Affiliation: University of Minnesota
- E3 ubiquitin ligases and their control of T cell autoreactivityJody L Bonnevier
Rheumatic and Autoimmune Diseases Division, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA
Arthritis Res Ther 7:233-42. 2005..In this review, we will discuss the mechanisms used by E3 ligases to control the activation of T cells and prevent the development of autoimmunity...
- Mechanisms maintaining peripheral toleranceDaniel L Mueller
Department of Medicine and Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA
Nat Immunol 11:21-7. 2010....
- E3 ubiquitin ligases as T cell anergy factorsDaniel L Mueller
Department of Medicine, Division of Rheumatic and Autoimmune Diseases, Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Nat Immunol 5:883-90. 2004..This review will discuss the relationship between the ubiquitination of select components of the antigen-sensing signaling apparatus in T cells and the development and maintenance of the clonal anergy state...
- Visualizing the first 50 hr of the primary immune response to a soluble antigenDrew M Catron
Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis 55455, USA
Immunity 21:341-7. 2004..The simulation highlights how lymph node structure facilitates antigen presentation to rare, naive, antigen-specific CD4+ T cells...
- Indirect minor histocompatibility antigen presentation by allograft recipient cells in the draining lymph node leads to the activation and clonal expansion of CD4+ T cells that cause obliterative airways diseaseDavid M Richards
Department of Medicine, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
J Immunol 172:3469-79. 2004....
- Sharing of class I MHC molecules between donor and host promotes the infiltration of allografts by mHAg-reactive CD8 T cellsStacy L Dalheimer
Department of Medicine and Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA
Am J Transplant 5:832-8. 2005..Therefore, class I MHC matching between donor and host may not always favor an avoidance of alloreactivity within the graft tissue...
- Gene regulation and chromatin remodeling by IL-12 and type I IFN in programming for CD8 T cell effector function and memoryPujya Agarwal
Center for Immunology and Department of Laboratory, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 183:1695-704. 2009....
- Proliferating CD4+ T cells undergo immediate growth arrest upon cessation of TCR signaling in vivoCory A Yarke
Department of Medicine, Center for Immunology, University of Minnesota Medical School, Minneapolis 55455, USA
J Immunol 180:156-62. 2008..Thus, CD4+ T cells scan for the presence Ag throughout their clonal expansion response, and continuously adjust their rate of cell growth and G1->S phase transition to match their intensity of TCR signaling...
- CD25+Foxp3+ regulatory T cells facilitate CD4+ T cell clonal anergy induction during the recovery from lymphopeniaTracy L Vanasek
Department of Medicine, Center for Immunology, University of Minnesota Medical School, 312 Church Street SE, Minneapolis, MN 55455, USA
J Immunol 176:5880-9. 2006..Thus, an early recovery of CD25(+) regulatory T cells following a lymphopenic event can prevent exuberant Ag-stimulated CD4(+) cell cycle progression and promote the development of clonal anergy...
- Trachea allograft class I molecules directly activate and retain CD8+ T cells that cause obliterative airways diseaseDavid M Richards
Department of Medicine and Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
J Immunol 171:6919-28. 2003..Thus, these experiments are the first to definitively show a role for directly alloreactive CD8(+) T cells in the chronic rejection that leads to OAD...
- Prolonged TCR/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of rapamycinSara Colombetti
Cancer Immunotherapy and Gene Therapy Program, San Raffaele Scientific Institute, Milan, Italy
J Immunol 176:2730-8. 2006..These data suggest that Ag persistence and the availability of costimulatory signals and of autocrine and paracrine growth factors individually shape T lymphocyte expansion in vivo...
- Linking diacylglycerol kinase to T cell anergyDaniel L Mueller
Nat Immunol 7:1132-4. 2006
- mTOR at the crossroads of T cell proliferation and toleranceAnna Mondino
San Raffaele Scientific Institute, Milan, Italy
Semin Immunol 19:162-72. 2007..The role of mTOR as a rheostat capable of integrating extracellular, plasma membrane-associated, and intracellular signals with relevance to T cell priming and tolerance is discussed...
- Tuning the immune system: competing positive and negative feedback loopsDaniel L Mueller
Nat Immunol 4:210-1. 2003
- Constitutive active p21ras enhances primary T cell responsiveness to Ca2+ signals without interfering with the induction of clonal anergyDaniela Crespi
Cancer Immunotherapy and Gene Therapy Program, DIBIT H S Raffaele, Milan, Italy
Eur J Immunol 32:2500-9. 2002....
- Regulation of IL-2 Gene Expression in T-cell AnergyDaniel Mueller; Fiscal Year: 2005..abstract_text> ..
- Immunobiology of Transplant Obliterative DiseaseDaniel Mueller; Fiscal Year: 2001..In addition, the information obtained in these experiments should serve as important preclinical data for the development of effective immunomodulatory approaches to the problem of alloantigen-specific transplantation tolerance. ..
- REGULATION OF IL-2 GENE EXPRESSION IN T CELL ANERGYDaniel Mueller; Fiscal Year: 2000..With this new information, this research project will target the TCR/p21ras/MAPK/AP-1 signal transduction pathway for further investigation, and define those biochemical alterations that impair the expression of the IL-2 gene. ..
- Epigenetic Control of T cell AutoimmunityDaniel L Mueller; Fiscal Year: 2010..abstract_text> ..