Matthew Muldoon

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Low central nervous system serotonergic responsivity is associated with the metabolic syndrome and physical inactivity
    Matthew F Muldoon
    Divisions of Clinical Pharmacology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Clin Endocrinol Metab 89:266-71. 2004
  2. ncbi Lower central serotonergic responsivity is associated with preclinical carotid artery atherosclerosis
    Matthew F Muldoon
    Center for Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Stroke 38:2228-33. 2007
  3. ncbi Effects of six anti-hypertensive medications on cognitive performance
    Matthew F Muldoon
    Division of Clinical Pharmacology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Hypertens 20:1643-52. 2002
  4. ncbi Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adults
    Matthew F Muldoon
    Center for Clinical Pharmacology, University of Pittsburgh, Pennsylvania 15260, USA
    Am J Med 117:823-9. 2004
  5. pmc Serum phospholipid docosahexaenonic acid is associated with cognitive functioning during middle adulthood
    Matthew F Muldoon
    Center for Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Nutr 140:848-53. 2010
  6. ncbi The metabolic syndrome is associated with reduced central serotonergic responsivity in healthy community volunteers
    Matthew F Muldoon
    Division of Clinical Pharmacology, Departments of Medicine and Epidemiology, University of Pittsburgh, 4015 O Hara Street, Pittsburgh, PA 15260, USA
    J Clin Endocrinol Metab 91:718-21. 2006
  7. ncbi Is cardiovascular reactivity associated with atherosclerosis among hypertensives?
    Peter J Gianaros
    Cardiovascular Behavioral Medicine Research Program, University of Pittsburgh, Pennsylvania, USA
    Hypertension 40:742-7. 2002
  8. doi Community socioeconomic status is associated with circulating interleukin-6 and C-reactive protein
    Karen L Petersen
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, Pennsylvania, USA
    Psychosom Med 70:646-52. 2008
  9. ncbi Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteers
    Sarah M Conklin
    Cardiovascular Behavioral Medicine Postdoctoral Training Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15260, United States
    Psychiatry Res 152:1-10. 2007
  10. pmc Lipid-lowering medication use and aggression scores in women: a report from the NHLBI-sponsored WISE study
    Marian B Olson
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Womens Health (Larchmt) 17:187-94. 2008

Research Grants

  1. EFFECTS OF OMEGA-3 FATTY ACIDS ON COGNITIVE PERFORMANCE
    Matthew F Muldoon; Fiscal Year: 2010
  2. Distress, Fish Oil, Inflammation, and Heart Disease
    Matthew Muldoon; Fiscal Year: 2006
  3. CHOLESTEROL REDUCTION EFFECTS ON BEHAVIOR
    Matthew Muldoon; Fiscal Year: 2001
  4. EFFECTS OF CHOLESTEROL REDUCTION ON BEHAVIOR
    Matthew Muldoon; Fiscal Year: 1993

Detail Information

Publications58

  1. ncbi Low central nervous system serotonergic responsivity is associated with the metabolic syndrome and physical inactivity
    Matthew F Muldoon
    Divisions of Clinical Pharmacology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Clin Endocrinol Metab 89:266-71. 2004
    ..These findings reveal a heretofore unrecognized association between reduced central serotonergic responsivity and the metabolic syndrome...
  2. ncbi Lower central serotonergic responsivity is associated with preclinical carotid artery atherosclerosis
    Matthew F Muldoon
    Center for Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Stroke 38:2228-33. 2007
    ..This investigation tested a hypothesized association between central serotonergic functioning and preclinical atherosclerosis...
  3. ncbi Effects of six anti-hypertensive medications on cognitive performance
    Matthew F Muldoon
    Division of Clinical Pharmacology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Hypertens 20:1643-52. 2002
    ..To describe and compare the effects of six different antihypertensive medications on cognitive performance...
  4. ncbi Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adults
    Matthew F Muldoon
    Center for Clinical Pharmacology, University of Pittsburgh, Pennsylvania 15260, USA
    Am J Med 117:823-9. 2004
    ..The current study was designed to confirm and extend those findings...
