B H Mulsant

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint A twelve-week, double-blind, randomized comparison of nortriptyline and paroxetine in older depressed inpatients and outpatients
    B H Mulsant
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 9:406-14. 2001
  2. ncbi request reprint Methodological issues in characterizing treatment response in demented patients with behavioral disturbances
    B H Mulsant
    Department of Psychiatry, University of Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 12:537-47. 1997
  3. ncbi request reprint The effects of perphenazine on the concentration of nortriptyline and its hydroxymetabolites in older patients
    B H Mulsant
    Geriatric Psychopharmacology Program, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychopharmacol 17:318-21. 1997
  4. ncbi request reprint Interrater reliability in clinical trials of depressive disorders
    Benoit H Mulsant
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Biostatistics, University of Pittsburgh Health Care System, PA, USA
    Am J Psychiatry 159:1598-600. 2002
  5. ncbi request reprint A double-blind randomized comparison of nortriptyline plus perphenazine versus nortriptyline plus placebo in the treatment of psychotic depression in late life
    B H Mulsant
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychiatry 62:597-604. 2001
  6. ncbi request reprint Serum anticholinergic activity in a community-based sample of older adults: relationship with cognitive performance
    Benoit H Mulsant
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Arch Gen Psychiatry 60:198-203. 2003
  7. ncbi request reprint Pharmacological treatment of depression in older primary care patients: the PROSPECT algorithm
    B H Mulsant
    Intervention Research Center for the Study of Late Life Mood Disorders, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 16:585-92. 2001
  8. ncbi request reprint The 5-HTTPR polymorphism confers liability to a combined phenotype of psychotic and aggressive behavior in Alzheimer disease
    R A Sweet
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
    Int Psychogeriatr 13:401-9. 2001
  9. ncbi request reprint Subjective health measures and acute treatment outcomes in geriatric depression
    E J Lenze
    The Intervention Research Center in Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Int J Geriatr Psychiatry 16:1149-55. 2001
  10. ncbi request reprint Paroxetine versus nortriptyline in the continuation and maintenance treatment of depression in the elderly
    G M Bump
    Intervention Research Center for Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Depress Anxiety 13:38-44. 2001

Collaborators

Detail Information

Publications91

  1. ncbi request reprint A twelve-week, double-blind, randomized comparison of nortriptyline and paroxetine in older depressed inpatients and outpatients
    B H Mulsant
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 9:406-14. 2001
    ....
  2. ncbi request reprint Methodological issues in characterizing treatment response in demented patients with behavioral disturbances
    B H Mulsant
    Department of Psychiatry, University of Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 12:537-47. 1997
    ....
  3. ncbi request reprint The effects of perphenazine on the concentration of nortriptyline and its hydroxymetabolites in older patients
    B H Mulsant
    Geriatric Psychopharmacology Program, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychopharmacol 17:318-21. 1997
    ....
  4. ncbi request reprint Interrater reliability in clinical trials of depressive disorders
    Benoit H Mulsant
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Biostatistics, University of Pittsburgh Health Care System, PA, USA
    Am J Psychiatry 159:1598-600. 2002
    ..The goal of this study was to review the reported methods of rater training, assessment of interrater reliability, and rater drift in clinical trials of treatments for depressive disorders...
  5. ncbi request reprint A double-blind randomized comparison of nortriptyline plus perphenazine versus nortriptyline plus placebo in the treatment of psychotic depression in late life
    B H Mulsant
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychiatry 62:597-604. 2001
    ..To conduct the first randomized study comparing the efficacy of an antidepressant alone versus an antidepressant plus a neuroleptic in the treatment of late-life psychotic depression...
  6. ncbi request reprint Serum anticholinergic activity in a community-based sample of older adults: relationship with cognitive performance
    Benoit H Mulsant
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Arch Gen Psychiatry 60:198-203. 2003
    ..To our knowledge, there has not yet been any systematic study of the prevalence of SAA and its effect on cognition in a community-based population...
