Research Topics
Genomes and Genes | Matthew MuldoonSummaryAffiliation: University of Pittsburgh Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Low central nervous system serotonergic responsivity is associated with the metabolic syndrome and physical inactivityMatthew F Muldoon
Divisions of Clinical Pharmacology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
J Clin Endocrinol Metab 89:266-71. 2004..These findings reveal a heretofore unrecognized association between reduced central serotonergic responsivity and the metabolic syndrome...- Lower central serotonergic responsivity is associated with preclinical carotid artery atherosclerosisMatthew F Muldoon
Center for Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Stroke 38:2228-33. 2007..This investigation tested a hypothesized association between central serotonergic functioning and preclinical atherosclerosis... - Effects of six anti-hypertensive medications on cognitive performanceMatthew F Muldoon
Division of Clinical Pharmacology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
J Hypertens 20:1643-52. 2002..To describe and compare the effects of six different antihypertensive medications on cognitive performance... - Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adultsMatthew F Muldoon
Center for Clinical Pharmacology, University of Pittsburgh, Pennsylvania 15260, USA
Am J Med 117:823-9. 2004..The current study was designed to confirm and extend those findings... 
Serum phospholipid docosahexaenonic acid is associated with cognitive functioning during middle adulthoodMatthew F Muldoon
Center for Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Nutr 140:848-53. 2010..These findings suggest that DHA is related to brain health throughout the lifespan and may have implications for clinical trials of neuropsychiatric disorders...- The metabolic syndrome is associated with reduced central serotonergic responsivity in healthy community volunteersMatthew F Muldoon
Division of Clinical Pharmacology, Departments of Medicine and Epidemiology, University of Pittsburgh, 4015 O Hara Street, Pittsburgh, PA 15260, USA
J Clin Endocrinol Metab 91:718-21. 2006..The pathobiology of the metabolic syndrome remains unclear. The central nervous system is likely to be involved via regulation of eating, physical activity, blood pressure, and metabolism... - Is cardiovascular reactivity associated with atherosclerosis among hypertensives?Peter J Gianaros
Cardiovascular Behavioral Medicine Research Program, University of Pittsburgh, Pennsylvania, USA
Hypertension 40:742-7. 2002..Among hypertensives, exaggerated behaviorally evoked cardiovascular reactivity appears to be uniquely associated with greater carotid intima-media thickness but not with carotid plaque occurrence... 
Community socioeconomic status is associated with circulating interleukin-6 and C-reactive proteinKaren L Petersen
Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, Pennsylvania, USA
Psychosom Med 70:646-52. 2008..e., interleukin (IL)-6 and C-reactive protein (CRP), in a midlife community sample. Growing evidence suggests that socioeconomic attributes of both individuals and communities confer risk for cardiovascular morbidity and mortality...- Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteersSarah M Conklin
Cardiovascular Behavioral Medicine Postdoctoral Training Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15260, United States
Psychiatry Res 152:1-10. 2007..These findings suggest that omega-3 fatty acid status is associated with variability in affect regulation, personality and impulse control... - Lipid-lowering medication use and aggression scores in women: a report from the NHLBI-sponsored WISE studyMarian B Olson
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Womens Health (Larchmt) 17:187-94. 2008..The aim of this study was to examine the association between the use of lipid-lowering medication and aggressive responding, hostility, cynicism, and depression scores in women undergoing coronary angiography... - Self-reported sleep quality is associated with the metabolic syndromeJ Richard Jennings
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Sleep 30:219-23. 2007..To determine whether a simple, structured self-report of overall sleep quality is associated with the presence of the metabolic syndrome and its component risk factors... - Negative emotions and 3-year progression of subclinical atherosclerosisJesse C Stewart
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Arch Gen Psychiatry 64:225-33. 2007.... - Brain imaging findings predict blood pressure response to pharmacological treatmentJ Richard Jennings
Departments of Psychiatry and Psychology, University of Pittsburgh, PA, USA
