Ilias Muhammad

Summary

Affiliation: University of Mississippi
Country: USA

Publications

  1. ncbi Antimicrobial and antiparasitic (+)-trans-hexahydrodibenzopyrans and analogues from Machaerium multiflorum
    Ilias Muhammad
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    J Nat Prod 66:804-9. 2003
  2. ncbi Constituents of Lepidium meyenii 'maca'
    Ilias Muhammad
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University MS 38677, USA
    Phytochemistry 59:105-10. 2002
  3. ncbi Antimalarial (+)-trans-hexahydrodibenzopyran derivatives from Machaerium multiflorum
    I Muhammad
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    J Nat Prod 64:1322-5. 2001
  4. ncbi Investigation of Uña De Gato I. 7-Deoxyloganic acid and 15N NMR spectroscopic studies on pentacyclic oxindole alkaloids from Uncaria tomentosa
    I Muhammad
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    Phytochemistry 57:781-5. 2001
  5. pmc Composition, standardization and chemical profiling of Banisteriopsis caapi, a plant for the treatment of neurodegenerative disorders relevant to Parkinson's disease
    Yan Hong Wang
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    J Ethnopharmacol 128:662-71. 2010
  6. pmc Indolizidine, antiinfective and antiparasitic compounds from Prosopis glandulosa var. glandulosa
    Volodymyr Samoylenko
    National Center for Natural Products Research and Department of Pharmacology, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA
    J Nat Prod 72:92-8. 2009
  7. ncbi A new antimalarial quassinoid from Simaba orinocensis
    Ilias Muhammad
    Departments of Pharmacognosy and Pharmacology, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA
    J Nat Prod 67:772-7. 2004
  8. ncbi Antiparasitic alkaloids from Psychotria klugii
    Ilias Muhammad
    National Center for Natural Products Research and Department of Pharmacology, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA
    J Nat Prod 66:962-7. 2003
  9. pmc Antiparasitic and antimicrobial indolizidines from the leaves of Prosopis glandulosa var. glandulosa
    Aziz Abdur Rahman
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    Planta Med 77:1639-43. 2011
  10. ncbi Cytotoxic sesquiterpene lactones from Centaurothamnus maximus and Vicoa pentanema
    Ilias Muhammad
    National Center for Natural Products Research, University of Mississippi, 38677, USA
    Phytother Res 17:168-73. 2003

