JOGESH MUKHERJEE

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Brain imaging of 18F-fallypride in normal volunteers: blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2/D-3 receptors
    Jogeshwar Mukherjee
    Department of Nuclear Medicine PET, Kettering Medical Center, Dayton, Ohio 45429, USA
    Synapse 46:170-88. 2002
  2. ncbi request reprint Evaluation of dopamine D-2 receptor occupancy by clozapine, risperidone, and haloperidol in vivo in the rodent and nonhuman primate brain using 18F-fallypride
    J Mukherjee
    Department of Internal Medicine Nuclear Medicine, Kettering Medical Center, Wright State University, Dayton, OH, USA
    Neuropsychopharmacology 25:476-88. 2001
  3. ncbi request reprint 11C-Fallypride: radiosynthesis and preliminary evaluation of a novel dopamine D2/D3 receptor PET radiotracer in non-human primate brain
    Jogeshwar Mukherjee
    Brain Imaging Center, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92697, USA
    Bioorg Med Chem 12:95-102. 2004
  4. ncbi request reprint Measurement of d-amphetamine-induced effects on the binding of dopamine D-2/D-3 receptor radioligand, 18F-fallypride in extrastriatal brain regions in non-human primates using PET
    Jogeshwar Mukherjee
    Brain Imaging Center, Department of Psychiatry and Human Behavior, University of California Irvine, 162 Irvine Hall, Irvine, CA 92697, USA
    Brain Res 1032:77-84. 2005
  5. ncbi request reprint Binding characteristics of high-affinity dopamine D2/D3 receptor agonists, 11C-PPHT and 11C-ZYY-339 in rodents and imaging in non-human primates by PET
    Jogeshwar Mukherjee
    Brain Imaging Center, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, California 92697, USA
    Synapse 54:83-91. 2004
  6. ncbi request reprint Quantitation of striatal and extrastriatal D-2 dopamine receptors using PET imaging of [(18)F]fallypride in nonhuman primates
    B T Christian
    Department of Internal Medicine Nuclear Medicine, Kettering Medical Center, Wright State University, Dayton, Ohio 45429, USA
    Synapse 38:71-9. 2000
  7. ncbi request reprint In vitro and in vivo evaluation of the binding of the dopamine D2 receptor agonist (11)C-(R,S)-5-hydroxy-2-(di-n-propylamino)tetralin in rodents and nonhuman primate
    J Mukherjee
    Department of Internal Medicine Nuclear Medicine, Kettering Medical Center, Wright State University, Dayton, OH 45429, USA
    Synapse 37:64-70. 2000
  8. ncbi request reprint Clinical utility of 11C-flumazenil positron emission tomography in intractable temporal lobe epilepsy
    M V Padma
    Department of Nuclear Medicine, Kettering Medical Center, Wright State University, Kettering, Ohio 45429, USA
    Neurol India 52:457-62. 2004
  9. ncbi request reprint D2/D3 dopamine receptor binding with [F-18]fallypride in thalamus and cortex of patients with schizophrenia
    Monte S Buchsbaum
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY 10029, USA
    Schizophr Res 85:232-44. 2006
  10. ncbi request reprint Synthesis and biologic evaluation of a novel serotonin 5-HT1A receptor radioligand, 18F-labeled mefway, in rodents and imaging by PET in a nonhuman primate
    Neil Saigal
    Brain Imaging Center, Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, California 92697 3960, USA
    J Nucl Med 47:1697-706. 2006

Research Grants

  1. Small Animal PET (microPET)
    JOGESH MUKHERJEE; Fiscal Year: 2007
  2. 18F-Mefway for Imaging Mood Disorders and Alzheimer's Disease
    JOGESH MUKHERJEE; Fiscal Year: 2007
  3. PET Imaging Agents for Nicotinic a4b2 Receptors
    JOGESH MUKHERJEE; Fiscal Year: 2007
  4. Dopamine D2/D3 Receptor Agonists for PET Imaging
    JOGESH MUKHERJEE; Fiscal Year: 2007

