Ramachandran Murali

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc A comprehensive analysis of the naturally occurring polymorphisms in HIV-1 Vpr: potential impact on CTL epitopes
    Alagarsamy Srinivasan
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virol J 5:99. 2008
  2. ncbi Structure-based design of immunologically active therapeutic peptides
    R Murali
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia 19104 6082, USA
    Immunol Res 17:163-9. 1998
  3. pmc Disabling TNF receptor signaling by induced conformational perturbation of tryptophan-107
    Ramachandran Murali
    Department of Pathology and Laboratory of Medicine and Abramson Cancer Research Center, University of Pennsylvania, 36th Hamilton Walk, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 102:10970-5. 2005
  4. pmc Human glucocorticoid-induced TNF receptor ligand regulates its signaling activity through multiple oligomerization states
    Zhaocai Zhou
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:5465-70. 2008
  5. ncbi Disabling of receptor activator of nuclear factor-kappaB (RANK) receptor complex by novel osteoprotegerin-like peptidomimetics restores bone loss in vivo
    Xin Cheng
    Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute for Cancer Research, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 279:8269-77. 2004
  6. pmc Fas-disabling small exocyclic peptide mimetics limit apoptosis by an unexpected mechanism
    Akihiro Hasegawa
    Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 252 John Morgan Building, 36th and Hamilton Walk, Philadelphia, PA 19104 6082, USA
    Proc Natl Acad Sci U S A 101:6599-604. 2004
  7. pmc Structural basis for ligand-mediated mouse GITR activation
    Zhaocai Zhou
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:641-5. 2008
  8. pmc Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope
    Zhaocai Zhou
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 287:5317-26. 2012
  9. pmc Fn14-TRAIL, a chimeric intercellular signal exchanger, attenuates experimental autoimmune encephalomyelitis
    Marjaneh Razmara
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Pathol 174:460-74. 2009
  10. ncbi Structure-based approaches to inhibition of erbB receptors with peptide mimetics
    Alan Berezov
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, and The Abramson Family Cancer Research Institute, Philadelphia, PA 19104, USA
    Immunol Res 27:303-8. 2003

Collaborators

  • Mark I Greene
  • Hongtao Zhang
  • Qiang Wang
  • Bin Li
  • Zheng Cai
  • Toshinori Nakayama
  • Jing Liu
  • Datta E Ponde
  • Hideo Yagita
  • P Peter Ghoroghchian
  • John Guardiola
  • Yongwon Choi
  • Michael S Marks
  • Youhai Chen
  • Keiichi Ohya
  • K E Sullivan
  • M Ishiguro
  • Alan Berezov
  • Zhaocai Zhou
  • Xin Cheng
  • Xiaomin Song
  • Marjaneh Razmara
  • Alagarsamy Srinivasan
  • Geng Zhang
  • Dalia Hope Levine
  • Kazuhiro Aoki
  • Veronique Guillemard
  • Akihiro Hasegawa
  • Masa Kinosaki
  • Kiichi Kajino
  • Nahmah Kim
  • Takeo Horie
  • David A Cowan
  • Marla Rosanne Yee
  • Shiaw Lin Wu
  • Emi Suzuki
  • Takako Mizuno
  • Xiulian Du
  • Barry L Karger
  • Mustafa Ghazanfar
  • Srikanth Yellayi
  • Azadeh K Ziarani
  • Mark L Tykocinski
  • Brendan Hilliard
  • Debduti Datta
  • Anthony Cristillo
  • Yanjing Li
  • Anne Boyd
  • Michael J Therien
  • Ronald G Collman
  • Daniel A Hammer
  • Sundarasamy Mahalingam
  • James D Lear
  • Jaclyn Freudenberg
  • Herman Waldmann
  • Bassel E Sawaya
  • Masahide Tone
  • Velpandi Ayyavoo
  • Keiji Furuuchi
  • Aarthi Kannan
  • Vaniambadi S Kalyanaraman
  • Yukiko Tone
  • Nelly Morellet
  • William C Horne
  • Cecile Itzstein
  • Patrick Mollat
  • Roland Baron
  • Pierre Deprez
  • Yoshifumi Suzuki
  • Roland Blanque
  • Masako Yoshimatsu
  • Anower Hussain Mian
  • Akira Yamaguchi
  • Tatsuya Shibata
  • Hiroaki Saito
  • Mariko Takahashi
  • Hinyu N Nedev
  • H Uri Saragovi
  • Kaoru Murata
  • Masamichi Takami
  • Dominique Piatier-Tonneau
  • Giovanna Bonomi
  • Lashon Ussin
  • Huizhen Zhao
  • Yuan Shen
  • Mary M Tomayko
  • Denise Gay
  • Bert M Bieler
  • Abdolmohamad Rostami
  • Jean Claude Mani

