Marcus Muench

Summary

Affiliation: Blood Systems Research Institute
Location: San Francisco, UCA
URL: http://web.mac.com/fogbank
Summary:
My research focus is on the development of the hematopoietic and hepatic systems. A driving force behind my basic research efforts is a desire for the research to be clinically applicable, particularly in the field of fetal medicine.

Publications

  1. ncbi A kinetic study of the murine mixed lymphocyte reaction by 5,6-carboxyfluorescein diacetate succinimidyl ester labeling
    Jeng Chang Chen
    Department of Surgery, University of California, San Francisco, CA, USA
    J Immunol Methods 279:123-33. 2003
  2. pmc Coexpression of CD14 and CD326 discriminate hepatic precursors in the human fetal liver
    Marina E Fomin
    Blood Systems Research Institute, San Francisco, California 94118, USA
    Stem Cells Dev 20:1247-57. 2011
  3. pmc Maternal microchimerism in the livers of patients with biliary atresia
    David L Suskind
    Department of Pediatrics, University of California, San Francisco, USA
    BMC Gastroenterol 4:14. 2004
  4. ncbi Haploidentical donor T cells fail to facilitate engraftment but lessen the immune response of host T cells in murine fetal transplantation
    Jeng Chang Chen
    Fetal Treatment Center, Department of Surgery, University of California, San Francisco, CA 94143 0793, USA
    Br J Haematol 126:377-84. 2004
  5. ncbi Megakaryocyte growth and development factor is a potent growth factor for primitive hematopoietic progenitors in the human fetus
    Marcus O Muench
    Department of Laboratory Medicine, University of California at San Francisco, San Francisco, CA 94143 0793, USA
    Pediatr Res 55:1050-6. 2004
  6. ncbi Stem cell transplantation in the fetus
    Marcus O Muench
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
    Cancer Control 11:105-18. 2004
  7. ncbi Searching for common stem cells of the hepatic and hematopoietic systems in the human fetal liver: CD34+ cytokeratin 7/8+ cells express markers for stellate cells
    David L Suskind
    Department of Pediatrics, University of California, San Francisco, CA 94143 0793, USA
    J Hepatol 40:261-8. 2004
  8. ncbi Isolation of definitive zone and chromaffin cells based upon expression of CD56 (neural cell adhesion molecule) in the human fetal adrenal gland
    Marcus O Muench
    Department of Laboratory Medicine and Center for Reproductive Sciences, University of California, San Francisco, San Francisco, California 94143, USA
    J Clin Endocrinol Metab 88:3921-30. 2003
  9. ncbi Ontogenic changes in CD95 expression on human leukocytes: prevalence of T-cells expressing activation markers and identification of CD95-CD45RO+ T-cells in the fetus
    Marcus O Muench
    Department of Laboratory Medicine, University of California, 533 Parnassus Ave, 94143 0793, San Francisco, CA, USA
    Dev Comp Immunol 27:899-914. 2003
  10. ncbi Broad distribution of colony-forming cells with erythroid, myeloid, dendritic cell, and NK cell potential among CD34(++) fetal liver cells
    M O Muench
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
    J Immunol 167:4902-9. 2001

Collaborators

Detail Information

Publications62

  1. ncbi A kinetic study of the murine mixed lymphocyte reaction by 5,6-carboxyfluorescein diacetate succinimidyl ester labeling
    Jeng Chang Chen
    Department of Surgery, University of California, San Francisco, CA, USA
    J Immunol Methods 279:123-33. 2003
    ..Among all the parameters, the relative number of daughter T-cells was the most practical for measuring MLR, after 5 days of culture, based upon the growth kinetics of responder T-cells and the survival of the stimulator cells...
  2. pmc Coexpression of CD14 and CD326 discriminate hepatic precursors in the human fetal liver
    Marina E Fomin
    Blood Systems Research Institute, San Francisco, California 94118, USA
    Stem Cells Dev 20:1247-57. 2011
    ....
  3. pmc Maternal microchimerism in the livers of patients with biliary atresia
    David L Suskind
    Department of Pediatrics, University of California, San Francisco, USA
    BMC Gastroenterol 4:14. 2004
    ..The aim of this study was to determine the presence and extent of maternal microchimerism (MM) in the livers of infants with BA...
