Peter Mundel

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. ncbi request reprint Proteinuria: an enzymatic disease of the podocyte?
    Peter Mundel
    Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Kidney Int 77:571-80. 2010
  2. pmc Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes
    Etsuko Yanagida-Asanuma
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Am J Pathol 171:415-27. 2007
  3. ncbi request reprint The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A
    Christian Faul
    Department of Medicine, University of Miami Miller School of Medicine, 1600 Northwest Tenth Avenue, Miami, Florida 33136, USA
    Nat Med 14:931-8. 2008
  4. pmc Protein kinase A, Ca2+/calmodulin-dependent kinase II, and calcineurin regulate the intracellular trafficking of myopodin between the Z-disc and the nucleus of cardiac myocytes
    Christian Faul
    Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Mol Cell Biol 27:8215-27. 2007
  5. ncbi request reprint Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling
    Katsuhiko Asanuma
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nat Cell Biol 8:485-91. 2006
  6. pmc Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease
    Stefanie Krick
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 105:14106-11. 2008
  7. ncbi request reprint Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton
    Christian Faul
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Trends Cell Biol 17:428-37. 2007
  8. pmc Dynamin-mediated Nephrin phosphorylation regulates glucose-stimulated insulin release in pancreatic beta cells
    Jongmin Jeon
    Diabetes Research Institute, University of Miami L Miller School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 287:28932-42. 2012
  9. pmc Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner
    Katsuhiko Asanuma
    Department of Medicine, Albert Einstein College of Medicine, New York, New York, USA
    J Clin Invest 115:1188-98. 2005
  10. pmc Nuclear relocation of the nephrin and CD2AP-binding protein dendrin promotes apoptosis of podocytes
    Katsuhiko Asanuma
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 104:10134-9. 2007

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Proteinuria: an enzymatic disease of the podocyte?
    Peter Mundel
    Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Kidney Int 77:571-80. 2010
    ..Finally, we describe signaling pathways controlling the podocyte actin cytoskeleton and motility and how these pathways can be manipulated for therapeutic benefit...
  2. pmc Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes
    Etsuko Yanagida-Asanuma
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Am J Pathol 171:415-27. 2007
    ..The identification of synaptopodin as an inhibitor of Cdc42:IRSp53:Mena signaling defines a novel antiproteinuric signaling pathway and offers new targets for the development of antiproteinuric therapeutic modalities...
  3. ncbi request reprint The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A
    Christian Faul
    Department of Medicine, University of Miami Miller School of Medicine, 1600 Northwest Tenth Avenue, Miami, Florida 33136, USA
    Nat Med 14:931-8. 2008
    ..Novel calcineurin substrates such as synaptopodin may provide promising starting points for antiproteinuric drugs that avoid the serious side effects of long-term CsA treatment...
  4. pmc Protein kinase A, Ca2+/calmodulin-dependent kinase II, and calcineurin regulate the intracellular trafficking of myopodin between the Z-disc and the nucleus of cardiac myocytes
    Christian Faul
    Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Mol Cell Biol 27:8215-27. 2007
    ..The identification of myopodin as a direct target of PKA, CaMKII, and calcineurin defines a novel intracellular signaling pathway whereby changes in Z-disc dynamics may translate into compartmentalized signal transduction in the heart...
  5. ncbi request reprint Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling
    Katsuhiko Asanuma
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nat Cell Biol 8:485-91. 2006
    ..Together, these data show that synaptopodin is essential for the integrity of the podocyte actin cytoskeleton and for the regulation of podocyte cell migration...
  6. pmc Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease
    Stefanie Krick
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 105:14106-11. 2008
    ..Our findings identify Mpv17l as a unique interacting protein and regulator of HtrA2 protease mediating antioxidant and antiapoptotic function in mitochondria...
  7. ncbi request reprint Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton
    Christian Faul
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Trends Cell Biol 17:428-37. 2007
    ..The fact that the dynamic regulation of the podocyte cytoskeleton is vital to kidney function has led to podocytes emerging as an excellent model system for studying actin cytoskeleton dynamics in a physiological context...