  5. pmc Serum phospholipid docosahexaenonic acid is associated with cognitive functioning during middle adulthood
    Matthew F Muldoon
    Center for Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Nutr 140:848-53. 2010
    ..These findings suggest that DHA is related to brain health throughout the lifespan and may have implications for clinical trials of neuropsychiatric disorders...
  6. ncbi The metabolic syndrome is associated with reduced central serotonergic responsivity in healthy community volunteers
    Matthew F Muldoon
    Division of Clinical Pharmacology, Departments of Medicine and Epidemiology, University of Pittsburgh, 4015 O Hara Street, Pittsburgh, PA 15260, USA
    J Clin Endocrinol Metab 91:718-21. 2006
    ..The pathobiology of the metabolic syndrome remains unclear. The central nervous system is likely to be involved via regulation of eating, physical activity, blood pressure, and metabolism...
  7. ncbi Is cardiovascular reactivity associated with atherosclerosis among hypertensives?
    Peter J Gianaros
    Cardiovascular Behavioral Medicine Research Program, University of Pittsburgh, Pennsylvania, USA
    Hypertension 40:742-7. 2002
    ..Among hypertensives, exaggerated behaviorally evoked cardiovascular reactivity appears to be uniquely associated with greater carotid intima-media thickness but not with carotid plaque occurrence...
  8. doi Community socioeconomic status is associated with circulating interleukin-6 and C-reactive protein
    Karen L Petersen
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, Pennsylvania, USA
    Psychosom Med 70:646-52. 2008
    ..e., interleukin (IL)-6 and C-reactive protein (CRP), in a midlife community sample. Growing evidence suggests that socioeconomic attributes of both individuals and communities confer risk for cardiovascular morbidity and mortality...
  9. ncbi Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteers
    Sarah M Conklin
    Cardiovascular Behavioral Medicine Postdoctoral Training Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15260, United States
    Psychiatry Res 152:1-10. 2007
    ..These findings suggest that omega-3 fatty acid status is associated with variability in affect regulation, personality and impulse control...
  10. pmc Lipid-lowering medication use and aggression scores in women: a report from the NHLBI-sponsored WISE study
    Marian B Olson
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Womens Health (Larchmt) 17:187-94. 2008
    ..The aim of this study was to examine the association between the use of lipid-lowering medication and aggressive responding, hostility, cynicism, and depression scores in women undergoing coronary angiography...
  11. ncbi Self-reported sleep quality is associated with the metabolic syndrome
    J Richard Jennings
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Sleep 30:219-23. 2007
    ..To determine whether a simple, structured self-report of overall sleep quality is associated with the presence of the metabolic syndrome and its component risk factors...
  12. ncbi Negative emotions and 3-year progression of subclinical atherosclerosis
    Jesse C Stewart
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Arch Gen Psychiatry 64:225-33. 2007
    ....
  13. pmc Brain imaging findings predict blood pressure response to pharmacological treatment
    J Richard Jennings
    Departments of Psychiatry and Psychology, University of Pittsburgh, PA, USA
    Hypertension 52:1113-9. 2008
    ..The state of the brain may be an important factor in the remediation of blood pressure...
  14. pmc Subjective socioeconomic status and presence of the metabolic syndrome in midlife community volunteers
    Stephen B Manuck
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Psychosom Med 72:35-45. 2010
    ....
  15. pmc Polymorphisms in the CRP gene moderate an association between depressive symptoms and circulating levels of C-reactive protein
    Indrani Halder
    Behavioral Physiology Laboratory, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Behav Immun 24:160-7. 2010
    ..In conclusion, we found that haplotypic variation in the CRP locus moderates an association of depressive symptoms with circulating CRP, which is partially mediated by BMI...
  16. pmc Cerebrovascular support for cognitive processing in hypertensive patients is altered by blood pressure treatment
    J Richard Jennings
    Department of Psychiatry, University of Pittsburgh, PA, USA
    Hypertension 52:65-71. 2008
    ....
  17. pmc Brain function, cognition, and the blood pressure response to pharmacological treatment
    J Richard Jennings
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Psychosom Med 72:702-11. 2010
    ..To extend evidence suggesting that essential hypertension influences neuropsychological performance and that brain function before treatment is related to the success of pharmacological lowering of blood pressure (BP)...