  4. ncbi Haploidentical donor T cells fail to facilitate engraftment but lessen the immune response of host T cells in murine fetal transplantation
    Jeng Chang Chen
    Fetal Treatment Center, Department of Surgery, University of California, San Francisco, CA 94143 0793, USA
    Br J Haematol 126:377-84. 2004
    ..The persistence of donor cells in the peritoneal cavity also correlated with tolerance induction...
  5. ncbi Megakaryocyte growth and development factor is a potent growth factor for primitive hematopoietic progenitors in the human fetus
    Marcus O Muench
    Department of Laboratory Medicine, University of California at San Francisco, San Francisco, CA 94143 0793, USA
    Pediatr Res 55:1050-6. 2004
    ....
  6. ncbi Stem cell transplantation in the fetus
    Marcus O Muench
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
    Cancer Control 11:105-18. 2004
    ..In utero transplantation (IUT) of hematopoietic stem cells has the potential to treat a large number of hematologic and metabolic diseases amenable to partial replacement of the hematopoietic system...
  7. ncbi Searching for common stem cells of the hepatic and hematopoietic systems in the human fetal liver: CD34+ cytokeratin 7/8+ cells express markers for stellate cells
    David L Suskind
    Department of Pediatrics, University of California, San Francisco, CA 94143 0793, USA
    J Hepatol 40:261-8. 2004
    ..Our aim was to determine if human fetal liver cells expressing CD34 and CK7/8 represent a common stem cell for both the hematopoietic and hepatic systems...
  8. ncbi Isolation of definitive zone and chromaffin cells based upon expression of CD56 (neural cell adhesion molecule) in the human fetal adrenal gland
    Marcus O Muench
    Department of Laboratory Medicine and Center for Reproductive Sciences, University of California, San Francisco, San Francisco, California 94143, USA
    J Clin Endocrinol Metab 88:3921-30. 2003
    ..These findings indicate that CD56 expression can be used to isolate DZ and chromaffin cells to further study their functional and developmental properties...
  9. ncbi Ontogenic changes in CD95 expression on human leukocytes: prevalence of T-cells expressing activation markers and identification of CD95-CD45RO+ T-cells in the fetus
    Marcus O Muench
    Department of Laboratory Medicine, University of California, 533 Parnassus Ave, 94143 0793, San Francisco, CA, USA
    Dev Comp Immunol 27:899-914. 2003
    ..Activation markers CD25, CD122, CD69 and CD80 were also present on fetal T-cells. These findings indicate that in the initial weeks following thymic maturation, a high frequency of T-cells is activated in the periphery of the fetus...
  10. ncbi Broad distribution of colony-forming cells with erythroid, myeloid, dendritic cell, and NK cell potential among CD34(++) fetal liver cells
    M O Muench
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
    J Immunol 167:4902-9. 2001
    ..Alternatively, some stem cells may be present among CD38(+) cells...
  11. ncbi High-efficiency retroviral transduction of fetal liver CD38-CD34++ cells: implications for in utero and ex utero gene therapy
    T Ohkubo
    Fetal Treatment Center, University of California at San Francisco, 94143-0793, USA
    Fetal Diagn Ther 16:299-307. 2001
    ..These results encourage further examination of in utero and ex utero gene therapy as a means of treating birth defects...
  12. ncbi Hematopoietic stem cell transplantation in utero produces sheep-goat chimeras
    S M Oppenheim
    Department of Animal Science, University of California, Davis, California 95616, USA
    Blood Cells Mol Dis 27:296-308. 2001
    ..The consistently low levels of chimerism observed in this study, as well as the poor results recently reported by others using these procedures, indicate that significant barriers exist to transplanting hematopoietic stem cells in utero...
  13. ncbi Transplantation of a fetus with paternal Thy-1(+)CD34(+)cells for chronic granulomatous disease
    M O Muench
    Fetal Treatment Center at the University of California, San Francisco 94143-0793, USA
    Bone Marrow Transplant 27:355-64. 2001
    ..The presence of these lymphocytes may contribute to the lack of donor cell engraftment in the human fetus...
  14. pmc Prevention of graft rejection by donor type II CD8(+) T cells (Tc2 cells) is not sufficient to improve engraftment in fetal transplantation
    Jeng Chang Chen
    Fetal Treatment Center, Department of Surgery, University of California, San Francisco, CA 94143, USA
    Fetal Diagn Ther 20:35-43. 2005
    ..The purpose of this study was to evaluate whether Tc2 cells could improve engraftment in fetal transplantation...