  7. ncbi request reprint Pharmacological treatment of depression in older primary care patients: the PROSPECT algorithm
    B H Mulsant
    Intervention Research Center for the Study of Late Life Mood Disorders, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 16:585-92. 2001
    ..However, treatments that are often poorly tolerated by elderly patients are given lower priority than treatments more likely to be tolerated. Similarly, trials that are simpler to implement in primary care are favored...
  8. ncbi request reprint The 5-HTTPR polymorphism confers liability to a combined phenotype of psychotic and aggressive behavior in Alzheimer disease
    R A Sweet
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
    Int Psychogeriatr 13:401-9. 2001
    ..We recently found that AD subjects homozygous for long alleles (l) of an insertion/deletion polymorphism in the promoter region of the serotonin transporter (5-HTTPR) had elevated rates of aggressive behavior...
  9. ncbi request reprint Subjective health measures and acute treatment outcomes in geriatric depression
    E J Lenze
    The Intervention Research Center in Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Int J Geriatr Psychiatry 16:1149-55. 2001
    ..However, successful treatment for depression has been associated with improvement in self-rated health and other health measures...
  10. ncbi request reprint Paroxetine versus nortriptyline in the continuation and maintenance treatment of depression in the elderly
    G M Bump
    Intervention Research Center for Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Depress Anxiety 13:38-44. 2001
    ..Paroxetine and nortriptyline demonstrated similar efficacy in relapse and recurrence prevention in elderly depressed patients over an 18-month period...
  11. ncbi request reprint The 5-HTTPR*S/*L polymorphism and aggressive behavior in Alzheimer disease
    D L Sukonick
    Division of Geriatrics and Neuropsychiatry, Department of Psychiatry, University of Pittsburgh, PA, USA
    Arch Neurol 58:1425-8. 2001
    ....
  12. ncbi request reprint Dual-task performance in depressed geriatric patients
    R D Nebes
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Psychiatry Res 102:139-51. 2001
    ....
  13. ncbi request reprint Influence of serotonin-transporter-linked promoter region polymorphism on platelet activation in geriatric depression
    E M Whyte
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Am J Psychiatry 158:2074-6. 2001
    ..Variations in the serotonin-transporter-linked promoter region (5-HTTLPR) polymorphism may influence the degree of activation. The authors examined the association among depression, platelet activation, and 5-HTTLPR genotype...
  14. ncbi request reprint Serum anticholinergicity in elderly depressed patients treated with paroxetine or nortriptyline
    B G Pollock
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Am J Psychiatry 155:1110-2. 1998
    ..The authors' goal was to compare serum anticholinergicity of 61 elderly depressed patients randomly assigned to double-blind treatment with paroxetine (N=31) or nortriptyline (N=30)...
  15. ncbi request reprint Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression
    B G Pollock
    Intervention Research Center for Late Life Mood Disorders and the Geriatric Psychopharmacology Program, Graduate School of Public Health, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 23:587-90. 2000
    ..Onset of response to nortriptyline was not affected. Allelic variation of 5-HTTLPR may contribute to the variable initial response of patients treated with a selective serotonin reuptake inhibitor...
  16. ncbi request reprint Determinants of spontaneous extrapyramidal symptoms in elderly psychiatric inpatients diagnosed with Alzheimer's disease, major depressive disorder, or psychotic disorders
    R A Sweet
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 10:68-77. 1998
    ..These findings suggest that rigidity is associated with DAT independently of any concurrent psychotic or depressive process, whereas bradykinesia does not appear to be specific to DAT among late-life neuropsychiatric illnesses...
  17. ncbi request reprint The effect of patient and visit characteristics on diagnosis of depression in primary care
    J S Harman
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara St, Suite 430, Pittsburgh, PA, 15213, USA
    J Fam Pract 50:1068. 2001
    ..The purpose of our study was to determine if factors other than the patient' clinical presentation were associated with the likelihood of depression being recognized during a physician office visit...
