Florian Muller

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi Architecture of the Qo site of the cytochrome bc1 complex probed by superoxide production
    Florian L Muller
    Institute of Biological Chemistry, Washington State University, 289 Clark Hall, Pullman, Washington 99164 6340, USA
    Biochemistry 42:6493-9. 2003
  2. doi Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance
    Muhammad A Abdul-Ghani
    Division of Diabetes, Univ of Texas Health Science Center, San Antonio, TX 78229, USA
    Am J Physiol Endocrinol Metab 295:E678-85. 2008
  3. ncbi Complex III releases superoxide to both sides of the inner mitochondrial membrane
    Florian L Muller
    Department of Cellular Biology, University of Texas Health Science Center, San Antonio, TX 78284 7762, USA
    J Biol Chem 279:49064-73. 2004
  4. ncbi H(2)S-induced ectothermy: relevance to aging
    Florian Muller
    Department of Cellular Biology, University of Texas Health Science Center, San Antonio, Texas 78284, USA
    Rejuvenation Res 8:135-7. 2005
  5. doi GAPDH is conformationally and functionally altered in association with oxidative stress in mouse models of amyotrophic lateral sclerosis
    Anson Pierce
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Mol Biol 382:1195-210. 2008
  6. pmc The in vivo gene expression signature of oxidative stress
    Eun Soo Han
    Department of Biological Science, University of Tulsa, Tulsa, Oklahoma, USA
    Physiol Genomics 34:112-26. 2008
  7. ncbi High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates
    Florian L Muller
    Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, Texas Research Park Campus, 15355 Lambda Drive, San Antonio, TX 78229 3900, USA
    Biochem J 409:491-9. 2008
  8. ncbi Trends in oxidative aging theories
    Florian L Muller
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Free Radic Biol Med 43:477-503. 2007
  9. ncbi Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production
    Florian L Muller
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, Barshop Institute for Longevity and Aging Studies, 15355 Lambda Drive, San Antonio, TX 78245 3207, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1159-68. 2007
  10. ncbi Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy
    Florian L Muller
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Free Radic Biol Med 40:1993-2004. 2006

Collaborators

Detail Information

Publications12

  1. ncbi Architecture of the Qo site of the cytochrome bc1 complex probed by superoxide production
    Florian L Muller
    Institute of Biological Chemistry, Washington State University, 289 Clark Hall, Pullman, Washington 99164 6340, USA
    Biochemistry 42:6493-9. 2003
    ..The fact that partial turnover of the Q(o) site is possible even with bound proximal Q(o) site inhibitors is consistent with the participation of two separate functional Q(o) binding niches, occupied simultaneously or sequentially...
  2. doi Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance
    Muhammad A Abdul-Ghani
    Division of Diabetes, Univ of Texas Health Science Center, San Antonio, TX 78229, USA
    Am J Physiol Endocrinol Metab 295:E678-85. 2008
    ..These acquired mitochondrial defects, caused by a physiological increase in the concentration of FFA metabolites, provide a mechanistic link between lipotoxicity, mitochondrial dysfunction, and muscle insulin resistance...
  3. ncbi Complex III releases superoxide to both sides of the inner mitochondrial membrane
    Florian L Muller
    Department of Cellular Biology, University of Texas Health Science Center, San Antonio, TX 78284 7762, USA
    J Biol Chem 279:49064-73. 2004
    ..This explains extramitochondrial release of superoxide but raises the question of how superoxide could reach the matrix. We discuss two models explaining this result...
  4. ncbi H(2)S-induced ectothermy: relevance to aging
    Florian Muller
    Department of Cellular Biology, University of Texas Health Science Center, San Antonio, Texas 78284, USA
    Rejuvenation Res 8:135-7. 2005
    ....
  5. doi GAPDH is conformationally and functionally altered in association with oxidative stress in mouse models of amyotrophic lateral sclerosis
    Anson Pierce
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Mol Biol 382:1195-210. 2008
    ..These data show that GAPDH is differentially affected structurally and functionally in vivo in accordance with the degree of oxidative stress associated with these two models of ALS...
  6. pmc The in vivo gene expression signature of oxidative stress
    Eun Soo Han
    Department of Biological Science, University of Tulsa, Tulsa, Oklahoma, USA
    Physiol Genomics 34:112-26. 2008
    ..A retrospective comparison with previous studies shows that induction of these p53 target genes is a conserved expression response to oxidative stress, in vivo and in vitro, in different species and different cells/organs...
  7. ncbi High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates
    Florian L Muller
    Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, Texas Research Park Campus, 15355 Lambda Drive, San Antonio, TX 78229 3900, USA
    Biochem J 409:491-9. 2008
    ....
  8. ncbi Trends in oxidative aging theories
    Florian L Muller
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Free Radic Biol Med 43:477-503. 2007
    ..Studies in mice argue for a role of oxidative stress in age-related disease, especially cancer; however, with regard to aging per se, the data either do not support or remain inconclusive on whether oxidative stress determines life span...
  9. ncbi Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production
    Florian L Muller
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, Barshop Institute for Longevity and Aging Studies, 15355 Lambda Drive, San Antonio, TX 78245 3207, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1159-68. 2007
    ..Seven days post-denervation, muscle mitochondrial ROS production increased nearly 30-fold. We conclude that enhanced generation of mitochondrial ROS may be a common factor in the mechanism underlying denervation-induced atrophy...
  10. ncbi Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy
    Florian L Muller
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Free Radic Biol Med 40:1993-2004. 2006
    ..Thus, the absence of CuZnSOD imposes elevated oxidative stress, loss of muscle mass, and physiological consequences that resemble an acceleration of normal age-related sarcopenia...
  11. ncbi Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging
    Abdellah Mansouri
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3901, USA
    Mech Ageing Dev 127:298-306. 2006
    ..In addition, increased oxidative stress generated by reduced activity of MnSOD does not exacerbate these alterations during aging...
  12. doi MnSOD deficiency has a differential effect on disease progression in two different ALS mutant mouse models
    Florian L Muller
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, Texas, USA
    Muscle Nerve 38:1173-83. 2008
    ....