John D Mountz

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint T cells of staphylococcal enterotoxin B-tolerized autoimmune MRL-lpr/lpr mice require co-stimulation through the B7-CD28/CTLA-4 pathway for activation and can be reanergized in vivo by stimulation of the T cell receptor in the absence of this co-stimulato
    T Zhou
    Department of Medicine, University of Alabama at Birmingham
    Eur J Immunol 24:1019-25. 1994
  2. ncbi request reprint Molecular imaging: new applications for biochemistry
    John D Mountz
    Division of Clinical Immunology and Rheumatology, Department of Medicine, Center for Nuclear Imaging Research, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Cell Biochem Suppl 39:162-71. 2002
  3. ncbi request reprint Beneficial influences of systemic cooperation and sociological behavior on longevity
    John D Mountz
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, 701 South 19th Street, LHRB 473, Birmingham, AL 35294 0007, USA
    Mech Ageing Dev 123:963-73. 2002
  4. ncbi request reprint Regulation of apoptosis of synovial fibroblasts
    J D Mountz
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham Veterans Administration Medical Center, Birmingham, Ala, USA
    Curr Dir Autoimmun 3:216-39. 2001
  5. ncbi request reprint Genetic dissection of age-related changes of immune function in mice
    J D Mountz
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Scand J Immunol 54:10-20. 2001
  6. ncbi request reprint Apoptosis and rheumatoid arthritis: past, present, and future directions
    J D Mountz
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, 701 South 19th Street, LHRB 473, Birmingham, AL 35294 0007, USA
    Curr Rheumatol Rep 3:70-8. 2001
  7. ncbi request reprint Cell death and longevity: implications of Fas-mediated apoptosis in T-cell senescence
    J D Mountz
    Department of Medicine, University of Alabama at Birmingham 35294 0007, USA
    Immunol Rev 160:19-30. 1997
  8. ncbi request reprint Clinical features associated with correction of T-cell senescence: increased acute-phase response, amyloidosis and arthritis
    J D Mountz
    University of Alabama at Birmingham, Department of Medicine 35294 0007, USA
    Dev Comp Immunol 21:509-23. 1997
  9. pmc Enhancement of cytotoxic T-lymphocyte response in aged mice by a novel treatment with recombinant AdIL-12 and wild-type adenovirus in rapid succession
    Jian Chen
    1Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Mol Ther 16:1500-6. 2008
  10. pmc CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis
    Zhongyu Liu
    Department of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Clin Invest 112:1332-41. 2003