  18. ncbi request reprint Treatment outcome in suicidal vs. non-suicidal elderly patients
    K Szanto
    Intervention Research Center for the Study of Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Am J Geriatr Psychiatry 9:261-8. 2001
    ..Our data suggest that elderly suicidal patients have an overall favorable treatment outcome. However, treatment response may be more brittle and may require the continuing use of adjunctive medications to prevent early relapse...
  19. ncbi request reprint Treatment as usual (TAU) control practices in the PROSPECT Study: managing the interaction and tension between research design and ethics
    C F Reynolds
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 16:602-8. 2001
    ....
  20. ncbi request reprint Pharmacologic profile of perphenazine's metabolites
    R A Sweet
    Geriatric Psychopharmacology, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Clin Psychopharmacol 20:181-7. 2000
    ..Further exploration of atypical properties of DAPZ should include de novo administration of this metabolite in animal models...
  21. ncbi request reprint Endogenous concentrations of DHEA and DHEA-S decrease with remission of depression in older adults
    T J Fabian
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pennsylvania 15261, USA
    Biol Psychiatry 50:767-74. 2001
    ..CONCLUSIONS: Our data suggest that the decrease in DHEA and DHEA-S in remitters is related to remission of depression rather than to a direct drug effect on steroids, as nonremitters had no change in hormone concentrations...
  22. ncbi request reprint PET imaging of serotonin type 2A receptors in late-life neuropsychiatric disorders
    C C Meltzer
    Department of Radiology, University of Pittsburgh, PA, USA
    Am J Psychiatry 156:1871-8. 1999
    ....
  23. ncbi request reprint Managing late-life depression in primary care practice: a case study of the Health Specialist's role
    H C Schulberg
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 16:577-84. 2001
    ..Evolution of this role and its rewards/stressors during the study's first year are described...
  24. ncbi request reprint Selective serotonin reuptake inhibitors for late-life depression: a comparative review
    L K Solai
    University of Pittsburgh School of Medicine, Pennsylvania, USA
    Drugs Aging 18:355-68. 2001
    ....
  25. ncbi request reprint Nortriptyline in the hospitalized elderly: tolerance and side effect reduction
    J Rosen
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213
    Psychopharmacol Bull 29:327-31. 1993
    ..Patients receiving bethanechol had reduced subjective complaints of anticholinergic side effects and showed improvement on an objective measure of salivary flow...
  26. ncbi request reprint Narrowing the gap in treatment of depression
    J S Harman
    University of Pittsburgh School of Medicine, Pennsylvania, USA
    Int J Psychiatry Med 31:239-53. 2001
    ..The purpose of this study is to assess treatment rates in 1993-1994 and 1996-1997...
  27. ncbi request reprint Antipsychotics in older patients. A safety perspective
    B G Pollock
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pennsylvania, USA
    Drugs Aging 6:312-23. 1995
    ..Prospective and frequent assessments for adverse effects are also essential...
  28. ncbi request reprint Comorbidity of depression and anxiety disorders in later life
    E J Lenze
    Intervention Research Centers in Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 14:86-93. 2001
    ..We also recommend directions for future research in the area of psychiatric comorbidity in late life...
  29. ncbi request reprint The association of late-life depression and anxiety with physical disability: a review of the literature and prospectus for future research
    E J Lenze
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Am J Geriatr Psychiatry 9:113-35. 2001
    ..The authors discuss how these findings inform current concepts of physical disability and discuss the implications for future intervention studies of late-life depression and anxiety disorders...
  30. pmc Two-year course of cognitive function and instrumental activities of daily living in older adults with bipolar disorder: evidence for neuroprogression?
    A G Gildengers
    University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA, USA
    Psychol Med 43:801-11. 2013
    ..We assessed IADLs using a criterion-referenced, performance-based instrument. We employed repeated-measures mixed-effects linear models to examine trajectory of cognitive function. We employed non-parametric tests for analysis of IADLs...
