M Mumby

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint A new role for protein methylation: switching partners at the phosphatase ball
    M Mumby
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Sci STKE 2001:pe1. 2001
  2. ncbi request reprint PP2A: unveiling a reluctant tumor suppressor
    Marc Mumby
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 130:21-4. 2007
  3. pmc Phosphoproteomics: new insights into cellular signaling
    Marc Mumby
    Department of Pharmacology and the Alliance for Cellular Signaling, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
    Genome Biol 6:230. 2005
  4. ncbi request reprint The 3D structure of protein phosphatase 2A: new insights into a ubiquitous regulator of cell signaling
    Marc Mumby
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    ACS Chem Biol 2:99-103. 2007
  5. ncbi request reprint Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line
    Hongjun Shu
    Protein Chemistry Laboratory, Alliance for Cellular Signaling, University of Texas Southwestern Medical Center, Dallas, TX 75390 9196, USA
    Mol Cell Proteomics 3:279-86. 2004
  6. pmc Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase
    Vincent A Bielinski
    Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9041, USA
    Exp Cell Res 313:3117-26. 2007
  7. ncbi request reprint A functional genomics analysis of the B56 isoforms of Drosophila protein phosphatase 2A
    Wei Liu
    Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
    Mol Cell Proteomics 6:319-32. 2007
  8. ncbi request reprint PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation
    Zhanyun Tang
    Department of Pharmacology, The University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390, USA
    Dev Cell 10:575-85. 2006
  9. ncbi request reprint The glycine 90 to aspartate alteration in the Abeta subunit of PP2A (PPP2R1B) associates with breast cancer and causes a deficit in protein function
    Edward D Esplin
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, 75390 9041, USA
    Genes Chromosomes Cancer 45:182-90. 2006
  10. ncbi request reprint Analysis of protein phosphatase function in Drosophila cells using RNA interference
    Adam M Silverstein
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
    Methods Enzymol 366:361-72. 2003

Research Grants

Collaborators

  • Hongtao Yu
  • Wei Liu
  • Edward D Esplin
  • Adam M Silverstein
  • Anthony J Davis
  • Hongjun Shu
  • Vincent A Bielinski
  • Zhanyun Tang
  • Zhen Yan
  • Bobbie Martinez
  • Wei Qi
  • Nadir A Mahmood
  • Deirdre L Brekken
  • Qun Bi
  • She Chen
  • Christina A Barrow