Detail Information

Publications19

  1. ncbi request reprint Brain imaging of 18F-fallypride in normal volunteers: blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2/D-3 receptors
    Jogeshwar Mukherjee
    Department of Nuclear Medicine PET, Kettering Medical Center, Dayton, Ohio 45429, USA
    Synapse 46:170-88. 2002
    ..PET studies with 18F-fallypride are thus suitable to study changes in D2/D3 receptors in striatal and extrastriatal brain regions...
  2. ncbi request reprint Evaluation of dopamine D-2 receptor occupancy by clozapine, risperidone, and haloperidol in vivo in the rodent and nonhuman primate brain using 18F-fallypride
    J Mukherjee
    Department of Internal Medicine Nuclear Medicine, Kettering Medical Center, Wright State University, Dayton, OH, USA
    Neuropsychopharmacology 25:476-88. 2001
    ..The following extent of D-2 receptor occupancies were measured in the monkey brain using PET: clozapine approximately 70% (dose of 9.7 mg/kg), risperidone approximately 75% (0.05 mg/kg), and haloperidol approximately 90% (0.05 mg/kg)...
  3. ncbi request reprint 11C-Fallypride: radiosynthesis and preliminary evaluation of a novel dopamine D2/D3 receptor PET radiotracer in non-human primate brain
    Jogeshwar Mukherjee
    Brain Imaging Center, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92697, USA
    Bioorg Med Chem 12:95-102. 2004
    ..This regional localization of (11)C-fallypride is similar to that observed previously for (18)F-fallypride. The results suggest (11)C-fallypride is a useful PET radiotracer for imaging dopamine D2/D3 receptors...
  4. ncbi request reprint Measurement of d-amphetamine-induced effects on the binding of dopamine D-2/D-3 receptor radioligand, 18F-fallypride in extrastriatal brain regions in non-human primates using PET
    Jogeshwar Mukherjee
    Brain Imaging Center, Department of Psychiatry and Human Behavior, University of California Irvine, 162 Irvine Hall, Irvine, CA 92697, USA
    Brain Res 1032:77-84. 2005
    ..Furthermore, our findings support the use of (18)F-fallypride to measure extrastriatal dopamine release...
  5. ncbi request reprint Binding characteristics of high-affinity dopamine D2/D3 receptor agonists, 11C-PPHT and 11C-ZYY-339 in rodents and imaging in non-human primates by PET
    Jogeshwar Mukherjee
    Brain Imaging Center, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, California 92697, USA
    Synapse 54:83-91. 2004
    ..These findings with 11C-PPHT and 11C-ZYY-339 indicate the possibility of in vivo imaging of high-affinity state of dopamine D2/D3 receptors in both the striata and the thalamus...
  6. ncbi request reprint Quantitation of striatal and extrastriatal D-2 dopamine receptors using PET imaging of [(18)F]fallypride in nonhuman primates
    B T Christian
    Department of Internal Medicine Nuclear Medicine, Kettering Medical Center, Wright State University, Dayton, Ohio 45429, USA
    Synapse 38:71-9. 2000
    ..For the extrastriatal regions, the effect of the k(2) term on DVR calculation is negligible. Repeatability measurements for all regions were found to be within 10% using the DVR parameter...
  7. ncbi request reprint In vitro and in vivo evaluation of the binding of the dopamine D2 receptor agonist (11)C-(R,S)-5-hydroxy-2-(di-n-propylamino)tetralin in rodents and nonhuman primate
    J Mukherjee
    Department of Internal Medicine Nuclear Medicine, Kettering Medical Center, Wright State University, Dayton, OH 45429, USA
    Synapse 37:64-70. 2000
    ..A PET study in a rhesus monkey showed selective localization of (11)C-5-OH-DPAT in the striata and the ratio between striata and cerebellum approached approximately 2 at 40 min postinjection...
  8. ncbi request reprint Clinical utility of 11C-flumazenil positron emission tomography in intractable temporal lobe epilepsy
    M V Padma
    Department of Nuclear Medicine, Kettering Medical Center, Wright State University, Kettering, Ohio 45429, USA
    Neurol India 52:457-62. 2004
    ..11C-flumazenil (FMZ) positron emission tomography (PET) is a new entrant into the armamentarium for pre-surgical evaluation of patients with intractable temporal lobe epilepsy (TLE)...
  9. ncbi request reprint D2/D3 dopamine receptor binding with [F-18]fallypride in thalamus and cortex of patients with schizophrenia
    Monte S Buchsbaum
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY 10029, USA
    Schizophr Res 85:232-44. 2006
    ....
  10. ncbi request reprint Synthesis and biologic evaluation of a novel serotonin 5-HT1A receptor radioligand, 18F-labeled mefway, in rodents and imaging by PET in a nonhuman primate
    Neil Saigal
    Brain Imaging Center, Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, California 92697 3960, USA
    J Nucl Med 47:1697-706. 2006
    ..We have synthesized N-{2-[4-(2-methoxyphenyl)piperazinyl]ethyl}-N-(2-pyridyl)-N-(4-18F-fluoromethylcyclohexane)carboxamide (18F-mefway), which contains a 18F on a primary carbon to make the compound more stable to defluorination...
