Surafel Mulugeta

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Surfactant protein C: its unique properties and emerging immunomodulatory role in the lung
    Surafel Mulugeta
    Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    Microbes Infect 8:2317-23. 2006
  2. pmc Disruption of N-linked glycosylation promotes proteasomal degradation of the human ATP-binding cassette transporter ABCA3
    Michael F Beers
    Pulmonary, Allergy, and Critical Care Division, Univ of Pennsylvania, Perelman School of Medicine, Smilow Center for Translational Research, Suite 11 111, 3400 Civic Center Blvd, Philadelphia, PA 19104 5159
    Am J Physiol Lung Cell Mol Physiol 305:L970-80. 2013
  3. pmc A non-BRICHOS surfactant protein c mutation disrupts epithelial cell function and intercellular signaling
    Markus Woischnik
    Department of Pneumology, Dr von Hauner Children s Hospital, Ludwig Maximilians University, Lindwurmstr 4, Munich 80337, Germany
    BMC Cell Biol 11:88. 2010
  4. ncbi request reprint Misfolded BRICHOS SP-C mutant proteins induce apoptosis via caspase-4- and cytochrome c-related mechanisms
    Surafel Mulugeta
    Pulmonary, Allergy, and Critical Care Division, Univ of Pennsylvania School of Medicine, Vernon and Shirley Hill Pavilion, Suite H418, 380 South Univ Ave, Philadelphia, PA 19104, USA
    Am J Physiol Lung Cell Mol Physiol 293:L720-9. 2007
  5. pmc A surfactant protein C precursor protein BRICHOS domain mutation causes endoplasmic reticulum stress, proteasome dysfunction, and caspase 3 activation
    Surafel Mulugeta
    Pulmonary and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    Am J Respir Cell Mol Biol 32:521-30. 2005
  6. ncbi request reprint Processing of surfactant protein C requires a type II transmembrane topology directed by juxtamembrane positively charged residues
    Surafel Mulugeta
    Lung Epithelial Cell Biology Laboratories, Pulmonary and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
    J Biol Chem 278:47979-86. 2003
  7. ncbi request reprint Nonspecific interstitial pneumonia, alveolar proteinosis, and abnormal proprotein trafficking resulting from a spontaneous mutation in the surfactant protein C gene
    Paul A Stevens
    Pulmonary and Critical Care Division, University of Pennsylvania School of Medicine, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
    Pediatr Res 57:89-98. 2005
  8. pmc A nonaggregating surfactant protein C mutant is misdirected to early endosomes and disrupts phospholipid recycling
    Michael F Beers
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Traffic 12:1196-210. 2011
  9. ncbi request reprint Deletion of exon 4 from human surfactant protein C results in aggresome formation and generation of a dominant negative
    Wen Jing Wang
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Cell Sci 116:683-92. 2003
  10. pmc Anterograde transport of surfactant protein C proprotein to distal processing compartments requires PPDY-mediated association with Nedd4 ubiquitin ligases
    Adam Kotorashvili
    Surfactant Biology Laboratories, Department of Medicine, University of Pennsylvania School of Medicine, and Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Biol Chem 284:16667-78. 2009

