SHERYL MOY

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Repetitive behavior profile and supersensitivity to amphetamine in the C58/J mouse model of autism
    Sheryl S Moy
    Carolina Institute for Developmental Disabilities, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA Electronic address
    Behav Brain Res 259:200-14. 2014
  2. pmc Disruption of social approach by MK-801, amphetamine, and fluoxetine in adolescent C57BL/6J mice
    Sheryl S Moy
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Neurotoxicol Teratol 36:36-46. 2013
  3. pmc Preweaning sensorimotor deficits and adolescent hypersociability in Grin1 knockdown mice
    Sheryl S Moy
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Dev Neurosci 34:159-73. 2012
  4. pmc Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains
    Sheryl S Moy
    North Carolina STAART Center for Autism Research, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Behav Brain Res 176:4-20. 2007
  5. ncbi request reprint Mouse models of autism spectrum disorders: the challenge for behavioral genetics
    Sheryl S Moy
    Neurodevelopmental Disorders Research Center, CB 7146, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Med Genet C Semin Med Genet 142:40-51. 2006
  6. ncbi request reprint Advances in behavioral genetics: mouse models of autism
    S S Moy
    Neurodevelopmental Disorders Research Center, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Psychiatry 13:4-26. 2008
  7. pmc Development of a mouse test for repetitive, restricted behaviors: relevance to autism
    Sheryl S Moy
    Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Behav Brain Res 188:178-94. 2008
  8. ncbi request reprint Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
    S S Moy
    North Carolina STAART Center for Autism Research, Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Genes Brain Behav 3:287-302. 2004
  9. pmc Social approach and repetitive behavior in eleven inbred mouse strains
    Sheryl S Moy
    Neurodevelopmental Disorders Research Center, CB 7146, University of North Carolina School of Medicine, Chapel Hill, NC 27599, United States
    Behav Brain Res 191:118-29. 2008
  10. pmc Social approach in genetically engineered mouse lines relevant to autism
    S S Moy
    Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Genes Brain Behav 8:129-42. 2009

Detail Information

Publications35

  1. pmc Repetitive behavior profile and supersensitivity to amphetamine in the C58/J mouse model of autism
    Sheryl S Moy
    Carolina Institute for Developmental Disabilities, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA Electronic address
    Behav Brain Res 259:200-14. 2014
    ..These studies suggest that specific repetitive phenotypes can be used to distinguish ASD mouse models, with implications for divergent underlying mechanisms for different repetitive behavior profiles. ..
  2. pmc Disruption of social approach by MK-801, amphetamine, and fluoxetine in adolescent C57BL/6J mice
    Sheryl S Moy
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Neurotoxicol Teratol 36:36-46. 2013
    ..Overall, these findings demonstrate that moderate alteration of NMDA, dopamine, or serotonin function can attenuate social preference in wild type mice...
  3. pmc Preweaning sensorimotor deficits and adolescent hypersociability in Grin1 knockdown mice
    Sheryl S Moy
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Dev Neurosci 34:159-73. 2012
    ....
  4. pmc Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains
    Sheryl S Moy
    North Carolina STAART Center for Autism Research, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Behav Brain Res 176:4-20. 2007
    ..Our multitask strategy for modeling symptoms of autism will be useful for investigating targeted and random gene mutations, QTLs, and microarray analyses...
  5. ncbi request reprint Mouse models of autism spectrum disorders: the challenge for behavioral genetics
    Sheryl S Moy
    Neurodevelopmental Disorders Research Center, CB 7146, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Med Genet C Semin Med Genet 142:40-51. 2006
    ..Research focusing on genes that mediate social behavior in mice may help identify neural circuitry essential for normal social interaction, and lead to novel genetic animal models of the autism behavioral phenotype...
