Benoit H Mulsant

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Correlates of anticholinergic activity in patients with dementia and psychosis treated with risperidone or olanzapine
    Benoit H Mulsant
    Western Psychiatric Institute and Clinic, Department of Psychiatry, Division of Geriatric Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 65:1708-14. 2004
  2. ncbi Serum anticholinergic activity and cognition in patients with moderate-to-severe dementia
    Marci L Chew
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 13:535-8. 2005
  3. ncbi Achieving long-term optimal outcomes in geriatric depression and anxiety
    Benoit H Mulsant
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    CNS Spectr 8:27-34. 2003
  4. ncbi Persistence of neuropsychologic deficits in the remitted state of late-life depression
    Rishi K Bhalla
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Geriatr Psychiatry 14:419-27. 2006
  5. ncbi Impact of prior treatment exposure on response to antidepressant treatment in late life
    James D Tew
    Advanced Center for Interventions and Services Research in Late-Life Mood Disorders, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:957-65. 2006
  6. ncbi Outcomes of late-life anxiety disorders during 32 weeks of citalopram treatment
    Stephen Blank
    Intervention Research Center for Late-Life Mood Disorders, The Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 67:468-72. 2006
  7. ncbi Residual symptoms and recurrence during maintenance treatment of late-life depression
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, United States
    J Affect Disord 103:77-82. 2007
  8. ncbi Recovery from major depression in older adults receiving augmentation of antidepressant pharmacotherapy
    Mary Amanda Dew
    Department of Psychiatry, University of Pittsburgh School of Medicine and Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 164:892-9. 2007
  9. ncbi Late-onset major depression: clinical and treatment-response variability
    Henry C Driscoll
    Intervention Research Center for Late-Life Mood Disorders, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 20:661-7. 2005
  10. ncbi Pilot study of augmentation with aripiprazole for incomplete response in late-life depression: getting to remission
    Meera Sheffrin
    Advanced Center in Interventions and Services Research for Late Life Mood Disorders ACISR LLMD and the John A Hartford Center of Excellence in Geriatric Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 70:208-13. 2009

Collaborators

Detail Information

Publications95

  1. ncbi Correlates of anticholinergic activity in patients with dementia and psychosis treated with risperidone or olanzapine
    Benoit H Mulsant
    Western Psychiatric Institute and Clinic, Department of Psychiatry, Division of Geriatric Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 65:1708-14. 2004
    ..Older individuals with dementia are highly sensitive to the effects of muscarinic receptor blockade...
  2. ncbi Serum anticholinergic activity and cognition in patients with moderate-to-severe dementia
    Marci L Chew
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 13:535-8. 2005
    ..The authors investigated the association between serum anticholinergic activity (SAA) and cognitive performance in a group of patients with moderate-to-severe dementia...
  3. ncbi Achieving long-term optimal outcomes in geriatric depression and anxiety
    Benoit H Mulsant
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    CNS Spectr 8:27-34. 2003
    ....
  4. ncbi Persistence of neuropsychologic deficits in the remitted state of late-life depression
    Rishi K Bhalla
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Geriatr Psychiatry 14:419-27. 2006
    ..In addition, a substantial proportion of older depressed individuals who are cognitively intact when depressed are likely to be impaired one year later, although their depression has remitted...
  5. ncbi Impact of prior treatment exposure on response to antidepressant treatment in late life
    James D Tew
    Advanced Center for Interventions and Services Research in Late-Life Mood Disorders, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:957-65. 2006
    ..Most TR and TI patients eventually respond, but TR patients may require more intensive and longer courses of treatment than TI and TN patients...
  6. ncbi Outcomes of late-life anxiety disorders during 32 weeks of citalopram treatment
    Stephen Blank
    Intervention Research Center for Late-Life Mood Disorders, The Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 67:468-72. 2006
    ..CONCLUSIONS: In this 32-week study of citalopram for elderly persons with anxiety disorders, 60% responded. Those who received a full course of treatment experience significant improvements in quality of life and sleep quality...
  7. ncbi Residual symptoms and recurrence during maintenance treatment of late-life depression
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, United States
    J Affect Disord 103:77-82. 2007
    ..Our study assesses the impact of these residual symptoms on the risk of recurrence during maintenance treatment of late-life depression...
