Research Topics
Species | SHERYL MOYSummaryAffiliation: University of North Carolina Country: USA Publications
Research Grants
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Detail Information
Publications
Disruption of social approach by MK-801, amphetamine, and fluoxetine in adolescent C57BL/6J miceSheryl S Moy
Department of Psychiatry, CB 7146, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA Carolina Institute for Developmental Disabilities, CB 7146, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA Electronic address
Neurotoxicol Teratol 36:36-46. 2013..Overall, these findings demonstrate that moderate alteration of NMDA, dopamine, or serotonin function can attenuate social preference in wild type mice...- Preweaning sensorimotor deficits and adolescent hypersociability in Grin1 knockdown miceSheryl S Moy
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Dev Neurosci 34:159-73. 2012.... 
Mouse models of autism spectrum disorders: the challenge for behavioral geneticsSheryl S Moy
Neurodevelopmental Disorders Research Center, CB 7146, University of North Carolina, Chapel Hill, NC 27599, USA
Am J Med Genet C Semin Med Genet 142:40-51. 2006..Research focusing on genes that mediate social behavior in mice may help identify neural circuitry essential for normal social interaction, and lead to novel genetic animal models of the autism behavioral phenotype...- Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strainsSheryl S Moy
North Carolina STAART Center for Autism Research, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Behav Brain Res 176:4-20. 2007..Our multitask strategy for modeling symptoms of autism will be useful for investigating targeted and random gene mutations, QTLs, and microarray analyses... - Advances in behavioral genetics: mouse models of autismS S Moy
Neurodevelopmental Disorders Research Center, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Mol Psychiatry 13:4-26. 2008..Research focusing on the effect of gene-by-gene interactions or genetic susceptibility to detrimental environmental challenges may further understanding of the complex etiology for autism... - Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in miceS S Moy
North Carolina STAART Center for Autism Research, Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Genes Brain Behav 3:287-302. 2004..This new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism... - Development of a mouse test for repetitive, restricted behaviors: relevance to autismSheryl S Moy
Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Behav Brain Res 188:178-94. 2008..Further work is required to determine the characteristics of optimal mouse social stimuli in the olfactory hole-board test... - Social approach and repetitive behavior in eleven inbred mouse strainsSheryl S Moy
Neurodevelopmental Disorders Research Center, CB 7146, University of North Carolina School of Medicine, Chapel Hill, NC 27599, United States
Behav Brain Res 191:118-29. 2008..Overall, this set of tasks and observational methods provides a strategy for evaluating novel mouse models in behavioral domains relevant to the autism phenotype... - Social approach in genetically engineered mouse lines relevant to autismS S Moy
Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Genes Brain Behav 8:129-42. 2009..Findings from the fragile X model suggest that the FVB/129 background confers enhanced susceptibility to consequences of Fmr1 mutation on social approach... - Impaired sociability and cognitive function in Nrcam-null miceSheryl S Moy
Neurodevelopmental Disorders Research Center, CB 7146, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Behav Brain Res 205:123-31. 2009..Reversal learning deficits were observed in both male and female Nrcam-null mice. These results provide evidence that NRCAM mediates domains of function relevant to symptoms observed in autism... - Deficient NRG1-ERBB signaling alters social approach: relevance to genetic mouse models of schizophreniaSheryl S Moy
Carolina Center for Developmental Disabilities, CB 7146, University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA
J Neurodev Disord 1:302-12. 2009..Nrg1+/- pups did not exhibit changes in isolation-induced ultrasonic vocalizations, a measure of emotional reactivity. Overall, these findings provide evidence that social behavior is mediated by NRG1-ERBB signaling... - Amphetamine-induced disruption of prepulse inhibition in mice with reduced NMDA receptor functionSheryl S Moy
Department of Psychiatry, and Neurodevelopmental Disorders Research Center, University of North Carolina at Chapel Hill, NC 27599, USA
Brain Res 1089:186-94. 2006..Overall, these findings suggest that the NR1-/- mouse may provide a model for enhanced sensitivity to dopamine agonist-induced disruption of PPI... - Large-scale gene expression differences across brain regions and inbred strains correlate with a behavioral phenotypeJessica J Nadler
Department of Genetics, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill 27599-7264, USA
Genetics 174:1229-36. 2006..Thus we can begin to identify expression profiles contributing to behavioral phenotypes through variation in gene expression... - Deficits in adult prefrontal cortex neurons and behavior following early post-natal NMDA antagonist treatmentLeon G Coleman
Curriculum in Neurobiology, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, United States
Pharmacol Biochem Behav 93:322-30. 2009..These findings indicate that early brain insults affecting glutamatergic neurotransmission lead to persistent brain pathology that could contribute to impulsivity and cognitive dysfunction... - Amphetamine-induced Fos is reduced in limbic cortical regions but not in the caudate or accumbens in a genetic model of NMDA receptor hypofunctionSeiya Miyamoto
Department of Psychiatry, the Mental Health and Neuroscience Clinical Research Center, USA
Neuropsychopharmacology 29:2180-8. 2004..The results suggest a neuroanatomically selective activation deficit to amphetamine challenge in the NR1-deficient mice... - Effect of acute and chronic olanzapine treatment on phencyclidine-induced behavioral sensitization in rats with neonatal dopamine lossSheryl S Moy
Department of Psychiatry, University of North Carolina, Chapel Hill 27599-7178, USA
Pharmacol Biochem Behav 78:47-56. 2004.... - Neonatal neurosteroid administration results in development-specific alterations in prepulse inhibition and locomotor activity: neurosteroids alter prepulse inhibition and locomotor activitySamantha S Gizerian
Curriculum in Neurobiology and Department of Psychiatry, University of North Carolina at Chapel Hill, 7023 Neurosciences Hospital, Chapel Hill, NC 27599, USA
Psychopharmacology (Berl) 186:334-42. 2006..The temporal exposure differences (P2 vs P5) and ontological-dependent effects (P20 and P80, but not P40 or P60) suggest critical windows of vulnerability to neurosteroid insult across development... - A 5-HT1A agonist and a 5-HT2c antagonist reduce social interaction deficit induced by multiple ethanol withdrawals in ratsDavid H Overstreet
Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, CB 7178, Chapel Hill, NC 27599 7178, USA
Psychopharmacology (Berl) 167:344-52. 2003..The deficits in social interaction behavior following withdrawal from continuous ethanol exposure can be reduced following acute treatments with 5-HT(2C) antagonists or 5-HT(1A) agonists... - Increased sensitivity to kainic acid in a genetic model of reduced NMDA receptor functionGary E Duncan
Department of Psychiatry, University of North Carolina at Chapel Hill, NC 27599, USA
Brain Res 1307:166-76. 2010..These findings suggest that selective kainate receptor antagonists could be novel therapeutic candidates for schizophrenia... - Neural activation deficits in a mouse genetic model of NMDA receptor hypofunction in tests of social aggression and swim stressGary E Duncan
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Brain Res 1265:186-95. 2009..The mutant mice also exhibited reduced Fos in response to swim stress in specific brain regions. These data suggest that the NR1 hypomorphic mice have functional activation deficits in response to social challenge and swim stress... - Integrative role for serotonergic and glutamatergic receptor mechanisms in the action of NMDA antagonists: potential relationships to antipsychotic drug actions on NMDA antagonist responsivenessGeorge R Breese
Department of Psychiatry, UNC School of Medicine, University of North Carolina, 3007 Thurston Bowles Bldg, Chapel Hill, NC 27599 7178, USA
Neurosci Biobehav Rev 26:441-55. 2002.... 
