Daniel Mueller

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen
    Justin J Taylor
    Department of Medicine and 2 Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Exp Med 209:2065-77. 2012
  2. pmc E3 ubiquitin ligases and their control of T cell autoreactivity
    Jody L Bonnevier
    Rheumatic and Autoimmune Diseases Division, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA
    Arthritis Res Ther 7:233-42. 2005
  3. doi request reprint Mechanisms maintaining peripheral tolerance
    Daniel L Mueller
    Department of Medicine and Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Nat Immunol 11:21-7. 2010
  4. ncbi request reprint E3 ubiquitin ligases as T cell anergy factors
    Daniel L Mueller
    Department of Medicine, Division of Rheumatic and Autoimmune Diseases, Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nat Immunol 5:883-90. 2004
  5. ncbi request reprint Visualizing the first 50 hr of the primary immune response to a soluble antigen
    Drew M Catron
    Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis 55455, USA
    Immunity 21:341-7. 2004
  6. ncbi request reprint Indirect minor histocompatibility antigen presentation by allograft recipient cells in the draining lymph node leads to the activation and clonal expansion of CD4+ T cells that cause obliterative airways disease
    David M Richards
    Department of Medicine, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Immunol 172:3469-79. 2004
  7. ncbi request reprint Sharing of class I MHC molecules between donor and host promotes the infiltration of allografts by mHAg-reactive CD8 T cells
    Stacy L Dalheimer
    Department of Medicine and Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA
    Am J Transplant 5:832-8. 2005
  8. ncbi request reprint Trachea allograft class I molecules directly activate and retain CD8+ T cells that cause obliterative airways disease
    David M Richards
    Department of Medicine and Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Immunol 171:6919-28. 2003
  9. pmc Gene regulation and chromatin remodeling by IL-12 and type I IFN in programming for CD8 T cell effector function and memory
    Pujya Agarwal
    Center for Immunology and Department of Laboratory, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 183:1695-704. 2009
  10. ncbi request reprint CD25+Foxp3+ regulatory T cells facilitate CD4+ T cell clonal anergy induction during the recovery from lymphopenia
    Tracy L Vanasek
    Department of Medicine, Center for Immunology, University of Minnesota Medical School, 312 Church Street SE, Minneapolis, MN 55455, USA
    J Immunol 176:5880-9. 2006

Research Grants

  1. Epigenetic Control of T cell Autoimmunity
    Daniel Mueller; Fiscal Year: 2009
  2. Regulation of IL-2 Gene Expression in T-cell Anergy
    Daniel Mueller; Fiscal Year: 2005
  3. Regulation of IL-2 Gene Expression in T-cell Anergy
    Daniel Mueller; Fiscal Year: 2004
  4. Regulation of IL-2 Gene Expression in T-cell Anergy
    Daniel Mueller; Fiscal Year: 2003
  5. Regulation of IL-2 Gene Expression in T-cell Anergy
    Daniel Mueller; Fiscal Year: 2002
  6. Immunobiology of Transplant Obliterative Disease
    Daniel Mueller; Fiscal Year: 2001
  7. REGULATION OF IL-2 GENE EXPRESSION IN T CELL ANERGY
    Daniel Mueller; Fiscal Year: 2000
  8. REGULATION OF IL-2 GENE EXPRESSION IN T CELL ANERGY
    Daniel Mueller; Fiscal Year: 1999
  9. Epigenetic Control of T cell Autoimmunity
    Daniel L Mueller; Fiscal Year: 2010