  31. doi request reprint Serotonin-norepinephrine reuptake inhibitor therapy in late-life depression is associated with increased marker of bone resorption
    M L O Shea
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Osteoporos Int 24:1741-9. 2013
    ..Bone resorption increased after antidepressant treatment, which may increase fracture risk...
  32. ncbi request reprint Pressure ulcer prevention in black and white nursing home residents: A QI initiative of enhanced ability, incentives, and management feedback
    Jules Rosen
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Adv Skin Wound Care 19:262-8. 2006
    ..To determine if educating nursing home staff about pressure ulcer prevention reduces the differential risk of pressure ulcer development in black and white nursing home residents...
  33. ncbi request reprint Outcomes of late-life anxiety disorders during 32 weeks of citalopram treatment
    Stephen Blank
    Intervention Research Center for Late Life Mood Disorders, The Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 67:468-72. 2006
    ..Anxiety disorders are common in later life, but little is known about the long-term benefits and risks of pharmacotherapy...
  34. ncbi request reprint A model of anticholinergic activity of atypical antipsychotic medications
    Marci L Chew
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Schizophr Res 88:63-72. 2006
    ..However, it is difficult with the available data to predict the likelihood of anticholinergic effects occurring with various doses of an atypical antipsychotic...
  35. ncbi request reprint Cardiovascular changes associated with venlafaxine in the treatment of late-life depression
    Ellyn M Johnson
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:796-802. 2006
    ..Potential cardiovascular side effects from venlafaxine-XR must be considered when prescribing this medication, especially in geriatric patients, who often present with comorbid medical conditions...
  36. ncbi request reprint A delusion assessment scale for psychotic major depression: Reliability, validity, and utility
    Barnett S Meyers
    Department of Psychiatry, Weill Medical College of Cornell University, New York Presbyterian Hospital Westchester Division, West Chester, New York 10605, USA
    Biol Psychiatry 60:1336-42. 2006
    ..The development and assessment of the Delusional Assessment Scale (DAS) are described...
  37. ncbi request reprint Impact of prior treatment exposure on response to antidepressant treatment in late life
    James D Tew
    Advanced Center for Interventions and Services Research in Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:957-65. 2006
    ..The objective of this study was to describe the correlates of prior antidepressant exposure and its association with response to protocolized treatment in older patients with major depression...
  38. ncbi request reprint Late-onset major depression: clinical and treatment-response variability
    Henry C Driscoll
    Intervention Research Center for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 20:661-7. 2005
    ..To explore clinical and treatment-response variability in late-onset vs early-onset non-bipolar, non-psychotic major depression...
  39. ncbi request reprint Discrepancies in information provided to primary care physicians by patients with and without dementia: the Steel Valley Seniors Survey
    Mary Ganguli
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Am J Geriatr Psychiatry 14:446-55. 2006
    ..The objective of this study was to examine associations between discrepancies in health information provided to primary care providers and severity of impairment in older patients with and without dementia...
  40. ncbi request reprint Persistence of neuropsychologic deficits in the remitted state of late-life depression
    Rishi K Bhalla
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Geriatr Psychiatry 14:419-27. 2006
    ..Cognitive impairment in late-life depression (LLD) is prevalent, disabling, and persists despite the remission of depressive symptoms. This article characterizes neuropsychologic functioning during remission in LLD...
  41. ncbi request reprint What is the optimal duration of a short-term antidepressant trial when treating geriatric depression?
    Benoit H Mulsant
    Advanced Center in Intervention and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychopharmacol 26:113-20. 2006
    ..To determine the optimal duration of an antidepressant trial in elderly patients, the authors examined the probability of eventually responding to treatment based on early improvement...
  42. ncbi request reprint Population pharmacokinetics as a method to detect variable risperidone exposure in patients suffering from dementia with behavioral disturbances
    Robert R Bies
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Geriatr Pharmacother 3:87-91. 2005
    ..This study was intended to compare the consistency of risperidone exposure in patients who have dementia and behavioral disturbances treated in a psychiatric hospital versus a community care setting...