  18. ncbi Serotonergic function in the central nervous system is associated with daily ratings of positive mood
    Janine D Flory
    Department of Psychology, University of Pittsburgh, 4015 O Hara Street, Pittsburgh, PA 15260, USA
    Psychiatry Res 129:11-9. 2004
    ..e., Neuroticism). These results suggest that deficiencies in serotonergic function may reflect the relative absence of positive mood...
  19. ncbi Interleukin-6 covaries inversely with cognitive performance among middle-aged community volunteers
    Anna L Marsland
    Behavioral Immunology Laboratory, Department of Psychology, 3943 O Hara Street, Pittsburgh, PA 15260, USA
    Psychosom Med 68:895-903. 2006
    ..The current investigation extends the study of relationships between plasma IL-6 and cognitive performance to healthy middle-aged adults and to an examination of more specific cognitive domains...
  20. ncbi Stimulated production of interleukin-8 covaries with psychosocial risk factors for inflammatory disease among middle-aged community volunteers
    Anna L Marsland
    Behavioral Immunology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA
    Brain Behav Immun 21:218-28. 2007
    ..Further exploration of this potential psychophysiological pathway is warranted...
  21. ncbi Experiences of demand and control during daily life are predictors of carotid atherosclerotic progression among healthy men
    Thomas W Kamarck
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Health Psychol 26:324-32. 2007
    ..They now present prospective findings on this relation...
  22. pmc Positive affective style covaries with stimulated IL-6 and IL-10 production in a middle-aged community sample
    Aric A Prather
    Behavioral Immunology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Brain Behav Immun 21:1033-7. 2007
    ..Further exploration of this potential psychophysiological pathway is warranted...
  23. pmc Self-reported sleep duration is associated with the metabolic syndrome in midlife adults
    Martica H Hall
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Sleep 31:635-43. 2008
    ..In the present study, we evaluated the relationship between sleep duration and presence of the metabolic syndrome, which is a cluster of physiologically interrelated risk factors for cardiometabolic disease...
  24. pmc Normative variation in self-reported sleep quality and sleep debt is associated with stimulated pro-inflammatory cytokine production
    Aric A Prather
    Department of Psychology, University of Pittsburgh, PA 15260, United States
    Biol Psychol 82:12-7. 2009
    ..Further exploration of this potential psychophysiological pathway linking sleep difficulty and inflammatory disease susceptibility is warranted...
  25. pmc Parental education is related to C-reactive protein among female middle-aged community volunteers
    Jennifer E Phillips
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Brain Behav Immun 23:677-83. 2009
    ..This association may help explain the increased risk of atherosclerotic cardiovascular morbidity and mortality conferred by low childhood socioeconomic status...
  26. pmc A urinary marker of oxidative stress covaries positively with hostility among midlife community volunteers
    Judith E Carroll
    MS, Behavioral Immunology Laboratory, University of Pittsburgh, Old Engineering Hall, Suite 600, 3943 O Hara St, Pittsburgh, PA 15260
    Psychosom Med 72:273-80. 2010
    ..One possibility is that hostility is associated with oxidative stress. Here, we explore relationships between hostility and a measure of systemic oxidative stress among a mid-life sample...
  27. pmc Systemic inflammation and the metabolic syndrome among middle-aged community volunteers
    Anna L Marsland
    Behavioral Immunology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Metabolism 59:1801-8. 2010
    ..The inclusion of inflammatory markers in the clinical definition of metabolic syndrome seems warranted and may improve prognostic assessment of risk of type 2 diabetes mellitus and cardiovascular disease...
  28. ncbi Community socioeconomic status is associated with carotid artery atherosclerosis in untreated, hypertensive men
    Karen L Petersen
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh School of Medicine, 4015 O Hara Street, Pittsburgh, PA 15218, USA
    Am J Hypertens 19:560-6. 2006
    ..In this study we examined whether community SES is similarly associated with preclinical vascular disease, as measured by carotid artery ultrasonography...