  8. ncbi Recovery from major depression in older adults receiving augmentation of antidepressant pharmacotherapy
    Mary Amanda Dew
    Department of Psychiatry, University of Pittsburgh School of Medicine and Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 164:892-9. 2007
    ..The authors examined likelihood, speed, and predictors of recovery in older adults receiving augmentation pharmacotherapy after inadequate response to standardized treatment with paroxetine plus interpersonal psychotherapy...
  9. ncbi Late-onset major depression: clinical and treatment-response variability
    Henry C Driscoll
    Intervention Research Center for Late-Life Mood Disorders, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 20:661-7. 2005
    ..Further study of biological, neuropsychologic, and psychosocial correlates of late-onset, recurrent depression is needed...
  10. ncbi Pilot study of augmentation with aripiprazole for incomplete response in late-life depression: getting to remission
    Meera Sheffrin
    Advanced Center in Interventions and Services Research for Late Life Mood Disorders ACISR LLMD and the John A Hartford Center of Excellence in Geriatric Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 70:208-13. 2009
    ....
  11. ncbi Geriatric depression treatment in nonresponders to selective serotonin reuptake inhibitors
    Ellen M Whyte
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 65:1634-41. 2004
    ....
  12. ncbi The nature and determinants of neuropsychological functioning in late-life depression
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Gen Psychiatry 61:587-95. 2004
    ..Further studies of neuropsychological functioning in remitted LLD patients are needed to parse episode-related and persistent factors and to relate them to underlying neural dysfunction...
  13. ncbi Which symptoms predict recurrence of depression in women treated with maintenance interpersonal psychotherapy?
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 25:1060-6. 2008
    ..We therefore examined the impact of persistent symptoms, including mood, insomnia, and anxiety symptoms, on time to recurrence in women receiving maintenance interpersonal psychotherapy (IPT-M) for recurrent depression...
  14. ncbi Good treatment outcomes in late-life depression with comorbid anxiety
    Eric J Lenze
    The Intervention Research Center in Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Affect Disord 77:247-54. 2003
    ..This study evaluated the impact of comorbid anxiety on response, dropouts, and side effects, in elderly subjects treated for depression...
  15. ncbi Maintenance treatment of major depression in old age
    Charles F Reynolds
    Advanced Center for Intervention and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    N Engl J Med 354:1130-8. 2006
    ..Elderly patients with major depression, including those having a first episode, are at high risk for recurrence of depression, disability, and death...
  16. ncbi Reducing suicidal ideation and depression in older primary care patients: 24-month outcomes of the PROSPECT study
    George S Alexopoulos
    Department of Psychiatry, Weill Cornell Medical College, 21 Bloomingdale Rd, White Plains, NY 10605, USA
    Am J Psychiatry 166:882-90. 2009
    ..This is the first report of outcomes over a 2-year period...
  17. ncbi Effect of comorbid anxiety on treatment response and relapse risk in late-life depression: controlled study
    Carmen Andreescu
    Western Psychiatric Institute and Clinic, 3811 O Hara Street, Room E 823, Pittsburgh, PA15213, USA
    Br J Psychiatry 190:344-9. 2007
    ..Comorbid anxiety is common in depressive disorders in both middle and late life, and it affects response to antidepressant treatment...
  18. ncbi Maintenance treatment of depression in old age: a randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapy
    Charles F Reynolds
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 68:51-60. 2011
    ..Cognitive impairment in late-life depression is a core feature of the illness...
  19. ncbi Cognition in older adults with bipolar disorder versus major depressive disorder
    Ariel G Gildengers
    Department of Psychiatry, University of Pittsburgh School of Medicine Department of Occupational Therapy, University of Pittsburgh School of Rehabilitation Sciences, Pittsburgh, PA 15213, USA
    Bipolar Disord 14:198-205. 2012
    ..The purpose of this study was to investigate for the first time the similarities and differences in the cognitive function of older adults with BD and MDD that may shed light on mechanisms of cognitive decline...
  20. ncbi A double-blind randomized controlled trial of olanzapine plus sertraline vs olanzapine plus placebo for psychotic depression: the study of pharmacotherapy of psychotic depression (STOP-PD)
    Barnett S Meyers
    Department of Psychiatry, Weill Medical College of Cornell University and New York Presbyterian Hospital, Westchester Division, White Plains, New York 10605, USA
    Arch Gen Psychiatry 66:838-47. 2009
    ..Evidence for the efficacy of combination pharmacotherapy has been limited and without positive trials in geriatric patients with major depression (MD) with psychotic features...
