Robert S Munford

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint A host lipase detoxifies bacterial lipopolysaccharides in the liver and spleen
    Baomei Shao
    Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas 75390 9113, USA
    J Biol Chem 282:13726-35. 2007
  2. ncbi request reprint The crucial role of systemic responses in the innate (non-adaptive) host defense
    R S Munford
    Molecular Host Defense Laboratory, Division of Infectious Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    J Endotoxin Res 7:327-32. 2001
  3. pmc Sensing gram-negative bacterial lipopolysaccharides: a human disease determinant?
    Robert S Munford
    Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    Infect Immun 76:454-65. 2008
  4. ncbi request reprint Severe sepsis and septic shock: the role of gram-negative bacteremia
    Robert S Munford
    Departments of Internal Medicine and Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    Annu Rev Pathol 1:467-96. 2006
  5. pmc Shield as signal: lipopolysaccharides and the evolution of immunity to gram-negative bacteria
    Robert S Munford
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    PLoS Pathog 2:e67. 2006
  6. ncbi request reprint Detoxifying endotoxin: time, place and person
    Robert S Munford
    Molecular Host Defense Laboratory, Departments of Internal Medicine and Microbiology, University of Texas Southwestern Medical School, Dallas, Texas 75390, USA
    J Endotoxin Res 11:69-84. 2005
  7. pmc Overproduction of acyloxyacyl hydrolase by macrophages and dendritic cells prevents prolonged reactions to bacterial lipopolysaccharide in vivo
    Noredia Ojogun
    Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX, USA
    J Infect Dis 200:1685-93. 2009
  8. pmc Host inactivation of bacterial lipopolysaccharide prevents prolonged tolerance following gram-negative bacterial infection
    Mingfang Lu
    Infectious Disease Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9113, USA
    Cell Host Microbe 4:293-302. 2008
  9. pmc Prolonged hepatomegaly in mice that cannot inactivate bacterial endotoxin
    Baomei Shao
    Infectious Diseases Division, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX, USA
    Hepatology 54:1051-62. 2011
  10. doi request reprint Hepatic uptake and deacylation of the LPS in bloodborne LPS-lipoprotein complexes
    Baomei Shao
    Department of Internal Medicine, Division of Infectious Diseases, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9113, USA
    Innate Immun 18:825-33. 2012

Research Grants

  1. ENDOGENOUSLY REGULATED IMMUNOMODULATION
    Robert Munford; Fiscal Year: 2003
  2. INTERACTIONS OF ENDOTOXIN WITH PLASMA AND CELLS
    Robert Munford; Fiscal Year: 2006
  3. INTERACTIONS OF ENDOTOXIN WITH HUMAN PLASMA AND CELLS
    Robert Munford; Fiscal Year: 1991
  4. INTERACTIONS OF ENDOTOXIN WITH PLASMA AND CELLS
    Robert Munford; Fiscal Year: 2007