  29. ncbi A genetic algorithm-based, hybrid machine learning approach to model selection
    Robert R Bies
    Department of Pharmaceutical Sciences and Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    J Pharmacokinet Pharmacodyn 33:195-221. 2006
    ..This includes structural, inter-individual random effects, covariate effects and residual error models using machine learning. This method is based on combinatorial optimization using genetic algorithm...
  30. ncbi Apolipoprotein E polymorphism and preclinical carotid artery disease in untreated hypertensive men
    Maria E Bleil
    Behavioral Physiology Laboratory, Department of Psychology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Eur J Cardiovasc Prev Rehabil 13:98-100. 2006
    ..The apolipoprotein E (apoE) polymorphism was evaluated alone, and in interaction with smoking status, in predicting carotid intima-medial thickness and plaque among 182 untreated, hypertensive, white men (mean age 56+/-8.9 years)...
  31. ncbi Psychological and cognitive function: predictors of adherence with cholesterol lowering treatment
    Carol S Stilley
    School of Nursing, University of Pittsburgh and Department of Psychiatry, University of Pittsburgh, USA
    Ann Behav Med 27:117-24. 2004
    ..Studies of mood and personality related to adherence show mixed results-compliance and objectively measured cognitive function are intuitively related but empirical support is lacking...
  32. ncbi A comparison of d, l-fenfluramine and citalopram challenges in healthy adults
    Janine D Flory
    Behavioral Physiology Laboratory 506 OEH, University of Pittsburgh, 4015 O Hara Street, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 174:376-80. 2004
    ..49, P's< or =0.02). The magnitude of the correlations is notable given the length of time between challenges. The results support the use of citalopram as an alternate neuroendocrine challenge to index CNS serotonergic responsivity...
  33. ncbi Experiences of demand and control in daily life as correlates of subclinical carotid atherosclerosis in a healthy older sample
    Thomas W Kamarck
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Health Psychol 23:24-32. 2004
    ..Previous findings linking job stress with cardiovascular disease may reflect the broader impact of daily psychological demands, not necessarily associated with the workplace...
  34. ncbi Blunted fenfluramine-evoked prolactin secretion in hypertensive rats
    Sean D Stocker
    Department of Neuroscience, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, Penn 15260, USA
    Hypertension 42:719-24. 2003
    ..Thus, the present findings are consistent with the human data and suggest that chronic hypertension is associated with a presynaptic alteration in brain serotonin function...
  35. ncbi Central nervous system serotonergic responsivity and aggressive disposition in men
    Stephen B Manuck
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, PA, USA
    Physiol Behav 77:705-9. 2002
    ..This finding suggests that association of the MAO-A promoter polymorphism with this behavioral phenotype may be mediated, in part, by allele-specific variation in central serotonergic responsivity...
  36. ncbi Psychosocial demands and ambulatory blood pressure: a field assessment approach
    Thomas W Kamarck
    Department of Psychology, University of Pittsburgh, 4501 Sennott Square, 210 South Bouquet Street, 15260, Pittsburgh, PA, USA
    Physiol Behav 77:699-704. 2002
    ..These results support the possibility that psychosocial factors may account for some of the unique predictive value associated with ABP, and they support the value of these field assessment methods...
  37. ncbi The incremental value of ambulatory blood pressure persists after controlling for methodological confounds: associations with carotid atherosclerosis in a healthy sample
    Thomas W Kamarck
    Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Hypertens 20:1535-41. 2002
    ..Ambulatory blood pressure assessments have been shown to be associated with subclinical and clinical endpoints even after controlling for the effects of clinic blood pressure...
  38. pmc Greater intima-media thickness in the carotid bulb is associated with reduced baroreflex sensitivity
    Peter J Gianaros
    Cardiovascular Behavioral Medicine Research Program, University of Pittsburgh, Pennsylvania, USA
    Am J Hypertens 15:486-91. 2002
    ..These results suggest that subclinical atherosclerosis, specifically in a region with high baroreceptor density, is associated with a reduced sensitivity of the baroreflex...
  39. ncbi Socio-economic status covaries with central nervous system serotonergic responsivity as a function of allelic variation in the serotonin transporter gene-linked polymorphic region
    Stephen B Manuck
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, 506 EH, 4015 O Hara Street, Pittsburgh, PA 15260, USA
    Psychoneuroendocrinology 29:651-68. 2004
    ..We conclude that allelic variation at 5-HTTLPR moderates the influence of social position on CNS serotonergic responsivity...
