Jennifer S Moylan

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. ncbi Neutral sphingomyelinase-3 mediates TNF-stimulated oxidant activity in skeletal muscle
    Jennifer S Moylan
    Department of Physiology, University of Kentucky, Lexington, KY, USA Center for Muscle Biology, University of Kentucky, Lexington, KY, USA
    Redox Biol 2:910-20. 2014
  2. pmc TNF induction of atrogin-1/MAFbx mRNA depends on Foxo4 expression but not AKT-Foxo1/3 signaling
    Jennifer S Moylan
    Department of Physiology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Am J Physiol Cell Physiol 295:C986-93. 2008
  3. pmc Sphingomyelinase depresses force and calcium sensitivity of the contractile apparatus in mouse diaphragm muscle fibers
    Leonardo F Ferreira
    Department of Physiology and Center for Muscle Biology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Appl Physiol (1985) 112:1538-45. 2012
  4. pmc Sphingomyelinase stimulates oxidant signaling to weaken skeletal muscle and promote fatigue
    Leonardo F Ferreira
    Department of Physiology and Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, USA
    Am J Physiol Cell Physiol 299:C552-60. 2010
  5. ncbi TNF-alpha acts via TNFR1 and muscle-derived oxidants to depress myofibrillar force in murine skeletal muscle
    Brian J Hardin
    Dept of Physiology, University of Kentucky, 800 Rose Street, Lexington, KY 40536 0298, USA
    J Appl Physiol (1985) 104:694-9. 2008
  6. pmc Stretch-stimulated glucose uptake in skeletal muscle is mediated by reactive oxygen species and p38 MAP-kinase
    Melissa A Chambers
    Department of Physiology, University of Kentucky, Lexington, 40536 0298, USA
    J Physiol 587:3363-73. 2009
  7. pmc Interleukin-1 stimulates catabolism in C2C12 myotubes
    Wei Li
    Department of Physiology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Am J Physiol Cell Physiol 297:C706-14. 2009
  8. pmc Doxorubicin acts through tumor necrosis factor receptor subtype 1 to cause dysfunction of murine skeletal muscle
    Laura A A Gilliam
    Department of Physiology, 3Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Appl Physiol (1985) 107:1935-42. 2009
  9. pmc Beyond atrophy: redox mechanisms of muscle dysfunction in chronic inflammatory disease
    Michael B Reid
    Department of Physiology, University of Kentucky, Lexington, KY 40536 0298, USA
    J Physiol 589:2171-9. 2011
  10. pmc Doxorubicin causes diaphragm weakness in murine models of cancer chemotherapy
    Laura A A Gilliam
    Department of Physiology, University of Kentucky, 800 Rose Street, MS 508, Lexington, Kentucky 40536 0298, USA
    Muscle Nerve 43:94-102. 2011