Collaborators

  • MARC KEVIN JENKINS
  • Drew M Catron
  • Andrea A Itano
  • Kathryn A Pape
  • Matthew F Mescher
  • Stacy L Dalheimer
  • David M Richards
  • Anna Mondino
  • Tracy L Vanasek
  • Justin J Taylor
  • Sara Colombetti
  • Na Zhang
  • Pujya Agarwal
  • Cory A Yarke
  • Sarada L Nandiwada
  • Jody L Bonnevier
  • Veronica Basso
  • Marshall I Hertz
  • Daniela Crespi
  • Stephanie R Thomas
  • Philip J Titcombe
  • Shoshana D Katzman
  • Ryan J Martinez
  • Laura O Barsness
  • Arvind Raghavan
  • Julie M Curtsinger
  • Paul R Bohjanen
  • Ruan Zhang
  • Benjamin D Ehst
  • Stefania Massa

Detail Information

Publications16

  1. pmc Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen
    Justin J Taylor
    Department of Medicine and 2 Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Exp Med 209:2065-77. 2012
    ..In contrast, a combination of deleting cells expressing receptors with high affinity for antigen with anergy of the undeleted lower affinity cells maintains tolerance to ubiquitous membrane-bound self-antigens...
  2. pmc E3 ubiquitin ligases and their control of T cell autoreactivity
    Jody L Bonnevier
    Rheumatic and Autoimmune Diseases Division, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA
    Arthritis Res Ther 7:233-42. 2005
    ..In this review, we will discuss the mechanisms used by E3 ligases to control the activation of T cells and prevent the development of autoimmunity...
  3. doi request reprint Mechanisms maintaining peripheral tolerance
    Daniel L Mueller
    Department of Medicine and Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Nat Immunol 11:21-7. 2010
    ....
  4. ncbi request reprint E3 ubiquitin ligases as T cell anergy factors
    Daniel L Mueller
    Department of Medicine, Division of Rheumatic and Autoimmune Diseases, Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nat Immunol 5:883-90. 2004
    ..This review will discuss the relationship between the ubiquitination of select components of the antigen-sensing signaling apparatus in T cells and the development and maintenance of the clonal anergy state...
  5. ncbi request reprint Visualizing the first 50 hr of the primary immune response to a soluble antigen
    Drew M Catron
    Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis 55455, USA
    Immunity 21:341-7. 2004
    ..The simulation highlights how lymph node structure facilitates antigen presentation to rare, naive, antigen-specific CD4+ T cells...
  6. ncbi request reprint Indirect minor histocompatibility antigen presentation by allograft recipient cells in the draining lymph node leads to the activation and clonal expansion of CD4+ T cells that cause obliterative airways disease
    David M Richards
    Department of Medicine, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Immunol 172:3469-79. 2004
    ....
  7. ncbi request reprint Sharing of class I MHC molecules between donor and host promotes the infiltration of allografts by mHAg-reactive CD8 T cells
    Stacy L Dalheimer
    Department of Medicine and Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA
    Am J Transplant 5:832-8. 2005
    ..Therefore, class I MHC matching between donor and host may not always favor an avoidance of alloreactivity within the graft tissue...
  8. ncbi request reprint Trachea allograft class I molecules directly activate and retain CD8+ T cells that cause obliterative airways disease
    David M Richards
    Department of Medicine and Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Immunol 171:6919-28. 2003
    ..Thus, these experiments are the first to definitively show a role for directly alloreactive CD8(+) T cells in the chronic rejection that leads to OAD...
  9. pmc Gene regulation and chromatin remodeling by IL-12 and type I IFN in programming for CD8 T cell effector function and memory
    Pujya Agarwal
    Center for Immunology and Department of Laboratory, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 183:1695-704. 2009
    ....
  10. ncbi request reprint CD25+Foxp3+ regulatory T cells facilitate CD4+ T cell clonal anergy induction during the recovery from lymphopenia
    Tracy L Vanasek
    Department of Medicine, Center for Immunology, University of Minnesota Medical School, 312 Church Street SE, Minneapolis, MN 55455, USA
    J Immunol 176:5880-9. 2006
    ..Thus, an early recovery of CD25(+) regulatory T cells following a lymphopenic event can prevent exuberant Ag-stimulated CD4(+) cell cycle progression and promote the development of clonal anergy...
  11. ncbi request reprint Proliferating CD4+ T cells undergo immediate growth arrest upon cessation of TCR signaling in vivo
    Cory A Yarke
    Department of Medicine, Center for Immunology, University of Minnesota Medical School, Minneapolis 55455, USA
    J Immunol 180:156-62. 2008
    ..Thus, CD4+ T cells scan for the presence Ag throughout their clonal expansion response, and continuously adjust their rate of cell growth and G1->S phase transition to match their intensity of TCR signaling...
  12. pmc mTOR at the crossroads of T cell proliferation and tolerance
    Anna Mondino
    San Raffaele Scientific Institute, Milan, Italy
    Semin Immunol 19:162-72. 2007
    ..The role of mTOR as a rheostat capable of integrating extracellular, plasma membrane-associated, and intracellular signals with relevance to T cell priming and tolerance is discussed...
  13. ncbi request reprint Linking diacylglycerol kinase to T cell anergy
    Daniel L Mueller
    Nat Immunol 7:1132-4. 2006
  14. ncbi request reprint Prolonged TCR/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of rapamycin
    Sara Colombetti
    Cancer Immunotherapy and Gene Therapy Program, San Raffaele Scientific Institute, Milan, Italy
    J Immunol 176:2730-8. 2006
    ..These data suggest that Ag persistence and the availability of costimulatory signals and of autocrine and paracrine growth factors individually shape T lymphocyte expansion in vivo...
  15. ncbi request reprint Tuning the immune system: competing positive and negative feedback loops
    Daniel L Mueller
    Nat Immunol 4:210-1. 2003
  16. ncbi request reprint Constitutive active p21ras enhances primary T cell responsiveness to Ca2+ signals without interfering with the induction of clonal anergy
    Daniela Crespi
    Cancer Immunotherapy and Gene Therapy Program, DIBIT H S Raffaele, Milan, Italy
    Eur J Immunol 32:2500-9. 2002
    ....

