Research Topics
Species | D MungasSummaryAffiliation: University of California Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Advanced psychometric analysis and the Alzheimer's Disease Neuroimaging Initiative: reports from the 2011 Friday Harbor conferenceDan Mungas
Department of Neurology, University of California, Davis, Davis, CA, USA
Brain Imaging Behav 6:485-8. 2012..The 13 articles in this series present innovative approaches to measuring cognition and studying determinants of cognitive decline in AD...- Heterogeneity of cognitive trajectories in diverse older personsDan Mungas
Department of Neurology, School of Medicine, University of California, Sacramento, CA 95817, USA
Psychol Aging 25:606-19. 2010.... 
Spanish and English neuropsychological assessment scales: relationship to demographics, language, cognition, and independent functionDan Mungas
Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
Neuropsychology 19:466-75. 2005....- Psychometrically matched measures of global cognition, memory, and executive function for assessment of cognitive decline in older personsDan Mungas
Department of Neurology, School of Medicine, University of California, Davis, Sacramento 95817, USA
Neuropsychology 17:380-92. 2003..Association of measures with quantitative structural magnetic resonance imaging variables followed expected patterns. This approach to scale development may have applications for other neuropsychological assessment problems... - Age and education effects on relationships of cognitive test scores with brain structure in demographically diverse older personsDan Mungas
Department of Neurology, School of Medicine, University of California, Davis, Sacremento, CA 95817, USA
Psychol Aging 24:116-28. 2009.... - Longitudinal volumetric MRI change and rate of cognitive declineD Mungas
Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
Neurology 65:565-71. 2005..To examine how baseline and change of volumetric MRI relate to cognitive decline in older individuals... - Measurement invariance of neuropsychological tests in diverse older personsDan Mungas
Department of Neurology, School of Medicine, University of California, Davis, 4860 Y Street, Suite 3700, Sacramento, CA 95817, USA
Neuropsychology 25:260-9. 2011..We examined the dimensional structure of a neuropsychological test battery in linguistically and demographically diverse older adults... - Volumetric MRI predicts rate of cognitive decline related to AD and cerebrovascular diseaseD Mungas
Department of Neurology, School of Medicine, University of California, Davis, USA
Neurology 59:867-73. 2002..To examine volumetric MRI correlates of longitudinal cognitive decline in normal aging, AD, and subcortical cerebrovascular brain injury (SCVBI)... - Spanish and English Neuropsychological Assessment Scales (SENAS): further development and psychometric characteristicsDan Mungas
Department of Neurology, University of California, Davis, 4860 Y Street, Suite 3700, Sacramento, CA 95817, USA
Psychol Assess 16:347-59. 2004..Effects of DIF on scale-level ability scores were limited. Results demonstrate an empirically guided psychometric approach to test construction for multiethnic and multilingual test applications... - Development of psychometrically matched English and Spanish language neuropsychological tests for older personsD Mungas
Department of Neurology, School of Medicine, University of California, Davis, Sacramento 95817, USA
Neuropsychology 14:209-23. 2000..The outcome supports the use of IRT methods in cross-cultural and multilingual test development and indicates that this strategy has potential for future neuropsychological test development... - Application of item response theory for development of a global functioning measure of dementia with linear measurement propertiesD Mungas
UC Davis Alzheimer s Disease Center, Department of Neurology, School of Medicine, University of California, Davis, USA
Stat Med 19:1631-44. 2000..Results have implications for development of a psychometrically sophisticated, brief measure of global functioning for clinical and research use in dementia... - Criterion-referenced validity of a neuropsychological test battery: equivalent performance in elderly Hispanics and non-Hispanic WhitesDan Mungas
Department of Neurology, School of Medicine, University of California, Davis, Sacramento, California 95817, USA
J Int Neuropsychol Soc 11:620-30. 2005..Object naming improved discrimination of CIND from demented beyond that of verbal memory alone. These results provide evidence of equivalent validity across Hispanics and Whites... - The effects of age on rate of progression of Alzheimer disease and dementia with associated cerebrovascular diseaseD Mungas