Hypertension 52:1113-9. 2008..The state of the brain may be an important factor in the remediation of blood pressure... - Subjective socioeconomic status and presence of the metabolic syndrome in midlife community volunteersStephen B Manuck
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA
Psychosom Med 72:35-45. 2010.... - Polymorphisms in the CRP gene moderate an association between depressive symptoms and circulating levels of C-reactive proteinIndrani Halder
Behavioral Physiology Laboratory, University of Pittsburgh, Pittsburgh, PA 15213, USA
Brain Behav Immun 24:160-7. 2010..In conclusion, we found that haplotypic variation in the CRP locus moderates an association of depressive symptoms with circulating CRP, which is partially mediated by BMI... - Cerebrovascular support for cognitive processing in hypertensive patients is altered by blood pressure treatmentJ Richard Jennings
Department of Psychiatry, University of Pittsburgh, PA, USA
Hypertension 52:65-71. 2008.... - Brain function, cognition, and the blood pressure response to pharmacological treatmentJ Richard Jennings
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Psychosom Med 72:702-11. 2010..To extend evidence suggesting that essential hypertension influences neuropsychological performance and that brain function before treatment is related to the success of pharmacological lowering of blood pressure (BP)... - Serotonergic function in the central nervous system is associated with daily ratings of positive moodJanine D Flory
Department of Psychology, University of Pittsburgh, 4015 O Hara Street, Pittsburgh, PA 15260, USA
Psychiatry Res 129:11-9. 2004..e., Neuroticism). These results suggest that deficiencies in serotonergic function may reflect the relative absence of positive mood... - Interleukin-6 covaries inversely with cognitive performance among middle-aged community volunteersAnna L Marsland
Behavioral Immunology Laboratory, Department of Psychology, 3943 O Hara Street, Pittsburgh, PA 15260, USA
Psychosom Med 68:895-903. 2006..The current investigation extends the study of relationships between plasma IL-6 and cognitive performance to healthy middle-aged adults and to an examination of more specific cognitive domains... - Stimulated production of interleukin-8 covaries with psychosocial risk factors for inflammatory disease among middle-aged community volunteersAnna L Marsland
Behavioral Immunology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA
Brain Behav Immun 21:218-28. 2007..Further exploration of this potential psychophysiological pathway is warranted... - Experiences of demand and control during daily life are predictors of carotid atherosclerotic progression among healthy menThomas W Kamarck
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Health Psychol 26:324-32. 2007..They now present prospective findings on this relation... - Positive affective style covaries with stimulated IL-6 and IL-10 production in a middle-aged community sampleAric A Prather
Behavioral Immunology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Brain Behav Immun 21:1033-7. 2007..Further exploration of this potential psychophysiological pathway is warranted... - Self-reported sleep duration is associated with the metabolic syndrome in midlife adultsMartica H Hall
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Sleep 31:635-43. 2008..In the present study, we evaluated the relationship between sleep duration and presence of the metabolic syndrome, which is a cluster of physiologically interrelated risk factors for cardiometabolic disease... - Normative variation in self-reported sleep quality and sleep debt is associated with stimulated pro-inflammatory cytokine productionAric A Prather
Department of Psychology, University of Pittsburgh, PA 15260, United States
Biol Psychol 82:12-7. 2009..Further exploration of this potential psychophysiological pathway linking sleep difficulty and inflammatory disease susceptibility is warranted... - Parental education is related to C-reactive protein among female middle-aged community volunteersJennifer E Phillips
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Brain Behav Immun 23:677-83. 2009..This association may help explain the increased risk of atherosclerotic cardiovascular morbidity and mortality conferred by low childhood socioeconomic status... - A urinary marker of oxidative stress covaries positively with hostility among midlife community volunteersJudith E Carroll
MS, Behavioral Immunology Laboratory, University of Pittsburgh, Old Engineering Hall, Suite 600, 3943 O Hara St, Pittsburgh, PA 15260