  8. pmc Dynamin-mediated Nephrin phosphorylation regulates glucose-stimulated insulin release in pancreatic beta cells
    Jongmin Jeon
    Diabetes Research Institute, University of Miami L Miller School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 287:28932-42. 2012
    ..Pharmacological modulation of Nephrin phosphorylation may thus facilitate pancreatic beta cell function...
  9. pmc Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner
    Katsuhiko Asanuma
    Department of Medicine, Albert Einstein College of Medicine, New York, New York, USA
    J Clin Invest 115:1188-98. 2005
    ..In concert, synaptopodin regulates the actin-bundling activity of alpha-actinin in highly dynamic cell compartments, such as podocyte FPs and the dendritic spine apparatus...
  10. pmc Nuclear relocation of the nephrin and CD2AP-binding protein dendrin promotes apoptosis of podocytes
    Katsuhiko Asanuma
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 104:10134-9. 2007
    ..Nuclear relocation of dendrin may provide a mechanism whereby changes in SD integrity could translate into alterations of podocyte survival under pathological conditions...
  11. ncbi request reprint Modification of kidney barrier function by the urokinase receptor
    Changli Wei
    Nephrology Division and Program in Glomerular Disease, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Nat Med 14:55-63. 2008
    ..Blockade of alphavbeta3 integrin reduces podocyte motility in vitro and lowers proteinuria in mice. Our findings show a physiological role for uPAR signaling in the regulation of kidney permeability...
  12. ncbi request reprint Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin
    Jochen Reiser
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Biol Chem 279:34827-32. 2004
    ..In summary, these data establish that podocyte foot process effacement is a migratory event involving a novel interplay between cathepsin L and alpha(3) integrin...
  13. ncbi request reprint A novel role for the adaptor molecule CD2-associated protein in transforming growth factor-beta-induced apoptosis
    Mario Schiffer
    Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10461, USA
    J Biol Chem 279:37004-12. 2004
    ..Together, our in vitro and in vivo findings suggest that TGF-beta-induced podocyte apoptosis is an early pathomechanism in mice developing focal-segmental glomerulosclerosis associated with functional impairment of CD2AP...
  14. pmc Cell biology and pathology of podocytes
    Anna Greka
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Annu Rev Physiol 74:299-323. 2012
    ..Although we attempt to be comprehensive, our goal is not to capture every membrane-mediated pathway but rather to emphasize that this approach may be fruitful in understanding the podocyte and its unique properties...
  15. pmc Nephrin is expressed on the surface of insulin vesicles and facilitates glucose-stimulated insulin release
    Alessia Fornoni
    Diabetes Research Institute, University of Miami L Miller School of Medicine, Miami, Florida, USA
    Diabetes 59:190-9. 2010
    ..The aim of this study was to investigate whether diabetes modulates nephrin expression in human pancreatic islets and to explore the role of nephrin in beta-cell function...
  16. pmc Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis
    Shaolin Shi
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Am Soc Nephrol 19:2159-69. 2008
    ..Taken together, these results provide a knowledge base for ongoing investigations to validate functional roles for the mir-30 miRNA family in podocyte homeostasis and podocytopathies...
  17. pmc Role of altered insulin signaling pathways in the pathogenesis of podocyte malfunction and microalbuminuria
    Alexandra Jauregui
    Division of Nephrology and Hypertension, University of Miami L Miller School of Medicine, Miami, Florida 33136, USA
    Curr Opin Nephrol Hypertens 18:539-45. 2009
    ..The possibility that altered insulin signaling in glomerular cells and particularly podocytes contributes to the development of diabetic nephropathy will be discussed...
  18. pmc Promotion of importin alpha-mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3
    Christian Faul
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Biol 169:415-24. 2005
    ..They provide a molecular explanation for the phosphorylation-dependent nuclear import of nuclear localization signal-containing cargo proteins...
  19. pmc TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function
    Jochen Reiser
    Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Nat Genet 37:739-44. 2005
    ..Two of the TRPC6 mutants had increased current amplitudes. These data show that TRPC6 channel activity at the slit diaphragm is essential for proper regulation of podocyte structure and function...