Collaborators

Detail Information

Publications19

  1. ncbi Neutral sphingomyelinase-3 mediates TNF-stimulated oxidant activity in skeletal muscle
    Jennifer S Moylan
    Department of Physiology, University of Kentucky, Lexington, KY, USA Center for Muscle Biology, University of Kentucky, Lexington, KY, USA
    Redox Biol 2:910-20. 2014
    ..The present study tested the hypothesis that nSMase3 protein is expressed in skeletal muscle and functions to regulate TNF-stimulated oxidant production...
  2. pmc TNF induction of atrogin-1/MAFbx mRNA depends on Foxo4 expression but not AKT-Foxo1/3 signaling
    Jennifer S Moylan
    Department of Physiology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Am J Physiol Cell Physiol 295:C986-93. 2008
    ..We conclude that TNF increases atrogin mRNA independent of AKT via Foxo4. These results suggest a mechanism by which inflammatory catabolic states may persist in the presence of adequate growth factors and nutrition...
  3. pmc Sphingomyelinase depresses force and calcium sensitivity of the contractile apparatus in mouse diaphragm muscle fibers
    Leonardo F Ferreira
    Department of Physiology and Center for Muscle Biology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Appl Physiol (1985) 112:1538-45. 2012
    ..Our study shows that the fall in specific force of intact muscle elicited by SMase is mediated by mitochondrial ROS and can be attributed largely to dysfunction of the contractile apparatus...
  4. pmc Sphingomyelinase stimulates oxidant signaling to weaken skeletal muscle and promote fatigue
    Leonardo F Ferreira
    Department of Physiology and Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, USA
    Am J Physiol Cell Physiol 299:C552-60. 2010
    ..05) and accelerated fatigue--effects opposed by treatment with NAC. In conclusion, our findings suggest that SMase stimulates a ceramide-oxidant signaling pathway that results in muscle weakness and fatigue...
  5. ncbi TNF-alpha acts via TNFR1 and muscle-derived oxidants to depress myofibrillar force in murine skeletal muscle
    Brian J Hardin
    Dept of Physiology, University of Kentucky, 800 Rose Street, Lexington, KY 40536 0298, USA
    J Appl Physiol (1985) 104:694-9. 2008
    ..We conclude that TNF acts via TNFR1 to stimulate oxidant activity and depress specific force. TNF effects on force are caused, at least in part, by decrements in function of calcium-activated myofibrillar proteins...
  6. pmc Stretch-stimulated glucose uptake in skeletal muscle is mediated by reactive oxygen species and p38 MAP-kinase
    Melissa A Chambers
    Department of Physiology, University of Kentucky, Lexington, 40536 0298, USA
    J Physiol 587:3363-73. 2009
    ..99). These data indicate that stretch-stimulated glucose uptake in skeletal muscle is mediated by a ROS- and p38 MAPK-dependent mechanism that appears to be AMPKalpha2- and PI3-K-independent...
  7. pmc Interleukin-1 stimulates catabolism in C2C12 myotubes
    Wei Li
    Department of Physiology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Am J Physiol Cell Physiol 297:C706-14. 2009
    ....
  8. pmc Doxorubicin acts through tumor necrosis factor receptor subtype 1 to cause dysfunction of murine skeletal muscle
    Laura A A Gilliam
    Department of Physiology, 3Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Appl Physiol (1985) 107:1935-42. 2009
    ..01). These results demonstrate that clinical doxorubicin concentrations disrupt limb muscle function in a TNFR1-dependent manner...
  9. pmc Beyond atrophy: redox mechanisms of muscle dysfunction in chronic inflammatory disease
    Michael B Reid
    Department of Physiology, University of Kentucky, Lexington, KY 40536 0298, USA
    J Physiol 589:2171-9. 2011
    ..Investigators in the field are pursuing these issues with the long-term goal of preserving muscle function in individuals afflicted by chronic disease...
  10. pmc Doxorubicin causes diaphragm weakness in murine models of cancer chemotherapy
    Laura A A Gilliam
    Department of Physiology, University of Kentucky, 800 Rose Street, MS 508, Lexington, Kentucky 40536 0298, USA
    Muscle Nerve 43:94-102. 2011
    ..These results suggest that clinically relevant doses of doxorubicin cause respiratory muscle weakness and that the loss of function depends, in part, on the route of administration...
  11. pmc TNF signals via neuronal-type nitric oxide synthase and reactive oxygen species to depress specific force of skeletal muscle
    Shawn A Stasko
    Department of Physiology and Center for Muscle Biology, University of Kentucky, Lexington, Kentucky 40356 0298, USA
    J Appl Physiol (1985) 114:1629-36. 2013
    ..These findings indicate that TNF signals via nNOS to depress contractile function, a response that requires ROS and NO as obligate co-mediators...
  12. pmc TNF/TNFR1 signaling mediates doxorubicin-induced diaphragm weakness
    Laura A A Gilliam
    Department of Physiology, Center for Muscle Biology, University of Kentucky, Lexington, 40536 0298, USA
    Am J Physiol Lung Cell Mol Physiol 300:L225-31. 2011
    ..05) in the diaphragm, along with colocalization of TNFR1 to the plasma membrane. These results suggest that doxorubicin increases diaphragm sensitivity to TNF by upregulating TNFR1, thereby causing respiratory muscle weakness...
  13. ncbi Physical inactivity and muscle weakness in the critically ill
    Melissa A Chambers
    Department of Physiology, University of Kentucky, Lexington, KY, USA
    Crit Care Med 37:S337-46. 2009
    ....
  14. pmc Prion protein expression and functional importance in skeletal muscle
    Jeffrey D Smith
    Department of Physiology, University of Kentucky, Lexington, 40536, USA
    Antioxid Redox Signal 15:2465-75. 2011
    ..Skeletal muscle expresses prion protein (PrP) that buffers oxidant activity in neurons...
  15. pmc Doxorubicin acts via mitochondrial ROS to stimulate catabolism in C2C12 myotubes
    Laura A A Gilliam
    Department of Physiology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Am J Physiol Cell Physiol 302:C195-202. 2012
    ..These findings suggest doxorubicin acts via mitochondrial ROS to stimulate myotube atrophy...
  16. ncbi IFN-gamma does not mimic the catabolic effects of TNF-alpha
    Melissa A Smith
    Department of Physiology, University of Kentucky, Lexington, KY 40536 0298, USA
    Am J Physiol Cell Physiol 293:C1947-52. 2007
    ..These data show that responses of myotubes to IFN-gamma and TNF-alpha differ markedly and provide little evidence for a direct catabolic effect of IFN-gamma on muscle...
  17. ncbi Oxidative stress, chronic disease, and muscle wasting
    Jennifer S Moylan
    Department of Physiology, University of Kentucky, 800 Rose Street, Room MS 509, Lexington, Kentucky 40536 0298, USA
    Muscle Nerve 35:411-29. 2007
    ..This review examines the relationship between oxidative stress, chronic disease, and muscle wasting, and the mechanisms by which oxidative stress acts as a catabolic signal...
  18. ncbi Doxorubicin causes diaphragm weakness in murine models of cancer chemotherapy
    Laura A A Gilliam
    Department of Physiology, University of Kentucky, 800 Rose Street, MS 508, Lexington, Kentucky 40536 0298, USA
    Muscle Nerve 43:94-102. 2011
    ..These results suggest that clinically relevant doses of doxorubicin cause respiratory muscle weakness and that the loss of function depends, in part, on the route of administration. Muscle Nerve, 2011...
  19. ncbi Bowman-Birk inhibitor concentrate prevents atrophy, weakness, and oxidative stress in soleus muscle of hindlimb-unloaded mice
    Sandrine Arbogast
    Dept of Physiology, University of Kentucky, Lexington, KY 40536 0298, USA
    J Appl Physiol 102:956-64. 2007
    ..We conclude that dietary supplementation with BBIC protects skeletal muscle during prolonged unloading, promoting redox homeostasis in muscle fibers and blunting atrophy-induced weakness...