Psychosom Med 72:273-80. 2010..One possibility is that hostility is associated with oxidative stress. Here, we explore relationships between hostility and a measure of systemic oxidative stress among a mid-life sample... - Systemic inflammation and the metabolic syndrome among middle-aged community volunteersAnna L Marsland
Behavioral Immunology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Metabolism 59:1801-8. 2010..The inclusion of inflammatory markers in the clinical definition of metabolic syndrome seems warranted and may improve prognostic assessment of risk of type 2 diabetes mellitus and cardiovascular disease... - Community socioeconomic status is associated with carotid artery atherosclerosis in untreated, hypertensive menKaren L Petersen
Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh School of Medicine, 4015 O Hara Street, Pittsburgh, PA 15218, USA
Am J Hypertens 19:560-6. 2006..In this study we examined whether community SES is similarly associated with preclinical vascular disease, as measured by carotid artery ultrasonography... - A genetic algorithm-based, hybrid machine learning approach to model selectionRobert R Bies
Department of Pharmaceutical Sciences and Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
J Pharmacokinet Pharmacodyn 33:195-221. 2006..This includes structural, inter-individual random effects, covariate effects and residual error models using machine learning. This method is based on combinatorial optimization using genetic algorithm... - Apolipoprotein E polymorphism and preclinical carotid artery disease in untreated hypertensive menMaria E Bleil
Behavioral Physiology Laboratory, Department of Psychology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
Eur J Cardiovasc Prev Rehabil 13:98-100. 2006..The apolipoprotein E (apoE) polymorphism was evaluated alone, and in interaction with smoking status, in predicting carotid intima-medial thickness and plaque among 182 untreated, hypertensive, white men (mean age 56+/-8.9 years)... - Psychological and cognitive function: predictors of adherence with cholesterol lowering treatmentCarol S Stilley
School of Nursing, University of Pittsburgh and Department of Psychiatry, University of Pittsburgh, USA
Ann Behav Med 27:117-24. 2004..Studies of mood and personality related to adherence show mixed results-compliance and objectively measured cognitive function are intuitively related but empirical support is lacking... - A comparison of d, l-fenfluramine and citalopram challenges in healthy adultsJanine D Flory
Behavioral Physiology Laboratory 506 OEH, University of Pittsburgh, 4015 O Hara Street, Pittsburgh, PA 15260, USA
Psychopharmacology (Berl) 174:376-80. 2004..49, P's< or =0.02). The magnitude of the correlations is notable given the length of time between challenges. The results support the use of citalopram as an alternate neuroendocrine challenge to index CNS serotonergic responsivity... - Experiences of demand and control in daily life as correlates of subclinical carotid atherosclerosis in a healthy older sampleThomas W Kamarck
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Health Psychol 23:24-32. 2004..Previous findings linking job stress with cardiovascular disease may reflect the broader impact of daily psychological demands, not necessarily associated with the workplace... - Blunted fenfluramine-evoked prolactin secretion in hypertensive ratsSean D Stocker
Department of Neuroscience, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, Penn 15260, USA
Hypertension 42:719-24. 2003..Thus, the present findings are consistent with the human data and suggest that chronic hypertension is associated with a presynaptic alteration in brain serotonin function... - Central nervous system serotonergic responsivity and aggressive disposition in menStephen B Manuck
Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, PA, USA
Physiol Behav 77:705-9. 2002..This finding suggests that association of the MAO-A promoter polymorphism with this behavioral phenotype may be mediated, in part, by allele-specific variation in central serotonergic responsivity... - Psychosocial demands and ambulatory blood pressure: a field assessment approachThomas W Kamarck
Department of Psychology, University of Pittsburgh, 4501 Sennott Square, 210 South Bouquet Street, 15260, Pittsburgh, PA, USA
Physiol Behav 77:699-704. 2002..These results support the possibility that psychosocial factors may account for some of the unique predictive value associated with ABP, and they support the value of these field assessment methods... - The incremental value of ambulatory blood pressure persists after controlling for methodological confounds: associations with carotid atherosclerosis in a healthy sampleThomas W Kamarck
Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Hypertens 20:1535-41. 2002..Ambulatory blood pressure assessments have been shown to be associated with subclinical and clinical endpoints even after controlling for the effects of clinic blood pressure... - Greater intima-media thickness in the carotid bulb is associated with reduced baroreflex sensitivityPeter J Gianaros
Cardiovascular Behavioral Medicine Research Program, University of Pittsburgh, Pennsylvania, USA
Am J Hypertens 15:486-91. 2002..These results suggest that subclinical atherosclerosis, specifically in a region with high baroreceptor density, is associated with a reduced sensitivity of the baroreflex... - Socio-economic status covaries with central nervous system serotonergic responsivity as a function of allelic variation in the serotonin transporter gene-linked polymorphic regionStephen B Manuck
Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, 506 EH, 4015 O Hara Street, Pittsburgh, PA 15260, USA
Psychoneuroendocrinology 29:651-68. 2004..We conclude that allelic variation at 5-HTTLPR moderates the influence of social position on CNS serotonergic responsivity... - Retest reliability of prolactin response to dl-fenfluramine challenge in adultsJanine D Flory
Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Neuropsychopharmacology 26:269-72. 2002..57 for PRL "area under the curve," p <.0001). These findings are consistent with speculation that variability in indices of central serotonergic function reflects a temporally stable dimension of individual differences... - Psychosocial stress and cardiovascular risk: what is the role of daily experience?Thomas W Kamarck
University of Pittsburgh, PA 15260, USA
J Pers 73:1749-74. 2005.... - The socio-economic status of communities predicts variation in brain serotonergic responsivityStephen B Manuck
Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, PA 15260, USA
Psychol Med 35:519-28. 2005..Here we examine whether serotonergic responsivity covaries similarly with the SES of communities, as indexed by US Census data in the same study sample... - Anger-related personality traits and carotid artery atherosclerosis in untreated hypertensive menMaria E Bleil
Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, 4015 O Hara St, Pittsburgh, PA 15260, USA
Psychosom Med 66:633-9. 2004..To determine whether anger-related personality traits are associated with carotid artery atherosclerosis in untreated hypertensive patients... - Neuroendocrine response to intravenous citalopram in healthy control subjects: pharmacokinetic influencesFrancis E Lotrich
Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
Psychopharmacology (Berl) 178:268-75. 2005..The neuroendocrine response to intravenous citalopram may provide an acute, functional, in vivo measure of the neural serotonin (5-HT) system... - Citalopram intervention for hostility: results of a randomized clinical trialThomas W Kamarck
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Consult Clin Psychol 77:174-88. 2009..04). The findings have implications for understanding the central nervous system correlates of hostility, its associations with other psychosocial risk factors for CVD, and, potentially, the design of effective interventions... - Statin treatment alters serum n-3 and n-6 fatty acids in hypercholesterolemic patientsJennifer I Harris
Department of Medicine, Center for Clinical Pharmacology, School of Medicine, University of Pittsburgh, 4015 O'Hara Street, Old Engineering Hall, Room 506, Pittsburgh, PA 15260, USA
Prostaglandins Leukot Essent Fatty Acids 71:263-9. 2004..5 to 18.8 (P<.01), and tended to increase the AA:DHA ratio (P=.053). Thus, simvastatin lowered serum fatty acid concentrations while also altering the relative percentages of important PUFAs... - White-coat hypertension and autonomic nervous system dysregulationSerina A Neumann
Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
Am J Hypertens 18:584-8. 2005..The current study asks whether individuals with white-coat hypertension have abnormal autonomic-cardiac regulation, similar to that observed in sustained or persistent hypertension... - Preclinical atherosclerosis covaries with individual differences in reactivity and functional connectivity of the amygdalaPeter J Gianaros
Department of Psychiatry and Psychology, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 65:943-50. 2009.... - Age-related changes of n-3 and n-6 polyunsaturated fatty acids in the anterior cingulate cortex of individuals with major depressive disorderSarah M Conklin
Medical Research Service, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