Department of Neurology, School of Medicine, University of California, Davis, USA
Arch Neurol 58:1243-7. 2001..Previous studies have found no differences in progression of Alzheimer disease and vascular dementia, but these studies have not specifically examined age effects... - MRI predictors of cognition in subcortical ischemic vascular disease and Alzheimer's diseaseD Mungas
Department of Neurology, School of Medicine University of California, Davis 95817, USA
Neurology 57:2229-35. 2001.... - Brain structure and cognition in a community sample of elderly LatinosC C Wu
Department of Neurology, University of California-Davis Medical Center, 4860 Y Street, Suite 3700, Sacramento, CA 95817, USA
Neurology 59:383-91. 2002..Because there is a synergistic effect between high WMH and hippocampal atrophy, interactions between vascular and degenerative processes may be important determinants of dementia... - Cognitive and anatomic contributions of metabolic decline in Alzheimer disease and cerebrovascular diseaseBeth Kuczynski
Helen Wills Neuroscience Institute and the Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
Arch Neurol 65:650-5. 2008..Understanding how each disease contributes to dementia is essential from both a pathophysiologic and diagnostic perspective... - White matter lesions impair frontal lobe function regardless of their locationM Tullberg
Department of Neurology, School of Medicine, University of California, Davis, USA
Neurology 63:246-53. 2004.... - Memory impairment, but not cerebrovascular disease, predicts progression of MCI to dementiaC DeCarli
Department of Neurology, University of California at San Francisco, USA
Neurology 63:220-7. 2004.... - Atrophy rates of entorhinal cortex in AD and normal agingA T Du
Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco 94121, USA
Neurology 60:481-6. 2003..93. CONCLUSION: ERC volume loss over time may be a better indicator for AD than cross-sectional measurements... - Neuropathological basis of magnetic resonance images in aging and dementiaWilliam J Jagust
School of Public Health and Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720 3190, USA
Ann Neurol 63:72-80. 2008..Magnetic resonance (MR) imaging is used widely for assessment of patients with cognitive impairment, but the pathological correlates are unclear, especially when multiple pathologies are present... - Diagnosing depression in Alzheimer disease with the national institute of mental health provisional criteriaEdmond Teng
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
Am J Geriatr Psychiatry 16:469-77. 2008.... - What does fluorodeoxyglucose PET imaging add to a clinical diagnosis of dementia?W Jagust
Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720 3190, USA
Neurology 69:871-7. 2007..Few studies have compared the accuracy of [(18)F]fluorodeoxyglucose (FDG) PET to the accuracy of clinical and pathologic diagnosis in dementia patients... - Cognitive impact of subcortical vascular and Alzheimer's disease pathologyHelena C Chui
Department of Neurology, University of Southern California, Los Angeles, USA
Ann Neurol 60:677-87. 2006..To assess the interactions among three types of pathology (ie, cerebrovascular disease, hippocampal sclerosis [HS], and Alzheimer's disease [AD]), cognitive status, and apolipoprotein E genotype... - Longitudinal MRI and cognitive change in healthy elderlyJoel H Kramer
Department of Neurology, San Francisco Medical Center, University of California, San Francisco, CA 94143, USA
Neuropsychology 21:412-8. 2007..The association between WMSH and EXEC further highlights the cognitive sequealae associated with cerebrovascular disease in normal elderly... - Brain imaging evidence of preclinical Alzheimer's disease in normal agingWilliam Jagust
School of Public Health, University of California, Berkeley, USA
Ann Neurol 59:673-81. 2006..The anatomical location of these findings suggests detection of preclinical Alzheimer's disease pathology... - Frontal lobe hypometabolism predicts cognitive decline in patients with lacunar infarctsB R Reed
Department of Neurology, University of California, Davis, CA, USA
Arch Neurol 58:493-7. 2001..Studies of Alzheimer disease have shown that imaging measures of temporal and parietal metabolism and blood flow predict disease course... - Subcortical lacunes are associated with executive dysfunction in cognitively normal elderlyCatherine L Carey
Department of Psychiatry, University of California, San Diego, 150 W Washington, 2nd Floor San Diego, CA 92103, USA
Stroke 39:397-402. 2008..We therefore hypothesized that MRI markers of SIVD would be selectively associated with worse executive functioning... - Preliminary evidence that estrogen protects against age-related hippocampal atrophyJ L Eberling
