Mary Mullins

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint The role of tolloid/mini fin in dorsoventral pattern formation of the zebrafish embryo
    S A Connors
    University of Pennsylvania School of Medicine, Department of Cell and Developmental Biology, 421 Curie Blvd, Philadelphia, PA 19104 6058, USA
    Development 126:3119-30. 1999
  2. pmc The zebrafish homologue of mammalian chimerin Rac-GAPs is implicated in epiboly progression during development
    Federico Coluccio Leskow
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    Proc Natl Acad Sci U S A 103:5373-8. 2006
  3. pmc The integrator complex subunit 6 (Ints6) confines the dorsal organizer in vertebrate embryogenesis
    Lee D Kapp
    Perelman School of Medicine at the University of Pennsylvania, Department of Cell and Developmental Biology, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 9:e1003822. 2013
  4. pmc An intermediate level of BMP signaling directly specifies cranial neural crest progenitor cells in zebrafish
    Jennifer A Schumacher
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e27403. 2011
  5. pmc Microtubule actin crosslinking factor 1 regulates the Balbiani body and animal-vegetal polarity of the zebrafish oocyte
    Tripti Gupta
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS Genet 6:e1001073. 2010
  6. pmc Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis
    Shawn C Little
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 1211 BRBII III, 421 Curie Boulevard, Philadelphia, PA 19104 6058, USA
    Nat Cell Biol 11:637-43. 2009
  7. ncbi request reprint Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes
    M C Mullins
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:81-93. 1996
  8. ncbi request reprint Holy Tolloido: Tolloid cleaves SOG/Chordin to free DPP/BMPs
    M C Mullins
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104 6058, USA
    Trends Genet 14:127-9. 1998
  9. ncbi request reprint Dorsoventral patterning in the zebrafish: bone morphogenetic proteins and beyond
    Matthias Hammerschmidt
    Hans Spemann Laboratories, Max Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Results Probl Cell Differ 40:72-95. 2002
  10. ncbi request reprint Zebrafish as a "biosensor"? Effects of ionizing radiation and amifostine on embryonic viability and development
    Geoffrey A Geiger
    Department of Radiation Oncology, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA
    Cancer Res 66:8172-81. 2006

Collaborators

  • TODD R EVANS
  • R N Kelsh
  • Y J Jiang
  • D A Kane
  • M Hammerschmidt
  • Jun Li
  • M Brand
  • Jonathan Epstein
  • KENNETH POSS
  • C P Heisenberg
  • EDWARD DE ROBERTIS
  • M Ekker
  • Manuel J Aybar
  • Robert Schwartz
  • Didier Y R Stainier
  • Francisco J Pelegri
  • Elke A Ober
  • Fabian Rentzsch
  • Shawn C Little
  • Daniel S Wagner
  • Florence L Marlow
  • Roland Dosch
  • Jennifer A Tucker
  • Keith A Mintzer
  • Lee D Kapp
  • Jennifer A Schumacher
  • Tripti Gupta
  • Greg Runke
  • Donghun Shin
  • Lisa J McReynolds
  • Vu H Nguyen
  • Stephanie A Connors
  • Geoffrey A Geiger
  • Federico Coluccio Leskow
  • Jessica A Panzer
  • Michael Granato
  • Joanne Birely
  • Anthony P Wiemelt
  • Celeste Tribulo
  • Michael Oelgeschlager
  • Fabian Chen
  • Carina Kramer
  • Elliott W Abrams
  • Megumi Hashiguchi
  • Katarzyna Mackiewicz
  • Dimitri Monos
  • Johannes Dapprich
  • Deborah Ferriola
  • S A Connors
  • Chong Hyun Shin
  • Jennifer Tucker
  • Maria E Figueroa
  • Sunny Gupta
  • Marcelo G Kazanietz
  • Beth A Holloway
  • Andrew P Beothy
  • HongBin Wang
  • Gary D Kao
  • Sharon E Parker
  • Daniel Wagner
  • Rita J Balice-Gordon
  • Sarah M Gibbs
  • Evelyn Santana
  • Valerie A Schneider
  • Shawn Little
  • Roberto Mayor
  • Juan LarraĆ­n
  • Bruno Reversade
  • Thomas Mayr
  • Kuangyu Jen
  • Robert Schnepp
  • Richard P Harvey
  • Hermann Bauer
  • Aaron D Gitler
  • Jiri Novotny
  • Yoshiyuki Imai
  • Matthias Nowak
  • Bettina Schmid
  • William S Talbot
  • Hyun Kook
  • Joel P Mackay
  • Ronniel Nazarian
  • Jennifer Schumacher
  • Rita Milewski
  • Christine Biben
  • Min Min Lu
  • J Trout