Prostaglandins Leukot Essent Fatty Acids 82:111-9. 2010..The present findings from postmortem brain tissue raise the possibility that an increased ratio of 20:4(n-6) to 22:6(n-3) may provide us with a biomarker for depression. Future research should further investigate these relationships... - Long-chain omega-3 fatty acid intake is associated positively with corticolimbic gray matter volume in healthy adultsSarah M Conklin
Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15260, United States
Neurosci Lett 421:209-12. 2007..Here, we test whether omega-3 fatty acid intake in humans varies with individual differences in gray matter volume, an in vivo, systems-level index of neuronal integrity... - Defining hypertension: never as simple as it seemsMatthew F Muldoon
J Hypertens 21:473-4. 2003 - Depressive symptoms moderate the influence of hostility on serum interleukin-6 and C-reactive proteinJesse C Stewart
Department of Psychology, Indiana University Purdue University Indianapolis, 402 North Blackford Street, LD 100E, Indianapolis, IN 46202, USA
Psychosom Med 70:197-204. 2008..In this report we examined the cross-sectional associations of depressive symptoms, hostility, and their interaction with circulating levels of two such inflammatory markers-interleukin-6 (IL-6) and C-reactive protein (CRP)... - Serum cholesterol concentrations are associated with visuomotor speed in men: findings from the third National Health and Nutrition Examination Survey, 1988-1994Jian Zhang
Division of Health and Family Studies, Institute for Families in Society, University of South Carolina, Columbia, SC, USA
Am J Clin Nutr 80:291-8. 2004..Current international recommendations advise aggressive treatment of relative hypercholesterolemia despite an incomplete understanding of any neurobehavioral effects of low or lowered serum cholesterol... - Effects of hemoconcentration and sympathetic activation on serum lipid responses to brief mental stressElizabeth A Bachen
Department of Psychology, Mills College, Oakland, CA 94613, USA
Psychosom Med 64:587-94. 2002..This study evaluated these two hypotheses by manipulation of sympathetically mediated responses to stress using a nonselective adrenoceptor antagonist, labetalol... - High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticismSarah M Conklin
Department of Psychology, Allegheny College, 520 North Main Street, Meadville, PA 16335 3902, USA
Psychosom Med 69:932-4. 2007..Previously we reported that the relative concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum covary with depressive symptomatology and neuroticism in hypercholesterolemic adults... - Cognitive performance is associated with macronutrient intake in healthy young and middle-aged adultsJian Zhang
Department of Epidemiology and Biostatistics, The Arnold School of Public Health, University of South Carolina, Columbia, SC, USA
Nutr Neurosci 9:179-87. 2006..The objective was to examine whether dietary intakes of macronutrients are associated with neuropsychological performance... - Association of serum cholesterol and history of school suspension among school-age children and adolescents in the United StatesJian Zhang
Division of Health and Family Studies, Institute for Families in Society, University of South Carolina, Columbia, USA
Am J Epidemiol 161:691-9. 2005.... - Dietary fat intake is associated with psychosocial and cognitive functioning of school-aged children in the United StatesJian Zhang
Division of Health and Family Studies, the Institute for Families in Society, University of South Carolina, Columbia, USA
J Nutr 135:1967-73. 2005..We conclude that high intake of PUFAs may contribute to an improved performance on the digit span test. In contrast, increased intake of cholesterol may be associated with a poorer performance...
Research Grants
- EFFECTS OF OMEGA-3 FATTY ACIDS ON COGNITIVE PERFORMANCEMatthew F Muldoon; Fiscal Year: 2010..Since some evidence links low intake with poor cognitive function, the planned research would test whether taking a supplement of omega-3 fatty acids improves mental speed, information processing, and memory. ..
- Distress, Fish Oil, Inflammation, and Heart DiseaseMatthew Muldoon; Fiscal Year: 2006..Results of the study could redirect current conceptualizations of the relationship between psychological factors and CHD risk, and lead to randomized clinical trials testing new interventions. ..
- CHOLESTEROL REDUCTION EFFECTS ON BEHAVIORMatthew Muldoon; Fiscal Year: 2001..The use of two treatment intensities will permit examination of the dose-response relationship between the degree of cholesterol lowering and cognitive performance. ..
- EFFECTS OF CHOLESTEROL REDUCTION ON BEHAVIORMatthew Muldoon; Fiscal Year: 1993..An additional 100 participants having desirable (untreated) serum cholesterol levels will be evaluated similarly for purposes of comparison...