Collaborators

Detail Information

Publications30

  1. ncbi Antimicrobial and antiparasitic (+)-trans-hexahydrodibenzopyrans and analogues from Machaerium multiflorum
    Ilias Muhammad
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    J Nat Prod 66:804-9. 2003
    ..0-3.5 microg/mL). In addition, machaeridiol B (4) demonstrated antiparasitic activities against Plasmodium falciparum D6 and W2 clones and Leishmania donavani with IC(50) values of 0.64, 0.22, and 0.9 microg/mL, respectively...
  2. ncbi Constituents of Lepidium meyenii 'maca'
    Ilias Muhammad
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University MS 38677, USA
    Phytochemistry 59:105-10. 2002
    ....
  3. ncbi Antimalarial (+)-trans-hexahydrodibenzopyran derivatives from Machaerium multiflorum
    I Muhammad
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    J Nat Prod 64:1322-5. 2001
    ..Both compounds showed no response at 100 000 ng/mL in both assays. Machaeriol B (2) demonstrated in vitro antimalarial activity (IC(50) = 120 ng/mL) against Plasmodium falciparum W-2 clone...
  4. ncbi Investigation of Uña De Gato I. 7-Deoxyloganic acid and 15N NMR spectroscopic studies on pentacyclic oxindole alkaloids from Uncaria tomentosa
    I Muhammad
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    Phytochemistry 57:781-5. 2001
    ....
  5. pmc Composition, standardization and chemical profiling of Banisteriopsis caapi, a plant for the treatment of neurodegenerative disorders relevant to Parkinson's disease
    Yan Hong Wang
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    J Ethnopharmacol 128:662-71. 2010
    ..The usefulness of Banisteriopsis caapi has been established for alleviating symptoms of neurological disorders including Parkinson's disease...
  6. pmc Indolizidine, antiinfective and antiparasitic compounds from Prosopis glandulosa var. glandulosa
    Volodymyr Samoylenko
    National Center for Natural Products Research and Department of Pharmacology, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA
    J Nat Prod 72:92-8. 2009
    ..Prosopilosine (1) also showed in vivo antimalarial activity, with an ED(50) value of approximately 2 mg/kg/day/ip against Plasmodium berghei-infected mice after 3 days of treatment...
  7. ncbi A new antimalarial quassinoid from Simaba orinocensis
    Ilias Muhammad
    Departments of Pharmacognosy and Pharmacology, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA
    J Nat Prod 67:772-7. 2004
    ..Orinocinolide (1) inhibited growth of human cancer cells SK-MEL, KB, BT-549, and SK-OV-3, but was less potent than 2 (IC(50) 0.8-1.9 vs 0.3-1.0 microg/mL) against these cells...
  8. ncbi Antiparasitic alkaloids from Psychotria klugii
    Ilias Muhammad
    National Center for Natural Products Research and Department of Pharmacology, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA
    J Nat Prod 66:962-7. 2003
    ..Alkaloids 1 and 3 exhibited potent antimalarial activity against Plasmodium falciparum clones W2 and D6 (IC(50) 27.7-46.3 ng/mL). Compound 3 was cytotoxic to SK-MEL, KB, BT-549, and SK-OV-3 human cancer cells, while 1 was inactive...
  9. pmc Antiparasitic and antimicrobial indolizidines from the leaves of Prosopis glandulosa var. glandulosa
    Aziz Abdur Rahman
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    Planta Med 77:1639-43. 2011
    ..neoformans and weakly active against other organisms...
  10. ncbi Cytotoxic sesquiterpene lactones from Centaurothamnus maximus and Vicoa pentanema
    Ilias Muhammad
    National Center for Natural Products Research, University of Mississippi, 38677, USA
    Phytother Res 17:168-73. 2003
    ..6-7.3 microgram/mL). Cell aggregation and cell adhesion assays, using HL-60 and HeLa cell lines, evaluated the effect of cytotoxic constituents 1-3, 10 and 14 on immune response and inflammation...
  11. ncbi Antiparasitic, nematicidal and antifouling constituents from Juniperus berries
    Volodymyr Samoylenko
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    Phytother Res 22:1570-6. 2008
    ..Using GC/MS, the two known abietanes totarol (6) and ferruginol (7) were identified from the berries of J. procera, J. excelsa and J. phoenicea...
  12. pmc Antimicrobial, antiparasitic and cytotoxic spermine alkaloids from Albizia schimperiana
    Volodymyr Samoylenko
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, Thad Cochran Research Center, The University of Mississippi, University, Mississippi 38677, USA
    Nat Prod Commun 4:791-6. 2009
    ..It was observed that hydroxyl substitution of the side chain of the budmunchiamines dramatically reduced the cytotoxicity and antimicrobial activity of the alkaloids 2 and 4 without decreasing antimalarial activity...
  13. ncbi A new naphthopyrone derivative from Cassia quinquangulata and structural revision of quinquangulin and its glycosides
    X C Li
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, MS 38677, USA
    J Nat Prod 64:1153-6. 2001
    ..The structures of two quinguangulin glycosides, 3 and 4, were also revised accordingly. Compound 2a exhibited activity against Staphylococcus aureus and methicillin-resistant S. aureus (MIC, 3.125 and 6.25 microg/mL, respectively)...
  14. ncbi Cytotoxic and antioxidant activities of alkylated benzoquinones from Maesa lanceolata
    Ilias Muhammad
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    Phytother Res 17:887-91. 2003
    ..1-4.2 microg/mL). All benzoquinones were found to be inactive against cell aggregation and cell adhesion assays, thus showing no effect on immune responses and inflammation...
  15. pmc Antiparasitic and antimicrobial isoflavanquinones from Abrus schimperi
    Aziz A Rahman
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, Mississippi 38677, USA
    Nat Prod Commun 6:1645-50. 2011