Detail Information

Publications30

  1. ncbi request reprint The role of tolloid/mini fin in dorsoventral pattern formation of the zebrafish embryo
    S A Connors
    University of Pennsylvania School of Medicine, Department of Cell and Developmental Biology, 421 Curie Blvd, Philadelphia, PA 19104 6058, USA
    Development 126:3119-30. 1999
    ..This extracellular mechanism is amplified by an autoregulatory loop for bmp gene expression...
  2. pmc The zebrafish homologue of mammalian chimerin Rac-GAPs is implicated in epiboly progression during development
    Federico Coluccio Leskow
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    Proc Natl Acad Sci U S A 103:5373-8. 2006
    ..Our results reveal a crucial role for chn1 in early development and implicate Rac as a key regulator of morphogenetic movements during zebrafish epiboly...
  3. pmc The integrator complex subunit 6 (Ints6) confines the dorsal organizer in vertebrate embryogenesis
    Lee D Kapp
    Perelman School of Medicine at the University of Pennsylvania, Department of Cell and Developmental Biology, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 9:e1003822. 2013
    ..Our results are consistent with a novel role for Ints6 in restricting the vertebrate organizer to a dorsal domain in embryonic patterning. ..
  4. pmc An intermediate level of BMP signaling directly specifies cranial neural crest progenitor cells in zebrafish
    Jennifer A Schumacher
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e27403. 2011
    ..Together these results add substantial evidence to a model in which graded BMP signaling acts as a morphogen to pattern the ectoderm, with an intermediate level acting in neural crest specification...
  5. pmc Microtubule actin crosslinking factor 1 regulates the Balbiani body and animal-vegetal polarity of the zebrafish oocyte
    Tripti Gupta
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS Genet 6:e1001073. 2010
    ..These data provide the first evidence for a role for spectraplakins in polarization of the vertebrate oocyte and egg...
  6. pmc Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis
    Shawn C Little
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 1211 BRBII III, 421 Curie Boulevard, Philadelphia, PA 19104 6058, USA
    Nat Cell Biol 11:637-43. 2009
    ....
  7. ncbi request reprint Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes
    M C Mullins
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:81-93. 1996
    ..This pathway provides ventral positional information, counteracting the dorsalizing instructions of the organizer, which is localized in the dorsal shield...
  8. ncbi request reprint Holy Tolloido: Tolloid cleaves SOG/Chordin to free DPP/BMPs
    M C Mullins
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104 6058, USA
    Trends Genet 14:127-9. 1998
  9. ncbi request reprint Dorsoventral patterning in the zebrafish: bone morphogenetic proteins and beyond
    Matthias Hammerschmidt
    Hans Spemann Laboratories, Max Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Results Probl Cell Differ 40:72-95. 2002
  10. ncbi request reprint Zebrafish as a "biosensor"? Effects of ionizing radiation and amifostine on embryonic viability and development
    Geoffrey A Geiger
    Department of Radiation Oncology, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA
    Cancer Res 66:8172-81. 2006
    ..These results together suggest the power and versatility of the zebrafish in assessing the effects of radiation and radiomodifiers on organ and tissue development...
  11. ncbi request reprint Extracellular modulation of BMP activity in patterning the dorsoventral axis
    Shawn C Little
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6058, USA
    Birth Defects Res C Embryo Today 78:224-42. 2006
    ..This review examines recent developments in the field of DV patterning by BMP signaling, focusing on extracellular modulation as a key mechanism in the formation of BMP signaling gradients in Drosophila, Xenopus, and zebrafish...
  12. ncbi request reprint Bmp and Fgf signaling are essential for liver specification in zebrafish
    Donghun Shin
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Liver Center, University of California, San Francisco, CA 94158, USA
    Development 134:2041-50. 2007
    ....
  13. pmc Smad1 and Smad5 differentially regulate embryonic hematopoiesis
    Lisa J McReynolds
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Blood 110:3881-90. 2007
    ..Our results suggest that specificity of BMP signaling output, with respect to hematopoiesis, can be explained by differential functions of Smad1 and Smad5...
  14. pmc The BMP signaling gradient patterns dorsoventral tissues in a temporally progressive manner along the anteroposterior axis
    Jennifer A Tucker
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Dev Cell 14:108-19. 2008
    ..We propose that a temporal cue regulates a cell's competence to respond to BMP signaling, allowing the acquisition of a cell's DV and AP identity simultaneously...
  15. ncbi request reprint Building-blocks of embryogenesis
    Mary C Mullins
    Nat Genet 31:125-6. 2002
  16. ncbi request reprint Modulation of BMP activity in dorsal-ventral pattern formation by the chordin and ogon antagonists
    Daniel S Wagner
    Department of Cell and Developmental Biology, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Dev Biol 245:109-23. 2002