  40. ncbi Retest reliability of prolactin response to dl-fenfluramine challenge in adults
    Janine D Flory
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuropsychopharmacology 26:269-72. 2002
    ..57 for PRL "area under the curve," p <.0001). These findings are consistent with speculation that variability in indices of central serotonergic function reflects a temporally stable dimension of individual differences...
  41. ncbi Psychosocial stress and cardiovascular risk: what is the role of daily experience?
    Thomas W Kamarck
    University of Pittsburgh, PA 15260, USA
    J Pers 73:1749-74. 2005
    ....
  42. ncbi The socio-economic status of communities predicts variation in brain serotonergic responsivity
    Stephen B Manuck
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, PA 15260, USA
    Psychol Med 35:519-28. 2005
    ..Here we examine whether serotonergic responsivity covaries similarly with the SES of communities, as indexed by US Census data in the same study sample...
  43. ncbi Anger-related personality traits and carotid artery atherosclerosis in untreated hypertensive men
    Maria E Bleil
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, 4015 O Hara St, Pittsburgh, PA 15260, USA
    Psychosom Med 66:633-9. 2004
    ..To determine whether anger-related personality traits are associated with carotid artery atherosclerosis in untreated hypertensive patients...
  44. ncbi Neuroendocrine response to intravenous citalopram in healthy control subjects: pharmacokinetic influences
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
    Psychopharmacology (Berl) 178:268-75. 2005
    ..The neuroendocrine response to intravenous citalopram may provide an acute, functional, in vivo measure of the neural serotonin (5-HT) system...
  45. pmc Citalopram intervention for hostility: results of a randomized clinical trial
    Thomas W Kamarck
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Consult Clin Psychol 77:174-88. 2009
    ..04). The findings have implications for understanding the central nervous system correlates of hostility, its associations with other psychosocial risk factors for CVD, and, potentially, the design of effective interventions...
  46. ncbi Statin treatment alters serum n-3 and n-6 fatty acids in hypercholesterolemic patients
    Jennifer I Harris
    Department of Medicine, Center for Clinical Pharmacology, School of Medicine, University of Pittsburgh, 4015 O Hara Street, Old Engineering Hall, Room 506, Pittsburgh, PA 15260, USA
    Prostaglandins Leukot Essent Fatty Acids 71:263-9. 2004
    ..5 to 18.8 (P<.01), and tended to increase the AA:DHA ratio (P=.053). Thus, simvastatin lowered serum fatty acid concentrations while also altering the relative percentages of important PUFAs...
  47. ncbi White-coat hypertension and autonomic nervous system dysregulation
    Serina A Neumann
    Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Am J Hypertens 18:584-8. 2005
    ..The current study asks whether individuals with white-coat hypertension have abnormal autonomic-cardiac regulation, similar to that observed in sustained or persistent hypertension...
  48. pmc Preclinical atherosclerosis covaries with individual differences in reactivity and functional connectivity of the amygdala
    Peter J Gianaros
    Department of Psychiatry and Psychology, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 65:943-50. 2009
    ....
  49. pmc Age-related changes of n-3 and n-6 polyunsaturated fatty acids in the anterior cingulate cortex of individuals with major depressive disorder
    Sarah M Conklin
    Medical Research Service, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
    Prostaglandins Leukot Essent Fatty Acids 82:111-9. 2010
    ..The present findings from postmortem brain tissue raise the possibility that an increased ratio of 20:4(n-6) to 22:6(n-3) may provide us with a biomarker for depression. Future research should further investigate these relationships...
  50. ncbi Long-chain omega-3 fatty acid intake is associated positively with corticolimbic gray matter volume in healthy adults
    Sarah M Conklin
    Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15260, United States
    Neurosci Lett 421:209-12. 2007
    ..Here, we test whether omega-3 fatty acid intake in humans varies with individual differences in gray matter volume, an in vivo, systems-level index of neuronal integrity...