  21. ncbi Cardiovascular changes associated with venlafaxine in the treatment of late-life depression
    Ellyn M Johnson
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:796-802. 2006
    ..Systematic monitoring of cardiovascular parameters during treatment with venlafaxine-XR should be strongly recommended, especially in the elderly...
  22. ncbi Treating depression to remission in older adults: a controlled evaluation of combined escitalopram with interpersonal psychotherapy versus escitalopram with depression care management
    Charles F Reynolds
    Department of Psychiatry, Advanced Center for Interventions and Services Research for Late Life Mood Disorders, Clinical Trials Management Unit, University of Pittsburgh School of Medicine, PA, USA
    Int J Geriatr Psychiatry 25:1134-41. 2010
    ....
  23. ncbi Executive functioning, illness course, and relapse/recurrence in continuation and maintenance treatment of late-life depression: is there a relationship?
    Meryl A Butters
    Intervention Research Center for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh Medical Center, USA
    Am J Geriatr Psychiatry 12:387-94. 2004
    ..The authors tested the hypothesis that impaired executive functioning leads to high rates of relapse and recurrence in late-life depression...
  24. ncbi A 12-week open-label pilot study of donepezil for cognitive functioning and instrumental activities of daily living in late-life bipolar disorder
    Ariel G Gildengers
    The Advanced Center for Intervention and Services Research, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 23:693-8. 2008
    ..To determine whether donepezil is effective in enhancing cognitive functioning and instrumental activities of daily living (IADLs) in older adults with bipolar disorder...
  25. ncbi What is the optimal duration of a short-term antidepressant trial when treating geriatric depression?
    Benoit H Mulsant
    Advanced Center in Intervention and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychopharmacol 26:113-20. 2006
    ..To determine the optimal duration of an antidepressant trial in elderly patients, the authors examined the probability of eventually responding to treatment based on early improvement...
  26. ncbi Pressure ulcer prevention in black and white nursing home residents: A QI initiative of enhanced ability, incentives, and management feedback
    Jules Rosen
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Adv Skin Wound Care 19:262-8. 2006
    ..The education intervention effectively reduced the rate of pressure ulcers for all residents and eliminated the racial disparity noted during the baseline period...
  27. ncbi High worry severity is associated with poorer acute and maintenance efficacy of antidepressants in late-life depression
    Carmen Andreescu
    The Advanced Center in Interventions and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 26:266-72. 2009
    ..We explored the impact of the dimensions of worry and panic on acute and maintenance treatment outcomes in LLD...
  28. ncbi Medical burden in late-life bipolar and major depressive disorders
    Ariel G Gildengers
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, The Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 16:194-200. 2008
    ..The authors compare medical burden in elderly patients with bipolar disorder with that in those with major depressive disorder...
  29. ncbi The Mood Disorder Burden Index: a scale for assessing the burden of caregivers to adults with unipolar or bipolar disorder
    Lynn M Martire
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States University Center for Social and Urban Research, Pittsburgh, PA, United States
    Psychiatry Res 168:67-77. 2009
    ..It will be important for future research to administer the MDBI to caregivers of middle-aged and older patients as well as those receiving treatment through inpatient settings or community outpatient clinics...
  30. ncbi The longitudinal course of cognition in older adults with bipolar disorder
    Ariel G Gildengers
    Intervention Research Center for Late life Mood Disorders and the Advanced Center for Intervention and Services Research, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Bipolar Disord 11:744-52. 2009
    ....
  31. ncbi Estimating treatment effects from longitudinal clinical trial data with missing values: comparative analyses using different methods
    Patricia R Houck
    Department of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and Clinic, UPMC Health System, Thomas Detre Hall, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Psychiatry Res 129:209-15. 2004
    ..No significant treatment differences were found. We conclude that attention to the missing-data mechanism should be an integral part in analysis of clinical trial data...