Department of Neurology and Center for Neuroscience, University of California, Davis, CA 95616, USA
Neurobiol Aging 24:725-32. 2003..These findings suggest a neuroprotective effect of estrogen... - Cognitive and neuroimaging predictors of instrumental activities of daily livingDeborah A Cahn-Weiner
Department of Neurology, University of California, San Francisco, California 94143 0138, USA
J Int Neuropsychol Soc 13:747-57. 2007..Perhaps executive function is particularly important with respect to maintaining IADLs. Alternatively, executive dysfunction may be a sentinel event indicating widespread cortical involvement and poor prognosis... - Earlier onset of Alzheimer disease symptoms in latino individuals compared with anglo individualsChristopher M Clark
Department of Neurology, Alzheimer s Disease Center, University of Pennsylvania, Philadelphia 19104, USA
Arch Neurol 62:774-8. 2005.... - Brain function and cognition in a community sample of elderly LatinosWilliam J Jagust
Department of Neurology, University of California Davis Medical Center, 4860 Y Street, Suite 3700, Sacramento, CA 95817, USA
Neurology 59:378-83. 2002..This study was designed to extend this finding to individuals selected from a population-based cohort of Mexican Americans with a wide spectrum of cognitive ability... - Forgetting in dementia with and without subcortical lacunesJoel H Kramer
San Francisco Medical Center, University of California, CA 94143, USA
Clin Neuropsychol 18:32-40. 2004..Three SIVD patients with rapid forgetting followed to autopsy all had AD pathology, further supporting the link between memory patterns and AD... 
FLAIR and diffusion MRI signals are independent predictors of white matter hyperintensitiesP Maillard
Imaging of Dementia and Aging Laboratory, University of California, Davis, Davis, California, USA
AJNR Am J Neuroradiol 34:54-61. 2013..We investigated the ability of FLAIR and DTI to characterize the longitudinal course of WMH development...- Executive dysfunction in subcortical ischaemic vascular diseaseJ H Kramer
San Francisco Medical Center, University of California, 401 Parnassus Avenue, San Francisco, CA 94143, USA
J Neurol Neurosurg Psychiatry 72:217-20. 2002..Executive dysfunction has been reported in patients with subcortical-frontal pathology, even in the absence of dementia... - Impaired acquisition and rapid forgetting of patterned visual stimuli in Alzheimer's diseaseB R Reed
Department of Neurology, University of California at Davis, USA
J Clin Exp Neuropsychol 20:738-49. 1998..DRR was also lower in an analysis of subgroups closely matched on initial performance. The findings suggest that forgetting is accelerated in AD because multiple aspects of memory processing, including storage, are impaired... - Progression of mild cognitive impairment to dementia in clinic- vs community-based cohortsSarah Tomaszewski Farias
Department of Neurology, University of California, Davis, 4860 Y St, Ste 3700, Sacramento, CA 95817, USA
Arch Neurol 66:1151-7. 2009..Annual conversion rates, however, vary across different studies with clinic samples showing higher rates of conversion than community-based samples... - The measurement of everyday cognition (ECog): scale development and psychometric propertiesSarah Tomaszewski Farias
Department of Neurology, University of California, CA 95817, USA
Neuropsychology 22:531-44. 2008..Different subtypes of MCI also showed different patterns. Results suggest the ECog shows promise as a useful tool for the measurement of general and domain-specific everyday functions in the elderly... - Longitudinal changes in memory and executive functioning are associated with longitudinal change in instrumental activities of daily living in older adultsSarah Tomaszewski Farias
Department of Neurology, School of Medicine, University of California, Davis, CA, USA
Clin Neuropsychol 23:446-61. 2009..Findings indicate that declines in MEM and EXEC over time make unique and independent contributions to declines in older adults' ability to function in daily life... - Brain behavior relationships among African Americans, whites, and HispanicsCharles DeCarli
Department of Neurology, University of California at Davis, Sacramento, CA 95817, USA
Alzheimer Dis Assoc Disord 22:382-91. 2008..Moreover, interesting and potentially biologically relevant differences were found that might stimulate further research related to the understanding of dementia etiology within an increasingly racially and ethnically diverse population... - Longitudinal influences of partner depression on cognitive functioning in latino spousal pairsLadson Hinton
Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, California 95817, USA
