Russell J Mumper

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. ncbi request reprint Genetic immunization by jet injection of targeted pDNA-coated nanoparticles
    Russell J Mumper
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 907 Rose Street, Lexington, KY 40536 0082, USA
    Methods 31:255-62. 2003
  2. pmc Development of new lipid-based paclitaxel nanoparticles using sequential simplex optimization
    Xiaowei Dong
    Department of Pharmaceutical Sciences, University of Kentucky, USA
    Eur J Pharm Biopharm 72:9-17. 2009
  3. pmc Preparation and characterization of novel coenzyme Q10 nanoparticles engineered from microemulsion precursors
    Cheng Hsuan Hsu
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    AAPS PharmSciTech 4:E32. 2003
  4. ncbi request reprint Intradermal immunization with novel plasmid DNA-coated nanoparticles via a needle-free injection device
    Zhengrong Cui
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    J Biotechnol 102:105-15. 2003
  5. doi request reprint Anthocyanin-rich fractions of blackberry extracts reduce UV-induced free radicals and oxidative damage in keratinocytes
    Patience Murapa
    University of Kentucky College of Medicine, Department of Pediatrics, The Markey Cancer Center, 800 Rose Street, Lexington, KY 40536, USA
    Phytother Res 26:106-12. 2012
  6. ncbi request reprint Specific association of thiamine-coated gadolinium nanoparticles with human breast cancer cells expressing thiamine transporters
    Moses O Oyewumi
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington 40536 0082, USA
    Bioconjug Chem 14:404-11. 2003
  7. ncbi request reprint Preparation and characterization of nickel nanoparticles for binding to his-tag proteins and antigens
    Jigna D Patel
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Pharm Res 24:343-52. 2007
  8. ncbi request reprint The effect of co-administration of adjuvants with a nanoparticle-based genetic vaccine delivery system on the resulting immune responses
    Zhengrong Cui
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
    Eur J Pharm Biopharm 55:11-8. 2003
  9. doi request reprint Enhanced intracellular delivery of the reactive oxygen species (ROS)-generating copper chelator D-penicillamine via a novel gelatin--D-penicillamine conjugate
    Anshul Gupte
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536 0082, USA
    Bioconjug Chem 19:1382-8. 2008
  10. ncbi request reprint Comparison of cell uptake, biodistribution and tumor retention of folate-coated and PEG-coated gadolinium nanoparticles in tumor-bearing mice
    Moses O Oyewumi
    Center for Pharmaceutical Science and Technology, Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 907 Rose Street, Lexington, KY 40536 0082, USA
    J Control Release 95:613-26. 2004

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Genetic immunization by jet injection of targeted pDNA-coated nanoparticles
    Russell J Mumper
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 907 Rose Street, Lexington, KY 40536 0082, USA
    Methods 31:255-62. 2003
    ....
  2. pmc Development of new lipid-based paclitaxel nanoparticles using sequential simplex optimization
    Xiaowei Dong
    Department of Pharmaceutical Sciences, University of Kentucky, USA
    Eur J Pharm Biopharm 72:9-17. 2009
    ..Sequential Simplex Optimization has been utilized to identify promising new lipid-based paclitaxel nanoparticles having useful attributes...
  3. pmc Preparation and characterization of novel coenzyme Q10 nanoparticles engineered from microemulsion precursors
    Cheng Hsuan Hsu
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    AAPS PharmSciTech 4:E32. 2003
    ..1 cells was over 4-fold higher than that of the CoQ10-free nanoparticles (P < .05). In conclusion, CoQ10-NPs with potential application for oral CoQ10 delivery were engineered readily from microemulsion precursors...
  4. ncbi request reprint Intradermal immunization with novel plasmid DNA-coated nanoparticles via a needle-free injection device
    Zhengrong Cui
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    J Biotechnol 102:105-15. 2003
    ..In conclusion, a combination of a novel cationic nanoparticle-based DNA delivery system with ID jet injection led to enhanced antibody production, Th-1/Th-2 balanced cytokine release, and enhanced splenocyte proliferation...
