Genomes and Genes
Affiliation: University of Alabama at Birmingham
- Kidney injury accelerates cystogenesis via pathways modulated by heme oxygenase and complementJuling Zhou
Department of Medicine, University of Alabama at Birmingham, USA
J Am Soc Nephrol 23:1161-71. 2012....
- Simulation of real-time ultrasound-guided renal biopsyMichal Mrug
Department of Medicine, Division of Nephrology and Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Kidney Int 78:705-7. 2010..Future controlled studies are needed to establish the efficacy of this simulation training in reducing discomfort and adverse renal biopsy outcomes in patients...
- Renal CD14 expression correlates with the progression of cystic kidney diseaseJuling Zhou
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
Kidney Int 78:550-60. 2010..But the association was significant when the analysis was confined to males. Clearly more studies need to be done to evaluate the utility of CD14 as a marker for outcomes in ADPKD...
- Kinesin family member 12 is a candidate polycystic kidney disease modifier in the cpk mouseMichal Mrug
Department of Medicine, University of Alabama at Birmingham, 740 Kaul Human Genetics Building, 720 20th Street South, Birmingham, AL 35294, USA
J Am Soc Nephrol 16:905-16. 2005..Therefore, the positional candidate gene, Kif12, fulfills the major criteria for QTL gene discovery established by the Complex Trait Consortium, and, thus, it is proposed that Kif12 is a cpk modifier gene...
- Validation of endogenous internal real-time PCR controls in renal tissuesXiangqin Cui
Department of Medicine, University of Alabama at Birmingham, 1900 University Blvd, Tinsley Harrison Tower 611J, Birmingham, AL 35294, USA
Am J Nephrol 30:413-7. 2009..Unfortunately, none of these controls fulfills this premise across a wide range of experimental conditions; consequently, none of them can be recommended for universal use...
- Refinement of the autosomal recessive polycystic kidney disease (PKHD1) interval and exclusion of an EF hand-containing gene as a PKHD1 candidate geneLuiz F Onuchic
Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
Am J Med Genet 110:346-52. 2002..This further refinement of the PKHD1 interval will facilitate efforts to identify the PKHD1 gene by positional cloning. These data also provide additional, highly polymorphic markers for haplotype-based diagnostic testing for ARPKD...
- Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney diseaseXiaoying Hou
Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, USA
J Clin Invest 109:533-40. 2002..We therefore propose that the single epithelial cilium is important in the functional differentiation of polarized epithelia and that ciliary dysfunction underlies the PKD phenotype in cpk mice...