John Murnane

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The role of ATM in the deficiency in nonhomologous end-joining near telomeres in a human cancer cell line
    Keiko Muraki
    Department of Radiation Oncology, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 9:e1003386. 2013
  2. pmc Mechanisms of telomere loss and their consequences for chromosome instability
    Keiko Muraki
    Department of Radiation Oncology, University of California at San Francisco San Francisco, CA, USA
    Front Oncol 2:135. 2012
  3. pmc Telomere dysfunction and chromosome instability
    John P Murnane
    Department of Radiation Oncology, University of California, San Francisco, CA 94143 1331, USA
    Mutat Res 730:28-36. 2012
  4. pmc Telomere loss as a mechanism for chromosome instability in human cancer
    John P Murnane
    Department of Radiation Oncology, University of California San Francisco, San Francisco, CA 94143 1331, USA
    Cancer Res 70:4255-9. 2010
  5. ncbi request reprint Chromosome rearrangements resulting from telomere dysfunction and their role in cancer
    John P Murnane
    Radiation Oncology Research Laboratory, University of California, San Francisco, CA 94103, USA
    Bioessays 26:1164-74. 2004
  6. ncbi request reprint Telomeres and chromosome instability
    John P Murnane
    Department of Radiation Oncology, University of California, San Francisco, 1855 Folsom Street, MCB 200, San Francisco, CA 94103, USA
    DNA Repair (Amst) 5:1082-92. 2006
  7. pmc DNA amplification by breakage/fusion/bridge cycles initiated by spontaneous telomere loss in a human cancer cell line
    Anthony W I Lo
    Radiation Oncology Research Laboratory, University of California, 1855 Folsom Street, MCB 200, San Francisco, CA 94103, USA
    Neoplasia 4:531-8. 2002
  8. pmc Effect of telomere proximity on telomere position effect, chromosome healing, and sensitivity to DNA double-strand breaks in a human tumor cell line
    Avanti Kulkarni
    Department of Radiation Oncology, University of California San Francisco, San Francisco, CA 94143 1331, USA
    Mol Cell Biol 30:578-89. 2010
  9. ncbi request reprint Telomere instability in a human tumor cell line expressing NBS1 with mutations at sites phosphorylated by ATM
    Yongli Bai
    Radiation Oncology Research Laboratory, University of California San Francisco, 1855 Folsom Street, San Francisco, CA 94103, USA
    Mol Cancer Res 1:1058-69. 2003
  10. pmc Chromosome instability as a result of double-strand breaks near telomeres in mouse embryonic stem cells
    Anthony W I Lo
    Radiation Oncology Research Laboratory, University of California, San Francisco, California 94103, USA
    Mol Cell Biol 22:4836-50. 2002

Collaborators

  • Elizabeth T Snow
  • Susan M Bailey
  • Laure Sabatier
  • Keiko Muraki
  • Anthony W I Lo
  • Gloria E Reynolds
  • Douglas Miller
  • Mehrdad Pedram
  • Avanti Kulkarni
  • Oliver Zschenker
  • Michelle Ricoul
  • Yongli Bai
  • Qing Gao
  • José F Morales
  • Géraldine Pottier
  • Limei Han
  • Carl N Sprung
  • Bijan Fouladi
  • Kristine Nyhan
  • Gloria Reynolds
  • Marine Granger-Locatelli
  • Henry Van Brocklin
  • Ella Jones
  • Mustafa Junabi
  • Benjamin L Franc
  • Lindsay Innes
  • Dong Wei Gao