    ..As has been proposed for the fly orthologue of chordin, short gastrulation, our paradoxical results can be explained by a model whereby Chordin both antagonizes and promotes BMP activity...
  17. ncbi request reprint Temporal and spatial action of tolloid (mini fin) and chordin to pattern tail tissues
    Stephanie A Connors
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 1211 BRBII, 421 Curie Blvd, Philadelphia, PA 19104 6058, USA
    Dev Biol 293:191-202. 2006
    ..Thus, fine modulation of BMP signaling levels through the negative and positive actions of Chordin and Tolloid, respectively, patterns tail tissues...
  18. ncbi request reprint Tolloid gets Sizzled competing with Chordin
    Mary C Mullins
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Dev Cell 10:154-6. 2006
    ..This competition protects Chordin from cleavage, thus allowing it to bind and limit BMP signaling...
  19. ncbi request reprint Maternally supplied Smad5 is required for ventral specification in zebrafish embryos prior to zygotic Bmp signaling
    Carina Kramer
    Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Dev Biol 250:263-79. 2002
    ..This indicates that maternally supplied Smad5 is already required to mediate ventral specification prior to zygotic Bmp2/7 signaling to establish the initial dorsoventral asymmetry...
  20. pmc The pro-BMP activity of Twisted gastrulation is independent of BMP binding
    Michael Oelgeschlager
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California Los Angeles, Los Angeles, CA 90095 1662, USA
    Development 130:4047-56. 2003
    ..The results suggest that xTsg interacts with additional CR-containing proteins that regulate dorsoventral development in embryos...
  21. ncbi request reprint Regulation of Msx genes by a Bmp gradient is essential for neural crest specification
    Celeste Tribulo
    Millennium Nucleus in Developmental Biology, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile
    Development 130:6441-52. 2003
    ..We propose a model where a gradient of Bmp activity specifies the expression of Msx genes in the neural folds, and that this expression is essential for the early specification of the neural crest...
  22. ncbi request reprint Maternal control of vertebrate development before the midblastula transition: mutants from the zebrafish I
    Roland Dosch
    Department of Cell and Developmental Biology, University of Pennsylvania, School of Medicine, 1211 BRBII III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Dev Cell 6:771-80. 2004
    ..These mutants exhibit phenotypes not previously observed in zygotic mutant screens. This collection of maternal-effect mutants provides the basis for a molecular genetic analysis of the maternal control of embryogenesis in vertebrates...
  23. ncbi request reprint Neuromuscular synaptogenesis in wild-type and mutant zebrafish
    Jessica A Panzer
    Department of Neuroscience, University of Pennsylvania School of Medicine, 215 Stemmler Hall, 3610 Hamilton Walk, Philadelphia, PA 19104 6074, USA
    Dev Biol 285:340-57. 2005
    ..Identification of the underlying genetic defects in these mutants will extend our understanding of the cellular and molecular mechanisms that underlie the formation and function of neuromuscular and other synapses...
  24. ncbi request reprint Maternal control of development at the midblastula transition and beyond: mutants from the zebrafish II
    Daniel S Wagner
    Department of Cell and Developmental Biology, University of Pennsylvania Medical School, 1211 BRBII III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Dev Cell 6:781-90. 2004
    ..These mutants provide powerful tools to dissect the maternal and paternal control of vertebrate embryogenesis...
  25. ncbi request reprint Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterning
    Shawn C Little
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 1211 BRBII III, 421 Curie Boulevard, Philadelphia, PA 19104 6058, USA
    Development 131:5825-35. 2004
    ..Our results support a model in which zebrafish Tsg1 promotes BMP signaling, and thus ventral cell fates, during DV axial patterning...
  26. ncbi request reprint Genetic screens for genes controlling motor nerve-muscle development and interactions
    Joanne Birely
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Dev Biol 280:162-76. 2005
    ..Together, the genes underlying these mutant phenotypes define pathways essential for nerve and muscle development and interactions between these two cell types...
  27. ncbi request reprint Hop is an unusual homeobox gene that modulates cardiac development
    Fabian Chen
    Department of Medicine, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    Cell 110:713-23. 2002
    ..Hop encodes an unusual homeodomain protein that modulates SRF-dependent cardiac-specific gene expression and cardiac development...
  28. ncbi request reprint Genetic screens for maternal-effect mutations
    Francisco Pelegri
    University of Wisconsin Madison, Laboratory of Genetics, Madison, Wisconsin 53706, USA
    Methods Cell Biol 77:21-51. 2004
  29. pmc Bucky ball functions in Balbiani body assembly and animal-vegetal polarity in the oocyte and follicle cell layer in zebrafish
    Florence L Marlow
    University of Pennsylvania School of Medicine, Department of Cell and Developmental Biology, 1211 BRB II, 421 Curie Boulevard, Philadelphia, PA 19104 6058, USA
    Dev Biol 321:40-50. 2008
    ..Finally, the expansion of animal identity in oocytes and somatic follicle cells suggests that somatic cell fate and oocyte polarity are interdependent...

