Research Topics
| Ilias MuhammadSummaryAffiliation: University of Mississippi Country: USA Publications
| Collaborators
|
Detail Information
Publications
Antimicrobial and antiparasitic (+)-trans-hexahydrodibenzopyrans and analogues from Machaerium multiflorumIlias Muhammad
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
J Nat Prod 66:804-9. 2003..0-3.5 microg/mL). In addition, machaeridiol B (4) demonstrated antiparasitic activities against Plasmodium falciparum D6 and W2 clones and Leishmania donavani with IC(50) values of 0.64, 0.22, and 0.9 microg/mL, respectively...- Investigation of Uña De Gato I. 7-Deoxyloganic acid and 15N NMR spectroscopic studies on pentacyclic oxindole alkaloids from Uncaria tomentosaI Muhammad
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
Phytochemistry 57:781-5. 2001.... - Antimalarial (+)-trans-hexahydrodibenzopyran derivatives from Machaerium multiflorumI Muhammad
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
J Nat Prod 64:1322-5. 2001..Both compounds showed no response at 100 000 ng/mL in both assays. Machaeriol B (2) demonstrated in vitro antimalarial activity (IC(50) = 120 ng/mL) against Plasmodium falciparum W-2 clone... - Constituents of Lepidium meyenii 'maca'Ilias Muhammad
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University MS 38677, USA
Phytochemistry 59:105-10. 2002.... 
Indolizidine, antiinfective and antiparasitic compounds from Prosopis glandulosa var. glandulosaVolodymyr Samoylenko
National Center for Natural Products Research and Department of Pharmacology, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA
J Nat Prod 72:92-8. 2009..Prosopilosine (1) also showed in vivo antimalarial activity, with an ED(50) value of approximately 2 mg/kg/day/ip against Plasmodium berghei-infected mice after 3 days of treatment...- Antiparasitic alkaloids from Psychotria klugiiIlias Muhammad
National Center for Natural Products Research and Department of Pharmacology, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA
J Nat Prod 66:962-7. 2003..Alkaloids 1 and 3 exhibited potent antimalarial activity against Plasmodium falciparum clones W2 and D6 (IC(50) 27.7-46.3 ng/mL). Compound 3 was cytotoxic to SK-MEL, KB, BT-549, and SK-OV-3 human cancer cells, while 1 was inactive... - A new antimalarial quassinoid from Simaba orinocensisIlias Muhammad
Departments of Pharmacognosy and Pharmacology, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA
J Nat Prod 67:772-7. 2004..Orinocinolide (1) inhibited growth of human cancer cells SK-MEL, KB, BT-549, and SK-OV-3, but was less potent than 2 (IC(50) 0.8-1.9 vs 0.3-1.0 microg/mL) against these cells... 
Composition, standardization and chemical profiling of Banisteriopsis caapi, a plant for the treatment of neurodegenerative disorders relevant to Parkinson's diseaseYan Hong Wang
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
J Ethnopharmacol 128:662-71. 2010..The usefulness of Banisteriopsis caapi has been established for alleviating symptoms of neurological disorders including Parkinson's disease...- Antiparasitic and antimicrobial indolizidines from the leaves of Prosopis glandulosa var. glandulosaAziz Abdur Rahman
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
Planta Med 77:1639-43. 2011..neoformans and weakly active against other organisms... - Cytotoxic sesquiterpene lactones from Centaurothamnus maximus and Vicoa pentanemaIlias Muhammad
National Center for Natural Products Research, University of Mississippi, 38677, USA
Phytother Res 17:168-73. 2003..6-7.3 microgram/mL). Cell aggregation and cell adhesion assays, using HL-60 and HeLa cell lines, evaluated the effect of cytotoxic constituents 1-3, 10 and 14 on immune response and inflammation... - Antiparasitic, nematicidal and antifouling constituents from Juniperus berriesVolodymyr Samoylenko
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
Phytother Res 22:1570-6. 2008..Using GC/MS, the two known abietanes totarol (6) and ferruginol (7) were identified from the berries of J. procera, J. excelsa and J. phoenicea... - Antimicrobial, antiparasitic and cytotoxic spermine alkaloids from Albizia schimperianaVolodymyr Samoylenko
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, Thad Cochran Research Center, The University of Mississippi, University, Mississippi 38677, USA
Nat Prod Commun 4:791-6. 2009..It was observed that hydroxyl substitution of the side chain of the budmunchiamines dramatically reduced the cytotoxicity and antimicrobial activity of the alkaloids 2 and 4 without decreasing antimalarial activity... - A new naphthopyrone derivative from Cassia quinquangulata and structural revision of quinquangulin and its glycosidesX C Li
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, MS 38677, USA
J Nat Prod 64:1153-6. 2001..The structures of two quinguangulin glycosides, 3 and 4, were also revised accordingly. Compound 2a exhibited activity against Staphylococcus aureus and methicillin-resistant S. aureus (MIC, 3.125 and 6.25 microg/mL, respectively)... - Cytotoxic and antioxidant activities of alkylated benzoquinones from Maesa lanceolataIlias Muhammad
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