Detail Information

Publications18

  1. pmc The role of ATM in the deficiency in nonhomologous end-joining near telomeres in a human cancer cell line
    Keiko Muraki
    Department of Radiation Oncology, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 9:e1003386. 2013
    ....
  2. pmc Mechanisms of telomere loss and their consequences for chromosome instability
    Keiko Muraki
    Department of Radiation Oncology, University of California at San Francisco San Francisco, CA, USA
    Front Oncol 2:135. 2012
    ..Understanding the mechanisms of telomere loss will therefore provide important insights into both human cancer and genetic disease...
  3. pmc Telomere dysfunction and chromosome instability
    John P Murnane
    Department of Radiation Oncology, University of California, San Francisco, CA 94143 1331, USA
    Mutat Res 730:28-36. 2012
    ..Knowledge concerning the factors promoting telomere loss and its consequences is therefore important for understanding chromosome instability in human cancer...
  4. pmc Telomere loss as a mechanism for chromosome instability in human cancer
    John P Murnane
    Department of Radiation Oncology, University of California San Francisco, San Francisco, CA 94143 1331, USA
    Cancer Res 70:4255-9. 2010
    ..Cancer Res; 70(11); 4255-9. (c)2010 AACR...
  5. ncbi request reprint Chromosome rearrangements resulting from telomere dysfunction and their role in cancer
    John P Murnane
    Radiation Oncology Research Laboratory, University of California, San Francisco, CA 94103, USA
    Bioessays 26:1164-74. 2004
    ..Thus, the loss of a single telomere can result in instability in multiple chromosomes, and generate many of the types of rearrangements commonly associated with human cancer...
  6. ncbi request reprint Telomeres and chromosome instability
    John P Murnane
    Department of Radiation Oncology, University of California, San Francisco, 1855 Folsom Street, MCB 200, San Francisco, CA 94103, USA
    DNA Repair (Amst) 5:1082-92. 2006
    ..Factors promoting spontaneous telomere loss and the resulting B/F/B cycles are therefore likely to be important in generating the karyotypic changes associated with human cancer...
  7. pmc DNA amplification by breakage/fusion/bridge cycles initiated by spontaneous telomere loss in a human cancer cell line
    Anthony W I Lo
    Radiation Oncology Research Laboratory, University of California, 1855 Folsom Street, MCB 200, San Francisco, CA 94103, USA
    Neoplasia 4:531-8. 2002
    ..The amplification of subtelomeric DNA on the marker chromosome provides conclusive evidence that B/F/B cycles initiated by spontaneous telomere loss are a mechanism for gene amplification in human cancer cells...
  8. pmc Effect of telomere proximity on telomere position effect, chromosome healing, and sensitivity to DNA double-strand breaks in a human tumor cell line
    Avanti Kulkarni
    Department of Radiation Oncology, University of California San Francisco, San Francisco, CA 94143 1331, USA
    Mol Cell Biol 30:578-89. 2010
    ..Conversely, the region 100 kb from the telomere was highly sensitive to double-strand breaks, demonstrating that the sensitive region is a relatively large target for ionizing radiation-induced chromosome instability...
  9. ncbi request reprint Telomere instability in a human tumor cell line expressing NBS1 with mutations at sites phosphorylated by ATM
    Yongli Bai
    Radiation Oncology Research Laboratory, University of California San Francisco, 1855 Folsom Street, San Francisco, CA 94103, USA
    Mol Cancer Res 1:1058-69. 2003
    ..Telomere loss showed no correlation with radiosensitivity or radioresistant DNA synthesis, demonstrating that NBS1(S278A/S343A) promotes telomere loss through a separate pathway from these other phenotypes associated with NBS...
  10. pmc Chromosome instability as a result of double-strand breaks near telomeres in mouse embryonic stem cells
    Anthony W I Lo
    Radiation Oncology Research Laboratory, University of California, San Francisco, California 94103, USA
    Mol Cell Biol 22:4836-50. 2002
    ....
  11. pmc Increased sensitivity of subtelomeric regions to DNA double-strand breaks in a human cancer cell line
    Oliver Zschenker
    Department of Radiation Oncology, University of California, 1855 Folsom St, MCB200, San Francisco, CA 94103, USA
    DNA Repair (Amst) 8:886-900. 2009
    ....
  12. ncbi request reprint Telomeric transgenes are silenced in adult mouse tissues and embryo fibroblasts but are expressed in embryonic stem cells
    Qing Gao
    Department of Radiation Oncology, University of California, 1855 Folsom Street, MCB 200, San Francisco, California 94103, USA
    Stem Cells 25:3085-92. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  13. ncbi request reprint Environmental factors affecting transcription of the human L1 retrotransposon. I. Steroid hormone-like agents
    José F Morales
    Radiation Oncology Research Laboratory, University of California San Francisco, 1855 Folsom Street, MCB 200, San Francisco, CA 94103, USA
    Mutagenesis 17:193-200. 2002
    ....
  14. pmc Telomere position effect and silencing of transgenes near telomeres in the mouse
    Mehrdad Pedram
    Department of Radiation Oncology, University of California, 1855 Folsom St, MCB 200, San Francisco, CA 94103, USA
    Mol Cell Biol 26:1865-78. 2006
    ..In contrast, telomeric transgenes were not silenced in ES cell lines isolated from 3-day-old preimplantation embryos, consistent with the hypothesis that TPE plays a role in the development of the embryo...
  15. ncbi request reprint Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein
    Yongli Bai
    Radiation Oncology Research Laboratory, University of California San Francisco, 1855 Folsom Street, MCB 200, San Francisco, CA 94103, USA
    Hum Genet 113:337-47. 2003
    ..Thus, telomere loss can contribute to chromosome instability in cells deficient in WRN regardless of the expression of telomerase activity...
  16. ncbi request reprint Environmental factors affecting transcription of the human L1 retrotransposon. II. Stressors
    José F Morales
    Radiation Oncology Research Laboratory, University of California San Francisco, 1855 Folsom Street, MCB 200, San Francisco, CA 94103, USA
    Mutagenesis 18:151-8. 2003
    ..No increase in beta-galactosidase activity was observed after exposure to X-rays or hydrogen peroxide...
  17. ncbi request reprint The loss of a single telomere can result in instability of multiple chromosomes in a human tumor cell line
    Laure Sabatier
    Laboratoire de Radiologie et Oncologie, Commissariat a l Energie Atomique, Fontenay aux Roses, France
    Mol Cancer Res 3:139-50. 2005
    ..Factors promoting telomere loss are therefore likely to have an important role in generating the karyotype evolution associated with human cancer...
  18. pmc Telomeres, chromosome instability and cancer
    Susan M Bailey
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Nucleic Acids Res 34:2408-17. 2006
    ..Thus, the loss of a single telomere can result in on-going instability, affect multiple chromosomes, and generate many of the types of rearrangements commonly associated with human cancer...