  5. doi request reprint Anthocyanin-rich fractions of blackberry extracts reduce UV-induced free radicals and oxidative damage in keratinocytes
    Patience Murapa
    University of Kentucky College of Medicine, Department of Pediatrics, The Markey Cancer Center, 800 Rose Street, Lexington, KY 40536, USA
    Phytother Res 26:106-12. 2012
    ..Furthermore, the fractions up-regulated the expression of catalase, MnSOD, Gpx1/2 and Gsta1 antioxidant enzymes. Thus, it is concluded that blackberry extracts may protect keratinocytes against UV-mediated oxidative damage...
  6. ncbi request reprint Specific association of thiamine-coated gadolinium nanoparticles with human breast cancer cells expressing thiamine transporters
    Moses O Oyewumi
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington 40536 0082, USA
    Bioconjug Chem 14:404-11. 2003
    ..Further studies are warranted to assess the potential of the engineered thiamine-coated gadolinium (Gd) nanoparticles in neutron capture therapy of tumors...
  7. ncbi request reprint Preparation and characterization of nickel nanoparticles for binding to his-tag proteins and antigens
    Jigna D Patel
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Pharm Res 24:343-52. 2007
    ....
  8. ncbi request reprint The effect of co-administration of adjuvants with a nanoparticle-based genetic vaccine delivery system on the resulting immune responses
    Zhengrong Cui
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
    Eur J Pharm Biopharm 55:11-8. 2003
    ..In conclusion, CT (topical) and LA (s.c.) are potential adjuvants to further enhance immune responses using a novel cationic nanoparticle-based DNA vaccine delivery system...
  9. doi request reprint Enhanced intracellular delivery of the reactive oxygen species (ROS)-generating copper chelator D-penicillamine via a novel gelatin--D-penicillamine conjugate
    Anshul Gupte
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536 0082, USA
    Bioconjug Chem 19:1382-8. 2008
    ..Further studies are warranted to assess the potential of D-pen conjugate in the delivery of D-pen as a ROS generating anticancer agent...
  10. ncbi request reprint Comparison of cell uptake, biodistribution and tumor retention of folate-coated and PEG-coated gadolinium nanoparticles in tumor-bearing mice
    Moses O Oyewumi
    Center for Pharmaceutical Science and Technology, Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 907 Rose Street, Lexington, KY 40536 0082, USA
    J Control Release 95:613-26. 2004
    ..The engineered nanoparticles may have potential in tumor-targeted delivery of Gd thereby enhancing the therapeutic success of NCT...
  11. ncbi request reprint Physical characterization and macrophage cell uptake of mannan-coated nanoparticles
    Zhengrong Cui
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536 0082, USA
    Drug Dev Ind Pharm 29:689-700. 2003
    ..DSC provided evidence that the nanoparticles were not a physical mixture of their individual components. Finally, cell binding and uptake studies demonstrated that the nanoparticles have potential application for cell-specific targeting...
  12. ncbi request reprint Novel D-penicillamine carrying nanoparticles for metal chelation therapy in Alzheimer's and other CNS diseases
    Zhengrong Cui
    Department of Pharmaceutical Sciences, Center for Pharmaceutical Science and Technology, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Eur J Pharm Biopharm 59:263-72. 2005
    ..These results indicate that nanoparticles have potential to deliver D-penicillamine to the brain for the prevention of Abeta (1-42) accumulation, as well as to reduce metal ion accumulation in other CNS diseases...
  13. ncbi request reprint HIV-1 Tat-coated nanoparticles result in enhanced humoral immune responses and neutralizing antibodies compared to alum adjuvant
    Jigna Patel
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Vaccine 24:3564-73. 2006
    ..Moreover, the anti-sera from all Tat (1-72) immunized groups contained Tat-neutralizing antibodies and were able to significantly inhibit Tat-mediated long terminal repeat (LTR) transactivation...