  20. pmc Role of angiotensin II in the development of nephropathy and podocytopathy of diabetes
    Kirk N Campbell
    Department of Medicine, Leonard Miller School of Medicine, University of Miami, 1580 NW 10th Avenue, Miami, FL 33136, USA
    Curr Diabetes Rev 7:3-7. 2011
    ..Recent relevant clinical trials on the role of RAS blockade in the treatment of diabetic kidney disease are discussed...
  21. pmc Rescue of tropomyosin deficiency in Drosophila and human cancer cells by synaptopodin reveals a role of tropomyosin α in RhoA stabilization
    Jenny S Wong
    Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    EMBO J 31:1028-40. 2012
    ..Our findings elucidate RhoA stabilization by structurally unrelated actin-binding proteins as a conserved mechanism for regulation of stress fibre dynamics and cell motility in a cell type-specific fashion...
  22. pmc Induction of B7-1 in podocytes is associated with nephrotic syndrome
    Jochen Reiser
    Department of Medicine, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 113:1390-7. 2004
    ..Our findings suggest a novel function for B7-1 in danger signaling by nonimmune cells...
  23. pmc Essential role for synaptopodin in dendritic spine plasticity of the developing hippocampus
    Xiao lei Zhang
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 33:12510-8. 2013
    ....
  24. ncbi request reprint Inhibitory smads and tgf-Beta signaling in glomerular cells
    Mario Schiffer
    Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Am Soc Nephrol 13:2657-66. 2002
    ..These data indicate an important role for Smad6 and Smad7 in glomerular cells in vivo that could be important for the cell homeostasis in physiologic and pathologic conditions...
  25. ncbi request reprint Glomerular endothelial fenestrae in vivo are not formed from caveolae
    Jenny Sorensson
    Department of Medicine, Division of Nephrology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Am Soc Nephrol 13:2639-47. 2002
    ..Localization of caveolin-1 to podocytes and their filtration slits is consistent with the view that the filtration slit plasma membrane represents a type of lipid raft microdomain...
  26. ncbi request reprint Effects of high glucose and TGF-beta1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes
    M Carmen Iglesias-de la Cruz
    Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, 700 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104 4218, USA
    Kidney Int 62:901-13. 2002
    ..Effects of high glucose and TGF-beta1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes...

Research Grants19

  1. CELL AND MOLECULAR BIOLOGICAL ANALYSIS OF SYNAPTOPODIN
    Peter Mundel; Fiscal Year: 2001
    ..These studies should reveal whether synaptopodin functions in stabilization of the actin cytoskeleton and in providing podocyte resistance to strain and whether synpo-!- mice may be prone to the development of glomerular injury. ..
  2. Role of B7-1 in Podocytes in Pathogenesis of Proteinuria
    Peter Mundel; Fiscal Year: 2009
    ..This should in the long-term enable us to develop novel, selective podocyte-protective therapies that tackle proteinuria and progression of glomerulosclerosis by blocking the activity of B7-1 in podocytes. ..
  3. CELL AND MOLECULAR BIOLOGICAL ANALYSIS OF SYNAPTOPODIN
    Peter Mundel; Fiscal Year: 2009
    ..This should in the long-term enable us to develop novel, selective podocyte-protective therapies that tackle proteinuria by promoting the synpo/ a-actinin-4 mediated recovery and maintenance of the normal FP architecture. ..
  4. Role of B7-1 in Podocytes in Pathogenesis of Proteinuria
    Peter Mundel; Fiscal Year: 2007
    ..This should in the long-term enable us to develop novel, selective podocyte-protective therapies that tackle proteinuria and progression of glomerulosclerosis by blocking the activity of B7-1 in podocytes. ..
  5. SYNAPTOPODIN: BIOGENESIS & PLASTICITY OF SPINE APPARATUS
    Peter Mundel; Fiscal Year: 2007
    ..This should in the long-term enable us to develop novel therapies that tackle learning deficiencies and memory loss by modulating the expression of synaptopodin thereby promoting the cellular plasticity of the dendritic spine apparatus. ..