  43. ncbi request reprint Comorbid anxiety disorder in late life depression: association with memory decline over four years
    Alison K DeLuca
    The Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 20:848-54. 2005
    ..The purpose of this study was to determine whether comorbid GAD or PD was associated with poorer long-term outcomes of late-life MDD, in terms of symptoms, functional disability, and cognitive status...
  44. ncbi request reprint Predictors of remission after electroconvulsive therapy in unipolar major depression
    Alexandre Y Dombrovski
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    J Clin Psychiatry 66:1043-9. 2005
    ..Electroconvulsive therapy (ECT) is the most effective biological treatment for major depression. However, there is little agreement about clinically useful predictors of acute ECT outcomes...
  45. pmc Statistical analysis of longitudinal psychiatric data with dropouts
    Sati Mazumdar
    Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    J Psychiatr Res 41:1032-41. 2007
    ....
  46. ncbi request reprint The evidence for electroconvulsive therapy (ECT) in the treatment of severe late-life depression. ECT: the preferred treatment for severe depression in late life
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, USA
    Int Psychogeriatr 19:10-4, 27-35; discussion 24-6. 2007
  47. doi request reprint Correlates of suicidality among patients with psychotic depression
    Ayal Schaffer
    Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Suicide Life Threat Behav 38:403-14. 2008
    ..These findings reinforce the evidence that patients with psychotic depression are at high risk for suicide and underscore the importance of examining correlates of suicidality specific to patients with psychotic depression...
  48. doi request reprint Nature and course of cognitive function in late-life schizophrenia: a systematic review
    Tarek K Rajji
    Department of Psychiatry, University of Toronto, and Geriatric Mental Health Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Schizophr Res 102:122-40. 2008
    ..To systematically review the literature on the nature and course of cognition in late-life schizophrenia (LLS)...
  49. pmc Medical burden in late-life bipolar and major depressive disorders
    Ariel G Gildengers
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, The Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 16:194-200. 2008
    ..The authors compare medical burden in elderly patients with bipolar disorder with that in those with major depressive disorder...
  50. ncbi request reprint Biomarkers in geriatric psychiatry
    Eric J Lenze
    Am J Geriatr Psychiatry 15:827-31. 2007
  51. ncbi request reprint A double-blind comparison of citalopram and risperidone for the treatment of behavioral and psychotic symptoms associated with dementia
    Bruce G Pollock
    Rotman Research Institute at Baycrest, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 15:942-52. 2007
    ..To compare citalopram and risperidone for the treatment of psychotic symptoms and agitation associated with dementia, with a priori hypotheses that risperidone would be more efficacious for psychosis and citalopram for agitation...
  52. ncbi request reprint Maintenance treatment for old-age depression preserves health-related quality of life: a randomized, controlled trial of paroxetine and interpersonal psychotherapy
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 55:1325-32. 2007
    ..To determine whether maintenance antidepressant pharmacotherapy and interpersonal psychotherapy sustain gains in health-related quality of life (HR-QOL) achieved during short-term treatment in older patients with depression...
  53. pmc Predicting 6-week treatment response to escitalopram pharmacotherapy in late-life major depressive disorder
    Ramin Saghafi
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
    Int J Geriatr Psychiatry 22:1141-6. 2007
    ..This study aims to characterize sociodemographic, clinical, and neuropsychologic correlates of full, partial, and non-response to escitalopram monotherapy of unipolar MDD in later life...
  54. ncbi request reprint Relapse during continuation pharmacotherapy after acute response to ECT: a comparison of usual care versus protocolized treatment
    James D Tew
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA USA
    Ann Clin Psychiatry 19:1-4. 2007
    ..quot; This study compares the effectiveness of usual care versus protocolized pharmacotherapy in preventing relapse following ECT...