  14. ncbi request reprint Copper chelation by D-penicillamine generates reactive oxygen species that are cytotoxic to human leukemia and breast cancer cells
    Anshul Gupte
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Free Radic Biol Med 43:1271-8. 2007
    ..The H(2)O(2)-mediated cytotoxicity was greater in leukemia cells compared to breast cancer cells. These results support the hypothesis that D-pen can be employed as a cytotoxic copper-chelating agent based on its ROS-generating ability...
  15. ncbi request reprint An investigation into copper catalyzed D-penicillamine oxidation and subsequent hydrogen peroxide generation
    Anshul Gupte
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 725 Rose Street, Lexington, KY 40536 0082, USA
    J Inorg Biochem 101:594-602. 2007
    ..The incubation of MCF-7 human breast cancer cells with D-penicillamine plus cupric sulfate resulted in the production of reactive oxygen species within the cell and cytotoxicity that was comparable to free hydrogen peroxide...
  16. ncbi request reprint Genetic immunization using nanoparticles engineered from microemulsion precursors
    Zhengrong Cui
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington 40536 0082, USA
    Pharm Res 19:939-46. 2002
    ..The IgG titer to expressed beta-galactosidase and the cytokine release from isolated splenocytes after stimulation were determined on 28 days...
  17. ncbi request reprint Microparticles and nanoparticles as delivery systems for DNA vaccines
    Zhengrong Cui
    Center for Pharmaceutical Science and Technology, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
    Crit Rev Ther Drug Carrier Syst 20:103-37. 2003
    ..In this review, the application of microparticles and nanoparticles as DNA vaccine delivery systems will be critically reviewed with a primary focus on those systems that have generated in vivo immune responses...
  18. ncbi request reprint Paclitaxel nanoparticles for the potential treatment of brain tumors
    Joanna M Koziara
    Division of Pharmaceutical Sciences, Center for Pharmaceutical Science and Technology, College of Pharmacy, University of Kentucky, 725 Rose Street, Lexington, KY 40536 0082, USA
    J Control Release 99:259-69. 2004
    ..It was hypothesized that PX NPs could mask paclitaxel characteristics and thus limit its binding to p-gp, which consequently would lead to higher brain and tumor cell uptake of the otherwise effluxed drug...
  19. pmc Doxorubicin and paclitaxel-loaded lipid-based nanoparticles overcome multidrug resistance by inhibiting P-glycoprotein and depleting ATP
    Xiaowei Dong
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky, USA
    Cancer Res 69:3918-26. 2009
    ..Nanoparticles may be used to target both drug and biological mechanisms to overcome multidrug resistance via P-gp inhibition and ATP depletion...
  20. doi request reprint Plant phenolics: extraction, analysis and their antioxidant and anticancer properties
    Jin Dai
    Four Tigers LLC, 1501 Bull Lea Road, Suite 105, Lexington, Kentucky 40511, USA
    Molecules 15:7313-52. 2010
    ..Finally, possible mechanisms of action involving antioxidant and pro-oxidant activity as well as interference with cellular functions are discussed...
  21. ncbi request reprint Novel ethanol-in-fluorocarbon microemulsions for topical genetic immunization
    Zhengrong Cui
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536 0082, USA
    Pharm Res 20:16-23. 2003
    ..We sought to enhance the immune responses induced by DNA-based vaccines after topical application by developing novel ethanol-in-fluorocarbon (E/F) microemulsion systems to aid in the delivery of plasmid DNA (pDNA)...
  22. pmc Antiviral effects of blackberry extract against herpes simplex virus type 1
    Robert J Danaher
    Department of Oral Health Practice, Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, Kentucky, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112:e31-5. 2011
    ..The aim of this study was to evaluate antiviral properties of blackberry extract against herpes simplex virus type 1 (HSV-1) in vitro...