  6. ncbi request reprint Advances in behavioral genetics: mouse models of autism
    S S Moy
    Neurodevelopmental Disorders Research Center, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Psychiatry 13:4-26. 2008
    ..Research focusing on the effect of gene-by-gene interactions or genetic susceptibility to detrimental environmental challenges may further understanding of the complex etiology for autism...
  7. pmc Development of a mouse test for repetitive, restricted behaviors: relevance to autism
    Sheryl S Moy
    Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Behav Brain Res 188:178-94. 2008
    ..Further work is required to determine the characteristics of optimal mouse social stimuli in the olfactory hole-board test...
  8. ncbi request reprint Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
    S S Moy
    North Carolina STAART Center for Autism Research, Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Genes Brain Behav 3:287-302. 2004
    ..This new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism...
  9. pmc Social approach and repetitive behavior in eleven inbred mouse strains
    Sheryl S Moy
    Neurodevelopmental Disorders Research Center, CB 7146, University of North Carolina School of Medicine, Chapel Hill, NC 27599, United States
    Behav Brain Res 191:118-29. 2008
    ..Overall, this set of tasks and observational methods provides a strategy for evaluating novel mouse models in behavioral domains relevant to the autism phenotype...
  10. pmc Social approach in genetically engineered mouse lines relevant to autism
    S S Moy
    Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Genes Brain Behav 8:129-42. 2009
    ..Findings from the fragile X model suggest that the FVB/129 background confers enhanced susceptibility to consequences of Fmr1 mutation on social approach...
  11. pmc Impaired sociability and cognitive function in Nrcam-null mice
    Sheryl S Moy
    Neurodevelopmental Disorders Research Center, CB 7146, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Behav Brain Res 205:123-31. 2009
    ..Reversal learning deficits were observed in both male and female Nrcam-null mice. These results provide evidence that NRCAM mediates domains of function relevant to symptoms observed in autism...
  12. pmc Deficient NRG1-ERBB signaling alters social approach: relevance to genetic mouse models of schizophrenia
    Sheryl S Moy
    Carolina Center for Developmental Disabilities, CB 7146, University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA
    J Neurodev Disord 1:302-12. 2009
    ..Nrg1+/- pups did not exhibit changes in isolation-induced ultrasonic vocalizations, a measure of emotional reactivity. Overall, these findings provide evidence that social behavior is mediated by NRG1-ERBB signaling...
  13. ncbi request reprint Amphetamine-induced disruption of prepulse inhibition in mice with reduced NMDA receptor function
    Sheryl S Moy
    Department of Psychiatry, and Neurodevelopmental Disorders Research Center, University of North Carolina at Chapel Hill, NC 27599, USA
    Brain Res 1089:186-94. 2006
    ..Overall, these findings suggest that the NR1-/- mouse may provide a model for enhanced sensitivity to dopamine agonist-induced disruption of PPI...
  14. pmc Large-scale gene expression differences across brain regions and inbred strains correlate with a behavioral phenotype
    Jessica J Nadler
    Department of Genetics, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill 27599 7264, USA
    Genetics 174:1229-36. 2006
    ..Thus we can begin to identify expression profiles contributing to behavioral phenotypes through variation in gene expression...
  15. pmc Deficits in adult prefrontal cortex neurons and behavior following early post-natal NMDA antagonist treatment
    Leon G Coleman
    Curriculum in Neurobiology, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, United States
    Pharmacol Biochem Behav 93:322-30. 2009
    ..These findings indicate that early brain insults affecting glutamatergic neurotransmission lead to persistent brain pathology that could contribute to impulsivity and cognitive dysfunction...
  16. ncbi request reprint Amphetamine-induced Fos is reduced in limbic cortical regions but not in the caudate or accumbens in a genetic model of NMDA receptor hypofunction
    Seiya Miyamoto
    Department of Psychiatry, the Mental Health and Neuroscience Clinical Research Center, USA
    Neuropsychopharmacology 29:2180-8. 2004
    ..The results suggest a neuroanatomically selective activation deficit to amphetamine challenge in the NR1-deficient mice...
