Bhramar Mukherjee

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. doi request reprint Principal interactions analysis for repeated measures data: application to gene-gene and gene-environment interactions
    Bhramar Mukherjee
    Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    Stat Med 31:2531-51. 2012
  2. pmc Variability in prescription drug expenditures explained by adjusted clinical groups (ACG) case-mix: a cross-sectional study of patient electronic records in primary care
    Alba Aguado
    Catalan Institute of Oncology, IDIBELL, L Hospitalet, Barcelona, Spain
    BMC Health Serv Res 8:53. 2008
  3. pmc Fitting stratified proportional odds models by amalgamating conditional likelihoods
    Bhramar Mukherjee
    Department of Biostatistics, University of Michigan, Ann Arbor, MI 48103, USA
    Stat Med 27:4950-71. 2008
  4. ncbi request reprint Exploiting gene-environment independence for analysis of case-control studies: an empirical Bayes-type shrinkage estimator to trade-off between bias and efficiency
    Bhramar Mukherjee
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Biometrics 64:685-94. 2008
  5. pmc Case-control studies of gene-environment interaction: Bayesian design and analysis
    Bhramar Mukherjee
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Biometrics 66:934-48. 2010
  6. ncbi request reprint Analysis of matched case-control data with multiple ordered disease states: possible choices and comparisons
    Bhramar Mukherjee
    Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    Stat Med 26:3240-57. 2007
  7. ncbi request reprint Semiparametric Bayesian analysis of case-control data under conditional gene-environment independence
    Bhramar Mukherjee
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Biometrics 63:834-44. 2007
  8. doi request reprint Tests for gene-environment interaction from case-control data: a novel study of type I error, power and designs
    Bhramar Mukherjee
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA
    Genet Epidemiol 32:615-26. 2008
  9. pmc Elevated risk of prostate cancer among men with Lynch syndrome
    Victoria M Raymond
    University of Michigan, 300 North Ingalls, Ann Arbor, MI 48109 5419, USA
    J Clin Oncol 31:1713-8. 2013
  10. doi request reprint High risk of colorectal and endometrial cancer in Ashkenazi families with the MSH2 A636P founder mutation
    Bhramar Mukherjee
    Department of Biostatistics, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA
    Gastroenterology 140:1919-26. 2011

Research Grants

Detail Information

Publications51

  1. doi request reprint Principal interactions analysis for repeated measures data: application to gene-gene and gene-environment interactions
    Bhramar Mukherjee
    Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    Stat Med 31:2531-51. 2012
    ..We carry out simulation studies under an array of classical interaction models and common epistasis models to illustrate the properties of the principal interactions analysis procedure in comparison with the classical alternatives...
  2. pmc Variability in prescription drug expenditures explained by adjusted clinical groups (ACG) case-mix: a cross-sectional study of patient electronic records in primary care
    Alba Aguado
    Catalan Institute of Oncology, IDIBELL, L Hospitalet, Barcelona, Spain
    BMC Health Serv Res 8:53. 2008
    ..We have estimated the variability in pharmacy costs explained by ACG in centers using patient electronic records, profiled centers and physicians and analyzed the correlation between cost and quality of prescription...
  3. pmc Fitting stratified proportional odds models by amalgamating conditional likelihoods
    Bhramar Mukherjee
    Department of Biostatistics, University of Michigan, Ann Arbor, MI 48103, USA
    Stat Med 27:4950-71. 2008
    ..We illustrate the methods via three real data examples related to biomedical research. Simulation results comparing the proposed method with a random effects model on the stratification parameters are also furnished...
  4. ncbi request reprint Exploiting gene-environment independence for analysis of case-control studies: an empirical Bayes-type shrinkage estimator to trade-off between bias and efficiency
    Bhramar Mukherjee
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Biometrics 64:685-94. 2008
    ..Both simulated and real data examples suggest that the proposed estimator strikes a balance between bias and efficiency depending on the true nature of the gene-environment association and the sample size for a given study...