  15. ncbi In utero transplantation: baby steps towards an effective therapy
    M O Muench
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143 0793, USA
    Bone Marrow Transplant 35:537-47. 2005
    ..Continued research appears likely to succeed in developing IUT into an effective form of therapy for a variety of diseases...
  16. ncbi Maintenance of proliferative capacity and retroviral transduction efficiency of human fetal CD38(-)/CD34(++) stem cells
    Marcus O Muench
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
    Stem Cells Dev 15:97-108. 2006
    ..0%. These findings encourage further investigation into the feasibility of ex utero gene therapy whereby fetal cells are isolated from the circulation, transduced, and expanded ex utero before being returned to the fetus...
  17. doi Characterization of tolerance induction through prenatal marrow transplantation: the requirement for a threshold level of chimerism to establish rather than maintain postnatal skin tolerance
    Jeng Chang Chen
    Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, 5 Fu Shin Street, Kweishan, Taoyuan, Taiwan
    Cell Transplant 19:1609-22. 2010
    ..Therefore, the diminution of hematopoietic chimerism below a threshold level does not nullify an existing tolerance state, but lessens the chance of enabling complete tolerance...
  18. ncbi Requirement of retinoids for the expression of CD38 on human hematopoietic progenitors in vitro
    M O Muench
    Fetal Treatment Center Research Laboratory, University of California at San Francisco, 513 Parnassus Avenue Room HSW 1601, San Francisco, CA 94143 0570, USA
    Cytotherapy 1:455-68. 1999
    ..In this study we sought to determine the feasibility of using CD34 and CD38 as markers of hematopoietic differentiation in vitro, using retinoids to induce the expression of CD38...
  19. pmc Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63
    Ilona Glowacka
    Institute of Virology, OE 5230, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Virol 84:1198-205. 2010
    ..Finally, SARS-CoV but not NL63 replicated efficiently in ACE2-positive Vero cells and reduced ACE2 expression, indicating robust receptor interference in the context of SARS-CoV but not NL63 infection...
  20. pmc Barley as a green factory for the production of functional Flt3 ligand
    Lýdur S Erlendsson
    ORF Genetics, Keldnaholt, Reykjavik, Iceland
    Biotechnol J 5:163-71. 2010
    ..The present results demonstrate that plant molecular farming is a viable approach for the bioproduction of human-derived growth factors...
  21. pmc Characterization of Chikungunya pseudotyped viruses: Identification of refractory cell lines and demonstration of cellular tropism differences mediated by mutations in E1 glycoprotein
    Beatriz Salvador
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    Virology 393:33-41. 2009
    ..CHIKV pseudotypes will serve as an important tool for the study of neutralizing antibodies and the analysis of envelope glycoprotein functions...
  22. pmc A new role for the human placenta as a hematopoietic site throughout gestation
    Alicia Barcena
    Institute for Regeneration Medicine, Human Embryonic Stem Cell Program, Department of Cell and Tissue Biology, University of California at San Francisco, California 94143, USA
    Reprod Sci 16:178-87. 2009
    ..Together, these data suggest that the human placenta is potentially an important hematopoietic organ, opening the possibility of banking placental hematopoietic stem cells along with cord blood for transplantation...
  23. pmc The human placenta is a hematopoietic organ during the embryonic and fetal periods of development
    Alicia Barcena
    Institute for Regeneration Medicine, Human Embryonic Stem Cell Program, Department of Cell and Tissue Biology, University of California, San Francisco, 513 Parnassus Avenue, HSE 1619, San Francisco, California 94143 0512, USA
    Dev Biol 327:24-33. 2009
    ..These data suggest that the human placenta is an important hematopoietic organ, raising the possibility of banking placental hematopoietic stem cells along with cord blood for transplantation...
  24. ncbi Transplantation NK'Oed in the first trimester
    Marcus O Muench
    Blood Systems Research Institute
    Blood 112:4790-1. 2008
  25. pmc Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero
    Jeff E Mold
    Division of Experimental Medicine, Department of Medicine, University of California at San Francisco UCSF, San Francisco, CA 94110, USA
    Science 322:1562-5. 2008
    ..These findings reveal a form of antigen-specific tolerance in humans, induced in utero and probably active in regulating immune responses after birth...
