Alysson Muotri

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Transcriptional signature and memory retention of human-induced pluripotent stem cells
    Maria C N Marchetto
    The Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, California, USA
    PLoS ONE 4:e7076. 2009
  2. pmc Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients
    Miguel Mitne-Neto
    University of California San Diego, School of Medicine, Department of Pediatrics Rady Children s Hospital San Diego, Department of Cellular and Molecular Medicine, Stem Cell Program, 9500 Gilman Dr, La Jolla, CA 92093, MC 0695, USA
    Hum Mol Genet 20:3642-52. 2011
  3. doi request reprint LINE-1 retrotransposition in the nervous system
    Charles A Thomas
    Department of Pediatrics Rady Children s Hospital San Diego, University of California San Diego, La Jolla, California 92093, USA
    Annu Rev Cell Dev Biol 28:555-73. 2012
  4. doi request reprint Modeling epilepsy with pluripotent human cells
    Alysson Renato Muotri
    Department of Pediatrics, Division of Genetics, VCSD Stem Cell Initiative, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Epilepsy Behav 14:81-5. 2009
  5. pmc Environmental influence on L1 retrotransposons in the adult hippocampus
    Alysson R Muotri
    Department of Pediatrics Cellular and Molecular Medicine, School of Medicine, UCSD Stem Cell Initiative, University of California, San Diego, 9500 Gilman Drive 0695, California, USA
    Hippocampus 19:1002-7. 2009
  6. pmc L1 retrotransposition in neurons is modulated by MeCP2
    Alysson R Muotri
    University of California San Diego, School of Medicine, Department of Pediatrics Rady Children s Hospital San Diego, La Jolla, California 92093 0695, USA
    Nature 468:443-6. 2010
  7. pmc Identification of a neuronal gene expression signature: role of cell cycle arrest in murine neuronal differentiation in vitro
    Hady Felfly
    Department of Pediatrics, School of Medicine, University of California San Diego, CA, USA
    Am J Physiol Regul Integr Comp Physiol 301:R727-45. 2011

Research Grants

  1. Modeling autism with human pluripotent cells
    Alysson Muotri; Fiscal Year: 2009

Collaborators

  • Mayana Zatz
  • Kinichi Nakashima
  • Gene W Yeo
  • Alexander C Zambon
  • Dan Zhou
  • Maria C N Marchetto
  • Charles A Thomas
  • Hady Felfly
  • Miguel Mitne-Neto
  • Apua C M Paquola
  • Acary S B Oliveira
  • Jin Xue
  • Mario H Bengtson
  • Hugo J Bellen
  • Helga C A Silva
  • Gabriel G Haddad
  • Marcela Machado-Costa
  • Monize Lazar
  • Hiroshi Tsuda
  • Claudio A Joazeiro
  • Osamu Kainohana
  • Martin Marsala
  • Fred H Gage

Detail Information

Publications7

  1. pmc Transcriptional signature and memory retention of human-induced pluripotent stem cells
    Maria C N Marchetto
    The Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, California, USA
    PLoS ONE 4:e7076. 2009
    ..Moreover, the episomal reprogramming strategy represents a safe way to generate human iPSCs for clinical purposes and basic research...
  2. pmc Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients
    Miguel Mitne-Neto
    University of California San Diego, School of Medicine, Department of Pediatrics Rady Children s Hospital San Diego, Department of Cellular and Molecular Medicine, Stem Cell Program, 9500 Gilman Dr, La Jolla, CA 92093, MC 0695, USA
    Hum Mol Genet 20:3642-52. 2011
    ..Our results suggest that optimal levels of VAPB may play a central role in the pathogenesis of ALS8, in agreement with the observed reduction of VAPB in sporadic ALS...
  3. doi request reprint LINE-1 retrotransposition in the nervous system
    Charles A Thomas
    Department of Pediatrics Rady Children s Hospital San Diego, University of California San Diego, La Jolla, California 92093, USA
    Annu Rev Cell Dev Biol 28:555-73. 2012
    ..In this review, we survey the literature related to neurodevelopmental retrotransposition and discuss possible relevance to neuronal function, evolution, and neurological disease...
  4. doi request reprint Modeling epilepsy with pluripotent human cells
    Alysson Renato Muotri
    Department of Pediatrics, Division of Genetics, VCSD Stem Cell Initiative, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Epilepsy Behav 14:81-5. 2009
    ..Here, I propose several strategies for how pluripotent stem cells, both human embryonic stem cells and induced pluripotent stem cells, can potentially be used to gain insights into the biology of temporal lobe epilepsy...
  5. pmc Environmental influence on L1 retrotransposons in the adult hippocampus
    Alysson R Muotri
    Department of Pediatrics Cellular and Molecular Medicine, School of Medicine, UCSD Stem Cell Initiative, University of California, San Diego, 9500 Gilman Drive 0695, California, USA
    Hippocampus 19:1002-7. 2009
    ..Such evidence suggests that experience-dependent L1 retrotransposition may contribute to the physiological consequences of neuronal plasticity...
  6. pmc L1 retrotransposition in neurons is modulated by MeCP2
    Alysson R Muotri
    University of California San Diego, School of Medicine, Department of Pediatrics Rady Children s Hospital San Diego, La Jolla, California 92093 0695, USA
    Nature 468:443-6. 2010
    ..Our findings add a new level of complexity to the molecular events that can lead to neurological disorders...
  7. pmc Identification of a neuronal gene expression signature: role of cell cycle arrest in murine neuronal differentiation in vitro
    Hady Felfly
    Department of Pediatrics, School of Medicine, University of California San Diego, CA, USA
    Am J Physiol Regul Integr Comp Physiol 301:R727-45. 2011
    ....

Research Grants1

  1. Modeling autism with human pluripotent cells
    Alysson Muotri; Fiscal Year: 2009
    ..The outcome of this study will increase our understanding of the mechanism behind autism, allowing better diagnoses and new therapeutic interventions. ..