  11. ncbi request reprint Effect of acetylcholinesterase inhibitors on the binding of nicotinic alpha4beta2 receptor PET radiotracer, (18)F-nifene: A measure of acetylcholine competition
    Balasubramaniam Easwaramoorthy
    Brain Imaging Center, Department of Psychiatry and Human Behavior, University of California, Irvine, California 92697, USA
    Synapse 61:29-36. 2007
    ..The effect is AChEI-concentration dependent and is greater for PHY than GAL. Thus (18)F-nifene has promise for assessing ACh levels and AChEI effects in vivo...
  12. ncbi request reprint Nicotinic alpha4beta2 receptor imaging agents: part II. Synthesis and biological evaluation of 2-[18F]fluoro-3-[2-((S)-3-pyrrolinyl)methoxy]pyridine (18F-nifene) in rodents and imaging by PET in nonhuman primate
    Rama Pichika
    Brain Imaging Center, Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697 3960, USA
    Nucl Med Biol 33:295-304. 2006
    ..Thalamus-to-cerebellum ratio peaked at 30-35 min postinjection to a value of 2.2 and subsequently reduced. The faster binding profile of 18F-nifene indicates promise as a PET imaging agent and thus needs further evaluation...
  13. ncbi request reprint Positron autoradiography for intravascular imaging: feasibility evaluation
    Polad M Shikhaliev
    Department of Radiological Sciences, University of California at Irvine, Irvine, CA 92697, USA
    Phys Med Biol 51:963-79. 2006
    ..Experiments showed that detecting the coronary plaques using the proposed technique is possible. The proposed technique has the potential for fast and accurate detection of vulnerable coronary and other intravascular plaques...
  14. ncbi request reprint Moderate-level prenatal alcohol exposure alters striatal dopamine system function in rhesus monkeys
    Mary L Schneider
    Department of Kinesiology, The Harlow Center for Biological Psychology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Alcohol Clin Exp Res 29:1685-97. 2005
    ..In this study, we manipulated the timing of moderate-level alcohol exposure and compared the risk of adverse effects on striatal dopamine (DA) system function in rhesus monkeys...
  15. ncbi request reprint Synthesis and evaluation of nicotine alpha4beta2 receptor radioligand, 5-(3'-18F-fluoropropyl)-3-(2-(S)-pyrrolidinylmethoxy)pyridine, in rodents and PET in nonhuman primate
    Sankha Chattopadhyay
    Department of Psychiatry and Human Behavior Brain Imaging Center, University of California, Irvine, CA 92697, USA
    J Nucl Med 46:130-40. 2005
    ..We report the development and evaluation of a putative antagonist, 5-(3'-fluoropropyl)-3-(2-(S)-pyrrolidinylmethoxy)pyridine (nifrolidine) as a PET agent for nicotine alpha(4)beta(2) receptors...
  16. ncbi request reprint Measuring the in vivo binding parameters of [18F]-fallypride in monkeys using a PET multiple-injection protocol
    Bradley T Christian
    Department of PET Nuclear Medicine, Kettering Medical Center, Dayton, OH, USA
    J Cereb Blood Flow Metab 24:309-22. 2004
    ....
  17. ncbi request reprint Synthesis and biological evaluation of the binding of dopamine D2/D3 receptor agonist, (R,S)-5-hydroxy-2-(N-propyl-N-(5'-(18)F-fluoropentyl)aminotetralin ((18)F-5-OH-FPPAT) in rodents and nonhuman primates
    Bingzhi Shi
    Department of Internal Medicine Nuclear Medicine, Kettering Medical Center, Wright State University, Dayton, OH 45429, USA
    Nucl Med Biol 31:303-11. 2004
    ..A PET study in rhesus monkeys showed selective localization of (18)F-5-OH-FPPAT in the striata and the ratio between striata and cerebellum approached approximately 2 at 40 min post-injection...
  18. pmc [11C]cyclopropyl-FLB 457: a PET radioligand for low densities of dopamine D2 receptors
    Anu J Airaksinen
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, S 17176 Stockholm, Sweden
    Bioorg Med Chem 16:6467-73. 2008
    ..Pre-treatment with raclopride (1 mg/kg as tartrate) caused high reduction of binding in extrastriatal regions, including cerebellum. [(11)C]4 is a promising radioligand for imaging D(2) receptors in low density regions in brain...
  19. ncbi request reprint 11C-L-methionine positron emission tomography in the clinical management of cerebral gliomas
    Tarun Singhal
    Department of Nuclear Medicine PET, Kettering Medical Center, Dayton, OH 45429, USA
    Mol Imaging Biol 10:1-18. 2008
    ....

Research Grants4

  1. Small Animal PET (microPET)
    JOGESH MUKHERJEE; Fiscal Year: 2007
    ..The microPET scanner will be under the direction of Dr. Jogesh Mukherjee, and a team from five different departments (Radiology, Medicine, Pharmacology, Neurobiology and Behavior and ..
  2. 18F-Mefway for Imaging Mood Disorders and Alzheimer's Disease
    JOGESH MUKHERJEE; Fiscal Year: 2007
    ....
  3. PET Imaging Agents for Nicotinic a4b2 Receptors
    JOGESH MUKHERJEE; Fiscal Year: 2007
    ..Continuation of this application will then study the role of these receptors in AD and nicotine dependency. ..
  4. Dopamine D2/D3 Receptor Agonists for PET Imaging
    JOGESH MUKHERJEE; Fiscal Year: 2007
    ..Finally PET studies will be carried out in monkeys with these agents to demonstrate HA-state binding and receptor subtype selectivity. ..