  17. ncbi request reprint Neonatal neurosteroid administration results in development-specific alterations in prepulse inhibition and locomotor activity: neurosteroids alter prepulse inhibition and locomotor activity
    Samantha S Gizerian
    Curriculum in Neurobiology and Department of Psychiatry, University of North Carolina at Chapel Hill, 7023 Neurosciences Hospital, Chapel Hill, NC 27599, USA
    Psychopharmacology (Berl) 186:334-42. 2006
    ..p.) alters the localization of prefrontal cortex (PFC) interneurons in adulthood. Such displacement could result in disinhibited behavior associated with impaired development of the mesocortical dopamine system...
  18. ncbi request reprint Effect of acute and chronic olanzapine treatment on phencyclidine-induced behavioral sensitization in rats with neonatal dopamine loss
    Sheryl S Moy
    Department of Psychiatry, University of North Carolina, Chapel Hill 27599 7178, USA
    Pharmacol Biochem Behav 78:47-56. 2004
    ....
  19. pmc Increased sensitivity to kainic acid in a genetic model of reduced NMDA receptor function
    Gary E Duncan
    Department of Psychiatry, University of North Carolina at Chapel Hill, NC 27599, USA
    Brain Res 1307:166-76. 2010
    ..These findings suggest that selective kainate receptor antagonists could be novel therapeutic candidates for schizophrenia...
  20. pmc A 5-HT1A agonist and a 5-HT2c antagonist reduce social interaction deficit induced by multiple ethanol withdrawals in rats
    David H Overstreet
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, CB 7178, Chapel Hill, NC 27599 7178, USA
    Psychopharmacology (Berl) 167:344-52. 2003
    ..The deficits in social interaction behavior following withdrawal from continuous ethanol exposure can be reduced following acute treatments with 5-HT(2C) antagonists or 5-HT(1A) agonists...
  21. ncbi request reprint Integrative role for serotonergic and glutamatergic receptor mechanisms in the action of NMDA antagonists: potential relationships to antipsychotic drug actions on NMDA antagonist responsiveness
    George R Breese
    Department of Psychiatry, UNC School of Medicine, University of North Carolina, 3007 Thurston Bowles Bldg, Chapel Hill, NC 27599 7178, USA
    Neurosci Biobehav Rev 26:441-55. 2002
    ....
  22. pmc Neural activation deficits in a mouse genetic model of NMDA receptor hypofunction in tests of social aggression and swim stress
    Gary E Duncan
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Brain Res 1265:186-95. 2009
    ..The mutant mice also exhibited reduced Fos in response to swim stress in specific brain regions. These data suggest that the NR1 hypomorphic mice have functional activation deficits in response to social challenge and swim stress...
  23. ncbi request reprint Phencyclidine supersensitivity in rats with neonatal dopamine loss
    Sheryl S Moy
    Neurodevelopmental Disorders Research Center and Skipper Bowles Center for Alcohol Studies, Department of Psychiatry, CB 7178, University of North Carolina, Chapel Hill 27599, USA
    Psychopharmacology (Berl) 161:255-62. 2002
    ....
  24. doi request reprint Effects of cage size and enrichment on reproductive performance and behavior in C57BL/6Tac mice
    Julia Whitaker
    Division of Laboratory Animal Medicine, Department of Pathology and Laboratory Medicine, 1100 Bioinformatics, CB 7115
    Lab Anim (NY) 38:24-34. 2009
    ....
  25. pmc SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in rats
    Darin J Knapp
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Alcohol 32:101-11. 2004
    ..Because anxiety may be a complicating factor in alcohol withdrawal and relapse, future studies of this type are needed to provide focus for the effort to define selective and novel antianxiety agents for these disorders...
  26. pmc Olfactory cues are sufficient to elicit social approach behaviors but not social transmission of food preference in C57BL/6J mice
    Bryce C Ryan
    Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Behav Brain Res 193:235-42. 2008
    ....