  26. pmc Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses
    Penelope M Drake
    Department of Chemistry, University of California, Berkeley, CA 94720, USA
    J Immunol 181:6850-8. 2008
    ..This is the first demonstration of polySia expression and regulation on myeloid cells, and the results in animal models suggest a role for polySia in immune regulation...
  27. ncbi Prenatal tolerance induction: relationship between cell dose, marrow T-cells, chimerism, and tolerance
    Jeng Chang Chen
    Department of Surgery, Chang Gung Children s Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Cell Transplant 17:495-506. 2008
    ..Thus, peripheral chimerism level can be a simple and straightforward test to predict the degree of prenatal immune tolerance...
  28. ncbi Persistence of allografts in the peritoneal cavity after prenatal transplantation in mice
    Jeng Chang Chen
    Department of Surgery, University of California, San Francisco, California, USA
    Transfusion 48:553-60. 2008
    ..In utero transplantation (IUT) is usually performed by intraperitoneal injection, but there is little information regarding the fate of intraperitoneally transplanted cells in the first weeks after transplantation...
  29. ncbi Midkine, a heparin-binding growth factor, selectively stimulates proliferation of definitive zone cells of the human fetal adrenal gland
    Hitoshi Ishimoto
    Center for Reproductive Sciences, 1450 Health Sciences West, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143 0556, USA
    J Clin Endocrinol Metab 91:4050-6. 2006
    ..Midkine (MK) is a heparin-binding growth factor with various bioactivities...
  30. ncbi Disparate regulation of human fetal erythropoiesis by the microenvironments of the liver and bone marrow
    M O Muench
    University of California, San Francisco, California 94143, USA
    Blood Cells Mol Dis 27:377-90. 2001
    ..These data implicate a critical role for the microenvironments of the liver and BM in regulating the disparate levels of erythropoiesis in these tissues...
  31. pmc Antibodies to human fetal erythroid cells from a nonimmune phage antibody library
    M A Huie
    Department of Dermatology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 98:2682-7. 2001
    ..Some of the antibodies may also have possible therapeutic utility for erythroleukemia...
  32. ncbi FLK-2/FLT-3 ligand regulates the growth of early myeloid progenitors isolated from human fetal liver
    M O Muench
    Human Immunology and Molecular Biology Departments, DNAX Research Institute, Palo Alto, CA
    Blood 85:963-72. 1995
    ..These results indicate that FL is part of a network of growth factors that regulate the growth and survival of early hematopoietic progenitors...
  33. ncbi In search of T-cell progenitors in the human foetal liver
    A Barcena
    DNAX Research Institute, Human Immunology Department, Palo Alto, CA
    Res Immunol 145:120-3; discussion 155-8. 1994
  34. pmc Identification of a common T/natural killer cell progenitor in human fetal thymus
    M J Sanchez
    Department of Human Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304
    J Exp Med 180:569-76. 1994
    ..These results represent the first definitive evidence of a common T/NK cell progenitor in the human fetal thymus and delineate the point in thymocyte differentiation where T and NK cells diverge...
  35. pmc Lymphoid and myeloid differentiation of fetal liver CD34+lineage- cells in human thymic organ culture
    A Barcena
    Human Immunology Department, DNAX Research Institute, Palo Alto, California 94304
    J Exp Med 180:123-32. 1994
    ..These results demonstrate that the microinjection of fetal liver hematopoietic progenitors into fetal thymic organ fragments results in multilineage differentiation in vitro...
  36. ncbi Expression of CD33, CD38, and HLA-DR on CD34+ human fetal liver progenitors with a high proliferative potential
    M O Muench
    Human Immunology Department, DNAX Research Institute, Palo Alto, CA
    Blood 83:3170-81. 1994
    ..These data suggest that FL HPP-CFC represent a heterogeneous compartment of primitive myeloid progenitors that may include stem cells...
  37. ncbi Radioprotection by murine and human tumor-necrosis factor: dose-dependent effects on hematopoiesis in the mouse
    L Slørdal
    James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan Kettering Cancer Center, New York, NY
    Eur J Haematol 43:428-34. 1989
    ..This suggests that TNF exerts it radioprotective effects on a pool of primitive multi-potential hematopoietic cells...
  38. ncbi Cytokine networks involved in the regulation of haemopoietic stem cell proliferation and differentiation
    M A Moore
    James Ewing Laboratory of Developmental Hematopoiesis, Memoral Sloan Kettering Cancer Center, New York, NY 10021
    Ciba Found Symp 148:43-58; discussion 58-61. 1990
    ..Induction of products of the cyclooxygenase and lipooxygenase pathways, as well as tumour necrosis factor and TGF-beta, modulate haemopoiesis...