Detail Information

Publications12

  1. ncbi request reprint A new role for protein methylation: switching partners at the phosphatase ball
    M Mumby
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Sci STKE 2001:pe1. 2001
    ..Mumby describes how PP2A is regulated and how methylation may alter its subcellular targeting and substrate specificity by influencing its interaction with regulatory subunits...
  2. ncbi request reprint PP2A: unveiling a reluctant tumor suppressor
    Marc Mumby
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 130:21-4. 2007
    ..Recent findings, including work in this issue by Junttila et al. (2007), provide convincing evidence that suppression of PP2A activity cooperates with other oncogenic changes to cause transformation of multiple cell types...
  3. pmc Phosphoproteomics: new insights into cellular signaling
    Marc Mumby
    Department of Pharmacology and the Alliance for Cellular Signaling, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
    Genome Biol 6:230. 2005
    ..This article presents a brief review of phosphoproteomics with an emphasis on the biological insights that have been derived so far...
  4. ncbi request reprint The 3D structure of protein phosphatase 2A: new insights into a ubiquitous regulator of cell signaling
    Marc Mumby
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    ACS Chem Biol 2:99-103. 2007
    ..The structures also explain how specific site mutations may lead to cancer and suggest a novel role for PP2A methylation in the formation of PP2A holoenzymes...
  5. ncbi request reprint Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line
    Hongjun Shu
    Protein Chemistry Laboratory, Alliance for Cellular Signaling, University of Texas Southwestern Medical Center, Dallas, TX 75390 9196, USA
    Mol Cell Proteomics 3:279-86. 2004
    ..The number of newly identified phosphoproteins indicates that B cell signaling pathways utilizing protein phosphorylation are likely to be more complex than previously appreciated...
  6. pmc Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase
    Vincent A Bielinski
    Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9041, USA
    Exp Cell Res 313:3117-26. 2007
    ..These results indicate that PP2A, but not other members of this subfamily, is likely to be a major S6K phosphatase in intact cells and is consistent with an important role for this phosphatase in the TOR pathway...
  7. ncbi request reprint A functional genomics analysis of the B56 isoforms of Drosophila protein phosphatase 2A
    Wei Liu
    Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
    Mol Cell Proteomics 6:319-32. 2007
    ..The results reveal that the B56-containing isoform of PP2A functions within multiple signaling pathways, including those that regulate expression of reaper and the response to oxidative stress, thus promoting cell survival in Drosophila...
  8. ncbi request reprint PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation
    Zhanyun Tang
    Department of Pharmacology, The University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390, USA
    Dev Cell 10:575-85. 2006
    ..Our findings suggest that Bub1 targets PP2A to centromeres, which in turn maintains Sgo1 at centromeres by counteracting Plk1-mediated chromosome removal of Sgo1...
  9. ncbi request reprint The glycine 90 to aspartate alteration in the Abeta subunit of PP2A (PPP2R1B) associates with breast cancer and causes a deficit in protein function
    Edward D Esplin
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, 75390 9041, USA
    Genes Chromosomes Cancer 45:182-90. 2006
    ....
  10. ncbi request reprint Analysis of protein phosphatase function in Drosophila cells using RNA interference
    Adam M Silverstein
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
    Methods Enzymol 366:361-72. 2003
    ..Finally, the physiology and signaling pathways of S2 cells have not been extensively studied. This lack of information limits the number of available readouts that can be used when assessing the effects of protein knockdowns...
  11. pmc Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits
    Adam M Silverstein
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
    Proc Natl Acad Sci U S A 99:4221-6. 2002
    ..Depletion of protein phosphatase 5 had no effects on MAP kinase, cell growth, or apoptosis...
  12. pmc Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunit
    Anthony J Davis
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9041, USA
    J Biol Chem 283:16104-14. 2008
    ..These observations indicate that PP2A can be targeted in a calcium-regulated manner to Cdc6 via the PR70 subunit, where it plays a role in regulating protein phosphorylation and stability...

Research Grants33

  1. IMMUNOLOGICAL ANALYSIS OF CARDIAC PROTEIN PHOSPHATASES
    Marc Mumby; Fiscal Year: 1991
    ..This will provide new information regarding the biological function(s) of these important regulatory enzymes...
  2. PROTEIN PHOSPHATASE 2A IN CELLULAR SIGNALLING
    Marc Mumby; Fiscal Year: 1993
    ..C subunit domains required for interaction with the A subunit will be identified by chemical crosslinking and deletional and site-directed mutagenesis...
  3. REGULATION OF PROTEIN DEPHOSPHORYLATION
    Marc Mumby; Fiscal Year: 2001
    ..The effects of these proteins on activity, subcellular localization, and in vivo function of PP2A will be determined. Additional candidate interacting proteins, identified in the two-hybrid screen will also be characterized. ..
  4. PROTEIN PHOSPHATASE 2A IN CELLULAR SIGNALING
    Marc Mumby; Fiscal Year: 2001
    ..C subunit domains required for interaction with the A subunit will be identified by chemical crosslinking and deletional and site-directed mutagenesis. ..
  5. REGULATION OF PROTEIN DEPHOSPHORYLATION
    Marc Mumby; Fiscal Year: 2005
    ..forms of the protein containing mutations identified in lung and colon tumors will be tested for their abilities to downregulate the Wnt signaling pathway and to reverse the tumorigenic potential of lung cancer cell lines ..
  6. Cell cycle regulation by protein phosphatase 2A
    Marc C Mumby; Fiscal Year: 2010
    ..The goals of this proposal are to test the hypothesis that PP2A mediates calcium-dependent regulation of the cell cycle through actions on these proteins. ..