G Mundy

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint Stimulation of bone formation in vitro and in rodents by statins
    G Mundy
    OsteoScreen, 2040 Babcock Road, San Antonio, TX 78229, USA
    Science 286:1946-9. 1999
  2. ncbi request reprint Hormonal control of calcium homeostasis
    G R Mundy
    University of Texas Health Science Center, Medicine Endocrinology, 7703 Floyd Curl Dr, San Antonio, TX 78284 7877, USA
    Clin Chem 45:1347-52. 1999
  3. ncbi request reprint The evolving role of bisphosphonates: cancer treatment-induced bone loss
    Gregory R Mundy
    Department of Cellular and Structural Biology, Division of Endocrinology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Oncology (Williston Park) 18:9-10. 2004
  4. ncbi request reprint How can bone turnover markers be best utilized for prediction of skeletal events in patients with solid tumors?
    Gregory R Mundy
    University of Texas Health Science Center at San Antonio, Department of Cellular and Structural Biology, TX 78229 3900, USA
    Nat Clin Pract Oncol 2:242-3. 2005
  5. ncbi request reprint Nutritional modulators of bone remodeling during aging
    Gregory R Mundy
    University of Texas Health Science Center at San Antonio, Texas 78229 3900, USA
    Am J Clin Nutr 83:427S-430S. 2006
  6. pmc Endothelin-1 and osteoblastic metastasis
    Gregory R Mundy
    Department of Cellular Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 100:10588-9. 2003
  7. ncbi request reprint Metastasis to bone: causes, consequences and therapeutic opportunities
    Gregory R Mundy
    Department of Molecular Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, MS 7877, San Antonio, Texas 78229 3900, USA
    Nat Rev Cancer 2:584-93. 2002
  8. ncbi request reprint Pathogenesis of osteoporosis and challenges for drug delivery
    G R Mundy
    Medicine Endocrinology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284 7877, USA
    Adv Drug Deliv Rev 42:165-73. 2000
  9. ncbi request reprint Directions of drug discovery in osteoporosis
    Gregory R Mundy
    Department of Medicine Endocrinology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229 3900, USA
    Annu Rev Med 53:337-54. 2002
  10. ncbi request reprint E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation
    Ming Zhao
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 278:27939-44. 2003

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Stimulation of bone formation in vitro and in rodents by statins
    G Mundy
    OsteoScreen, 2040 Babcock Road, San Antonio, TX 78229, USA
    Science 286:1946-9. 1999
    ..Thus, in appropriate doses, statins may have therapeutic applications for the treatment of osteoporosis...
  2. ncbi request reprint Hormonal control of calcium homeostasis
    G R Mundy
    University of Texas Health Science Center, Medicine Endocrinology, 7703 Floyd Curl Dr, San Antonio, TX 78284 7877, USA
    Clin Chem 45:1347-52. 1999
    ..Over- or underproduction of these hormones or the tumor peptide, parathyroid hormone-related peptide, are the major causes of aberrant extracellular fluid calcium concentrations. These hormonal defense mechanisms are reviewed here...
  3. ncbi request reprint The evolving role of bisphosphonates: cancer treatment-induced bone loss
    Gregory R Mundy
    Department of Cellular and Structural Biology, Division of Endocrinology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Oncology (Williston Park) 18:9-10. 2004
  4. ncbi request reprint How can bone turnover markers be best utilized for prediction of skeletal events in patients with solid tumors?
    Gregory R Mundy
    University of Texas Health Science Center at San Antonio, Department of Cellular and Structural Biology, TX 78229 3900, USA
    Nat Clin Pract Oncol 2:242-3. 2005
  5. ncbi request reprint Nutritional modulators of bone remodeling during aging
    Gregory R Mundy
    University of Texas Health Science Center at San Antonio, Texas 78229 3900, USA
    Am J Clin Nutr 83:427S-430S. 2006
    ..To ease the future burden of osteoporosis, focusing on prevention will be key, and this could include dietary interventions to stimulate bone formation...