Research Grants27

  1. TELOMERIC REPEATS AND THE RESPONSE TO IONIZING RADIATION
    John Murnane; Fiscal Year: 2003
    ..The ability to observe chromosome healing and fusion in the same system will also allow us to test the hypothesis proposed by McClintock that chromosome healing can prevent the chromosome instability resulting from chromosome fusion. ..
  2. MECHANISMS OF FORMATION OF TERMINAL DELETIONS
    John Murnane; Fiscal Year: 2003
    ....
  3. TELOMERIC REPEATS AND THE RESPONSE TO IONIZING RADIATION
    John Murnane; Fiscal Year: 2004
    ..The ability to observe chromosome healing and fusion in the same system will also allow us to test the hypothesis proposed by McClintock that chromosome healing can prevent the chromosome instability resulting from chromosome fusion. ..
  4. MECHANISMS OF FORMATION OF TERMINAL DELETIONS
    John Murnane; Fiscal Year: 2004
    ....
  5. MECHANISMS OF FORMATION OF TERMINAL DELETIONS
    John Murnane; Fiscal Year: 2005
    ....
  6. MECHANISMS OF FORMATION OF TERMINAL DELETIONS
    John Murnane; Fiscal Year: 2006
    ....
  7. Chromosome instability resulting from double-strand breaks near telomeres
    John Murnane; Fiscal Year: 2006
    ..These studies are important in that they will provide new insights into mechanisms of chromosome instability in cancer and lead to new approaches for the development of therapies for preventing CIN in cancer cells. ..
  8. MECHANISMS OF FORMATION OF TERMINAL DELETIONS
    John Murnane; Fiscal Year: 2007
    ....
  9. Chromosome instability resulting from double-strand breaks near telomeres
    John Murnane; Fiscal Year: 2007
    ..These studies are important in that they will provide new insights into mechanisms of chromosome instability in cancer and lead to new approaches for the development of therapies for preventing CIN in cancer cells. ..
  10. Chromosome instability resulting from double-strand breaks near telomeres
    John Murnane; Fiscal Year: 2009
    ..These studies are important in that they will provide new insights into mechanisms of chromosome instability in cancer and lead to new approaches for the development of therapies for preventing CIN in cancer cells. ..
  11. TELOMERIC REPEATS AND THE RESPONSE TO IONIZING RADIATION
    John Murnane; Fiscal Year: 2002
    ..The ability to observe chromosome healing and fusion in the same system will also allow us to test the hypothesis proposed by McClintock that chromosome healing can prevent the chromosome instability resulting from chromosome fusion. ..
  12. MECHANISM OF FORMATION OF TERMINAL DELETIONS
    John Murnane; Fiscal Year: 2002
    ..The ability of this system to monitor telomere length and the rate of telomere loss will also provide a means of investigating the role of different genes in maintaining telomere stability. ..
  13. TELOMERIC REPEATS AND THE RESPONSE TO IONIZING RADIATION
    John Murnane; Fiscal Year: 2001
    ..The ability to observe chromosome healing and fusion in the same system will also allow us to test the hypothesis proposed by McClintock that chromosome healing can prevent the chromosome instability resulting from chromosome fusion. ..
  14. MECHANISM OF FORMATION OF TERMINAL DELETIONS
    John Murnane; Fiscal Year: 2000
    ..The ability of this system to monitor telomere length and the rate of telomere loss will also provide a means of investigating the role of different genes in maintaining telomere stability. ..
  15. TELOMERIC REPEATS AND THE RESPONSE TO IONIZING RADIATION
    John Murnane; Fiscal Year: 2000
    ..The ability to observe chromosome healing and fusion in the same system will also allow us to test the hypothesis proposed by McClintock that chromosome healing can prevent the chromosome instability resulting from chromosome fusion. ..
  16. MECHANISM OF FORMATION OF TERMINAL DELETIONS
    John Murnane; Fiscal Year: 2001
    ..The ability of this system to monitor telomere length and the rate of telomere loss will also provide a means of investigating the role of different genes in maintaining telomere stability. ..
  17. Chromosome instability resulting from double-strand breaks near telomeres
    John P Murnane; Fiscal Year: 2010
    ..These studies are important in that they will provide new insights into mechanisms of chromosome instability in cancer and lead to new approaches for the development of therapies for preventing CIN in cancer cells. ..