Research Grants12

  1. Epigenetic Control of T cell Autoimmunity
    Daniel Mueller; Fiscal Year: 2009
    ..abstract_text> ..
  2. Regulation of IL-2 Gene Expression in T-cell Anergy
    Daniel Mueller; Fiscal Year: 2005
    ..abstract_text> ..
  3. Regulation of IL-2 Gene Expression in T-cell Anergy
    Daniel Mueller; Fiscal Year: 2004
    ..abstract_text> ..
  4. Regulation of IL-2 Gene Expression in T-cell Anergy
    Daniel Mueller; Fiscal Year: 2003
    ..abstract_text> ..
  5. Regulation of IL-2 Gene Expression in T-cell Anergy
    Daniel Mueller; Fiscal Year: 2002
    ..abstract_text> ..
  6. Immunobiology of Transplant Obliterative Disease
    Daniel Mueller; Fiscal Year: 2001
    ..In addition, the information obtained in these experiments should serve as important preclinical data for the development of effective immunomodulatory approaches to the problem of alloantigen-specific transplantation tolerance. ..
  7. REGULATION OF IL-2 GENE EXPRESSION IN T CELL ANERGY
    Daniel Mueller; Fiscal Year: 2000
    ..With this new information, this research project will target the TCR/p21ras/MAPK/AP-1 signal transduction pathway for further investigation, and define those biochemical alterations that impair the expression of the IL-2 gene. ..
  8. REGULATION OF IL-2 GENE EXPRESSION IN T CELL ANERGY
    Daniel Mueller; Fiscal Year: 1999
    ..With this new information, this research project will target the TCR/p21ras/MAPK/AP-1 signal transduction pathway for further investigation, and define those biochemical alterations that impair the expression of the IL-2 gene. ..
  9. Epigenetic Control of T cell Autoimmunity
    Daniel L Mueller; Fiscal Year: 2010
    ..abstract_text> ..