  39. ncbi Purification and partial characterization of a human hematopoietic precursor population
    C Smith
    Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021
    Blood 77:2122-8. 1991
    ....
  40. ncbi Accelerated recovery of peripheral blood cell counts in mice transplanted with in vitro cytokine-expanded hematopoietic progenitors
    M O Muench
    James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    Exp Hematol 20:611-8. 1992
    ..The expansion of BM progenitor cells without loss of long-term proliferative potential may be of clinical importance in the fields of BM transplantation and gene therapy...
  41. ncbi Ex vivo differentiation therapy as a method of leukemic cell purging in murine bone marrow expansion cultures
    M O Muench
    James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    Cancer Res 52:6576-82. 1992
    ..The addition of G-CSF, mutein, and ATRA to delta-cultures did not result in any impairment of hematopoietic stem cells when measured 5 wk after transplantation...
  42. ncbi Interactions among colony-stimulating factors, IL-1 beta, IL-6, and kit-ligand in the regulation of primitive murine hematopoietic cells
    M O Muench
    James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan Kettering Cancer Center, New York, New York
    Exp Hematol 20:339-49. 1992
    ..The ability to expand early progenitor cells in delta-cultures was further demonstrated by the greater than 100-fold expansions of day-12 spleen colony-forming units (CFU-S) by the synergistic interactions of IL-1 with IL-3 or KL...
  43. ncbi The in vitro growth of murine high proliferative potential-colony forming cells is not enhanced by growth in a low oxygen atmosphere
    M O Muench
    James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan Kettering Cancer Center, New York, NY 10021
    Cytokine 4:488-94. 1992
    ..These results demonstrate that the growth of murine HPP-CFC was not compromised when cultured at ambient O2 concentration...
  44. ncbi [Birth-conditioned cerebral vascular disorders in children]
    A I Kaĭsarova
    Vopr Okhr Materin Det 23:49-52. 1978
  45. ncbi Tracing the expression of CD7 and other antigens during T- and myeloid-cell differentiation in the human fetal liver and thymus
    A Barcena
    Human Immunology Department, DNAX Research Institute for Cellular and Molecular Biology, Palo Alto, California 94304, USA
    Leuk Lymphoma 17:1-11. 1995
    ..In addition, we present an hypothetical model of hematopoiesis in the fetal liver and thymus...
  46. ncbi Phenotypic and functional analysis of T-cell precursors in the human fetal liver and thymus: CD7 expression in the early stages of T- and myeloid-cell development
    A Barcena
    Human Immunology Department, DNAX Research Institute, Palo Alto, CA 94304 1104
    Blood 82:3401-14. 1993
    ....
  47. ncbi Progress in the ex vivo expansion of hematopoietic progenitors
    M O Muench
    Human Immunology Department, DNAX Research Institute, Palo Alto, CA 94304 1104
    Leuk Lymphoma 16:1-11. 1994
    ..Thus, ex vivo progenitor expansion may soon be of use in transplantation protocols to accelerate hematopoietic reconstitution and in gene therapy protocols if hematopoietic stem cells can be maintained during ex vivo culture...
  48. ncbi Differential effects of interleukin-3, interleukin-7, interleukin 15, and granulocyte-macrophage colony-stimulating factor in the generation of natural killer and B cells from primitive human fetal liver progenitors
    M O Muench
    The Fetal Treatment Center Research Laboratory, UCSF Cancer Research Center, University of California, San Francisco, CA, USA
    Exp Hematol 28:961-73. 2000
    ..These findings indicate a differential regulation of NK and B lymphopoiesis beginning in the early stages of hematopoiesis as exemplified by the distinctive roles of IL-7, IL-15, GM-CSF, and IL-3...
  49. ncbi Fetal bone marrow as a source of stem cells for in utero or postnatal transplantation
    F Golfier
    Department of Surgery, Fetal Treatment Center Research Laboratory at the University of California, San Francisco, CA 94143 0570, USA
    Br J Haematol 109:173-81. 2000
    ..Thus, FBM is a safe source of stem cells. The large number of progenitors and candidate stem cells that can be obtained from FBM makes it suitable for in utero and possibly postnatal transplantation...