  55. ncbi request reprint Effect of comorbid anxiety on treatment response and relapse risk in late-life depression: controlled study
    Carmen Andreescu
    Western Psychiatric Institute and Clinic, 3811 O Hara Street, Room E 823, Pittsburgh, PA15213, USA
    Br J Psychiatry 190:344-9. 2007
    ..Comorbid anxiety is common in depressive disorders in both middle and late life, and it affects response to antidepressant treatment...
  56. pmc Onset of confusion in the context of late-life depression
    Benoit H Mulsant
    Department of Psychiatry University of Toronto, Toronto, Ont
    J Psychiatry Neurosci 32:152. 2007
  57. pmc Residual symptoms and recurrence during maintenance treatment of late-life depression
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, United States
    J Affect Disord 103:77-82. 2007
    ..Our study assesses the impact of these residual symptoms on the risk of recurrence during maintenance treatment of late-life depression...
  58. pmc The effects of memory, attention, and executive dysfunction on outcomes of depression in a primary care intervention trial: the PROSPECT study
    Hillary R Bogner
    Department of Family Medicine and Community Health, University of Pennsylvania, Philadelphia, PA 19104, USA
    Int J Geriatr Psychiatry 22:922-9. 2007
    ..To describe the influence of domains of cognition on remission and response of depression in an intervention trial among older primary care patients...
  59. ncbi request reprint Cognitive functioning and instrumental activities of daily living in late-life bipolar disorder
    Ariel G Gildengers
    Advanced Center for Intervention and Services Research for Late Life Disorders, Department of Psychiatry, Bipolar Disorder Center for Pennsylvanians, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 15:174-9. 2007
    ..The authors report on the relationship between cognitive functioning and instrumental activities of daily living (IADLs) in elderly, clinically euthymic adults with bipolar disorder...
  60. ncbi request reprint Speed of improvement in sleep disturbance and anxiety compared with core mood symptoms during acute treatment of depression in old age
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:550-4. 2006
    ..The objective of this study was to examine the relative speed of improvement in sleep disturbance and anxiety symptoms compared with core mood symptoms in acute treatment of late-life major depression...
  61. ncbi request reprint Somatic symptoms in late-life anxiety: treatment issues
    Eric J Lenze
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Geriatr Psychiatry Neurol 18:89-96. 2005
    ..However, additional treatment and integrated approaches are likely to be necessary for many such individuals...
  62. ncbi request reprint alpha1-acid glycoprotein in late-life depression: relationship to medical burden and genetics
    Opeolu M Adeoye
    Department of Emergency Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    J Geriatr Psychiatry Neurol 16:235-9. 2003
    ..Frequency differences in ORM1 allelic variants apparently did not influence increased AAG concentrations in depressed patients...
  63. ncbi request reprint Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late life
    Dennis S Charney
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 60:664-72. 2003
    ..To review progress made during the past decade in late-life mood disorders and to identify areas of unmet need in health care delivery and research...
  64. ncbi request reprint Occurrence and course of suicidality during short-term treatment of late-life depression
    Katalin Szanto
    Department of Psychiatry, The Intervention Research Center for the Study of Late Life Mood Disorders, Pittsburgh, PA, USA
    Arch Gen Psychiatry 60:610-7. 2003
    ....
  65. ncbi request reprint A randomized comparison of high-charge right unilateral electroconvulsive therapy and bilateral electroconvulsive therapy in older depressed patients who failed to respond to 5 to 8 moderate-charge right unilateral treatments
    James D Tew
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 63:1102-5. 2002
    ....
  66. ncbi request reprint Clinically relevant behaviors in elderly hip fracture inpatients
    Helen H Dorra
    University of Pittsburgh School of Medicine, USA
    Int J Psychiatry Med 32:249-59. 2002
    ..To examine the range of behaviors documented by inpatient rehabilitation staff and the association of these behaviors with functional outcome, in elderly persons undergoing rehabilitation after hip fracture...