  51. ncbi Defining hypertension: never as simple as it seems
    Matthew F Muldoon
    J Hypertens 21:473-4. 2003
  52. doi Depressive symptoms moderate the influence of hostility on serum interleukin-6 and C-reactive protein
    Jesse C Stewart
    Department of Psychology, Indiana University Purdue University Indianapolis, 402 North Blackford Street, LD 100E, Indianapolis, IN 46202, USA
    Psychosom Med 70:197-204. 2008
    ..In this report we examined the cross-sectional associations of depressive symptoms, hostility, and their interaction with circulating levels of two such inflammatory markers-interleukin-6 (IL-6) and C-reactive protein (CRP)...
  53. ncbi Serum cholesterol concentrations are associated with visuomotor speed in men: findings from the third National Health and Nutrition Examination Survey, 1988-1994
    Jian Zhang
    Division of Health and Family Studies, Institute for Families in Society, University of South Carolina, Columbia, SC, USA
    Am J Clin Nutr 80:291-8. 2004
    ..Current international recommendations advise aggressive treatment of relative hypercholesterolemia despite an incomplete understanding of any neurobehavioral effects of low or lowered serum cholesterol...
  54. ncbi Effects of hemoconcentration and sympathetic activation on serum lipid responses to brief mental stress
    Elizabeth A Bachen
    Department of Psychology, Mills College, Oakland, CA 94613, USA
    Psychosom Med 64:587-94. 2002
    ..This study evaluated these two hypotheses by manipulation of sympathetically mediated responses to stress using a nonselective adrenoceptor antagonist, labetalol...
  55. ncbi High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism
    Sarah M Conklin
    Department of Psychology, Allegheny College, 520 North Main Street, Meadville, PA 16335 3902, USA
    Psychosom Med 69:932-4. 2007
    ..Previously we reported that the relative concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum covary with depressive symptomatology and neuroticism in hypercholesterolemic adults...
  56. ncbi Cognitive performance is associated with macronutrient intake in healthy young and middle-aged adults
    Jian Zhang
    Department of Epidemiology and Biostatistics, The Arnold School of Public Health, University of South Carolina, Columbia, SC, USA
    Nutr Neurosci 9:179-87. 2006
    ..The objective was to examine whether dietary intakes of macronutrients are associated with neuropsychological performance...
  57. ncbi Association of serum cholesterol and history of school suspension among school-age children and adolescents in the United States
    Jian Zhang
    Division of Health and Family Studies, Institute for Families in Society, University of South Carolina, Columbia, USA
    Am J Epidemiol 161:691-9. 2005
    ....
  58. ncbi Dietary fat intake is associated with psychosocial and cognitive functioning of school-aged children in the United States
    Jian Zhang
    Division of Health and Family Studies, the Institute for Families in Society, University of South Carolina, Columbia, USA
    J Nutr 135:1967-73. 2005
    ..We conclude that high intake of PUFAs may contribute to an improved performance on the digit span test. In contrast, increased intake of cholesterol may be associated with a poorer performance...

Research Grants13

  1. EFFECTS OF OMEGA-3 FATTY ACIDS ON COGNITIVE PERFORMANCE
    Matthew F Muldoon; Fiscal Year: 2010
    ..Since some evidence links low intake with poor cognitive function, the planned research would test whether taking a supplement of omega-3 fatty acids improves mental speed, information processing, and memory. ..
  2. Distress, Fish Oil, Inflammation, and Heart Disease
    Matthew Muldoon; Fiscal Year: 2006
    ..Results of the study could redirect current conceptualizations of the relationship between psychological factors and CHD risk, and lead to randomized clinical trials testing new interventions. ..
  3. CHOLESTEROL REDUCTION EFFECTS ON BEHAVIOR
    Matthew Muldoon; Fiscal Year: 2001
    ..The use of two treatment intensities will permit examination of the dose-response relationship between the degree of cholesterol lowering and cognitive performance. ..
  4. EFFECTS OF CHOLESTEROL REDUCTION ON BEHAVIOR
    Matthew Muldoon; Fiscal Year: 1993
    ..An additional 100 participants having desirable (untreated) serum cholesterol levels will be evaluated similarly for purposes of comparison...