  50. ncbi Mid-trimester fetal livers are a rich source of CD34+/++ cells for transplantation
    F Golfier
    Department of Surgery, Fetal Treatment Center Research Laboratory, University of California, San Francisco, CA 94143 0570, USA
    Bone Marrow Transplant 24:451-61. 1999
    ..In conclusion, purification of FL progenitors between 16 and 24 weeks of gestation results in a large number of early progenitors suitable for in utero and possibly post-natal transplantation...
  51. ncbi Role of CD95/Fas and its ligand in the regulation of the growth of human CD34(++)CD38(-) fetal liver cells
    A Barcena
    The Fetal Treatment Center Research Laboratory, University of California, San Francisco 94143 0570, USA
    Exp Hematol 27:1428-39. 1999
    ..We conclude that the endogenous CD95L has an inhibitory effect on fetal candidate HSCs, which can be blocked by sCD95L and CH-11 mAb...
  52. ncbi Administration of Flk2/Flt3 ligand induces expansion of human high-proliferative potential colony-forming cells in the SCID-hu mouse
    R Namikawa
    DNAX Research Institute of Molecular and Cellular Biology, Inc, Palo Alto, CA, USA
    Exp Hematol 27:1029-37. 1999
    ..These results indicate that FL induces the expansion of primitive hematopoietic progenitor cells in vivo and, therefore, may be useful in treating patients to promote an early hematopoietic recovery after cytoablative therapies...
  53. ncbi The biology and ethics of banking fetal liver hematopoietic stem cells for in utero transplantation
    G B Mychaliska
    Department of Surgery, The Fetal Treatment Center, University of California, San Francisco 94143 0570, USA
    J Pediatr Surg 33:394-9. 1998
    ..The authors describe their methods for processing fetal liver free of known human pathogens while maximizing HSC activity after cryopreservation...
  54. ncbi Colony-forming cells expressing high levels of CD34 are the main targets for granulocyte colony-stimulating factor and macrophage colony-stimulating factor in the human fetal liver
    M O Muench
    Human Immunology Department, DNAX Research Institute, Palo Alto, CA, USA
    Exp Hematol 25:277-87. 1997
    ..These data help to define the potential roles of cytokines in human fetal hematopoiesis...
  55. ncbi Phenotypic and functional evidence for the expression of CD4 by hematopoietic stem cells isolated from human fetal liver
    M O Muench
    Human Immunology Department, DNAX Research Institute, Palo Alto, CA 94304 1104, USA
    Blood 89:1364-75. 1997
    ..Furthermore, all CD4+ CD34++ Lin- fetal liver cells also expressed CD13 and CD33...
  56. ncbi Regulatory roles of the ligand for Flk2/Flt3 tyrosine kinase receptor on human hematopoiesis
    R Namikawa
    DNAX Research Institute of Molecular and Cellular Biology, Inc, Palo Alto, California 94304, USA
    Stem Cells 14:388-95. 1996
    ..Thus, FL plays important roles in regulating the proliferation of hematopoietic progenitor cells and, therefore, may have therapeutic applications...
  57. ncbi The FLK2/FLT3 ligand synergizes with interleukin-7 in promoting stromal-cell-independent expansion and differentiation of human fetal pro-B cells in vitro
    R Namikawa
    Human Immunology Department, DNAX Research Institute of Molecular and Cellular Biology, Inc, Palo Alto, CA, USA
    Blood 87:1881-90. 1996
    ....
  58. ncbi Development of a lacZ marked WEHI-3B D+ murine leukemic cell line as an in-vivo model of acute non-lymphocytic leukemia
    C Smith
    Division of Hematologic Oncology, Memorial Sloan Kettering Cancer Center, New York, NY
    Leukemia 7:310-7. 1993
    ..Results indicate that treatment of mice inoculated with WEHI-3B D+/lacZ 2.8 cells with G-CSF administration causes detectable but limited differentiation...
  59. ncbi Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs
    C Hannum
    DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304 1104
    Nature 368:643-8. 1994
    ....
  60. ncbi Interleukin-11 expression in donor bone marrow cells improves hematological reconstitution in lethally irradiated recipient mice
    S R Paul
    Genetics Institute, Cambridge, MA 02140
    Exp Hematol 22:295-301. 1994
    ..No abnormal cell proliferation or other histopathology was observed in the hIL-11-expressing mice...