  23. ncbi request reprint Influence of formulation parameters on gadolinium entrapment and tumor cell uptake using folate-coated nanoparticles
    Moses O Oyewumi
    Division of Pharmaceutical Sciences, Center for Pharmaceutical Science and Technology, College of Pharmacy, University of Kentucky, 907 Rose Street, Lexington, KY 40536 0082, USA
    Int J Pharm 251:85-97. 2003
    ..01; t-test). The results showed that GdH entrapment and cell uptake were optimized and suggested that engineered folate-coated nanoparticles may serve as effective carrier systems for Gd-NCT of tumors...
  24. doi request reprint Elevated copper and oxidative stress in cancer cells as a target for cancer treatment
    Anshul Gupte
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Cancer Treat Rev 35:32-46. 2009
    ..Therefore, the elevated copper levels and increased oxidative stress in cancer cells provide for a prospect of selective cancer treatment...
  25. ncbi request reprint Plasmid DNA-entrapped nanoparticles engineered from microemulsion precursors: in vitro and in vivo evaluation
    Zhengrong Cui
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536 0082, USA
    Bioconjug Chem 13:1319-27. 2002
    ..Due to the apparent stability of these pDNA-entrapped nanoparticles in the blood, they may have potential for systemic gene therapy applications requiring cell and/or tissue-specific delivery...
  26. ncbi request reprint Engineering tumor-targeted gadolinium hexanedione nanoparticles for potential application in neutron capture therapy
    Moses O Oyewumi
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536 0082, USA
    Bioconjug Chem 13:1328-35. 2002
    ..001 mM of free folic acid. The results suggested that these tumor-targeted nanoparticles containing high concentrations of Gd may have potential for neutron capture therapy...
  27. ncbi request reprint In-vivo efficacy of novel paclitaxel nanoparticles in paclitaxel-resistant human colorectal tumors
    Joanna M Koziara
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    J Control Release 112:312-9. 2006
    ..It was concluded that the enhanced efficacy of PX NPs over Taxol in the xenograft model was due to both overcoming paclitaxel resistance and an antiangiogenic effect...
  28. ncbi request reprint Buccal transmucosal delivery of calcitonin in rabbits using thin-film composites
    Zhengrong Cui
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536 0082, USA
    Pharm Res 19:1901-6. 2002
    ..Alternative and more cost-effective dosage forms for the delivery of calcitonin are needed. We sought to deliver sCT transmucosally using a previously reported mucoadhesive bilayer thin-film composite (TFC) via the buccal route...
  29. ncbi request reprint Strong T cell type-1 immune responses to HIV-1 Tat (1-72) protein-coated nanoparticles
    Zhengrong Cui
    Center for Pharmaceutical Science and Technology, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Vaccine 22:2631-40. 2004
    ..3-fold greater than that from mice immunized with Tat and Alum. These studies warrant further investigation of these nanoparticles to enhance both antibody and cellular-based immune responses...
  30. ncbi request reprint Near-infrared spectroscopy for the determination of testosterone in thin-film composites
    William Fountain
    Division of Pharmaceutical Sciences, Center for Pharmaceutical Science and Technology, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    J Pharm Biomed Anal 33:181-9. 2003
    ..Therefore, the NIR assay may have significant potential for use in the quality control of pharmaceutical films containing drugs...
  31. ncbi request reprint Coating of cationized protein on engineered nanoparticles results in enhanced immune responses
    Zhengrong Cui
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Int J Pharm 238:229-39. 2002
    ..In contrast, cGal-coated nanoparticles significantly enhanced both the Th1 and Th2 cytokines. The results demonstrated the utility of antigen-coated nanoparticles to enhance both the humoral and Th1-type immune responses, in parallel...