  5. pmc Case-control studies of gene-environment interaction: Bayesian design and analysis
    Bhramar Mukherjee
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Biometrics 66:934-48. 2010
    ..The Bayesian design and analysis strategies are compared with their corresponding frequentist counterparts...
  6. ncbi request reprint Analysis of matched case-control data with multiple ordered disease states: possible choices and comparisons
    Bhramar Mukherjee
    Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    Stat Med 26:3240-57. 2007
    ..A simulation study compares the different ordinal methods with methods ignoring sub-classification of the ordered disease states...
  7. ncbi request reprint Semiparametric Bayesian analysis of case-control data under conditional gene-environment independence
    Bhramar Mukherjee
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Biometrics 63:834-44. 2007
    ..The results reflect that the semiparametric Bayesian model allows incorporation of key scientific evidence in the form of a prior and offers a flexible, robust alternative when standard parametric model assumptions do not hold...
  8. doi request reprint Tests for gene-environment interaction from case-control data: a novel study of type I error, power and designs
    Bhramar Mukherjee
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA
    Genet Epidemiol 32:615-26. 2008
    ....
  9. pmc Elevated risk of prostate cancer among men with Lynch syndrome
    Victoria M Raymond
    University of Michigan, 300 North Ingalls, Ann Arbor, MI 48109 5419, USA
    J Clin Oncol 31:1713-8. 2013
    ..Previous studies quantifying prostate cancer risk in LS have provided conflicting results...
  10. doi request reprint High risk of colorectal and endometrial cancer in Ashkenazi families with the MSH2 A636P founder mutation
    Bhramar Mukherjee
    Department of Biostatistics, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA
    Gastroenterology 140:1919-26. 2011
    ..4%-0.7%. Estimates of age-specific cumulative risk and lifetime risk for colorectal cancer (CRC) and endometrial cancer (EC) specific to carriers of this mutation are not available...
  11. doi request reprint Point source modeling of matched case-control data with multiple disease subtypes
    Shi Li
    Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
    Stat Med 31:3617-37. 2012
    ..We illustrate the methods by analyzing Medicaid claims data corresponding to the pediatric asthma population in Detroit, Michigan, from 2004 to 2006...
  12. pmc Cumulative lead exposure and age-related hearing loss: the VA Normative Aging Study
    Sung Kyun Park
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    Hear Res 269:48-55. 2010
    ..Our results suggest that chronic low-level lead exposure may be an important risk factor for age-related hearing loss and reduction of lead exposure could help prevent or delay development of age-related hearing loss...
  13. pmc Missing exposure data in stereotype regression model: application to matched case-control study with disease subclassification
    Jaeil Ahn
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Biometrics 67:546-58. 2011
    ..We illustrate our methods by using data from an ongoing matched case-control study of colorectal cancer. Simulation results are presented under various missing data mechanisms and departures from modeling assumptions...
  14. pmc HFE H63D polymorphism as a modifier of the effect of cumulative lead exposure on pulse pressure: the Normative Aging Study
    Aimin Zhang
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Environ Health Perspect 118:1261-6. 2010
    ..Polymorphisms in the hemochromatosis gene (HFE) have been shown to modify the impact of cumulative lead exposure on measures of adult cognition and cardiac function...
  15. pmc Incorporating auxiliary information for improved prediction in high-dimensional datasets: an ensemble of shrinkage approaches
    Philip S Boonstra
    Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    Biostatistics 14:259-72. 2013
    ..mRNA expression measured via quantitative real-time polymerase chain reaction is used to predict survival time in lung cancer patients, with auxiliary information from microarray technology available on a larger sample...
  16. pmc Environmental cadmium and lead exposures and hearing loss in U.S. adults: the National Health and Nutrition Examination Survey, 1999 to 2004
    Yoon Hyeong Choi
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA
    Environ Health Perspect 120:1544-50. 2012
    ..Although cadmium and lead are known risk factors for hearing loss in animal models, few epidemiologic studies have been conducted on their associations with hearing ability in the general population...