Phytother Res 17:887-91. 2003..1-4.2 microg/mL). All benzoquinones were found to be inactive against cell aggregation and cell adhesion assays, thus showing no effect on immune responses and inflammation... - Antiparasitic and antimicrobial isoflavanquinones from Abrus schimperiAziz A Rahman
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, Mississippi 38677, USA
Nat Prod Commun 6:1645-50. 2011..In addition, the absolute stereochemistry of the isolated compounds 1 and 2 was revised as C-(3S) based on Circular Dichroism experiments. This appears to be the first report of amorphaquinone (1) and pendulone (2) from the genus Abrus... - Banisteriopsis caapi, a unique combination of MAO inhibitory and antioxidative constituents for the activities relevant to neurodegenerative disorders and Parkinson's diseaseVolodymyr Samoylenko
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
J Ethnopharmacol 127:357-67. 2010.... - New alkamides from maca (Lepidium meyenii)Jianping Zhao
Department of Pharmacognosy and National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, MS 38677, USA
J Agric Food Chem 53:690-3. 2005..In addition, the identity of N-benzyl-15Z-tetracosenamide (4) was confirmed by synthesis. These compounds have been found from only L. meyenii and could be used as markers for authentication and standardization... - Phenolic compounds from Miconia myriantha inhibiting Candida aspartic proteasesX C Li
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
J Nat Prod 64:1282-5. 2001..Compounds 1 and 4 showed inhibitory effects against Candida albicans secreted aspartic proteases, with IC(50) of 8.4 and 10.5 microM, respectively... - Bioactive (+)-manzamine A and (+)-8-hydroxymanzamine A tertiary bases and salts from Acanthostrongylophora ingens and their preparationsVolodymyr Samoylenko
National Center for Natural Products Research, School of Pharmacy, University of Mississippi, 38677, USA
Nat Prod Commun 4:185-92. 2009.... - Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cellsYu-Dong Zhou
National Center for Natural Products Research and Department of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, 38677, USA
J Nat Prod 68:947-50. 2005..2, 1.1, and 0.11 muM, respectively). Compounds 1, 2, and 4 inhibited both hypoxia- and iron chelator-induced HIF-1 activation by blocking HIF-1alpha protein accumulation... - New constituents from noni (Morinda citrifolia) fruit juiceVolodymyr Samoylenko
National Center for Natural Products Research, University of Mississippi, University, Mississippi 38677, USA
J Agric Food Chem 54:6398-402. 2006.... - Chemical profiling and standardization of Lepidium meyenii (Maca) by reversed phase high performance liquid chromatographyMarkus Ganzera
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University 38577, USA
Chem Pharm Bull (Tokyo) 50:988-91. 2002..The percentage of total markers in the preparations varied from 0.15 to 0.84%, resulting in daily intakes for the consumer from 1.52 to 14.88 mg, respectively... - Genomic and genetic approaches for the identification of antifungal drug targetsA K Agarwal
National Center for Natural Products Research, Department of Pharmacology, Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA
Infect Disord Drug Targets 8:2-15. 2008.... - New antimycobacterial saponin from Colubrina retusaH N ElSohly
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, Thad Cochran Research Center, The University of Mississippi, University, Mississippi 38677, USA
J Nat Prod 62:1341-2. 1999..The antimycobacterial activity expressed as minimum inhibitory concentration (MIC) for compound 4 was 10 microg/mL... - Three ginkgolide hydrates from Ginkgo biloba L.: ginkgolide A monohydrate, ginkgolide C sesquihydrate and ginkgolide J dihydrate, all determined at 120 KJianping Zhao
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
Acta Crystallogr C 58:o195-8. 2002..The conformations of the six five-membered rings are quite similar across ginkgolides A-C and J, except for the A and F rings of ginkgolide A... - Antimalarial quassinoids: past, present and futureIlias Muhammad
The University of Mississippi, NCNPR, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University, MS 38677, USA 1 662 915 1051 1 662 915 7989
Expert Opin Drug Discov 2:1065-84. 2007..Many antimalarial quassinoids are discovered from simaroubaceous plants that are used traditionally to treat fever and malaria, thereby reiterating the critical role of ethnopharmacology as a rich source of novel drug discovery... - A new lignan glycoside from Eleutherococcus senticosusX C Li
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, Mississippi 38677, USA
Planta Med 67:776-8. 2001..The structure of 1 was established by spectral interpretations as episyringaresinol 4"-O-beta-D-glucopyranoside. Compound 2 is described here for the first time as a naturally occurring compound... - Indolopyridoquinazoline alkaloid from Leptothyrsa spruceiX C Li
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS, USA
Phytochemistry 58:627-9. 2001..The usefulness of the gradient 1H-15N HMBC NMR spectroscopy in the structure elucidation of 3-hydroxyrutaecarpine is noted...