Effects of cage size and enrichment on reproductive performance and behavior in C57BL/6Tac miceJulia Whitaker
Division of Laboratory Animal Medicine, Department of Pathology and Laboratory Medicine, 1100 Bioinformatics, CB 7115
Lab Anim (NY) 38:24-34. 2009....- Phencyclidine supersensitivity in rats with neonatal dopamine lossSheryl S Moy
Neurodevelopmental Disorders Research Center and Skipper Bowles Center for Alcohol Studies, Department of Psychiatry, CB 7178, University of North Carolina, Chapel Hill 27599, USA
Psychopharmacology (Berl) 161:255-62. 2002.... - Olfactory cues are sufficient to elicit social approach behaviors but not social transmission of food preference in C57BL/6J miceBryce C Ryan
Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Behav Brain Res 193:235-42. 2008.... - SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in ratsDarin J Knapp
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Alcohol 32:101-11. 2004..Because anxiety may be a complicating factor in alcohol withdrawal and relapse, future studies of this type are needed to provide focus for the effort to define selective and novel antianxiety agents for these disorders... - Effects of haloperidol, clozapine, and quetiapine on sensorimotor gating in a genetic model of reduced NMDA receptor functionGary E Duncan
Department of Psychiatry, CB 7090, University of North Carolina School of Medicine, Chapel Hill, NC, 27599 7090, USA
Psychopharmacology (Berl) 184:190-200. 2006..These mice show increased acoustic startle reactivity and deficits in prepulse inhibition (PPI) of acoustic startle... - The neonate-6-hydroxydopamine-lesioned rat: a model for clinical neuroscience and neurobiological principlesGeorge R Breese
Department of Psychiatry, UNC School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7178, USA
Brain Res Brain Res Rev 48:57-73. 2005..Despite an extraordinary legacy from studies of the neurobiology of this treatment, a host of unknowns remain that will inspire future investigations... - Typical and atypical antipsychotic drug effects on locomotor hyperactivity and deficits in sensorimotor gating in a genetic model of NMDA receptor hypofunctionGary E Duncan
Department of Psychiatry, University of North Carolina at Chapel Hill, USA
Pharmacol Biochem Behav 85:481-91. 2006..Since both haloperidol and the atypical drugs increased PPI, it is likely that D2 dopamine receptor blockade is responsible for the drug effects on sensorimotor gating... - The effect of cage size on reproductive performance and behavior of C57BL/6 miceJulia Whitaker
Division of Laboratory Animal Medicine, Department of Pathology and Laboratory Medicine, 1100 Bioinformatics, CB 7115, University of North Carolina, Chapel Hill, NC 27599, USA
Lab Anim (NY) 36:32-9. 2007..Cage size had no significant effect on any of the reproductive parameters measured and few or inconsistent effects on behavior in weaned pups... - Deficits in sensorimotor gating and tests of social behavior in a genetic model of reduced NMDA receptor functionGary E Duncan
Department of Psychiatry, University of North Carolina School of Medicine, CB 7090, Chapel Hill, NC 27599 7090, USA
Behav Brain Res 153:507-19. 2004..The NR1 hypomorphic mice could represent a model system to explore novel treatment and preventative strategies for certain symptoms of schizophrenia... - Disruption of axo-glial junctions causes cytoskeletal disorganization and degeneration of Purkinje neuron axonsGerman P Garcia-Fresco
Curriculum in Neurobiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Proc Natl Acad Sci U S A 103:5137-42. 2006..Together, these findings establish a physiologically relevant link between AGJs and axonal cytoskeleton and raise the possibility that some neurodegenerative disorders arise from disruption of the AGJs... - A de novo deafwaddler mutation of Pmca2 arising in ES cells and hitchhiking with a targeted modification of the Pparg geneYau Sheng Tsai
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, 27599, USA
Mamm Genome 17:716-22. 2006..Our findings represent a cautionary example since, although rare, spontaneous mutations do arise in ES cells during culture and hitchhike onto the targeted gene mutation... - Social approach behaviors in oxytocin knockout mice: comparison of two independent lines tested in different laboratory environmentsJacqueline N Crawley
Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA
Neuropeptides 41:145-63. 2007.... - Oxidative stress and dopamine deficiency in a genetic mouse model of Lesch-Nyhan diseaseJasper E Visser
Department of Neurology, Meyer 6 181, Johns Hopkins Hospital, Baltimore, MD 21287, USA
Brain Res Dev Brain Res 133:127-39. 2002..Overall, these data provide evidence for increased oxidative stress, but the failure to protect the knockout mice by over-expressing SOD1 argues that oxidative stress is not the sole process responsible for the loss of striatal dopamine...
Research Grants
- Early Intervention in a mouse model of NMDA hypofunctionSheryl S Moy; Fiscal Year: 2010....
- Early Intervention in a mouse model of NMDA hypofunctionSHERYL MOY; Fiscal Year: 2009....