Dement Geriatr Cogn Disord 27:491-500. 2009..e. health or mental health) on cognitive decline has received little attention. This study examined the influence of baseline depressive symptoms in one spouse on cognitive functioning in the other... - Degree of discrepancy between self and other-reported everyday functioning by cognitive status: dementia, mild cognitive impairment, and healthy eldersSarah Tomaszewski Farias
Department of Neurology, School of Public Health, University of California Davis, 4860 Y Street, Sacramento, CA 95817, USA
Int J Geriatr Psychiatry 20:827-34. 2005..In this study we examined whether degree of discrepancy between patient and informant-reported everyday functioning was associated with cognitive status... - Measuring cognitive reserve based on the decomposition of episodic memory varianceBruce R Reed
Department of Neurology, School of Medicine, University of California, Davis, CA, USA
Brain 133:2196-209. 2010..Decomposing the variance in cognitive function scores offers a promising new approach to the measure and study of cognitive reserve... - Neuropsychiatric symptoms in Latino elders with dementia or cognitive impairment without dementia and factors that modify their association with caregiver depressionLadson Hinton
Department of Psychiatry, University of California, Davis, USA
Gerontologist 43:669-77. 2003.... - Everyday functioning in relation to cognitive functioning and neuroimaging in community-dwelling Hispanic and non-Hispanic older adultsSarah Tomaszewski Farias
Department of Neurology, School of Medicine, University of California, Davis, USA
J Int Neuropsychol Soc 10:342-54. 2004..The relationships between cognitive variables and functional status, as well as between the imaging variables and the IQCODE, did not differ across language-ethnic groups... - Effects of white matter lesions and lacunes on cortical functionBruce R Reed
University of California Davis Alzheimer s Disease Center, Martinez, CA 94553, USA
Arch Neurol 61:1545-50. 2004..Whether small-vessel disease in fact predominantly affects the frontal lobes is not well documented... - MCI is associated with deficits in everyday functioningSarah T Farias
Department of Neurology, University of California, Davis, CA, USA
Alzheimer Dis Assoc Disord 20:217-23. 2006..The current findings suggest that individuals with MCI demonstrate deficits in a wide range of everyday functions but that the magnitude of these changes is greatest for those functional abilities that rely heavily on memory... - Correlates of memory function in community-dwelling elderly: the importance of white matter hyperintensitiesChristopher I Petkov
Center for Neuroscience, University of California at Davis, 95616, USA
J Int Neuropsychol Soc 10:371-81. 2004..We conclude that WMH are an important pathological substrate that affects certain memory functions in normal individuals and those with mild memory loss and discuss how tasks associated with WMH may rely upon frontal lobe function... - Memory in the aging brain: doubly dissociating the contribution of the hippocampus and entorhinal cortexAndrew P Yonelinas
Department of Psychology, University of California, Davis, California 95616, USA
Hippocampus 17:1134-40. 2007.... - Differences in brain volume, hippocampal volume, cerebrovascular risk factors, and apolipoprotein E4 among mild cognitive impairment subtypesJing He
Department of Neurology, and the Imaging of Dementia and Aging Laboratory, Center for Neuroscience Preventive Medicine, University of California at Davis, Sacramento, CA 95817, USA
Arch Neurol 66:1393-9. 2009..To evaluate demographics, magnetic resonance imaging (MRI) measures, and vascular risk among mild cognitive impairment (MCI) subtypes... - Hippocampal volume and retention in Alzheimer's diseaseJoel H Kramer
Department of Neurology, University of California at San Francisco, 94143, USA
J Int Neuropsychol Soc 10:639-43. 2004..Results suggest that the role of the hippocampus is relatively specific to the consolidation of new memories... - Walking stabilizes cognitive functioning in Alzheimer's disease (AD) across one yearJ Winchester
Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, United States Alzheimer s Disease Research Center, University of California, Irvine, CA 92697, United States
Arch Gerontol Geriatr 56:96-103. 2013..Structured clinical trials which seek to increase the amount of time AD patients were engaged in walking activities and evaluate the nature and scope of beneficial effects in the brain are warranted... - Imaging Interactions between Alzheimer's disease and cerebrovascular diseaseChristine C Wu
Department of Neurology, University of California-Davis, 4860 Y Street, Sacramento, CA 95616, USA