  6. pmc Endothelin-1 and osteoblastic metastasis
    Gregory R Mundy
    Department of Cellular Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 100:10588-9. 2003
  7. ncbi request reprint Metastasis to bone: causes, consequences and therapeutic opportunities
    Gregory R Mundy
    Department of Molecular Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, MS 7877, San Antonio, Texas 78229 3900, USA
    Nat Rev Cancer 2:584-93. 2002
    ....
  8. ncbi request reprint Pathogenesis of osteoporosis and challenges for drug delivery
    G R Mundy
    Medicine Endocrinology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284 7877, USA
    Adv Drug Deliv Rev 42:165-73. 2000
    ..These will be reviewed in this chapter...
  9. ncbi request reprint Directions of drug discovery in osteoporosis
    Gregory R Mundy
    Department of Medicine Endocrinology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229 3900, USA
    Annu Rev Med 53:337-54. 2002
    ..Possible approaches to identifying more effective resorption inhibitors and new anabolic agents are discussed...
  10. ncbi request reprint E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation
    Ming Zhao
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 278:27939-44. 2003
    ..Smurf1 therefore appears to be an important regulatory factor in osteoblast differentiation and a potential molecular target for identification of bone anabolic agents...
  11. ncbi request reprint The effect of the bisphosphonate ibandronate on breast cancer metastasis to visceral organs
    Toshimi Michigami
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Breast Cancer Res Treat 75:249-58. 2002
    ..Our results suggest that BPs cause no adverse effects on visceral metastases when administered in the manners that breast cancer patients usually receive...
  12. ncbi request reprint Advances in the management of myeloma bone disease
    Claire M Shipman
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Expert Opin Pharmacother 6:2781-91. 2005
    ..However, as our understanding of the molecular mechanisms involved in the development of myeloma bone disease increases, new molecular targets have been identified for the treatment of this devastating bone disease...
  13. ncbi request reprint Stimulation of new bone formation by the proteasome inhibitor, bortezomib: implications for myeloma bone disease
    Babatunde O Oyajobi
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Br J Haematol 139:434-8. 2007
    ..Clinical trials in patients with myeloma bone disease are needed to validate these results...
  14. pmc Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif: a model for impaired mineralization in X-linked rickets (HYP)
    Peter S N Rowe
    Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA
    Bone 36:33-46. 2005
    ..The binding of MEPE and ASARM peptide by PHEX may explain why loss of functional osteoblast-expressed PHEX results in defective mineralization in HYP...
  15. ncbi request reprint Detection of myeloma in skeleton of mice by whole-body optical fluorescence imaging
    Babatunde O Oyajobi
    Department of Cellular and Structural Biology MSC 7762, University of Texas Health Science Center at San Antonio, Texas 78229 3900, USA
    Mol Cancer Ther 6:1701-8. 2007
    ..Whole-body GFP imaging is practical, convenient, inexpensive, and rapid, and these advantages should enable a high throughput when evaluating in vivo efficacy of new potential antimyeloma therapeutics and assessing response to treatment...
  16. pmc The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling
    Ming Zhao
    Department of Cellular and Structural Biology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Mol Cell Biol 26:6197-208. 2006
    ..Taken together, these results indicate that Gli2 mediates hedgehog signaling in osteoblasts and is a powerful activator of BMP-2 gene expression, which is required in turn for normal osteoblast differentiation...
  17. pmc Smurf1 inhibits osteoblast differentiation and bone formation in vitro and in vivo
    Ming Zhao
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    J Biol Chem 279:12854-9. 2004
    ..In these transgenic mice, bone formation was significantly reduced during postnatal life. Our results demonstrate for the first time that Smurf1 plays a specific role in osteoblast differentiation and bone formation in vivo...
  18. pmc Caspase-2 deficiency enhances aging-related traits in mice
    Yingpei Zhang
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, United States
    Mech Ageing Dev 128:213-21. 2007
    ..Collectively, these results suggest that caspase-2 deficiency affects aging in the mice. This study thus demonstrates for the first time that disruption of a key apoptotic gene has a significant impact on aging...