Collaborators

Detail Information

Publications22

  1. ncbi request reprint A host lipase detoxifies bacterial lipopolysaccharides in the liver and spleen
    Baomei Shao
    Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas 75390 9113, USA
    J Biol Chem 282:13726-35. 2007
    ..AOAH-mediated deacylation is a previously unappreciated mechanism that prevents prolonged inflammatory reactions to Gram-negative bacteria and LPS in the liver and spleen...
  2. ncbi request reprint The crucial role of systemic responses in the innate (non-adaptive) host defense
    R S Munford
    Molecular Host Defense Laboratory, Division of Infectious Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    J Endotoxin Res 7:327-32. 2001
    ..Together, these forces help concentrate activated phagocytes at injured or infected local sites while preventing potentially damaging inflammation in uninvolved tissues...
  3. pmc Sensing gram-negative bacterial lipopolysaccharides: a human disease determinant?
    Robert S Munford
    Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    Infect Immun 76:454-65. 2008
  4. ncbi request reprint Severe sepsis and septic shock: the role of gram-negative bacteremia
    Robert S Munford
    Departments of Internal Medicine and Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    Annu Rev Pathol 1:467-96. 2006
    ..Bacteremia and severe sepsis are not so closely linked that the most striking cases can be a model for the rest. Intravascular and extravascular triggers may warrant different approaches to prevention and therapy...
  5. pmc Shield as signal: lipopolysaccharides and the evolution of immunity to gram-negative bacteria
    Robert S Munford
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    PLoS Pathog 2:e67. 2006
  6. ncbi request reprint Detoxifying endotoxin: time, place and person
    Robert S Munford
    Molecular Host Defense Laboratory, Departments of Internal Medicine and Microbiology, University of Texas Southwestern Medical School, Dallas, Texas 75390, USA
    J Endotoxin Res 11:69-84. 2005
    ..They may have evolved to confine infection and inflammation to extravascular sites of infection while preventing harmful systemic reactions. Integration of endotoxin sensing and detoxification is essential for successful host defense...
  7. pmc Overproduction of acyloxyacyl hydrolase by macrophages and dendritic cells prevents prolonged reactions to bacterial lipopolysaccharide in vivo
    Noredia Ojogun
    Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX, USA
    J Infect Dis 200:1685-93. 2009
    ..Our results suggest that the extent to which macrophages and dendritic cells produce AOAH may influence the outcome of many gram-negative bacterial diseases...
  8. pmc Host inactivation of bacterial lipopolysaccharide prevents prolonged tolerance following gram-negative bacterial infection
    Mingfang Lu
    Infectious Disease Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9113, USA
    Cell Host Microbe 4:293-302. 2008
    ..coli challenge. Inactivating LPS, an immunostimulatory microbial molecule, is thus important for restoring effective host defenses following Gram-negative bacterial infection in animals...
  9. pmc Prolonged hepatomegaly in mice that cannot inactivate bacterial endotoxin
    Baomei Shao
    Infectious Diseases Division, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX, USA
    Hepatology 54:1051-62. 2011
    ..The striking findings in this mouse model should encourage studies to find out how AOAH contributes to human liver physiology and disease...
  10. doi request reprint Hepatic uptake and deacylation of the LPS in bloodborne LPS-lipoprotein complexes
    Baomei Shao
    Department of Internal Medicine, Division of Infectious Diseases, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9113, USA
    Innate Immun 18:825-33. 2012
    ..Our observations suggest that KCs and AOAH play important roles in clearing and catabolizing both free LPS and the LPS in circulating LPS-HDL complexes...
  11. ncbi request reprint Lipopolysaccharide deacylation by an endogenous lipase controls innate antibody responses to Gram-negative bacteria
    Mingfang Lu
    Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nat Immunol 6:989-94. 2005
    ..Control of lipopolysaccharide activation by acyloxyacyl hydrolase indicates that mammals can regulate immune responses to bacterial infection by chemical modification of a Toll-like receptor agonist...
  12. pmc Identification of acyloxyacyl hydrolase, a lipopolysaccharide-detoxifying enzyme, in the murine urinary tract
    J Amelia Feulner
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    Infect Immun 72:3171-8. 2004
    ..In addition, mature AOAH is found in the urine. We suggest that cortical tubule cells may produce and secrete AOAH to limit inflammatory responses to gram-negative bacteria throughout the urinary tract...
  13. ncbi request reprint Endotoxin-binding proteins modulate the susceptibility of bacterial endotoxin to deacylation by acyloxyacyl hydrolase
    Theresa L Gioannini
    Inflammation Program, Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 282:7877-84. 2007
    ..The susceptibility of the monomeric endotoxin-CD14 complex to AOAH may help constrain endotoxin-induced TLR4 activation when endotoxin and membrane CD14 are present in excess of MD-2/TLR-4...
  14. ncbi request reprint Recurrent exposure to Histoplasma capsulatum in modern air-conditioned buildings
    James P Luby
    University of Texas Southwestern Medical Center, Dallas, TX 75390 9113, USA
    Clin Infect Dis 41:170-6. 2005
    ..Between 1989 and 1996, an epidemic of histoplasmosis occurred on a medical school campus. There had been numerous construction projects on the campus that involved previously wooded land and were adjacent to a large bird sanctuary...
  15. ncbi request reprint The G-->A single nucleotide polymorphism at the -308 position in the tumor necrosis factor-alpha promoter increases the risk for severe sepsis after trauma
    GRANT E O'KEEFE
    Department of Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9158, USA
    J Trauma 52:817-25; discussion 825-6. 2002
    ..Clinical factors do not adequately explain why some patients develop severe sepsis after trauma and why others do not. We sought to determine whether genetic factors contribute to this risk...
  16. ncbi request reprint Acute inflammation and infection maintain circulating phospholipid levels and enhance lipopolysaccharide binding to plasma lipoproteins
    Richard L Kitchens
    Departments of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9113, USA
    J Lipid Res 44:2339-48. 2003
    ....
  17. pmc Stimulus-dependent deacylation of bacterial lipopolysaccharide by dendritic cells
    Mingfang Lu
    Department of Internal Medicine, University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    J Exp Med 197:1745-54. 2003
    ..Enzymatic deacylation of LPS is an intrinsic, regulated mechanism by which DCs may modulate host responses to this potent bacterial agonist...
  18. pmc Innate immunity genes influence the severity of acute appendicitis
    Fernando A Rivera-Chavez
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Ann Surg 240:269-77. 2004
    ..Using acute appendicitis as a model, we tested the hypothesis that polymorphisms in genes involved in host defense can be associated with the severity of local infection-inflammation in humans...
  19. pmc Regional and systemic cytokine responses to acute inflammation of the vermiform appendix
    Fernando A Rivera-Chavez
    Department of Surgery, The University of Texas Southwestern Medical Center, Dallas, USA
    Ann Surg 237:408-16. 2003
    ..To measure local (peritoneal fluid) and systemic (plasma) cytokine profiles in patients with infection-inflammation of the vermiform appendix, a relatively mild, localized inflammatory process...
  20. pmc Is severe sepsis a neuroendocrine disease?
    Robert S Munford
    Laboratory of Molecular Host Defense, Infectious Disease Division, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    Mol Med 8:437-42. 2002
  21. ncbi request reprint Risks and benefits of activated protein C treatment for severe sepsis
    H Shaw Warren
    Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 347:1027-30. 2002
  22. ncbi request reprint A tribute to Ernst Th. Rietschel: the gentleman scientist
    Jean Marc Cavaillon
    J Endotoxin Res 13:3-5. 2007

Research Grants27

  1. ENDOGENOUSLY REGULATED IMMUNOMODULATION
    Robert Munford; Fiscal Year: 2003
    ..abstract_text> ..
  2. INTERACTIONS OF ENDOTOXIN WITH PLASMA AND CELLS
    Robert Munford; Fiscal Year: 2006
    ..Finding out the functions of this highly conserved enzyme should shed new light on how animals control their inflammatory and immune reactions to gram-negative bacteria. ..
  3. INTERACTIONS OF ENDOTOXIN WITH HUMAN PLASMA AND CELLS
    Robert Munford; Fiscal Year: 1991
    ..We hope that understanding its biological role(s) will suggest new strategies for controlling inflammatory responses to LPS and consequently improve the outcome of gram-negative bacterial diseases in man...
  4. INTERACTIONS OF ENDOTOXIN WITH PLASMA AND CELLS
    Robert Munford; Fiscal Year: 2007
    ..abstract_text> ..