Research Grants27

  1. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary Mullins; Fiscal Year: 2000
    ....
  2. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary C Mullins; Fiscal Year: 2010
    ....
  3. Genetic analysis of male gonadal development
    Mary C Mullins; Fiscal Year: 2010
    ..Identification of the genes responsible for these defects in the zebrafish will provide candidate genes responsible for the human defects, which could ultimately lead to genetic testing or therapeutic intervention. ..
  4. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary Mullins; Fiscal Year: 1999
    ....
  5. Genetic analysis of ovary development and oogenesis
    Mary Mullins; Fiscal Year: 2006
    ..Identification of the mutant zebrafish genes will provide candidate genes responsible for the human defects, which could ultimately lead to genetic testing or therapeutic intervention. ..
  6. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary Mullins; Fiscal Year: 2006
    ..These studies are directly relevant to the study of human disease, since some of the genes in this pathway have been shown or are implicated in the cause of multiple human disease states and human inherited disorders. ..
  7. Genetic Analysis of Maternal Factors in Embryonic Devel*
    Mary Mullins; Fiscal Year: 2003
    ..These studies will be relevant to the nature of human sterilities, birth defects, and human inherited disorders. ..
  8. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary Mullins; Fiscal Year: 2007
    ..Thus it is critical to identify and study all the genetic players in this process. ..
  9. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary Mullins; Fiscal Year: 2005
    ..These studies are directly relevant to the study of human disease, since some of the genes in this pathway have been shown or are implicated in the cause of multiple human disease states and human inherited disorders. ..
  10. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary Mullins; Fiscal Year: 2003
    ....
  11. Genetic Analysis of Maternal Factors in Embryonic Devel*
    Mary Mullins; Fiscal Year: 2002
    ..These studies will be relevant to the nature of human sterilities, birth defects, and human inherited disorders. ..
  12. Genetic Analysis of Maternal Factors in Embryonic Devel*
    Mary Mullins; Fiscal Year: 2005
    ..These studies will be relevant to the nature of human sterilities, birth defects, and human inherited disorders. ..
  13. DORSAL/VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary Mullins; Fiscal Year: 1999
    ....
  14. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary Mullins; Fiscal Year: 2004
    ..These studies are directly relevant to the study of human disease, since some of the genes in this pathway have been shown or are implicated in the cause of multiple human disease states and human inherited disorders. ..
  15. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary C Mullins; Fiscal Year: 2010
    ....
  16. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary Mullins; Fiscal Year: 2009
    ....
  17. Genetic Analysis of Maternal Factors in Embryonic Devel*
    Mary Mullins; Fiscal Year: 2001
    ..These studies will be relevant to the nature of human sterilities, birth defects, and human inherited disorders. ..
  18. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary Mullins; Fiscal Year: 2001
    ....
  19. Genetic analysis of ovary development and oogenesis
    Mary Mullins; Fiscal Year: 2007
    ..Identification of the mutant zebrafish genes will provide candidate genes responsible for the human defects, which could ultimately lead to genetic testing or therapeutic intervention. ..
  20. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary Mullins; Fiscal Year: 2003
    ..These studies are directly relevant to the study of human disease, since some of the genes in this pathway have been shown or are implicated in the cause of multiple human disease states and human inherited disorders. ..
  21. Genetic analysis of ovary development and oogenesis
    Mary Mullins; Fiscal Year: 2009
    ..Identification of the mutant zebrafish genes will provide candidate genes responsible for the human defects, which could ultimately lead to genetic testing or therapeutic intervention. ..
  22. Genetic analysis of ovary development and oogenesis
    Mary Mullins; Fiscal Year: 2005
    ..Identification of the mutant zebrafish genes will provide candidate genes responsible for the human defects, which could ultimately lead to genetic testing or therapeutic intervention. ..
  23. Genetic Analysis of Maternal Factors in Embryonic Devel*
    Mary Mullins; Fiscal Year: 2004
    ..These studies will be relevant to the nature of human sterilities, birth defects, and human inherited disorders. ..