  32. ncbi Trajectories of treatment response in late-life depression: psychosocial and clinical correlates
    Ariel G Gildengers
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Clin Psychopharmacol 25:S8-13. 2005
    ..Further study focusing on risk factors associated with slower response may help optimize treatment in elderly patients who do not respond quickly to first-line therapies...
  33. ncbi Cognitive functioning and instrumental activities of daily living in late-life bipolar disorder
    Ariel G Gildengers
    Advanced Center for Intervention and Services Research for Late Life Disorders, Department of Psychiatry, Bipolar Disorder Center for Pennsylvanians, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 15:174-9. 2007
    ..The authors report on the relationship between cognitive functioning and instrumental activities of daily living (IADLs) in elderly, clinically euthymic adults with bipolar disorder...
  34. ncbi Speed of improvement in sleep disturbance and anxiety compared with core mood symptoms during acute treatment of depression in old age
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:550-4. 2006
    ..CONCLUSIONS: Anxiety symptoms tend to persist in patients with late-life depression...
  35. ncbi Bipolar disorder center for Pennsylvanians: implementing an effectiveness trial to improve treatment for at-risk patients
    David J Kupfer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Psychiatr Serv 60:888-97. 2009
    ..This report highlights the methods used to recruit, screen, and enroll a cohort of difficult-to-recruit individuals with bipolar disorder...
  36. ncbi Remission in depressed geriatric primary care patients: a report from the PROSPECT study
    George S Alexopoulos
    Department of Psychiatry, Weill Medical College of Cornell University, New York, USA
    Am J Psychiatry 162:718-24. 2005
    ..In addition, it sought to identify risk factors for nonremission that could guide treatment planning and referral to care managers or specialists...
  37. ncbi Efficacy and tolerability of citalopram in the treatment of late-life anxiety disorders: results from an 8-week randomized, placebo-controlled trial
    Eric J Lenze
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine and VA Healthcare System, PA, USA
    Am J Psychiatry 162:146-50. 2005
    ..Anxiety disorders are highly prevalent in elderly persons. However, to date, the efficacy of selective serotonin reuptake inhibitors (SSRIs) for the treatment of anxiety disorders in this age group has not been established...
  38. ncbi Serotonin transporter triallelic genotype and response to citalopram and risperidone in dementia with behavioral symptoms
    Alexandre Y Dombrovski
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Advanced Center for Interventions and Services Research in Late Life Mood Disorders, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Int Clin Psychopharmacol 25:37-45. 2010
    ..Our findings of intolerance of a second-generation antipsychotics and persistence of psychosis in patients with low-expression alleles needs to be replicated...
  39. ncbi Cognitive impairment in late-life generalized anxiety disorder
    Rose C Mantella
    Advanced Center in Interventions and Services Research for Late Life Mood Disorders and the John A Hartford Center of Excellence in Geriatric Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Geriatr Psychiatry 15:673-9. 2007
    ..This study sought to characterize cognitive functioning in elderly patients with generalized anxiety disorder (GAD), as compared with normal comparison subjects and patients with major depression...
  40. ncbi Risk factors for falls during treatment of late-life depression
    Jin H Joo
    Intervention Research Center for Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychiatry 63:936-41. 2002
    ..Additionally, augmenting paroxetine with bupropion may also increase the risk of falls, and this medication combination should be used with caution in elderly patients...
  41. ncbi Multisite, open-label, prospective trial of lamotrigine for geriatric bipolar depression: a preliminary report
    Martha Sajatovic
    Department of Psychiatry, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, OH, USA
    Bipolar Disord 13:294-302. 2011
    ..This is a multisite, 12-week, open-label trial of lamotrigine augmentation in 57 older adults (≥ 60 years; mean ± SD age = 66.5 ± 6.7 years) with either type I or type II bipolar depression...
  42. ncbi Comorbid anxiety disorder in late life depression: association with memory decline over four years
    Alison K DeLuca
    The Intervention Research Center for Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 20:848-54. 2005
    ..The data also suggest that anxiety disorders with an onset later in life may be associated with cognitive impairment, although further study is needed to confirm this finding...
  43. ncbi Predicting 6-week treatment response to escitalopram pharmacotherapy in late-life major depressive disorder
    Ramin Saghafi
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
    Int J Geriatr Psychiatry 22:1141-6. 2007
    ..This study aims to characterize sociodemographic, clinical, and neuropsychologic correlates of full, partial, and non-response to escitalopram monotherapy of unipolar MDD in later life...