  17. pmc Bayesian modeling for genetic anticipation in presence of mutational heterogeneity: a case study in Lynch syndrome
    Philip S Boonstra
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Biometrics 67:1627-37. 2011
    ..We find evidence for a decrease in AOO between generations in this article. Our model predicts family-level anticipation effects that are potentially useful in genetic counseling clinics for high-risk families...
  18. pmc MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers
    Eduardo Vilar
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Cancer Res 71:2632-42. 2011
    ..We conclude that MSI colorectal tumors deficient in DSB repair secondary to mutation in MRE11 show a higher sensitivity to PARP-1 inhibition. Further clinical investigation of PARP-1 inhibitors is warranted in MSI CRCs...
  19. doi request reprint Association of daily asthma emergency department visits and hospital admissions with ambient air pollutants among the pediatric Medicaid population in Detroit: time-series and time-stratified case-crossover analyses with threshold effects
    Shi Li
    Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 48109 2029, USA
    Environ Res 111:1137-47. 2011
    ..In such study designs, threshold effects of air pollutants on asthma outcomes have been relatively unexplored, which are of potential interest for exploring concentration-response relationships...
  20. pmc Bone lead level prediction models and their application to examine the relationship of lead exposure and hypertension in the Third National Health and Nutrition Examination Survey
    Sung Kyun Park
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    J Occup Environ Med 51:1422-36. 2009
    ..We developed prediction models for bone lead using blood lead levels and other standard covariates in a community-based cohort of older men...
  21. pmc Risk of colorectal cancer in self-reported inflammatory bowel disease and modification of risk by statin and NSAID use
    N Jewel Samadder
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA
    Cancer 117:1640-8. 2011
    ..The objective of this study was to quantify the relative risk of inflammatory bowel disease (IBD) as a risk factor for CRC and to estimate whether this risk may be modified by long-term use of NSAIDs or statins...
  22. pmc Statistical strategies for constructing health risk models with multiple pollutants and their interactions: possible choices and comparisons
    Zhichao Sun
    Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI USA
    Environ Health 12:85. 2013
    ....
  23. doi request reprint A latent variable approach to study gene-environment interactions in the presence of multiple correlated exposures
    Brisa N Sanchez
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Biometrics 68:466-76. 2012
    ..We demonstrate the methods with an example from the Early Life Exposures in Mexico City to Neuro-Toxicants Study of lead exposure, iron metabolism genes, and birth weight...
  24. pmc Risk of non-melanoma cancers in first-degree relatives of CDKN2A mutation carriers
    Bhramar Mukherjee
    Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA
    J Natl Cancer Inst 104:953-6. 2012
    ..0% by age 85 years (95% CI = 39.0% to 75.4%) by the kin-cohort method, under the standard assumptions of Mendelian genetics on the genotype distribution of FDRs conditional on proband genotype...
  25. pmc Testing gene-environment interaction in large-scale case-control association studies: possible choices and comparisons
    Bhramar Mukherjee
    Department of Biostatistics, School of Public Health, The University of Michigan, Ann Arbor, USA
    Am J Epidemiol 175:177-90. 2012
    ....
  26. pmc Asthma exacerbation and proximity of residence to major roads: a population-based matched case-control study among the pediatric Medicaid population in Detroit, Michigan
    Shi Li
    Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA
    Environ Health 10:34. 2011
    ..The relationship between asthma and traffic-related pollutants has received considerable attention. The use of individual-level exposure measures, such as residence location or proximity to emission sources, may avoid ecological biases...
  27. pmc Occupational noise exposure assessment using O*NET and its application to a study of hearing loss in the US general population
    Yoon Hyeong Choi
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Occup Environ Med 69:176-83. 2012
    ....
  28. pmc Bayesian inference for the stereotype regression model: Application to a case-control study of prostate cancer
    Jaeil Ahn
    Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, U S A
    Stat Med 28:3139-57. 2009
    ..We use clinical staging of prostate cancer in terms of Tumors, Nodes and Metastasis as the categorical response of interest...
  29. doi request reprint A review of statistical methods for testing genetic anticipation: looking for an answer in Lynch syndrome
    Philip S Boonstra
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA
    Genet Epidemiol 34:756-68. 2010
    ..An expanded dataset from the Danish HNPCC-register is analyzed by this alternative set of methods...