  19. ncbi request reprint Proteolysis of latent transforming growth factor-beta (TGF-beta )-binding protein-1 by osteoclasts. A cellular mechanism for release of TGF-beta from bone matrix
    Sarah L Dallas
    Department of Medicine, Division of Endocrinology and Metabolism, University of Texas Health Science Center, San Antonio, Texas 78284, USA
    J Biol Chem 277:21352-60. 2002
    ....
  20. pmc Guanosine nucleotides inhibit different syndromes of PTHrP excess caused by human cancers in vivo
    Wolfgang E Gallwitz
    OsteoScreen Ltd, San Antonio, Texas 78229, USA
    J Clin Invest 110:1559-72. 2002
    ..These results suggest that the PTHrP gene promoter may be a suitable target for treating the skeletal effects of malignancy...
  21. ncbi request reprint Receptor activator of NF-kappaB ligand, macrophage inflammatory protein-1alpha, and the proteasome: novel therapeutic targets in myeloma
    Babatunde O Oyajobi
    Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Cancer 97:813-7. 2003
    ..We provide "proof of principle" in preclinical myeloma models that these are indeed valid molecular targets in development of novel therapeutics...
  22. ncbi request reprint Mechanisms of osteolytic bone metastases in breast carcinoma
    Sanna Maria Käkönen
    University of Texas Health Science Center, Department of Molecular Medicine, Institute for Drug Development, San Antonio, Texas 78229 3900, USA
    Cancer 97:834-9. 2003
    ..Identification of the molecular mechanisms responsible for osteolytic metastases is crucial in designing effective therapy for this devastating complication...
  23. ncbi request reprint Dual effects of macrophage inflammatory protein-1alpha on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease
    Babatunde O Oyajobi
    Department of Cellular and Structural Biology MSC 7762, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Blood 102:311-9. 2003
    ..Because, in the 5TGM1 model, blockade of osteoclastic resorption in other situations does not decrease tumor burden, we conclude that MIP-1alpha exerts a dual effect in myeloma, on osteoclasts, and tumor cells...
  24. ncbi request reprint Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-beta type I receptor kinase inhibitor
    Abhik Bandyopadhyay
    Department of Cellular and Structural Biology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Cancer Res 66:6714-21. 2006
    ....
  25. pmc Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation
    Ming Zhao
    Department of Medicine, Division of Endocrinology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Cell Biol 157:1049-60. 2002
    ..These studies show the effects of alterations in BMP receptor function targeted to the osteoblast lineage and demonstrate a necessary role of BMP receptor signaling in postnatal bone growth and bone formation in vivo...
  26. ncbi request reprint Preclinical models of bone metastases
    G Mundy
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Semin Oncol 28:2-8. 2001
    ..These different models should enable mechanisms to be elucidated and contribute background information for the design of further clinical trials...
  27. ncbi request reprint The hedgehog signaling molecule Gli2 induces parathyroid hormone-related peptide expression and osteolysis in metastatic human breast cancer cells
    Julie A Sterling
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Cancer Res 66:7548-53. 2006
    ..Together, these data suggest that PTHrP expression and osteolysis in vivo in human breast cancer cells is driven at least in part by Gli2...
  28. pmc Transdermal lovastatin enhances fracture repair in rats
    Gloria E Gutierrez
    OsteoScreen, San Antonio, Texas, USA
    J Bone Miner Res 23:1722-30. 2008
    ..These studies provide valuable information on the potential of statins and TD delivery as a new and effective therapeutic modality in fracture repair...
  29. pmc The pathogenesis of the bone disease of multiple myeloma
    Claire M Edwards
    Vanderbilt Center for Bone Biology, Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, USA
    Bone 42:1007-13. 2008
    ..This review discusses the many different factors which have been implicated in myeloma bone disease, including the evidence for their role in myeloma and subsequent therapeutic implications...
  30. doi request reprint Hedgehog coordination of postnatal osteoclast and osteoblast activities
    Gregory R Mundy
    Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Cell 14:637-8. 2008
    ..and Mak et al. in this edition of Developmental Cell suggest that Hh signaling may exert delicate control over the activities of osteoclasts and osteoblasts, the cell types primarily responsible for bone resorption and formation...