Detail Information

Publications22

  1. pmc A comprehensive analysis of the naturally occurring polymorphisms in HIV-1 Vpr: potential impact on CTL epitopes
    Alagarsamy Srinivasan
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virol J 5:99. 2008
    ..The available data on naturally occurring polymorphisms will be useful to assess their potential effect on the structural and functional constraints of Vpr and also on the fitness of HIV-1 for replication...
  2. ncbi Structure-based design of immunologically active therapeutic peptides
    R Murali
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia 19104 6082, USA
    Immunol Res 17:163-9. 1998
    ..In this article, two molecular targets are discussed: (1) immunoglobulin fold-containing CD4 receptor and (2) cystine-knot-containing TNF receptor (TNFR)...
  3. pmc Disabling TNF receptor signaling by induced conformational perturbation of tryptophan-107
    Ramachandran Murali
    Department of Pathology and Laboratory of Medicine and Abramson Cancer Research Center, University of Pennsylvania, 36th Hamilton Walk, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 102:10970-5. 2005
    ..Thus, disabling receptor function by induced conformational changes of active binding surfaces represents an innovative paradigm in structure-based drug design...
  4. pmc Human glucocorticoid-induced TNF receptor ligand regulates its signaling activity through multiple oligomerization states
    Zhaocai Zhou
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:5465-70. 2008
    ..The studies address the functional implications and structural models for a process by which hGITRL utilizes multiple oligomerization states to regulate GITR-mediated signaling during T cell costimulation...
  5. ncbi Disabling of receptor activator of nuclear factor-kappaB (RANK) receptor complex by novel osteoprotegerin-like peptidomimetics restores bone loss in vivo
    Xin Cheng
    Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute for Cancer Research, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 279:8269-77. 2004
    ....
  6. pmc Fas-disabling small exocyclic peptide mimetics limit apoptosis by an unexpected mechanism
    Akihiro Hasegawa
    Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 252 John Morgan Building, 36th and Hamilton Walk, Philadelphia, PA 19104 6082, USA
    Proc Natl Acad Sci U S A 101:6599-604. 2004
    ..This event desensitizes FasL-mediated apoptosis by inhibiting extracellular signal regulated kinase activity and up-regulating NF-kappaB...
  7. pmc Structural basis for ligand-mediated mouse GITR activation
    Zhaocai Zhou
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:641-5. 2008
    ..We hypothesize that specific oligomeric forms of GITRL may be used as a means to differentially control GITR receptor signaling in diverse cells...
  8. pmc Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope
    Zhaocai Zhou
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 287:5317-26. 2012
    ..These findings provide the structural basis for understanding the function and the regulation of the LINC complex...
  9. pmc Fn14-TRAIL, a chimeric intercellular signal exchanger, attenuates experimental autoimmune encephalomyelitis
    Marjaneh Razmara
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Pathol 174:460-74. 2009
    ..Its functional pleiotropism was manifest in its additional ability to attenuate the enhanced permeability of the blood-brain barrier that typically accompanies autoimmune encephalomyelitis...
  10. ncbi Structure-based approaches to inhibition of erbB receptors with peptide mimetics
    Alan Berezov
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, and The Abramson Family Cancer Research Institute, Philadelphia, PA 19104, USA
    Immunol Res 27:303-8. 2003
    ..An alternative structure-based strategy of erbB receptor blockade with peptide mimetics by targeting receptor dimerization interfaces is also described...
  11. pmc ErbB receptors: from oncogenes to targeted cancer therapies
    Hongtao Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6082, USA
    J Clin Invest 117:2051-8. 2007
    ..However, current therapy has not yet been optimized, allowing for opportunities for optimization of the next generation of targeted therapy, particularly with regards to inhibiting heteromeric ErbB family receptor complexes...