  30. pmc Sustainable control of water-related infectious diseases: a review and proposal for interdisciplinary health-based systems research
    Stuart Batterman
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA
    Environ Health Perspect 117:1023-32. 2009
    ..Here we review historical practices in water-related infectious disease research and propose an interdisciplinary public health oriented systems approach to research and intervention design...
  31. doi request reprint Propensity score-based diagnostics for categorical response regression models
    Philip S Boonstra
    Department of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, U S A
    Stat Med 33:455-69. 2014
    ..Copyright © 2013 John Wiley & Sons, Ltd. ..
  32. doi request reprint Bayesian Analysis of Time-Series Data under Case-Crossover Designs: Posterior Equivalence and Inference
    Shi Li
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, U S A
    Biometrics 69:925-36. 2013
    ..The proposed methods are illustrated through the Detroit Asthma Morbidity, Air Quality and Traffic study, which examines the association between acute asthma risk and ambient air pollutant concentrations. ..
  33. pmc Hypertension: development of a prediction model to adjust self-reported hypertension prevalence at the community level
    Graciela Mentz
    Department of Health Behavior and Health Education, School of Public Health, University of Michigan, Ann Arbor, MI, USA
    BMC Health Serv Res 12:312. 2012
    ....
  34. pmc Where science meets policy: comparing longitudinal and cross-sectional designs to address diarrhoeal disease burden in the developing world
    Amanda R Markovitz
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48104, USA
    Int J Epidemiol 41:504-13. 2012
    ....
  35. doi request reprint PM2.5-induced changes in cardiac function of hypertensive rats depend on wind direction and specific sources in Steubenville, Ohio
    Ali S Kamal
    University of Michigan, Ann Arbor, MI, USA
    Inhal Toxicol 23:417-30. 2011
    ..Conclusions: Acute cardiovascular changes in response to ambient PM(2.5) exposure can be attributed to specific PM constituents and sources linked with incineration, metal processing, and iron/steel production...
  36. doi request reprint Modeling and analysis of personal exposures to VOC mixtures using copulas
    Feng Chiao Su
    Environmental Health Sciences, School of Public Health, University of Michigan, USA
    Environ Int 63:236-45. 2014
    ..Copulas may be the method of choice for VOC mixtures, particularly for the highest exposures or extreme events, cases that poorly fit lognormal distributions and that represent the greatest risks. ..
  37. doi request reprint Determinants of personal, indoor and outdoor VOC concentrations: an analysis of the RIOPA data
    Feng Chiao Su
    Environmental Health Sciences, School of Public Health, University of Michigan, M6075 SPH II, 1415 Washington Heights, Ann Arbor, MI 48109 2029, USA
    Environ Res 126:192-203. 2013
    ..City, personal activities, household characteristics and meteorology were significant determinants...
  38. pmc Interaction of fatty acid genotype and diet on changes in colonic fatty acids in a Mediterranean diet intervention study
    Shannon R Porenta
    University of Michigan, 1500 E Medical Center Drive, Room 2150 Cancer Center, Ann Arbor, MI 48109 5930
    Cancer Prev Res (Phila) 6:1212-21. 2013
    ..These results indicate that FADS genotype could modify the effects of changes in dietary fat intakes on arachidonic acid concentrations in the colon...
  39. doi request reprint Novel likelihood ratio tests for screening gene-gene and gene-environment interactions with unbalanced repeated-measures data
    Yi An Ko
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Genet Epidemiol 37:581-91. 2013
    ..We use the proposed methods to examine the interplay between the hemochromatosis gene and cumulative lead exposure on pulse pressure in the Normative Aging Study. ..
  40. pmc Associations between brominated flame retardants in house dust and hormone levels in men
    Paula I Johnson
    Department of Environmental Health Sciences, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109, USA
    Sci Total Environ 445:177-84. 2013
    ....