    ..In addition, the absolute stereochemistry of the isolated compounds 1 and 2 was revised as C-(3S) based on Circular Dichroism experiments. This appears to be the first report of amorphaquinone (1) and pendulone (2) from the genus Abrus...
  16. pmc Banisteriopsis caapi, a unique combination of MAO inhibitory and antioxidative constituents for the activities relevant to neurodegenerative disorders and Parkinson's disease
    Volodymyr Samoylenko
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    J Ethnopharmacol 127:357-67. 2010
    ....
  17. ncbi New alkamides from maca (Lepidium meyenii)
    Jianping Zhao
    Department of Pharmacognosy and National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, MS 38677, USA
    J Agric Food Chem 53:690-3. 2005
    ..In addition, the identity of N-benzyl-15Z-tetracosenamide (4) was confirmed by synthesis. These compounds have been found from only L. meyenii and could be used as markers for authentication and standardization...
  18. ncbi Phenolic compounds from Miconia myriantha inhibiting Candida aspartic proteases
    X C Li
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    J Nat Prod 64:1282-5. 2001
    ..Compounds 1 and 4 showed inhibitory effects against Candida albicans secreted aspartic proteases, with IC(50) of 8.4 and 10.5 microM, respectively...
  19. ncbi Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida
    Mohamed A Zaki
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, Mississippi 38677, United States
    J Nat Prod 76:679-84. 2013
    ..Interestingly, 2 showed antioxidant activity by inhibition of ROS generation to 50% at 33.3 μM in PMA-induced HL-60 cells, while 1 was inactive at 100 μM (vs Trolox 1.4 μM)...
  20. pmc Bioactive (+)-manzamine A and (+)-8-hydroxymanzamine A tertiary bases and salts from Acanthostrongylophora ingens and their preparations
    Volodymyr Samoylenko
    National Center for Natural Products Research, School of Pharmacy, University of Mississippi, 38677, USA
    Nat Prod Commun 4:185-92. 2009
    ....
  21. pmc Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells
    Yu Dong Zhou
    National Center for Natural Products Research and Department of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, 38677, USA
    J Nat Prod 68:947-50. 2005
    ..2, 1.1, and 0.11 muM, respectively). Compounds 1, 2, and 4 inhibited both hypoxia- and iron chelator-induced HIF-1 activation by blocking HIF-1alpha protein accumulation...
  22. ncbi New constituents from noni (Morinda citrifolia) fruit juice
    Volodymyr Samoylenko
    National Center for Natural Products Research, University of Mississippi, University, Mississippi 38677, USA
    J Agric Food Chem 54:6398-402. 2006
    ....
  23. ncbi Chemical profiling and standardization of Lepidium meyenii (Maca) by reversed phase high performance liquid chromatography
    Markus Ganzera
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University 38577, USA
    Chem Pharm Bull (Tokyo) 50:988-91. 2002
    ..The percentage of total markers in the preparations varied from 0.15 to 0.84%, resulting in daily intakes for the consumer from 1.52 to 14.88 mg, respectively...
  24. ncbi Genomic and genetic approaches for the identification of antifungal drug targets
    A K Agarwal
    National Center for Natural Products Research, Department of Pharmacology, Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA
    Infect Disord Drug Targets 8:2-15. 2008
    ....
  25. ncbi New antimycobacterial saponin from Colubrina retusa
    H N ElSohly
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, Thad Cochran Research Center, The University of Mississippi, University, Mississippi 38677, USA
    J Nat Prod 62:1341-2. 1999
    ..The antimycobacterial activity expressed as minimum inhibitory concentration (MIC) for compound 4 was 10 microg/mL...
  26. ncbi Three ginkgolide hydrates from Ginkgo biloba L.: ginkgolide A monohydrate, ginkgolide C sesquihydrate and ginkgolide J dihydrate, all determined at 120 K
    Jianping Zhao
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    Acta Crystallogr C 58:o195-8. 2002
    ..The conformations of the six five-membered rings are quite similar across ginkgolides A-C and J, except for the A and F rings of ginkgolide A...
  27. ncbi Preparation and application of reversed phase Chromatorotor for the isolation of natural products by centrifugal preparative chromatography
    Ilias Muhammad
    National Center for Natural Products Research, School of Pharmacy, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, MS 38677, USA
    Nat Prod Commun 8:311-4. 2013
    ....
  28. doi Antimalarial quassinoids: past, present and future
    Ilias Muhammad
    The University of Mississippi, NCNPR, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University, MS 38677, USA 1 662 915 1051 1 662 915 7989
    Expert Opin Drug Discov 2:1065-84. 2007
    ..Many antimalarial quassinoids are discovered from simaroubaceous plants that are used traditionally to treat fever and malaria, thereby reiterating the critical role of ethnopharmacology as a rich source of novel drug discovery...
  29. ncbi A new lignan glycoside from Eleutherococcus senticosus
    X C Li
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, Mississippi 38677, USA
    Planta Med 67:776-8. 2001
    ..The structure of 1 was established by spectral interpretations as episyringaresinol 4"-O-beta-D-glucopyranoside. Compound 2 is described here for the first time as a naturally occurring compound...
  30. ncbi Indolopyridoquinazoline alkaloid from Leptothyrsa sprucei
    X C Li
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS, USA
    Phytochemistry 58:627-9. 2001
    ..The usefulness of the gradient 1H-15N HMBC NMR spectroscopy in the structure elucidation of 3-hydroxyrutaecarpine is noted...