  6. Role of B7-1 in Podocytes in Pathogenesis of Proteinuria
    Peter Mundel; Fiscal Year: 2006
    ..This should in the long-term enable us to develop novel, selective podocyte-protective therapies that tackle proteinuria and progression of glomerulosclerosis by blocking the activity of B7-1 in podocytes. ..
  7. SYNAPTOPODIN: BIOGENESIS & PLASTICITY OF SPINE APPARATUS
    Peter Mundel; Fiscal Year: 2006
    ..This should in the long-term enable us to develop novel therapies that tackle learning deficiencies and memory loss by modulating the expression of synaptopodin thereby promoting the cellular plasticity of the dendritic spine apparatus. ..
  8. CELL AND MOLECULAR BIOLOGICAL ANALYSIS OF SYNAPTOPODIN
    Peter Mundel; Fiscal Year: 2005
    ..These studies should reveal whether synaptopodin functions in stabilization of the actin cytoskeleton and in providing podocyte resistance to strain and whether synpo-!- mice may be prone to the development of glomerular injury. ..
  9. CELL AND MOLECULAR BIOLOGICAL ANALYSIS OF SYNAPTOPODIN
    Peter Mundel; Fiscal Year: 2006
    ..This should in the long-term enable us to develop novel, selective podocyte-protective therapies that tackle proteinuria by promoting the synpo/ a-actinin-4 mediated recovery and maintenance of the normal FP architecture. ..
  10. SYNAPTOPODIN: BIOGENESIS & PLASTICITY OF SPINE APPARATUS
    Peter Mundel; Fiscal Year: 2005
    ..This should in the long-term enable us to develop novel therapies that tackle learning deficiencies and memory loss by modulating the expression of synaptopodin thereby promoting the cellular plasticity of the dendritic spine apparatus. ..
  11. Role of B7-1 in Podocytes in Pathogenesis of Proteinuria
    Peter Mundel; Fiscal Year: 2005
    ..This should in the long-term enable us to develop novel, selective podocyte-protective therapies that tackle proteinuria and progression of glomerulosclerosis by blocking the activity of B7-1 in podocytes. ..
  12. Role of B7-1 in Podocytes in Pathogenesis of Proteinuria
    Peter Mundel; Fiscal Year: 2004
    ..This should in the long-term enable us to develop novel, selective podocyte-protective therapies that tackle proteinuria and progression of glomerulosclerosis by blocking the activity of B7-1 in podocytes. ..
  13. SYNAPTOPODIN: BIOGENESIS & PLASTICITY OF SPINE APPARATUS
    Peter Mundel; Fiscal Year: 2004
    ..This should in the long-term enable us to develop novel therapies that tackle learning deficiencies and memory loss by modulating the expression of synaptopodin thereby promoting the cellular plasticity of the dendritic spine apparatus. ..
  14. CELL AND MOLECULAR BIOLOGICAL ANALYSIS OF SYNAPTOPODIN
    Peter Mundel; Fiscal Year: 2004
    ..These studies should reveal whether synaptopodin functions in stabilization of the actin cytoskeleton and in providing podocyte resistance to strain and whether synpo-!- mice may be prone to the development of glomerular injury. ..
  15. CELL AND MOLECULAR BIOLOGICAL ANALYSIS OF SYNAPTOPODIN
    Peter Mundel; Fiscal Year: 2003
    ..These studies should reveal whether synaptopodin functions in stabilization of the actin cytoskeleton and in providing podocyte resistance to strain and whether synpo-!- mice may be prone to the development of glomerular injury. ..
  16. CELL AND MOLECULAR BIOLOGICAL ANALYSIS OF SYNAPTOPODIN
    Peter Mundel; Fiscal Year: 2002
    ..These studies should reveal whether synaptopodin functions in stabilization of the actin cytoskeleton and in providing podocyte resistance to strain and whether synpo-!- mice may be prone to the development of glomerular injury. ..