  41. doi request reprint Air-Pollution and Cardiometabolic Diseases (AIRCMD): a prospective study investigating the impact of air pollution exposure and propensity for type II diabetes
    Zhichao Sun
    Department of Biostatistics, The University of Michigan, Ann Arbor, MI, USA
    Sci Total Environ 448:72-8. 2013
    ..We believe that AIRCMD will allow for unprecedented new investigations into the association between environmental risk factors and CM disorders...
  42. doi request reprint The effect of acute exposure to coarse particulate matter air pollution in a rural location on circulating endothelial progenitor cells: results from a randomized controlled study
    Robert D Brook
    Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48106, USA
    Inhal Toxicol 25:587-92. 2013
    ..However, the impact of coarse PM on EPCs is unknown...
  43. pmc Adenoma-infiltrating lymphocytes (AILs) are a potential marker of hereditary nonpolyposis colorectal cancer
    Alexandros D Polydorides
    Department of Pathology, University of Michigan Health System, Ann Arbor, MI 48109 0054, USA
    Am J Surg Pathol 32:1661-6. 2008
    ..Therefore, increased numbers of AILs and decreased numbers of apoptoses in colorectal adenomas are simple and inexpensive markers that raise the possibility of HNPCC...
  44. doi request reprint A new comorbidity index: the health-related quality of life comorbidity index
    Bhramar Mukherjee
    Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
    J Clin Epidemiol 64:309-19. 2011
    ..To derive and validate the health-related quality of life comorbidity index (HRQL-CI)...
  45. pmc Distribution, variability, and predictors of urinary concentrations of phenols and parabens among pregnant women in Puerto Rico
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, United States
    Environ Sci Technol 47:3439-47. 2013
    ..Our results can inform future epidemiology studies and strategies to reduce exposure to these chemicals or their precursors...
  46. pmc Association between 24-hour urinary cadmium and pulmonary function among community-exposed men: the VA Normative Aging Study
    Brad J Lampe
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Environ Health Perspect 116:1226-30. 2008
    ..High levels of cadmium exposure are known to cause emphysema in occupationally exposed workers, but little has been reported to date on the association between chronic environmental cadmium exposure and pulmonary function...
  47. pmc Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway
    Eduardo Vilar
    Department of Internal Medicine, The University of Michigan Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Clin Cancer Res 15:2829-39. 2009
    ..Our objective was to identify low molecular weight compounds with preferential activity against MSI colorectal cancers using combined gene expression data sets...
  48. ncbi request reprint Bayesian semiparametric modeling for matched case-control studies with multiple disease states
    Samiran Sinha
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Biometrics 60:41-9. 2004
    ..A. and Lemeshow, S., 2000, Applied Logistic Regression) with two possible disease groups matched with a control group...
  49. ncbi request reprint Modeling unobserved sources of heterogeneity in animal abundance using a Dirichlet process prior
    Robert M Dorazio
    U S Geological Survey and Department of Statistics, University of Florida, Gainesville, Florida 32611 0339, USA
    Biometrics 64:635-44. 2008
    ..Results of our data analysis and simulation studies suggest that our implementation of the Dirichlet process prior has several attractive features not shared by conventional, fully parametric alternatives...
  50. ncbi request reprint A score test for determining sample size in matched case-control studies with categorical exposure
    Samiran Sinha
    Department of Statistics, Texas A and M University, College Station 77843, USA
    Biom J 48:35-53. 2006
    ..Our methods are illustrated with two datasets, one is a real dataset on colorectal cancer in rats and the other a simulated dataset for studying disease-gene association...
  51. ncbi request reprint Accounting for error due to misclassification of exposures in case-control studies of gene-environment interaction
    Li Zhang
    Department of Quantitative Health Sciences, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Stat Med 27:2756-83. 2008
    ..A real data set on a case-control study of colorectal cancer where a validation subsample is available for assessing genotyping error is used to illustrate our methods...

Research Grants2

  1. Synergism of Gene and Environment in Cancer Studies: A New Bayesian Approach
    Bhramar Mukherjee; Fiscal Year: 2007
    ..The methods developed may be routinely applied to various epidemiological studies of gene-environment interaction. ..