  44. ncbi Generalized anxiety disorder in late life: lifetime course and comorbidity with major depressive disorder
    Eric J Lenze
    Intervention Research Center in Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 13:77-80. 2005
    ..The authors assessed the course and comorbidity of late-life GAD and MDD...
  45. ncbi A pilot study of standardized treatment in geriatric bipolar disorder
    Ariel G Gildengers
    Intervention Research Center for Late-Life Mood Disorders, Department of Psychiatry, the Bipolar Disorder Center for Pennsylvanians, University of Pittsburgh School of Medicine 15213, USA
    Am J Geriatr Psychiatry 13:319-23. 2005
    ..CONCLUSIONS: Treating older adults with bipolar disorder under standardized treatment is feasible and is associated with low symptom levels. However, most older adults with bipolar disorder do not experience sustained recovery...
  46. ncbi Relapse during continuation pharmacotherapy after acute response to ECT: a comparison of usual care versus protocolized treatment
    James D Tew
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA USA
    Ann Clin Psychiatry 19:1-4. 2007
    ..quot; This study compares the effectiveness of usual care versus protocolized pharmacotherapy in preventing relapse following ECT...
  47. ncbi An open-label pilot study of acetylcholinesterase inhibitors to promote functional recovery in elderly cognitively impaired stroke patients
    Ellen M Whyte
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63108, USA
    Cerebrovasc Dis 26:317-21. 2008
    ..We investigated the feasibility of using acetylcholinesterase inhibitors in older patients with acute post-stroke cognitive impairment and examined their effects on functional recovery...
  48. ncbi Incomplete response in late-life depression: getting to remission
    Eric J Lenze
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO, USA
    Dialogues Clin Neurosci 10:419-30. 2008
    ..Such studies may advance us toward the goal of personalized treatment in late-life depression...
  49. ncbi Correlates of treatment response in depressed older adults with bipolar disorder
    Ariel Gildengers
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    J Geriatr Psychiatry Neurol 25:37-42. 2012
    ..To identify baseline clinical factors associated with acute treatment response in depressed older adults with bipolar disorder (BD) receiving lamotrigine...
  50. ncbi Maintenance treatment for old-age depression preserves health-related quality of life: a randomized, controlled trial of paroxetine and interpersonal psychotherapy
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 55:1325-32. 2007
    ..To determine whether maintenance antidepressant pharmacotherapy and interpersonal psychotherapy sustain gains in health-related quality of life (HR-QOL) achieved during short-term treatment in older patients with depression...
  51. ncbi Clinical outcome of ECT in patients with major depression and comorbid borderline personality disorder
    Ulrike Feske
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 161:2073-80. 2004
    ..The authors compared the acute outcome of ECT in depressed patients with borderline personality disorder, with personality disorders other than borderline personality disorder, and with no personality disorder...
  52. ncbi Persisting low use of antipsychotics in the treatment of major depressive disorder with psychotic features
    Carmen Andreescu
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 68:194-200. 2007
    ..We assessed the extent to which the pharmacotherapy received by patients with MD-Psy under usual care conforms to these recommendations...
  53. ncbi Empirically derived decision trees for the treatment of late-life depression
    Carmen Andreescu
    Advanced Center in Intervention and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
    Am J Psychiatry 165:855-62. 2008
    ..The aim of this analysis was to develop a clinically useful algorithm that would allow clinicians to predict which patients will likely respond to treatment and thereby guide clinical decision making...
  54. ncbi Somatic symptoms of depression in elderly patients with medical comorbidities
    Rebecca A Drayer
    Center for Research on Health Care, Division of General Internal Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 20:973-82. 2005
    ..Rating scales emphasizing somatic symptoms associated with depression may provide a more accurate measure of depression severity than those excluding such symptoms...
  55. ncbi Reducing suicidal ideation and depressive symptoms in depressed older primary care patients: a randomized controlled trial
    Martha L Bruce
    Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY, USA
    JAMA 291:1081-91. 2004
    ..The intervention's effectiveness in reducing suicidal ideation, regardless of depression severity, reinforces its role as a prevention strategy to reduce risk factors for suicide in late life...
