Research Topics
Species | Bhramar MukherjeeSummaryAffiliation: University of Michigan Country: USA Publications
Research Grants
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Publications
Principal interactions analysis for repeated measures data: application to gene-gene and gene-environment interactionsBhramar Mukherjee
Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
Stat Med 31:2531-51. 2012..We carry out simulation studies under an array of classical interaction models and common epistasis models to illustrate the properties of the principal interactions analysis procedure in comparison with the classical alternatives...
Variability in prescription drug expenditures explained by adjusted clinical groups (ACG) case-mix: a cross-sectional study of patient electronic records in primary careAlba Aguado
Catalan Institute of Oncology, IDIBELL, L Hospitalet, Barcelona, Spain
BMC Health Serv Res 8:53. 2008..We have estimated the variability in pharmacy costs explained by ACG in centers using patient electronic records, profiled centers and physicians and analyzed the correlation between cost and quality of prescription...
Exploiting gene-environment independence for analysis of case-control studies: an empirical Bayes-type shrinkage estimator to trade-off between bias and efficiencyBhramar Mukherjee
Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
Biometrics 64:685-94. 2008..Both simulated and real data examples suggest that the proposed estimator strikes a balance between bias and efficiency depending on the true nature of the gene-environment association and the sample size for a given study...- Fitting stratified proportional odds models by amalgamating conditional likelihoodsBhramar Mukherjee
Department of Biostatistics, University of Michigan, Ann Arbor, MI 48103, USA
Stat Med 27:4950-71. 2008..We illustrate the methods via three real data examples related to biomedical research. Simulation results comparing the proposed method with a random effects model on the stratification parameters are also furnished... - Case-control studies of gene-environment interaction: Bayesian design and analysisBhramar Mukherjee
Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
Biometrics 66:934-48. 2010..The Bayesian design and analysis strategies are compared with their corresponding frequentist counterparts... - Semiparametric Bayesian analysis of case-control data under conditional gene-environment independenceBhramar Mukherjee
Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
Biometrics 63:834-44. 2007..The results reflect that the semiparametric Bayesian model allows incorporation of key scientific evidence in the form of a prior and offers a flexible, robust alternative when standard parametric model assumptions do not hold... - Analysis of matched case-control data with multiple ordered disease states: possible choices and comparisonsBhramar Mukherjee
Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
Stat Med 26:3240-57. 2007..A simulation study compares the different ordinal methods with methods ignoring sub-classification of the ordered disease states... - Tests for gene-environment interaction from case-control data: a novel study of type I error, power and designsBhramar Mukherjee
Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA
Genet Epidemiol 32:615-26. 2008.... - High risk of colorectal and endometrial cancer in Ashkenazi families with the MSH2 A636P founder mutationBhramar Mukherjee
Department of Biostatistics, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA
Gastroenterology 140:1919-26. 2011..4%-0.7%. Estimates of age-specific cumulative risk and lifetime risk for colorectal cancer (CRC) and endometrial cancer (EC) specific to carriers of this mutation are not available... - HFE H63D polymorphism as a modifier of the effect of cumulative lead exposure on pulse pressure: the Normative Aging StudyAimin Zhang
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
Environ Health Perspect 118:1261-6. 2010..Polymorphisms in the hemochromatosis gene (HFE) have been shown to modify the impact of cumulative lead exposure on measures of adult cognition and cardiac function... - Cumulative lead exposure and age-related hearing loss: the VA Normative Aging StudySung Kyun Park
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
Hear Res 269:48-55. 2010..Our results suggest that chronic low-level lead exposure may be an important risk factor for age-related hearing loss and reduction of lead exposure could help prevent or delay development of age-related hearing loss... - Missing exposure data in stereotype regression model: application to matched case-control study with disease subclassificationJaeil Ahn
Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
Biometrics 67:546-58. 2011..We illustrate our methods by using data from an ongoing matched case-control study of colorectal cancer. Simulation results are presented under various missing data mechanisms and departures from modeling assumptions... - Bayesian modeling for genetic anticipation in presence of mutational heterogeneity: a case study in Lynch syndromePhilip S Boonstra
Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
Biometrics 67:1627-37. 2011..We find evidence for a decrease in AOO between generations in this article. Our model predicts family-level anticipation effects that are potentially useful in genetic counseling clinics for high-risk families... - MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancersEduardo Vilar
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
Cancer Res 71:2632-42. 2011..We conclude that MSI colorectal tumors deficient in DSB repair secondary to mutation in MRE11 show a higher sensitivity to PARP-1 inhibition. Further clinical investigation of PARP-1 inhibitors is warranted in MSI CRCs... - Association of daily asthma emergency department visits and hospital admissions with ambient air pollutants among the pediatric Medicaid population in Detroit: time-series and time-stratified case-crossover analyses with threshold effectsShi Li
Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 48109 2029, USA
Environ Res 111:1137-47. 2011..In such study designs, threshold effects of air pollutants on asthma outcomes have been relatively unexplored, which are of potential interest for exploring concentration-response relationships... - Bone lead level prediction models and their application to examine the relationship of lead exposure and hypertension in the Third National Health and Nutrition Examination SurveySung Kyun Park
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
J Occup Environ Med 51:1422-36. 2009..We developed prediction models for bone lead using blood lead levels and other standard covariates in a community-based cohort of older men... - Risk of colorectal cancer in self-reported inflammatory bowel disease and modification of risk by statin and NSAID useN Jewel Samadder
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA
Cancer 117:1640-8. 2011..The objective of this study was to quantify the relative risk of inflammatory bowel disease (IBD) as a risk factor for CRC and to estimate whether this risk may be modified by long-term use of NSAIDs or statins... - A latent variable approach to study gene-environment interactions in the presence of multiple correlated exposuresBrisa N Sanchez
Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
Biometrics 68:466-76. 2012..We demonstrate the methods with an example from the Early Life Exposures in Mexico City to Neuro-Toxicants Study of lead exposure, iron metabolism genes, and birth weight... - Risk of non-melanoma cancers in first-degree relatives of CDKN2A mutation carriersBhramar Mukherjee
Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA
J Natl Cancer Inst 104:953-6. 2012..0% by age 85 years (95% CI = 39.0% to 75.4%) by the kin-cohort method, under the standard assumptions of Mendelian genetics on the genotype distribution of FDRs conditional on proband genotype... - Testing gene-environment interaction in large-scale case-control association studies: possible choices and comparisonsBhramar Mukherjee
Department of Biostatistics, School of Public Health, The University of Michigan, Ann Arbor, USA
Am J Epidemiol 175:177-90. 2012.... - Asthma exacerbation and proximity of residence to major roads: a population-based matched case-control study among the pediatric Medicaid population in Detroit, MichiganShi Li
Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA
Environ Health 10:34. 2011..The relationship between asthma and traffic-related pollutants has received considerable attention. The use of individual-level exposure measures, such as residence location or proximity to emission sources, may avoid ecological biases... - Occupational noise exposure assessment using O*NET and its application to a study of hearing loss in the US general populationYoon Hyeong Choi
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
Occup Environ Med 69:176-83. 2012.... - A review of statistical methods for testing genetic anticipation: looking for an answer in Lynch syndromePhilip S Boonstra
Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA
Genet Epidemiol 34:756-68. 2010..An expanded dataset from the Danish HNPCC-register is analyzed by this alternative set of methods... - Bayesian inference for the stereotype regression model: Application to a case-control study of prostate cancerJaeil Ahn
Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, U S A
Stat Med 28:3139-57. 2009..We use clinical staging of prostate cancer in terms of Tumors, Nodes and Metastasis as the categorical response of interest... - Sustainable control of water-related infectious diseases: a review and proposal for interdisciplinary health-based systems researchStuart Batterman
Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA
Environ Health Perspect 117:1023-32. 2009..Here we review historical practices in water-related infectious disease research and propose an interdisciplinary public health oriented systems approach to research and intervention design... - Environmental cadmium and lead exposures and hearing loss in U.S. adults: the National Health and Nutrition Examination Survey, 1999 to 2004Yoon Hyeong Choi