  67. ncbi request reprint Rates and predictors of mortality in an aging, rural, community-based cohort: the role of depression
    Mary Ganguli
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213 2593, USA
    Arch Gen Psychiatry 59:1046-52. 2002
    ..Depression, functional disability, cognitive impairment, and self-rated health all predict mortality in the elderly population. There is no consensus on their relative contributions when examined together...
  68. ncbi request reprint Risk factors for falls during treatment of late-life depression
    Jin H Joo
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychiatry 63:936-41. 2002
    ..This study evaluated the time course and potential risk factors for falls in a treatment protocol for late-life depression to identify specific at-risk periods and risk factors for falls in this population...
  69. ncbi request reprint Anxiety symptoms in elderly patients with depression: what is the best approach to treatment?
    Eric J Lenze
    Department of Psychiatry, Intervention Research Center in Late Life Mood Disorders, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Drugs Aging 19:753-60. 2002
    ..Therefore, optimism should be maintained when treating the depressed elderly individual, even when comorbid anxiety is present...
  70. ncbi request reprint Response speed and rate of remission in primary and specialty care of elderly patients with depression
    Leslie Thomas
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 10:583-91. 2002
    ....
  71. ncbi request reprint Glucose metabolic response to total sleep deprivation, recovery sleep, and acute antidepressant treatment as functional neuroanatomic correlates of treatment outcome in geriatric depression
    Gwenn S Smith
    Department of Psychiatry Research, Hillside Hospital of the North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Am J Geriatr Psychiatry 10:561-7. 2002
    ....
  72. ncbi request reprint Course and rate of antidepressant response in the very old
    Ariel G Gildengers
    The Intervention Research Centers for Late Life and Mid Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Affect Disord 69:177-84. 2002
    ..The authors examined elderly patients with major depression to determine the relationship of current age to treatment response course and success rate...
  73. ncbi request reprint Risperidone and 9-hydroxyrisperidone concentrations are not dependent on age or creatinine clearance among elderly subjects
    Rae Ann Maxwell
    Pharmacy Department, Western Psychiatric Institute and Clinic, VA Pittsburgh Health System, Pennsylvania, USA
    J Geriatr Psychiatry Neurol 15:77-81. 2002
    ..These results were unchanged when concentrations were corrected for total daily risperidone dose. Among elderly subjects, risperidone and 9-OH clearance do not decline with increasing age or declining CrCl...
  74. ncbi request reprint Cognitive and behavioral correlates of low vitamin B12 levels in elderly patients with progressive dementia
    Ellen M Whyte
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Geriatr Psychiatry 10:321-7. 2002
    ..In AD, the prevalence of low vitamin B12 serum levels is consistent with that found in community-dwelling elderly persons in general but is associated with greater overall cognitive impairment...
  75. ncbi request reprint APOE is associated with age-of-onset, but not cognitive functioning, in late-life depression
    Meryl A Butters
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 18:1075-81. 2003
    ..We also predicted that APOE4 allele frequency would be increased among subjects with LLD...
  76. ncbi request reprint Achieving long-term optimal outcomes in geriatric depression and anxiety
    Benoit H Mulsant
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    CNS Spectr 8:27-34. 2003
    ....
  77. ncbi request reprint Reducing suicidal ideation and depressive symptoms in depressed older primary care patients: a randomized controlled trial
    Martha L Bruce
    Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY, USA
    JAMA 291:1081-91. 2004
    ..Depression is the strongest risk factor for late-life suicide and for suicide's precursor, suicidal ideation...
  78. ncbi request reprint Does education moderate neuropsychological impairment in late-life depression?
    Rishi K Bhalla
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
    Int J Geriatr Psychiatry 20:413-7. 2005
    ..This study examined whether educational level influences the degree of neuropsychological impairment associated with late-life depression...
  79. pmc Remission in depressed geriatric primary care patients: a report from the PROSPECT study
    George S Alexopoulos
    Department of Psychiatry, Weill Medical College of Cornell University, New York, USA
    Am J Psychiatry 162:718-24. 2005
    ..In addition, it sought to identify risk factors for nonremission that could guide treatment planning and referral to care managers or specialists...