  12. ncbi Study of disabling T-cell activation and inhibiting T-cell-mediated immunopathology reveals a possible inverse agonist activity of CD4 peptidomimetics
    Takeo Horie
    Department of Pathology and School of Medicine, University of Pensylvania, Philadelphia, Pennsylvania 19104, USA
    Exp Mol Pathol 73:93-103. 2002
    ..The structure-activity relationship of mimetics reveals that a minor change in the net hydropathic value is enough to alter the dynamic nature of the receptor-ligand complex...
  13. pmc Development of anti-EGF receptor peptidomimetics (AERP) as tumor imaging agent
    Datta E Ponde
    Department of Radiology, Cyclotron Facility, 420 Curie Blvd, University of Pennsylvania, Philadelphia, PA 19104, United States
    Bioorg Med Chem Lett 21:2550-3. 2011
    ..6±0.1%ID/g and tumor to muscle ratio was 5.5. Our studies suggest that this novel peptidomimetic, AERP-2, warrants further development as an EGFR specific tumor-imaging agent...
  14. doi Targeting erbB receptors
    Zheng Cai
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 6082, USA
    Semin Cell Dev Biol 21:961-6. 2010
    ....
  15. ncbi The centrosome in normal and transformed cells
    Qiang Wang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    DNA Cell Biol 23:475-89. 2004
    ..Here we review the current understanding of how the centrosome is assembled and duplicated. We also discuss the possible mechanisms by which centrosome abnormality contributes to the development of malignant phenotype...
  16. ncbi Disabling receptor ensembles with rationally designed interface peptidomimetics
    Alan Berezov
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine and the Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:28330-9. 2002
    ..Small dimerization inhibitors described herein can be useful as probes to elucidate different erbB signaling pathways and may be developed as therapeutic agents...
  17. ncbi The TNF receptor superfamily: role in immune inflammation and bone formation
    Xin Cheng
    Department of Pathology, Abramson Institute for Cancer Research, University of Pennsylvania, Philadelphia, PA 19104 6082, USA
    Immunol Res 27:287-94. 2003
    ..These mimetics can be used as a probe to understand the molecular basis of osteoclastogenesis and also as a platform to create useful therapeutic agent...
  18. pmc Polymersomes: a new multi-functional tool for cancer diagnosis and therapy
    Dalia Hope Levine
    Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104 6082, USA
    Methods 46:25-32. 2008
    ..Hence, polymersomes hold enormous potential as nanostructured biomaterials for future in vivo drug delivery and diagnostic imaging applications...
  19. ncbi TNFalpha inhibition in MRL/lpr mice ameliorates pulmonary but not renal disease
    Nahmah Kim
    Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Autoimmun 19:215-22. 2002
    ..This has important implications for designing therapeutics for SLE...
  20. ncbi Characterization of mouse tGolgin-1 (golgin-245/trans-golgi p230/256 kD golgin) and its upregulation during oligodendrocyte development
    David A Cowan
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6082, USA
    DNA Cell Biol 21:505-17. 2002
    ..This expression pattern suggests that tGolgin-1 may play a role in specialized transport processes associated with maturation and/or differentiation of oligodendrocyte precursors...
  21. ncbi HER2-mediated internalization of a targeted prodrug cytotoxic conjugate is dependent on the valency of the targeting ligand
    Veronique Guillemard
    McGill University, Pharmacology and Therapeutics and Oncology Cancer Center, Lady Davis Research Institute Jewish General Hospital, Montreal, Quebec, Canada
    DNA Cell Biol 24:350-8. 2005
    ..This work links HER2 receptor internalization and growth arrest, and the chemical conjugation strategy may yield improved and HER2 selective therapeutics...
  22. pmc A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss
    Kazuhiro Aoki
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520 8044, USA
    J Clin Invest 116:1525-34. 2006
    ..These results suggest that a peptide that mimics a TNFR ligand contact site blocks bone resorption by interfering with recruitment and activation of osteoclasts by both RANKL and TNF...