3:139-50. 2005
    ..Factors promoting telomere loss are therefore likely to have an important role in generating the karyotype evolution associated with human cancer...
  20. pmc Telomeres, chromosome instability and cancer
    Susan M Bailey
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Nucleic Acids Res 34:2408-17. 2006
    ..Thus, the loss of a single telomere can result in on-going instability, affect multiple chromosomes, and generate many of the types of rearrangements commonly associated with human cancer...