Collaborators

Detail Information

Publications91

  1. ncbi request reprint T cells of staphylococcal enterotoxin B-tolerized autoimmune MRL-lpr/lpr mice require co-stimulation through the B7-CD28/CTLA-4 pathway for activation and can be reanergized in vivo by stimulation of the T cell receptor in the absence of this co-stimulato
    T Zhou
    Department of Medicine, University of Alabama at Birmingham
    Eur J Immunol 24:1019-25. 1994
    ..Nonresponsiveness was not due to deletion of V beta 8+ CD28+ T cells, as the number of these cells was increased after treatment with SEB and the CTLA-4-Ig fusion protein.(ABSTRACT TRUNCATED AT 250 WORDS)..
  2. ncbi request reprint Molecular imaging: new applications for biochemistry
    John D Mountz
    Division of Clinical Immunology and Rheumatology, Department of Medicine, Center for Nuclear Imaging Research, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Cell Biochem Suppl 39:162-71. 2002
    ..Advances in genomics and proteomics combine with new peptide-chemistry approaches should provide a large number of targets and tracers in the near future to achieve these imaging objectives...
  3. ncbi request reprint Beneficial influences of systemic cooperation and sociological behavior on longevity
    John D Mountz
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, 701 South 19th Street, LHRB 473, Birmingham, AL 35294 0007, USA
    Mech Ageing Dev 123:963-73. 2002
    ....
  4. ncbi request reprint Regulation of apoptosis of synovial fibroblasts
    J D Mountz
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham Veterans Administration Medical Center, Birmingham, Ala, USA
    Curr Dir Autoimmun 3:216-39. 2001
    ..Some studies indicate that there is decreased apoptosis of parenchymal cells such as RASF that undergo hyperplasia. Gene therapy and other modulators of apoptosis, such as wortmannin, can be used to faciliate apoptosis of RASF...
  5. ncbi request reprint Genetic dissection of age-related changes of immune function in mice
    J D Mountz
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Scand J Immunol 54:10-20. 2001
    ..This review outlines ongoing and future strategies that will enable the mapping and identification of these genes...
  6. ncbi request reprint Apoptosis and rheumatoid arthritis: past, present, and future directions
    J D Mountz
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, 701 South 19th Street, LHRB 473, Birmingham, AL 35294 0007, USA
    Curr Rheumatol Rep 3:70-8. 2001
    ....
  7. ncbi request reprint Cell death and longevity: implications of Fas-mediated apoptosis in T-cell senescence
    J D Mountz
    Department of Medicine, University of Alabama at Birmingham 35294 0007, USA
    Immunol Rev 160:19-30. 1997
    ..We observed that cell lines derived from human premature aging diseases have a higher sensitivity to Fas-mediated apoptosis. The implications of these observations are discussed...
  8. ncbi request reprint Clinical features associated with correction of T-cell senescence: increased acute-phase response, amyloidosis and arthritis
    J D Mountz
    University of Alabama at Birmingham, Department of Medicine 35294 0007, USA
    Dev Comp Immunol 21:509-23. 1997
    ..These data suggest that restoration of the T-cell immune function in aged individuals must be carried out in concert with correction of other immune factors that down modulate the acute-phase response to prevent undesirable side-effects...
  9. pmc Enhancement of cytotoxic T-lymphocyte response in aged mice by a novel treatment with recombinant AdIL-12 and wild-type adenovirus in rapid succession
    Jian Chen
    1Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Mol Ther 16:1500-6. 2008
    ....
  10. pmc CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis
    Zhongyu Liu
    Department of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Clin Invest 112:1332-41. 2003
    ..Our results suggest that CII-DC-AdTRAIL+DOX cell gene therapy is a safe and effective method for inhibiting the development of CIA...
  11. pmc IL-17 activates the canonical NF-kappaB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16
    Shutao Xie
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 184:2289-96. 2010
    ..These findings identify the signaling pathway regulated by IL-17 to contribute to the development of spontaneous germinal centers in autoimmune BXD2 mice...
  12. ncbi request reprint In vivo analysis of adenovirus-specific cytotoxic T lymphocyte response in mice deficient in CD28, fas ligand, and perforin
    Jian Chen
    Department of Medicine, University of Alabama at Birmingham, and Veterans Administration Medical Center, Birmingham, AL 35294, USA
    Hum Gene Ther 17:669-82. 2006
    ..These results provide important implications concerning the development of safe and effective Ad vectors for gene therapy and vaccines...
  13. pmc Maintenance of naïve CD8 T cells in nonagenarians by leptin, IGFBP3 and T3
    Jian Chen
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mech Ageing Dev 131:29-37. 2010
    ..These results suggest a model in which IGFBP3, leptin and T3 act as non-immune factors to maintain a larger pool of naïve CD8 T cells in healthy nonagenarians...
  14. pmc IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells
    Yanna Ding
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 191:1614-24. 2013
    ..These data suggest a novel concept that TFH differentiation and its stabilization in the LZ are two separate checkpoints and that IL-21 and IL-17 act at each checkpoint to enable pathogenic GC development. ..
  15. pmc Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblasts
    Xinwen Yang
    Department of Medicine, University of Alabama at Birmingham, and the Birmingham Veterans Administration Medical Center, Birmingham, AL 35294 0007, USA
    Am J Pathol 167:705-19. 2005
    ..Taken together, our findings suggest a unique role for caspase-4 in cleaving vimentin and releasing cytosolic p53 for nuclear translocation, events that may regulate the sensitivity of RASFs to receptor-mediated apoptosis...
  16. pmc Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice
    Hui Chen Hsu
    University of Alabama at Birmingham, Birmingham, AL, USA
    Arthritis Rheum 63:2038-48. 2011
    ..To determine whether functional suppression of the catalytic domain of activation-induced cytidine deaminase (AID) can suppress the hyperreactive germinal center (GC) responses in BXD2 mice...
  17. pmc Marginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunity
    John H Wang
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 184:442-51. 2010
    ....
  18. ncbi request reprint Age-related increase of tumor susceptibility is associated with myeloid-derived suppressor cell mediated suppression of T cell cytotoxicity in recombinant inbred BXD12 mice
    William E Grizzle
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Mech Ageing Dev 128:672-80. 2007