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA
Environ Health Perspect 120:1544-50. 2012..Although cadmium and lead are known risk factors for hearing loss in animal models, few epidemiologic studies have been conducted on their associations with hearing ability in the general population... - Where science meets policy: comparing longitudinal and cross-sectional designs to address diarrhoeal disease burden in the developing worldAmanda R Markovitz
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48104, USA
Int J Epidemiol 41:504-13. 2012.... - PM2.5-induced changes in cardiac function of hypertensive rats depend on wind direction and specific sources in Steubenville, OhioAli S Kamal
University of Michigan, Ann Arbor, MI, USA
Inhal Toxicol 23:417-30. 2011..Conclusions: Acute cardiovascular changes in response to ambient PM(2.5) exposure can be attributed to specific PM constituents and sources linked with incineration, metal processing, and iron/steel production... - Incorporating auxiliary information for improved prediction in high-dimensional datasets: an ensemble of shrinkage approachesPhilip S Boonstra
Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
Biostatistics 14:259-72. 2013..mRNA expression measured via quantitative real-time polymerase chain reaction is used to predict survival time in lung cancer patients, with auxiliary information from microarray technology available on a larger sample... - Point source modeling of matched case-control data with multiple disease subtypesShi Li
Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
Stat Med 31:3617-37. 2012..We illustrate the methods by analyzing Medicaid claims data corresponding to the pediatric asthma population in Detroit, Michigan, from 2004 to 2006... - A new comorbidity index: the health-related quality of life comorbidity indexBhramar Mukherjee
Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
J Clin Epidemiol 64:309-19. 2011..To derive and validate the health-related quality of life comorbidity index (HRQL-CI)... - Adenoma-infiltrating lymphocytes (AILs) are a potential marker of hereditary nonpolyposis colorectal cancerAlexandros D Polydorides
Department of Pathology, University of Michigan Health System, Ann Arbor, MI 48109 0054, USA
Am J Surg Pathol 32:1661-6. 2008..Therefore, increased numbers of AILs and decreased numbers of apoptoses in colorectal adenomas are simple and inexpensive markers that raise the possibility of HNPCC... - Association between 24-hour urinary cadmium and pulmonary function among community-exposed men: the VA Normative Aging StudyBrad J Lampe
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
Environ Health Perspect 116:1226-30. 2008..High levels of cadmium exposure are known to cause emphysema in occupationally exposed workers, but little has been reported to date on the association between chronic environmental cadmium exposure and pulmonary function... - Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathwayEduardo Vilar
Department of Internal Medicine, The University of Michigan Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Clin Cancer Res 15:2829-39. 2009..Our objective was to identify low molecular weight compounds with preferential activity against MSI colorectal cancers using combined gene expression data sets... - A score test for determining sample size in matched case-control studies with categorical exposureSamiran Sinha
Department of Statistics, Texas A and M University, College Station 77843, USA
Biom J 48:35-53. 2006..Our methods are illustrated with two datasets, one is a real dataset on colorectal cancer in rats and the other a simulated dataset for studying disease-gene association... - Modeling unobserved sources of heterogeneity in animal abundance using a Dirichlet process priorRobert M Dorazio
U S Geological Survey and Department of Statistics, University of Florida, Gainesville, Florida 32611 0339, USA
Biometrics 64:635-44. 2008..Results of our data analysis and simulation studies suggest that our implementation of the Dirichlet process prior has several attractive features not shared by conventional, fully parametric alternatives... - Accounting for error due to misclassification of exposures in case-control studies of gene-environment interactionLi Zhang
Department of Quantitative Health Sciences, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Stat Med 27:2756-83. 2008..A real data set on a case-control study of colorectal cancer where a validation subsample is available for assessing genotyping error is used to illustrate our methods... - Bayesian semiparametric modeling for matched case-control studies with multiple disease statesSamiran Sinha
Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
Biometrics 60:41-9. 2004..A. and Lemeshow, S., 2000, Applied Logistic Regression) with two possible disease groups matched with a control group...
Research Grants
- Synergism of Gene and Environment in Cancer Studies: A New Bayesian ApproachBhramar Mukherjee; Fiscal Year: 2007..The methods developed may be routinely applied to various epidemiological studies of gene-environment interaction. ..