  80. ncbi request reprint Body pain and treatment response in late-life depression
    Jordan F Karp
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 13:188-94. 2005
    ..They hypothesized that higher levels of body pain would predict a longer time to and lower likelihood of response, and increased levels of suicidal ideation...
  81. ncbi request reprint Generalized anxiety disorder in late life: lifetime course and comorbidity with major depressive disorder
    Eric J Lenze
    Intervention Research Center in Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 13:77-80. 2005
    ..The authors assessed the course and comorbidity of late-life GAD and MDD...
  82. ncbi request reprint Correlates of anticholinergic activity in patients with dementia and psychosis treated with risperidone or olanzapine
    Benoit H Mulsant
    Western Psychiatric Institute and Clinic, Department of Psychiatry, Division of Geriatric Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 65:1708-14. 2004
    ..Older individuals with dementia are highly sensitive to the effects of muscarinic receptor blockade...
  83. ncbi request reprint Geriatric depression treatment in nonresponders to selective serotonin reuptake inhibitors
    Ellen M Whyte
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 65:1634-41. 2004
    ....
  84. ncbi request reprint Efficacy and tolerability of citalopram in the treatment of late-life anxiety disorders: results from an 8-week randomized, placebo-controlled trial
    Eric J Lenze
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine and VA Healthcare System, PA, USA
    Am J Psychiatry 162:146-50. 2005
    ..Anxiety disorders are highly prevalent in elderly persons. However, to date, the efficacy of selective serotonin reuptake inhibitors (SSRIs) for the treatment of anxiety disorders in this age group has not been established...
  85. ncbi request reprint Estimating treatment effects from longitudinal clinical trial data with missing values: comparative analyses using different methods
    Patricia R Houck
    Department of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and Clinic, UPMC Health System, Thomas Detre Hall, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Psychiatry Res 129:209-15. 2004
    ..No significant treatment differences were found. We conclude that attention to the missing-data mechanism should be an integral part in analysis of clinical trial data...
  86. ncbi request reprint Serotonin 1A receptor binding and treatment response in late-life depression
    Carolyn Cidis Meltzer
    Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA
    Neuropsychopharmacology 29:2258-65. 2004
    ..Further, this work indicates that dysfunction in autoreceptor activity may play a central role in the mechanisms underlying treatment response to selective serotonin reuptake inhibitors in late-life depression...
  87. ncbi request reprint Executive functioning, illness course, and relapse/recurrence in continuation and maintenance treatment of late-life depression: is there a relationship?
    Meryl A Butters
    Intervention Research Center for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh Medical Center, USA
    Am J Geriatr Psychiatry 12:387-94. 2004
    ..The authors tested the hypothesis that impaired executive functioning leads to high rates of relapse and recurrence in late-life depression...
  88. ncbi request reprint The nature and determinants of neuropsychological functioning in late-life depression
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Gen Psychiatry 61:587-95. 2004
    ..Cognitive impairment in late-life depression (LLD) is highly prevalent, disabling, poorly understood, and likely related to long-term outcome...
  89. ncbi request reprint Depression after stroke: a prospective epidemiological study
    Ellen M Whyte
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 52:774-8. 2004
    ..To elucidate the relationship between stroke and depressive symptoms and to determine whether disability or cerebrovascular risk factors mediate that relationship...
  90. ncbi request reprint Cognitive functioning in late-life bipolar disorder
    Ariel G Gildengers
    Information Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Psychiatry 161:736-8. 2004
    ..This study characterized cognitive functioning in elderly patients with bipolar disorder...
  91. ncbi request reprint Identification of suicidal ideation and prevention of suicidal behaviour in the elderly
    Katalin Szanto
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Drugs Aging 19:11-24. 2002
    ..Prevention and treatment trials are underway to detect the effectiveness of improved treatment of depression by primary care physicians as a means of reducing the prevalence of depressive symptoms, hopelessness and suicidal ideation...