Ann N Y Acad Sci 977:403-10. 2002..In this article, we review two recent studies from our laboratory that use MRI and PET to begin to reveal the nature and mechanisms of the relationship between AD, CVD, and dementia... - Prevalence of dementia in older latinos: the influence of type 2 diabetes mellitus, stroke and genetic factorsMary N Haan
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA
J Am Geriatr Soc 51:169-77. 2003..To estimate dementia prevalence in older Mexican Americans, determine the distribution of dementia by etiology, and evaluate the contribution of type 2 diabetes mellitus, stroke, and apolipoprotein E (ApoE) genotype to dementia... - Fraction of total plasma vitamin B12 bound to transcobalamin correlates with cognitive function in elderly Latinos with depressive symptomsMarjorie G Garrod
Department of Medical Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, CA, USA
Clin Chem 54:1210-7. 2008..The fraction of total plasma vitamin B(12) bound to transcobalamin (holoTC/B12 ratio) may reflect tissue levels of the vitamin, but its clinical relevance is unclear... - Profiles of neuropsychological impairment in autopsy-defined Alzheimer's disease and cerebrovascular diseaseBruce R Reed
University of California, Davis, CA, USA
Brain 130:731-9. 2007.... - Homocysteine, B vitamins, and the incidence of dementia and cognitive impairment: results from the Sacramento Area Latino Study on AgingMary N Haan
Epidemiology Program, School of Public Health, University of Michigan, Ann Arbor, MI 48104, USA
Am J Clin Nutr 85:511-7. 2007..High concentrations of homocysteine have been linked to a greater risk of Alzheimer disease, dementia, and cognitive decline... - Clinical and neuropsychological features in autopsy-defined vascular dementiaBruce R Reed
Alzheimer s Disease Center, University of California, Davis 94553, USA
Clin Neuropsychol 18:63-74. 2004..A illustrative case example is included. We conclude that the profile of cognitive impairment in IVD is highly variable, but that in clinical settings neuropsychological readings may contribute to the differential diagnosis of dementia... - Homocysteine and cognitive function in the Sacramento Area Latino Study on AgingJoshua W Miller
Department of Medical Pathology, School of Medicine, University of California, Davis, USA
Am J Clin Nutr 78:441-7. 2003.... - Multivariate modeling of two associated cognitive outcomes in a longitudinal studyDanielle J Harvey
Department of Epidemiology and Preventive Medicine, School of Medicine, University of California, Davis 95616 8638, USA
J Alzheimers Dis 5:357-65. 2003..We provide data that include information on two underlying processes of cognitive function, namely memory and executive function, to illustrate this methodology... - Low folate status is associated with impaired cognitive function and dementia in the Sacramento Area Latino Study on AgingMarisa I Ramos
School of Medicine, Department of Medical Pathology, University of California, Davis, USA
Am J Clin Nutr 82:1346-52. 2005..CONCLUSION: RBC folate is directly associated with cognitive function scores and is inversely associated with dementia in elderly Latinos despite folic acid fortification...
Research Grants
- ENGLISH AND SPANISH ASSESSMENT OF COGNITION IN ELDERLYDan Mungas; Fiscal Year: 2007..Patients with CIND and selected normals and demented patients will be clinically evaluated and followed longitudinally to assess sensitivity of the SENAS to early cognitive decline. ..
- ENGLISH AND SPANISH ASSESSMENT OF COGNITION IN ELDERLYDan Mungas; Fiscal Year: 2006..Patients with CIND and selected normals and demented patients will be clinically evaluated and followed longitudinally to assess sensitivity of the SENAS to early cognitive decline. ..
- ENGLISH AND SPANISH ASSESSMENT OF COGNITION IN ELDERLYDan Mungas; Fiscal Year: 2003..Patients with CIND and selected normals and demented patients will be clinically evaluated and followed longitudinally to assess sensitivity of the SENAS to early cognitive decline. ..
- ENGLISH AND SPANISH ASSESSMENT OF COGNITION IN ELDERLYDan Mungas; Fiscal Year: 2000....
- ENGLISH AND SPANISH ASSESSMENT OF COGNITION IN ELDERLYDan Mungas; Fiscal Year: 1993..sample will occur during months 7 to 30. Statistical analysis, item selection, calculation of provisional norms, and evaluation of efficacy of test development procedures will be completed during months 31 to 36...
- ENGLISH AND SPANISH ASSESSMENT OF COGNITION IN ELDERLYDan M Mungas; Fiscal Year: 2010..It will provide information that will increase understanding of cognitive decline in older people and will improve our ability to measure these changes. ..