Affiliation: University of Pennsylvania
Vourekas A, Zheng K, Fu Q, Maragkakis M, Alexiou P, Ma J, et al
. The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing. Genes Dev. 2015;29:617-29 pubmed publisher
..Our results support a model in which MOV10L1 RNA helicase activity promotes unwinding and funneling of the single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing. ..
Vourekas A, Mourelatos Z. Set Phasers to Cleave: PIWI Cleavage Directs All piRNA Biogenesis. Mol Cell. 2018;71:651-652 pubmed publisher
..In this issue of Molecular Cell, Gainetdinov et al. (2018) show that PIWI proteins direct both piRNA biogenesis and piRNA function in most animals. ..
Ibrahim F, Maragkakis M, Alexiou P, Mourelatos Z. Ribothrypsis, a novel process of canonical mRNA decay, mediates ribosome-phased mRNA endonucleolysis. Nat Struct Mol Biol. 2018;25:302-310 pubmed publisher
Liu X, Zheng Q, Vrettos N, Maragkakis M, Alexiou P, Gregory B, et al
. A MicroRNA precursor surveillance system in quality control of MicroRNA synthesis. Mol Cell. 2014;55:868-879 pubmed publisher
..Our study reveals a pre-miRNA surveillance system that comprises TUT7, TUT4, and the exosome in quality control of miRNA synthesis. ..