Research Topics
| M MumbySummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
A new role for protein methylation: switching partners at the phosphatase ballM Mumby
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Sci STKE 2001:pe1. 2001..Mumby describes how PP2A is regulated and how methylation may alter its subcellular targeting and substrate specificity by influencing its interaction with regulatory subunits...- PP2A: unveiling a reluctant tumor suppressorMarc Mumby
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Cell 130:21-4. 2007..Recent findings, including work in this issue by Junttila et al. (2007), provide convincing evidence that suppression of PP2A activity cooperates with other oncogenic changes to cause transformation of multiple cell types... 
Phosphoproteomics: new insights into cellular signalingMarc Mumby
Department of Pharmacology and the Alliance for Cellular Signaling, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
Genome Biol 6:230. 2005..This article presents a brief review of phosphoproteomics with an emphasis on the biological insights that have been derived so far...- The 3D structure of protein phosphatase 2A: new insights into a ubiquitous regulator of cell signalingMarc Mumby
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
ACS Chem Biol 2:99-103. 2007..The structures also explain how specific site mutations may lead to cancer and suggest a novel role for PP2A methylation in the formation of PP2A holoenzymes... - Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell lineHongjun Shu
Protein Chemistry Laboratory, Alliance for Cellular Signaling, University of Texas Southwestern Medical Center, Dallas, TX 75390-9196, USA
Mol Cell Proteomics 3:279-86. 2004..The number of newly identified phosphoproteins indicates that B cell signaling pathways utilizing protein phosphorylation are likely to be more complex than previously appreciated... - Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinaseVincent A Bielinski
Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9041, USA
Exp Cell Res 313:3117-26. 2007..These results indicate that PP2A, but not other members of this subfamily, is likely to be a major S6K phosphatase in intact cells and is consistent with an important role for this phosphatase in the TOR pathway... - A functional genomics analysis of the B56 isoforms of Drosophila protein phosphatase 2AWei Liu
Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
Mol Cell Proteomics 6:319-32. 2007..The results reveal that the B56-containing isoform of PP2A functions within multiple signaling pathways, including those that regulate expression of reaper and the response to oxidative stress, thus promoting cell survival in Drosophila... - PP2A is required for centromeric localization of Sgo1 and proper chromosome segregationZhanyun Tang
Department of Pharmacology, The University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390, USA
Dev Cell 10:575-85. 2006..Our findings suggest that Bub1 targets PP2A to centromeres, which in turn maintains Sgo1 at centromeres by counteracting Plk1-mediated chromosome removal of Sgo1... - The glycine 90 to aspartate alteration in the Abeta subunit of PP2A (PPP2R1B) associates with breast cancer and causes a deficit in protein functionEdward D Esplin
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, 75390 9041, USA
Genes Chromosomes Cancer 45:182-90. 2006.... - Analysis of protein phosphatase function in Drosophila cells using RNA interferenceAdam M Silverstein
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9041, USA
Methods Enzymol 366:361-72. 2003..Finally, the physiology and signaling pathways of S2 cells have not been extensively studied. This lack of information limits the number of available readouts that can be used when assessing the effects of protein knockdowns... - Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunitsAdam M Silverstein
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
Proc Natl Acad Sci U S A 99:4221-6. 2002..Depletion of protein phosphatase 5 had no effects on MAP kinase, cell growth, or apoptosis... - Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunitAnthony J Davis
Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9041, USA
J Biol Chem 283:16104-14. 2008..These observations indicate that PP2A can be targeted in a calcium-regulated manner to Cdc6 via the PR70 subunit, where it plays a role in regulating protein phosphorylation and stability...
Research Grants
- IMMUNOLOGICAL ANALYSIS OF CARDIAC PROTEIN PHOSPHATASESMarc Mumby; Fiscal Year: 1991..This will provide new information regarding the biological function(s) of these important regulatory enzymes...
- PROTEIN PHOSPHATASE 2A IN CELLULAR SIGNALLINGMarc Mumby; Fiscal Year: 1993..C subunit domains required for interaction with the A subunit will be identified by chemical crosslinking and deletional and site-directed mutagenesis...
- REGULATION OF PROTEIN DEPHOSPHORYLATIONMarc Mumby; Fiscal Year: 2001..The effects of these proteins on activity, subcellular localization, and in vivo function of PP2A will be determined. Additional candidate interacting proteins, identified in the two-hybrid screen will also be characterized. ..
- PROTEIN PHOSPHATASE 2A IN CELLULAR SIGNALINGMarc Mumby; Fiscal Year: 2001..C subunit domains required for interaction with the A subunit will be identified by chemical crosslinking and deletional and site-directed mutagenesis. ..
- REGULATION OF PROTEIN DEPHOSPHORYLATIONMarc Mumby; Fiscal Year: 2005..forms of the protein containing mutations identified in lung and colon tumors will be tested for their abilities to downregulate the Wnt signaling pathway and to reverse the tumorigenic potential of lung cancer cell lines ..
- Cell cycle regulation by protein phosphatase 2AMarc C Mumby; Fiscal Year: 2010..The goals of this proposal are to test the hypothesis that PP2A mediates calcium-dependent regulation of the cell cycle through actions on these proteins. ..