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Surfactant protein C: its unique properties and emerging immunomodulatory role in the lung
    Surafel Mulugeta
    Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    Microbes Infect 8:2317-23. 2006
    ....
  2. pmc Disruption of N-linked glycosylation promotes proteasomal degradation of the human ATP-binding cassette transporter ABCA3
    Michael F Beers
    Pulmonary, Allergy, and Critical Care Division, Univ of Pennsylvania, Perelman School of Medicine, Smilow Center for Translational Research, Suite 11 111, 3400 Civic Center Blvd, Philadelphia, PA 19104 5159
    Am J Physiol Lung Cell Mol Physiol 305:L970-80. 2013
    ..These results suggest that cotranslational N-linked glycosylation at N124 and N140 is critical for ABCA3 stability, and its disruption results in protein destabilization and proteasomal degradation. ..
  3. pmc A non-BRICHOS surfactant protein c mutation disrupts epithelial cell function and intercellular signaling
    Markus Woischnik
    Department of Pneumology, Dr von Hauner Children s Hospital, Ludwig Maximilians University, Lindwurmstr 4, Munich 80337, Germany
    BMC Cell Biol 11:88. 2010
    ..The most frequent SFTPC mutation in ILD patients leads to a threonine for isoleucine substitution at position 73 (I73T) of the SP-C preprotein (proSP-C), however little is known about the cellular consequences of SP-CI73T expression...
  4. ncbi request reprint Misfolded BRICHOS SP-C mutant proteins induce apoptosis via caspase-4- and cytochrome c-related mechanisms
    Surafel Mulugeta
    Pulmonary, Allergy, and Critical Care Division, Univ of Pennsylvania School of Medicine, Vernon and Shirley Hill Pavilion, Suite H418, 380 South Univ Ave, Philadelphia, PA 19104, USA
    Am J Physiol Lung Cell Mol Physiol 293:L720-9. 2007
    ..These results suggest common cellular responses, including initiation of cell-death signaling pathways, to these lung disease-associated BRISPC proteins...
  5. pmc A surfactant protein C precursor protein BRICHOS domain mutation causes endoplasmic reticulum stress, proteasome dysfunction, and caspase 3 activation
    Surafel Mulugeta
    Pulmonary and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    Am J Respir Cell Mol Biol 32:521-30. 2005
    ....
  6. ncbi request reprint Processing of surfactant protein C requires a type II transmembrane topology directed by juxtamembrane positively charged residues
    Surafel Mulugeta
    Lung Epithelial Cell Biology Laboratories, Pulmonary and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
    J Biol Chem 278:47979-86. 2003
    ..Moreover this study provides a likely precedent for a mechanism in disorders associated with mutations in the membrane-flanking region of integral membrane proteins...
  7. ncbi request reprint Nonspecific interstitial pneumonia, alveolar proteinosis, and abnormal proprotein trafficking resulting from a spontaneous mutation in the surfactant protein C gene
    Paul A Stevens
    Pulmonary and Critical Care Division, University of Pennsylvania School of Medicine, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
    Pediatr Res 57:89-98. 2005
    ..We propose that, similar to other storage disorders, lung injury results from induction of a toxic gain of function induced by the mutant product that is subject to genetic modifiers and environmental influences...
  8. pmc A nonaggregating surfactant protein C mutant is misdirected to early endosomes and disrupts phospholipid recycling
    Michael F Beers
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Traffic 12:1196-210. 2011
    ..Our data provide evidence for a novel cellular mechanism for conformational protein-associated diseases and suggest a paradigm for mistargeted proteins involved in the disruption of the endosomal/lysosomal sorting machinery...
  9. ncbi request reprint Deletion of exon 4 from human surfactant protein C results in aggresome formation and generation of a dominant negative
    Wen Jing Wang
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Cell Sci 116:683-92. 2003
    ..The heterotypic oligomerization of hSP-C(1-197) and hSP-C(deltaExon4) provides a molecular mechanism for the dominant-negative effect observed in vivo...
  10. pmc Anterograde transport of surfactant protein C proprotein to distal processing compartments requires PPDY-mediated association with Nedd4 ubiquitin ligases
    Adam Kotorashvili
    Surfactant Biology Laboratories, Department of Medicine, University of Pennsylvania School of Medicine, and Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Biol Chem 284:16667-78. 2009
    ..We speculate that the Nedd4/proSP-C tandem is part of a larger protein complex containing a ubiquitinated component that further directs its transport...
  11. pmc A novel conserved targeting motif found in ABCA transporters mediates trafficking to early post-Golgi compartments
    Michael F Beers
    Department of Medicine, Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, Philadelphia, PA, USA
    J Lipid Res 52:1471-82. 2011
    ....
  12. ncbi request reprint Biosynthesis of surfactant protein C (SP-C). Sorting of SP-C proprotein involves homomeric association via a signal anchor domain
    Wen Jing Wang
    Lung Epithelial Cell Biology Laboratories, Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:19929-37. 2002
    ..We speculate that heterotypic oligomerization of wild type with SP-C folding mutants produces a dominant negative thus contributing to the pathology of chronic lung disease associated with patients heterozygous for mutant SP-C alleles...
  13. ncbi request reprint Identification of LBM180, a lamellar body limiting membrane protein of alveolar type II cells, as the ABC transporter protein ABCA3
    Surafel Mulugeta
    Institute for Environmental Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:22147-55. 2002
    ....
  14. pmc Multiple ways to die: delineation of the unfolded protein response and apoptosis induced by Surfactant Protein C BRICHOS mutants
    Jean Ann Maguire
    Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4539, United States
    Int J Biochem Cell Biol 44:101-12. 2012
    ....
  15. pmc Endoplasmic reticulum stress induced by surfactant protein C BRICHOS mutants promotes proinflammatory signaling by epithelial cells
    Jean Ann Maguire
    Surfactant Biology Laboratories, Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    Am J Respir Cell Mol Biol 44:404-14. 2011
    ..Taken together, the results support the role of JNK signaling in mediating SP-C BRICHOS-induced cytokine release, and provide a link between SP-C BRICHOS mutants and proinflammatory cytokine signaling...
  16. ncbi request reprint Surfactant protein C biosynthesis and its emerging role in conformational lung disease
    Michael F Beers
    Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6061, USA
    Annu Rev Physiol 67:663-96. 2005
    ....

Research Grants4

  1. ABCA3: Biosynthesis, Trafficking, and Cellular Responses in Health and Disease
    Surafel Mulugeta; Fiscal Year: 2009
    ..We believe the knowledge gained from this project will have a broad application not only toward a better understanding of lung pathogenesis but will offer insights for targeted therapeutic intervention. ..
  2. ABCA3: Biosynthesis, Trafficking, and Cellular Responses in Health and Disease
    Surafel Mulugeta; Fiscal Year: 2010
    ..We believe the knowledge gained from this project will have a broad application not only toward a better understanding of lung pathogenesis but will offer insights for targeted therapeutic intervention. ..
  3. ABCA3: Biosynthesis, Trafficking, and Cellular Responses in Health and Disease
    Surafel Mulugeta; Fiscal Year: 2009
    ..We believe the knowledge gained from this project will have a broad application not only toward a better understanding of lung pathogenesis but will offer insights for targeted therapeutic intervention. ..