Affiliation: University of California
- Radiation, atherosclerotic risk factors, and stroke risk in survivors of pediatric cancer: a report from the Childhood Cancer Survivor StudySabine Mueller
Department of Neurology, Pediatrics and Neurosurgery, University of California, San Francisco, San Francisco, California 94158, USA
Int J Radiat Oncol Biol Phys 86:649-55. 2013..To test the hypotheses that (1) the increased risk of stroke conferred by childhood cranial radiation therapy (CRT) persists into adulthood; and (2) atherosclerotic risk factors further increase the stroke risk in cancer survivors...
- Risk of first and recurrent stroke in childhood cancer survivors treated with cranial and cervical radiation therapySabine Mueller
Department of Neurology, University of California, San Francisco, California 94148, USA
Int J Radiat Oncol Biol Phys 86:643-8. 2013..To assess, in a retrospective cohort study, rates and predictors of first and recurrent stroke in patients treated with cranial irradiation (CRT) and/or cervical irradiation at ≤18 years of age...
- Poly (ADP-Ribose) polymerase inhibitor MK-4827 together with radiation as a novel therapy for metastatic neuroblastomaSabine Mueller
Department of Neurology, University of California, San Francisco, 675 Nelson Ring, Sandler Neuroscience Center, UCSF, San Francisco, CA 94148, USA
Anticancer Res 33:755-62. 2013..To assess poly (ADP-ribose) polymerase (PARP) inhibitor MK-4827 together with radiation for the treatment of neuroblastoma...
- Pediatric brain tumors: current treatment strategies and future therapeutic approachesSabine Mueller
Department of Neurology, Division of Child Neurology, University of San Francisco, San Francisco, California, USA
Neurotherapeutics 6:570-86. 2009..This article will outline current and future therapeutic strategies for the most common pediatric CNS tumors, including primitive neuroectodermal tumors such as medulloblastoma, as well as astrocytomas and ependymomas...
- Cooperation of the HDAC inhibitor vorinostat and radiation in metastatic neuroblastoma: efficacy and underlying mechanismsSabine Mueller
Department of Neurology, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0106, USA
Cancer Lett 306:223-9. 2011..DNA repair enzyme Ku-86 was reduced in several neuroblastoma cells treated with vorinostat. Thus, vorinostat potentiates anti-neoplastic effects of radiation in neuroblastoma possibly due to down-regulation of DNA repair enzyme Ku-86...
- Effect of imaging and catheter characteristics on clinical outcome for patients in the PRECISE studySabine Mueller
Department of Neurology, University of San Francisco, 350 Parnassus Ave, Suite 609, San Francisco, CA 94117, USA
J Neurooncol 101:267-77. 2011..55; PFS: P = 0.35) or imaging changes on day 43 MRI (P = 0.88). Catheter positioning scores and overall catheter placement scores were not associated with clinical outcome in this large prospective trial...
- High-grade gliomas in childrenTene A Cage
Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143 0112, USA
Neurosurg Clin N Am 23:515-23. 2012..This article reviews clinical, diagnostic, and pathologic features of HGG and current treatments and potential future therapies specific to pediatric patients with HGGs...
- Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomideGautam Prasad
Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA
Neuro Oncol 13:384-92. 2011..05) with a trend toward improvement in median survival (logrank p = 0.09) compared with TMZ alone. XL765 shows activity as monotherapy and in combination with conventional therapeutics in a range of genetically diverse GBM xenografts...
- Feasibility, safety, and indications for surgical biopsy of intrinsic brainstem tumors in childrenTene A Cage
Department of Neurological Surgery, Pediatric Neurosurgery, University of California, San Francisco, 505 Parnassus Ave, Room M779, San Francisco, CA, 94143 0112, USA
Childs Nerv Syst 29:1313-9. 2013..We have reviewed the results of biopsy for DIPGs in children at a single institution and compared our results to those available in the literature to elucidate the utility of biopsy for DIPGs...
- The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expressionKui Ming Chan
Department of Biochemistry and Molecular Biology, University of California at San Francisco, San Francisco, California 94143, USA
Genes Dev 27:985-90. 2013..These results indicate that H3.3K27M mutation reprograms epigenetic landscape and gene expression, which may drive tumorigenesis...
- PTEN promoter methylation and activation of the PI3K/Akt/mTOR pathway in pediatric gliomas and influence on clinical outcomeSabine Mueller
Department of Pediatrics, University of California, San Francisco, CA, USA
Neuro Oncol 14:1146-52. 2012..0475). Tumors with no PTEN expression had a higher MIB labeling index (P= .007). The majority of pediatric gliomas show activation of the PI3K/Akt/mTOR pathway, with methylation of the PTEN promoter occurring commonly in these tumors...
- Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systemsSwati S More
Departments of Bioengineering and Therapeutic Sciences, UCSF School of Medicine and UCSF Benioff Children s Hospital, San Francisco, California 94158, USA
Clin Cancer Res 17:2339-49. 2011....
- Neuroblastoma: biology and stagingSabine Mueller
Department of Pediatric Hematology Oncology, University of California, San Francisco School of Medicine, M647, 505 Parnassus Avenue, San Francisco, CA 94143, USA
Curr Oncol Rep 11:431-8. 2009..This review discusses the biology of these tumors, current and new risk classification, and staging recommendations, with a brief outline of preferred treatment strategies...
- The superiority of conservative resection and adjuvant radiation for craniopharyngiomasAdam Schoenfeld
Department of Radiation Oncology, University of California, San Francisco UCSF, San Francisco, CA 94143 1708, USA
J Neurooncol 108:133-9. 2012..014). In conclusion, for patients with craniopharyngioma, STR + RT may provide superior clinical outcome, achieving better disease control than STR and limiting side effects associated with aggressive surgical resection...
- Multidisciplinary care of patients with brain tumorsTannie Huang
Division of Hematology Oncology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94143, USA
Surg Oncol Clin N Am 22:161-78. 2013..This article examines the roles of these subspecialists, with the goal of summarizing standard-of-care practices, recent therapeutic advances, and ongoing clinical investigations within each subspecialty...
- Characterization of a diffuse intrinsic pontine glioma cell line: implications for future investigations and treatmentRintaro Hashizume
Department of Neurological Surgery, Brain Tumor Research Center, University of California San Francisco, San Francisco, CA 94143 0520, USA
J Neurooncol 110:305-13. 2012..The hTERT modified cells are tumorigenic in athymic rodents, and produce brainstem tumors that recapitulate the infiltrative growth of brainstem gliomas in patients...