  27. ncbi request reprint Effects of haloperidol, clozapine, and quetiapine on sensorimotor gating in a genetic model of reduced NMDA receptor function
    Gary E Duncan
    Department of Psychiatry, CB 7090, University of North Carolina School of Medicine, Chapel Hill, NC, 27599 7090, USA
    Psychopharmacology (Berl) 184:190-200. 2006
    ..These mice show increased acoustic startle reactivity and deficits in prepulse inhibition (PPI) of acoustic startle...
  28. pmc Typical and atypical antipsychotic drug effects on locomotor hyperactivity and deficits in sensorimotor gating in a genetic model of NMDA receptor hypofunction
    Gary E Duncan
    Department of Psychiatry, University of North Carolina at Chapel Hill, USA
    Pharmacol Biochem Behav 85:481-91. 2006
    ..Since both haloperidol and the atypical drugs increased PPI, it is likely that D2 dopamine receptor blockade is responsible for the drug effects on sensorimotor gating...
  29. ncbi request reprint The neonate-6-hydroxydopamine-lesioned rat: a model for clinical neuroscience and neurobiological principles
    George R Breese
    Department of Psychiatry, UNC School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7178, USA
    Brain Res Brain Res Rev 48:57-73. 2005
    ..Despite an extraordinary legacy from studies of the neurobiology of this treatment, a host of unknowns remain that will inspire future investigations...
  30. ncbi request reprint The effect of cage size on reproductive performance and behavior of C57BL/6 mice
    Julia Whitaker
    Division of Laboratory Animal Medicine, Department of Pathology and Laboratory Medicine, 1100 Bioinformatics, CB 7115, University of North Carolina, Chapel Hill, NC 27599, USA
    Lab Anim (NY) 36:32-9. 2007
    ..Cage size had no significant effect on any of the reproductive parameters measured and few or inconsistent effects on behavior in weaned pups...
  31. ncbi request reprint Deficits in sensorimotor gating and tests of social behavior in a genetic model of reduced NMDA receptor function
    Gary E Duncan
    Department of Psychiatry, University of North Carolina School of Medicine, CB 7090, Chapel Hill, NC 27599 7090, USA
    Behav Brain Res 153:507-19. 2004
    ..The NR1 hypomorphic mice could represent a model system to explore novel treatment and preventative strategies for certain symptoms of schizophrenia...
  32. pmc Disruption of axo-glial junctions causes cytoskeletal disorganization and degeneration of Purkinje neuron axons
    German P Garcia-Fresco
    Curriculum in Neurobiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 103:5137-42. 2006
    ..Together, these findings establish a physiologically relevant link between AGJs and axonal cytoskeleton and raise the possibility that some neurodegenerative disorders arise from disruption of the AGJs...
  33. ncbi request reprint A de novo deafwaddler mutation of Pmca2 arising in ES cells and hitchhiking with a targeted modification of the Pparg gene
    Yau Sheng Tsai
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, 27599, USA
    Mamm Genome 17:716-22. 2006
    ..Our findings represent a cautionary example since, although rare, spontaneous mutations do arise in ES cells during culture and hitchhike onto the targeted gene mutation...
  34. ncbi request reprint Social approach behaviors in oxytocin knockout mice: comparison of two independent lines tested in different laboratory environments
    Jacqueline N Crawley
    Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA
    Neuropeptides 41:145-63. 2007
    ....
  35. ncbi request reprint Oxidative stress and dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease
    Jasper E Visser
    Department of Neurology, Meyer 6 181, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Brain Res Dev Brain Res 133:127-39. 2002
    ..Overall, these data provide evidence for increased oxidative stress, but the failure to protect the knockout mice by over-expressing SOD1 argues that oxidative stress is not the sole process responsible for the loss of striatal dopamine...

Research Grants4