  31. pmc Eph receptors and ephrin signaling pathways: a role in bone homeostasis
    Claire M Edwards
    Vanderbilt Center for Bone Biology, Departments of Cancer Biology and Clinical Pharmacology Medicine, Vanderbilt University, Nashville, TN 37232 0575, USA
    Int J Med Sci 5:263-72. 2008
    ....
  32. ncbi request reprint Osteoporosis and inflammation
    Gregory R Mundy
    Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 0575, USA
    Nutr Rev 65:S147-51. 2007
    ..Early data are promising...
  33. ncbi request reprint Bone metastasis: can osteoclasts be excluded?
    T John Martin
    St Vincent s Institute of Medical Research, Fitzroy, Victoria 3065
    Nature 445:E19; discussion E19-20. 2007
    ..However, we question whether these surprising conclusions are rigorously supported by their data...
  34. ncbi request reprint C-SRC tyrosine kinase activity is associated with tumor colonization in bone and lung in an animal model of human breast cancer metastasis
    Akira Myoui
    Osaka University, Graduate School of Medicine, Department of Orthopaedics, Suita, Osaka 565 0871, Japan
    Cancer Res 63:5028-33. 2003
    ....
  35. ncbi request reprint Anti-alpha4 integrin antibody suppresses the development of multiple myeloma and associated osteoclastic osteolysis
    Yoshihisa Mori
    Division of Endocrinology and Metabolism, Department of Medicine, The University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    Blood 104:2149-54. 2004
    ....
  36. ncbi request reprint Boning up on ephrin signaling
    Gregory R Mundy
    Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN, USA
    Cell 126:441-3. 2006
    ..Such bidirectional signaling limits osteoclast activity while stimulating osteoblast differentiation...
  37. ncbi request reprint NF-kappaB specifically activates BMP-2 gene expression in growth plate chondrocytes in vivo and in a chondrocyte cell line in vitro
    Jian Q Feng
    Department of Oral Biology, School of Dentistry, University of Missouri, Kansas City, Missouri 64108, USA
    J Biol Chem 278:29130-5. 2003
    ..Therefore, in postnatal growth plate chondrocytes, expression of BMP-2 is regulated by NF-kappaB, which may play an important role in chondrogenesis...
  38. ncbi request reprint Bone morphogenetic proteins
    Di Chen
    School of Medicine and Dentistry, Department of Orthopaedics, University of Rochester, Rochester, NY 14642, USA
    Growth Factors 22:233-41. 2004
    ..A significant advancement about the understanding of in vivo functions of BMP ligands, receptors and signaling molecules has been achieved in recent years...
  39. doi request reprint Model structure and control of bone remodeling: a theoretical study
    Peter Pivonka
    Department of Civil and Environmental Engineering, University of Melbourne, VIC 3010, Australia
    Bone 43:249-63. 2008
    ..The methodological approach for the investigation of model structure described here offers a theoretical explanation as to why TGF-beta has its particular suite of biological effects on bone-cell differentiation rates...
  40. ncbi request reprint In memoriam; Dr. Gideon Rodan
    Gregory R Mundy
    Bone 38:297-99. 2006
  41. ncbi request reprint Bisphosphonates and tumor burden
    Gregory R Mundy
    J Clin Oncol 20:3191-2. 2002
  42. pmc Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo
    Claire M Edwards
    Department of Cancer Biology, Vanderbilt Center for Bone Biology, Vanderbilt University, Nashville, TN 37232, USA
    Blood 111:2833-42. 2008
    ....
  43. ncbi request reprint The osteoclast-not always guilty
    Gregory R Mundy
    Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN 37232 0575, USA
    Cell Metab 6:157-9. 2007
    ....
  44. doi request reprint PTH-related peptide (PTHrP) in hypercalcemia
    Gregory R Mundy
    Vanderbilt Center for Bone Biology, 1235 Medical Research Building IV, Nashville, TN 37232 0575, USA
    J Am Soc Nephrol 19:672-5. 2008
    ....