  56. ncbi Discrepancies in information provided to primary care physicians by patients with and without dementia: the Steel Valley Seniors Survey
    Mary Ganguli
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Am J Geriatr Psychiatry 14:446-55. 2006
    ..The objective of this study was to examine associations between discrepancies in health information provided to primary care providers and severity of impairment in older patients with and without dementia...
  57. ncbi Occurrence and course of suicidality during short-term treatment of late-life depression
    Katalin Szanto
    Department of Psychiatry, The Intervention Research Center for the Study of Late-Life Mood Disorders, Pittsburgh, PA, USA
    Arch Gen Psychiatry 60:610-7. 2003
    ..Suicidal elderly persons with depression require special attention during depression treatment because they have a lower response rate and need a longer time to respond...
  58. ncbi Web-based training and interrater reliability testing for scoring the Hamilton Depression Rating Scale
    Jules Rosen
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States
    Psychiatry Res 161:126-30. 2008
    ..The advantages and limitations of using interactive video technology to improve the quality of clinical trials are discussed...
  59. ncbi Body pain and treatment response in late-life depression
    Jordan F Karp
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 13:188-94. 2005
    ..They hypothesized that higher levels of body pain would predict a longer time to and lower likelihood of response, and increased levels of suicidal ideation...
  60. ncbi Neuropathologic correlates of late-onset major depression
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neuropsychopharmacology 29:2242-50. 2004
    ..These preliminary findings suggest that AD is the predominant neuropathologic condition in LLMD subjects with dementia. Further assessment of the role of comorbid cerebrovascular disease and comorbid DLB is needed...
  61. ncbi Does education moderate neuropsychological impairment in late-life depression?
    Rishi K Bhalla
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
    Int J Geriatr Psychiatry 20:413-7. 2005
    ..This study examined whether educational level influences the degree of neuropsychological impairment associated with late-life depression...
  62. ncbi Predictors of remission after electroconvulsive therapy in unipolar major depression
    Alexandre Y Dombrovski
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    J Clin Psychiatry 66:1043-9. 2005
    ..CONCLUSIONS: In patients with major depression, lower rates of remission after acute ECT are associated with medication resistance and chronicity, but not with age or burden of physical illness...
  63. ncbi Accelerating symptom-reduction in late-life depression: a double-blind, randomized, placebo-controlled trial of sleep deprivation
    Charles F Reynolds
    Intervention Research Center for Late Life Mood Disorders IRC LLMD, Univ of Pittsburgh School of Medicine, 3811 O Hara Street, E 113521, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 13:353-8. 2005
    ..Authors tested the hypothesis that one night of total sleep deprivation (TSD) would accelerate antidepressant response to paroxetine, as compared with TSD+placebo (PBO) and paroxetine-alone, in late-life major depression...
  64. ncbi Emergence, persistence, and resolution of suicidal ideation during treatment of depression in old age
    Katalin Szanto
    University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, Pennsylvania 15213, United States
    J Affect Disord 98:153-61. 2007
    ..To determine the rate and clinical correlates of emergent, persistent, and resolved suicidal ideation during treatment of major depression in the elderly...
  65. ncbi A delusion assessment scale for psychotic major depression: Reliability, validity, and utility
    Barnett S Meyers
    Department of Psychiatry, Weill Medical College of Cornell University, New York Presbyterian Hospital Westchester Division, West Chester, New York 10605, USA
    Biol Psychiatry 60:1336-42. 2006
    ..The development and assessment of the Delusional Assessment Scale (DAS) are described...
  66. ncbi Depression after stroke: a prospective epidemiological study
    Ellen M Whyte
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 52:774-8. 2004
    ....
  67. ncbi Clinically relevant behaviors in elderly hip fracture inpatients
    Helen H Dorra
    University of Pittsburgh School of Medicine, USA
    Int J Psychiatry Med 32:249-59. 2002
    ..It is recommended that staff observations be routinely added to mental health evaluations. Additionally, routine mental health screening and required staff documentation of behaviors would improve case detection rate...
  68. ncbi Course and rate of antidepressant response in the very old
    Ariel G Gildengers
    The Intervention Research Centers for Late-Life and Mid-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Affect Disord 69:177-84. 2002
    ..RESULTS: Older-old patients responded as quickly and successfully as the young- and middle-old. CONCLUSIONS: Major depression in the very old can be treated as successfully as in early old age...