  32. ncbi request reprint Intranasal administration of plasmid DNA-coated nanoparticles results in enhanced immune responses
    Zhengrong Cui
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington 40536 0082, USA
    J Pharm Pharmacol 54:1195-203. 2002
    ..An enhanced splenocyte proliferative response was also observed after immunization with the pDNA-coated nanoparticles. It was concluded that these plasmid DNA-coated nanoparticles may have potential for immunization via the nasal route...
  33. ncbi request reprint Topical immunization using nanoengineered genetic vaccines
    Zhengrong Cui
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    J Control Release 81:173-84. 2002
    ..All pDNA-coated nanoparticles, especially the mannan-coated pDNA-nanoparticles with DOPE, resulted in significant enhancement in both antigen-specific IgG titers (16-fold) and splenocyte proliferation over 'naked' pDNA alone...
  34. ncbi request reprint Characterization of blackberry extract and its antiproliferative and anti-inflammatory properties
    Jin Dai
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky, USA
    J Med Food 10:258-65. 2007
    ....
  35. pmc Nanomedicinal strategies to treat multidrug-resistant tumors: current progress
    Xiaowei Dong
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Nanomedicine (Lond) 5:597-615. 2010
    ..This article focuses on nanotechnology-based formulations and current nanomedicine approaches to address MDR in tumors and discusses the proposed mechanisms of action...
  36. ncbi request reprint Aqueous liquid scintillation counting with fluor-containing nanosuspensions
    James C Weekley
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Appl Radiat Isot 60:887-91. 2004
    ..Monte Carlo calculations demonstrated that the size and concentration of the nanoparticles were appropriate for optimum detection efficiency...
  37. ncbi request reprint Gadolinium-loaded nanoparticles engineered from microemulsion templates
    Moses O Oyewumi
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington 40536 0082, USA
    Drug Dev Ind Pharm 28:317-28. 2002
    ....
  38. ncbi request reprint In situ blood-brain barrier transport of nanoparticles
    Joanna M Koziara
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Pharm Res 20:1772-8. 2003
    ..Two novel types of nanoparticles were evaluated as poten tial carriers for drugs across the blood-brain barrier (BBB)...
  39. ncbi request reprint Transmucosal delivery of testosterone in rabbits using novel bi-layer mucoadhesive wax-film composite disks
    Steven Jay
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 907 Rose Street, Lexington, Kentucky 40536 0082, USA
    J Pharm Sci 91:2016-25. 2002
    ..2 +/- 3.2% with a coefficient of variation of 6.4%. It was concluded that these bi-layer mucoadhesive WFCs disks could deliver physiologically relevant amounts of insoluble drugs such as testosterone across the buccal mucosa...
  40. ncbi request reprint Bilayer films for mucosal (genetic) immunization via the buccal route in rabbits
    Zhengrong Cui
    Division of Pharmaceutical Sciences College of Pharmacy University of Kentucky, Lexington 40536 0082, USA
    Pharm Res 19:947-53. 2002
    ..A novel mucoadhesive bilayer film was developed to test the feasibility of this route of immunization in rabbits...
  41. ncbi request reprint Brain uptake of thiamine-coated nanoparticles
    Paul R Lockman
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University HSC, Amarillo, TX 79106 1712, USA
    J Control Release 93:271-82. 2003
    ..0 +/- 0.3 x 10(-3) ml/s/g). It was concluded that the thiamine ligand facilitated binding and/or association with blood-brain barrier thiamine transporters, which may be a viable mechanism for nanoparticle mediated brain drug delivery...
  42. ncbi request reprint In vivo and in vitro assessment of baseline blood-brain barrier parameters in the presence of novel nanoparticles
    Paul R Lockman
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University HSC, 1300 So Coulter Dr, Amarillo, Texas 79106 1712, USA
    Pharm Res 20:705-13. 2003
    ..Nanoparticles have advantage as CNS drug delivery vehicles given they disguise drug permeation limiting characteristics. Conflicting toxicological data, however, is published with regard to blood-brain barrier integrity and gross mortality...