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Genomes and Genes | Jennifer S MoylanSummaryAffiliation: University of Kentucky Country: USA Publications
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Publications
TNF induction of atrogin-1/MAFbx mRNA depends on Foxo4 expression but not AKT-Foxo1/3 signalingJennifer S Moylan
Department of Physiology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
Am J Physiol Cell Physiol 295:C986-93. 2008..We conclude that TNF increases atrogin mRNA independent of AKT via Foxo4. These results suggest a mechanism by which inflammatory catabolic states may persist in the presence of adequate growth factors and nutrition...- Sphingomyelinase depresses force and calcium sensitivity of the contractile apparatus in mouse diaphragm muscle fibersLeonardo F Ferreira
Department of Physiology and Center for Muscle Biology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
J Appl Physiol 112:1538-45. 2012..Our study shows that the fall in specific force of intact muscle elicited by SMase is mediated by mitochondrial ROS and can be attributed largely to dysfunction of the contractile apparatus... - Sphingomyelinase stimulates oxidant signaling to weaken skeletal muscle and promote fatigueLeonardo F Ferreira
Department of Physiology and Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, USA
Am J Physiol Cell Physiol 299:C552-60. 2010..05) and accelerated fatigue--effects opposed by treatment with NAC. In conclusion, our findings suggest that SMase stimulates a ceramide-oxidant signaling pathway that results in muscle weakness and fatigue... 
TNF-alpha acts via TNFR1 and muscle-derived oxidants to depress myofibrillar force in murine skeletal muscleBrian J Hardin
Dept of Physiology, University of Kentucky, 800 Rose Street, Lexington, KY 40536 0298, USA
J Appl Physiol 104:694-9. 2008..We conclude that TNF acts via TNFR1 to stimulate oxidant activity and depress specific force. TNF effects on force are caused, at least in part, by decrements in function of calcium-activated myofibrillar proteins...- Stretch-stimulated glucose uptake in skeletal muscle is mediated by reactive oxygen species and p38 MAP-kinaseMelissa A Chambers
Department of Physiology, University of Kentucky, Lexington, 40536 0298, USA
J Physiol 587:3363-73. 2009..99). These data indicate that stretch-stimulated glucose uptake in skeletal muscle is mediated by a ROS- and p38 MAPK-dependent mechanism that appears to be AMPKalpha2- and PI3-K-independent... - Beyond atrophy: redox mechanisms of muscle dysfunction in chronic inflammatory diseaseMichael B Reid
Department of Physiology, University of Kentucky, Lexington, KY 40536 0298, USA
J Physiol 589:2171-9. 2011..Investigators in the field are pursuing these issues with the long-term goal of preserving muscle function in individuals afflicted by chronic disease... - Interleukin-1 stimulates catabolism in C2C12 myotubesWei Li
Department of Physiology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
Am J Physiol Cell Physiol 297:C706-14. 2009.... - Doxorubicin acts through tumor necrosis factor receptor subtype 1 to cause dysfunction of murine skeletal muscleLaura A A Gilliam
Department of Physiology, 3Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
J Appl Physiol 107:1935-42. 2009..01). These results demonstrate that clinical doxorubicin concentrations disrupt limb muscle function in a TNFR1-dependent manner... - Doxorubicin causes diaphragm weakness in murine models of cancer chemotherapyLaura A A Gilliam
Department of Physiology, University of Kentucky, 800 Rose Street, MS 508, Lexington, Kentucky 40536 0298, USA
Muscle Nerve 43:94-102. 2011..These results suggest that clinically relevant doses of doxorubicin cause respiratory muscle weakness and that the loss of function depends, in part, on the route of administration... - TNF/TNFR1 signaling mediates doxorubicin-induced diaphragm weaknessLaura A A Gilliam
Department of Physiology, Center for Muscle Biology, University of Kentucky, Lexington, 40536 0298, USA
Am J Physiol Lung Cell Mol Physiol 300:L225-31. 2011..05) in the diaphragm, along with colocalization of TNFR1 to the plasma membrane. These results suggest that doxorubicin increases diaphragm sensitivity to TNF by upregulating TNFR1, thereby causing respiratory muscle weakness... - Physical inactivity and muscle weakness in the critically illMelissa A Chambers
Department of Physiology, University of Kentucky, Lexington, KY, USA
Crit Care Med 37:S337-46. 2009.... - Prion protein expression and functional importance in skeletal muscleJeffrey D Smith
Department of Physiology, University of Kentucky, Lexington, 40536, USA
Antioxid Redox Signal 15:2465-75. 2011..Conclusions: PrP content varies among murine skeletal muscles and is essential for maintaining normal redox homeostasis, muscle size, and contractile function in adult animals... - Doxorubicin acts via mitochondrial ROS to stimulate catabolism in C2C12 myotubesLaura A A Gilliam
Department of Physiology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
Am J Physiol Cell Physiol 302:C195-202. 2012..These findings suggest doxorubicin acts via mitochondrial ROS to stimulate myotube atrophy... 
IFN-gamma does not mimic the catabolic effects of TNF-alphaMelissa A Smith
Department of Physiology, University of Kentucky, Lexington, KY 40536 0298, USA
Am J Physiol Cell Physiol 293:C1947-52. 2007..These data show that responses of myotubes to IFN-gamma and TNF-alpha differ markedly and provide little evidence for a direct catabolic effect of IFN-gamma on muscle...- Oxidative stress, chronic disease, and muscle wastingJennifer S Moylan
Department of Physiology, University of Kentucky, 800 Rose Street, Room MS 509, Lexington, Kentucky 40536 0298, USA
Muscle Nerve 35:411-29. 2007..This review examines the relationship between oxidative stress, chronic disease, and muscle wasting, and the mechanisms by which oxidative stress acts as a catabolic signal... - Doxorubicin causes diaphragm weakness in murine models of cancer chemotherapyLaura A A Gilliam
Department of Physiology, University of Kentucky, 800 Rose Street, MS 508, Lexington, Kentucky 40536 0298, USA
Muscle Nerve 43:94-102. 2011..These results suggest that clinically relevant doses of doxorubicin cause respiratory muscle weakness and that the loss of function depends, in part, on the route of administration. Muscle Nerve, 2011... - Bowman-Birk inhibitor concentrate prevents atrophy, weakness, and oxidative stress in soleus muscle of hindlimb-unloaded miceSandrine Arbogast
Dept of Physiology, University of Kentucky, Lexington, KY 40536 0298, USA
J Appl Physiol 102:956-64. 2007..We conclude that dietary supplementation with BBIC protects skeletal muscle during prolonged unloading, promoting redox homeostasis in muscle fibers and blunting atrophy-induced weakness...