  69. ncbi A model of anticholinergic activity of atypical antipsychotic medications
    Marci L Chew
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Schizophr Res 88:63-72. 2006
    ..CONCLUSIONS: Therapeutic doses of clozapine, olanzapine, and, to a lesser extent, quetiapine are associated with clinically relevant AA...
  70. ncbi Response speed and rate of remission in primary and specialty care of elderly patients with depression
    Leslie Thomas
    Intervention Research Center for Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 10:583-91. 2002
    ..CONCLUSION: Notwithstanding these differences in speed and rate of symptom resolution, good treatment can work well in geriatric depression in the primary care sector...
  71. ncbi APOE is associated with age-of-onset, but not cognitive functioning, in late-life depression
    Meryl A Butters
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 18:1075-81. 2003
    ..We also predicted that APOE4 allele frequency would be increased among subjects with LLD...
  72. ncbi Serum anticholinergic activity in a community-based sample of older adults: relationship with cognitive performance
    Benoit H Mulsant
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Arch Gen Psychiatry 60:198-203. 2003
    ..To our knowledge, there has not yet been any systematic study of the prevalence of SAA and its effect on cognition in a community-based population...
  73. ncbi A randomized comparison of high-charge right unilateral electroconvulsive therapy and bilateral electroconvulsive therapy in older depressed patients who failed to respond to 5 to 8 moderate-charge right unilateral treatments
    James D Tew
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 63:1102-5. 2002
    ..Larger future studies will be needed to compare clinical response in patients switched from moderate-dose RUL ECT to higher-dose RUL or to BL ECT...
  74. ncbi Verification of scale sub-domains in elderly patients with dementia: a confirmatory factor-analytic approach
    Kari B Kastango
    Department of Biostatistics, University of Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 10:706-14. 2002
    ..CONCLUSION: Authors advocate the use of a confirmatory factor-analytic approach to verify scale sub-domains in other, more widely used rating scales for patients with dementia...
  75. ncbi Rates and predictors of mortality in an aging, rural, community-based cohort: the role of depression
    Mary Ganguli
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213 2593, USA
    Arch Gen Psychiatry 59:1046-52. 2002
    ..Depression, functional disability, cognitive impairment, and self-rated health all predict mortality in the elderly population. There is no consensus on their relative contributions when examined together...
  76. ncbi Anxiety symptoms in elderly patients with depression: what is the best approach to treatment?
    Eric J Lenze
    Department of Psychiatry, Intervention Research Center in Late Life Mood Disorders, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Drugs Aging 19:753-60. 2002
    ..Therefore, optimism should be maintained when treating the depressed elderly individual, even when comorbid anxiety is present...
  77. ncbi The relationship of bipolar disorder lifetime duration and vascular burden to cognition in older adults
    Ariel G Gildengers
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Bipolar Disord 12:851-8. 2010
    ..We also examine whether there are negative, synergistic effects between lifetime duration of BD and vascular disease burden on cognition...
  78. ncbi Risperidone and 9-hydroxyrisperidone concentrations are not dependent on age or creatinine clearance among elderly subjects
    Rae Ann Maxwell
    Pharmacy Department, Western Psychiatric Institute and Clinic, VA Pittsburgh Health System, Pennsylvania, USA
    J Geriatr Psychiatry Neurol 15:77-81. 2002
    ..These results were unchanged when concentrations were corrected for total daily risperidone dose. Among elderly subjects, risperidone and 9-OH clearance do not decline with increasing age or declining CrCl...
  79. ncbi The evidence for electroconvulsive therapy (ECT) in the treatment of severe late-life depression. ECT: the preferred treatment for severe depression in late life
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, USA
    Int Psychogeriatr 19:10-4, 27-35; discussion 24-6. 2007
  80. ncbi Cognitive functioning in late-life bipolar disorder
    Ariel G Gildengers
    Information Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Psychiatry 161:736-8. 2004
    ..This study characterized cognitive functioning in elderly patients with bipolar disorder...
  81. ncbi Identification of suicidal ideation and prevention of suicidal behaviour in the elderly
    Katalin Szanto
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Drugs Aging 19:11-24. 2002
    ..Prevention and treatment trials are underway to detect the effectiveness of improved treatment of depression by primary care physicians as a means of reducing the prevalence of depressive symptoms, hopelessness and suicidal ideation...
  82. ncbi Population pharmacokinetics as a method to detect variable risperidone exposure in patients suffering from dementia with behavioral disturbances
    Robert R Bies
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Geriatr Pharmacother 3:87-91. 2005
    ..This study was intended to compare the consistency of risperidone exposure in patients who have dementia and behavioral disturbances treated in a psychiatric hospital versus a community care setting...
  83. ncbi Somatic symptoms in late-life anxiety: treatment issues
    Eric J Lenze
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Geriatr Psychiatry Neurol 18:89-96. 2005
    ..However, additional treatment and integrated approaches are likely to be necessary for many such individuals...
  84. ncbi Correlates of suicidality among patients with psychotic depression
    Ayal Schaffer
    Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Suicide Life Threat Behav 38:403-14. 2008
    ..These findings reinforce the evidence that patients with psychotic depression are at high risk for suicide and underscore the importance of examining correlates of suicidality specific to patients with psychotic depression...
  85. ncbi Statistical analysis of longitudinal psychiatric data with dropouts
    Sati Mazumdar
    Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    J Psychiatr Res 41:1032-41. 2007
    ....
  86. ncbi The effects of memory, attention, and executive dysfunction on outcomes of depression in a primary care intervention trial: the PROSPECT study
    Hillary R Bogner
    Department of Family Medicine and Community Health, University of Pennsylvania, Philadelphia, PA 19104, USA
    Int J Geriatr Psychiatry 22:922-9. 2007
    ..To describe the influence of domains of cognition on remission and response of depression in an intervention trial among older primary care patients...
  87. ncbi Glucose metabolic response to total sleep deprivation, recovery sleep, and acute antidepressant treatment as functional neuroanatomic correlates of treatment outcome in geriatric depression
    Gwenn S Smith
    Department of Psychiatry Research, Hillside Hospital of the North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Am J Geriatr Psychiatry 10:561-7. 2002
    ....
  88. ncbi Onset of confusion in the context of late-life depression
    Benoit H Mulsant
    Department of Psychiatry University of Toronto, Toronto, Ont
    J Psychiatry Neurosci 32:152. 2007
  89. ncbi A double-blind comparison of citalopram and risperidone for the treatment of behavioral and psychotic symptoms associated with dementia
    Bruce G Pollock
    Rotman Research Institute at Baycrest, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 15:942-52. 2007
    ..To compare citalopram and risperidone for the treatment of psychotic symptoms and agitation associated with dementia, with a priori hypotheses that risperidone would be more efficacious for psychosis and citalopram for agitation...
  90. ncbi Biomarkers in geriatric psychiatry
    Eric J Lenze
    Am J Geriatr Psychiatry 15:827-31. 2007
  91. ncbi Serotonin 1A receptor binding and treatment response in late-life depression
    Carolyn Cidis Meltzer
    Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA
    Neuropsychopharmacology 29:2258-65. 2004
    ..Further, this work indicates that dysfunction in autoreceptor activity may play a central role in the mechanisms underlying treatment response to selective serotonin reuptake inhibitors in late-life depression...
  92. ncbi Nature and course of cognitive function in late-life schizophrenia: a systematic review
    Tarek K Rajji
    Department of Psychiatry, University of Toronto, and Geriatric Mental Health Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Schizophr Res 102:122-40. 2008
    ..To systematically review the literature on the nature and course of cognition in late-life schizophrenia (LLS)...
  93. ncbi Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late life
    Dennis S Charney
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 60:664-72. 2003
    ....
  94. ncbi alpha1-acid glycoprotein in late-life depression: relationship to medical burden and genetics
    Opeolu M Adeoye
    Department of Emergency Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    J Geriatr Psychiatry Neurol 16:235-9. 2003
    ..Frequency differences in ORM1 allelic variants apparently did not influence increased AAG concentrations in depressed patients...
  95. ncbi Cognitive and behavioral correlates of low vitamin B12 levels in elderly patients with progressive dementia
    Ellen M Whyte
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Geriatr Psychiatry 10:321-7. 2002
    ..In AD, the prevalence of low vitamin B12 serum levels is consistent with that found in community-dwelling elderly persons in general but is associated with greater overall cognitive impairment...