    ..Thus, the accumulation of immunosuppresssing myeloid cells appears to contribute to the increase of tumor susceptibility as the age of mice increases...
  19. pmc Hepatic DR5 induces apoptosis and limits adenovirus gene therapy product expression in the liver
    Huang Ge Zhang
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Virol 76:5692-700. 2002
    ....
  20. ncbi request reprint Principal component analysis of quantitative trait loci for immune response to adenovirus in mice
    Solomon K Musani
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, AL 35294 0007, USA
    Hereditas 143:189-97. 2006
    ..01 and 31.01 cM) and 15 (29.21, 36.01, and 56.31 cM). These results illustrate the use of principal component analysis in mapping QTLs using multiple correlated traits...
  21. ncbi request reprint IL-12 inhibits thymic involution by enhancing IL-7- and IL-2-induced thymocyte proliferation
    Lina Li
    Department of Pathology, Veterans Administration Medical Center, Birmingham, AL 35233, USA
    J Immunol 172:2909-16. 2004
    ..Our data strongly support the role of IL-12 as an enhancement cytokine, which acts through its interactions with other cytokines to maintain thymic T cell function and development during aging...
  22. ncbi request reprint Overexpression of activation-induced cytidine deaminase in B cells is associated with production of highly pathogenic autoantibodies
    Hui Chen Hsu
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 178:5357-65. 2007
    ..Taken together, our data indicate that AID expression in B cells is a promising therapeutic target for the treatment of autoimmune diseases and that suppression of this gene may be a molecular target of CTLA4-Ig therapy...
  23. ncbi request reprint BXD recombinant inbred mice represent a novel T cell-mediated immune response tumor model
    William E Grizzle
    Department of Pathology, University of Alabama at Birmingham, AL 35294 0007, USA
    Int J Cancer 101:270-9. 2002
    ..The T-cell immune response minimized tumor development in types III and IV since T-cell depletion of the BXD RI mice resulted in aggressively growing tumors in these strains...
  24. ncbi request reprint Synovial fibroblasts promote osteoclast formation by RANKL in a novel model of spontaneous erosive arthritis
    Yalei Wu
    University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Arthritis Rheum 52:3257-68. 2005
    ..This study was undertaken to explore the roles of hyperproliferating synovial fibroblasts and macrophages in abnormal osteoclast formation, using the recently described BXD2 mouse model of RA...
  25. pmc Cutting Edge: defective follicular exclusion of apoptotic antigens due to marginal zone macrophage defects in autoimmune BXD2 mice
    Hao Li
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 190:4465-9. 2013
    ..Lack of clearance of apoptotic debris by MZMs drives follicular Ag-transportation by MZ-P B cells to stimulate an autoimmune response...
  26. pmc Type I interferon-dependent CD86(high) marginal zone precursor B cells are potent T cell costimulators in mice
    John H Wang
    University of Alabama, Birmingham, AL, USA
    Arthritis Rheum 63:1054-64. 2011
    ..To investigate the role of CD86(high) marginal zone (MZ) precursor B cells in type I interferon (IFN)-induced T cell-dependent responses in autoimmune BXD2 mice...
  27. pmc IL-17 promotes tumor development through the induction of tumor promoting microenvironments at tumor sites and myeloid-derived suppressor cells
    Donggou He
    Department of Dermatology, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 184:2281-8. 2010
    ..The study provides novel insights into the role of IL-17 in tumor development and has major implications for targeting IL-17 in treatment of tumors...
  28. ncbi request reprint CD8 T-cell immune phenotype of successful aging
    Hui Chen Hsu
    The University of Alabama at Birmingham, Department of Medicine, Division of Clinical Immunology Rheumatology, 701 South 19th Street, LHRB 473, Birmingham, AL 35294, USA
    Mech Ageing Dev 127:231-9. 2006
    ..Increased AICD may result in enhanced rejuvenation capacity of T cells and limit the impact of aging on T cell function in nonagenarians...
  29. ncbi request reprint Tumor necrosis factor ligand-receptor superfamily and arthritis
    Hui Chen Hsu
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Curr Dir Autoimmun 9:37-54. 2006
    ....
  30. ncbi request reprint Genetic analysis of the antibody response to AAV2 and factor IX
    Huang Ge Zhang
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, 701 South 19th Street, LHRB 473, Birmingham, AL 35294, USA
    Mol Ther 11:866-74. 2005
    ..66) for anti-cF.IX. These results indicate that multiple genetic loci independently regulate the isotype-specific antibody response to the AAV2 capsid and the cF.IX transgene...
  31. ncbi request reprint Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11
    Hui Chen Hsu
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, 701 South 19th Street, LHRB 473, Birmingham, AL 35294 0007, USA
    Mech Ageing Dev 123:1145-58. 2002
    ..6 cM, and 18.0 cM, respectively. Our results suggest that several genetic loci regulate the intra-thymic T-cell maturation process and play an important role in determining age-related decline in thymic T-cell development...
  32. ncbi request reprint Novel tumor necrosis factor alpha-regulated genes in rheumatoid arthritis
    Huang Ge Zhang
    The University of Alabama at Birmingham, and the Birmingham Department of Veterans Affairs Medical Center, Birmingham, AL 35294 0007, USA
    Arthritis Rheum 50:420-31. 2004
    ..To determine novel genes regulated by tumor necrosis factor alpha (TNFalpha) signaling in primary rheumatoid arthritis synovial fibroblasts (RASFs)...
  33. ncbi request reprint Immunobiology of tumor necrosis factor receptor superfamily
    Tong Zhou
    Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Immunol Res 26:323-36. 2002
    ....
  34. ncbi request reprint Specific deletion of autoreactive T cells by adenovirus-transfected, Fas ligand-producing antigen-presenting cells
    Huang Ge Zhan
    Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Immunol Res 26:235-46. 2002
    ....
  35. ncbi request reprint Production of a novel class of polyreactive pathogenic autoantibodies in BXD2 mice causes glomerulonephritis and arthritis
    Hui Chen Hsu
    University of Alabama at Birmingham, 701 South 19th Street, Birmingham, AL 35294, USA
    Arthritis Rheum 54:343-55. 2006
    ..The goal of this study was to identify the antigenic target proteins and epitopes and to unravel the mechanisms by which the related conditions arise in BXD2 mice...
  36. ncbi request reprint Increased acute-phase response and renal amyloidosis in aged CD2-fas-transgenic mice
    H C Hsu
    Department of Medicine, University of Alabama at Birmingham, and the Birmingham Veterans Administration Medical Center, 35294, USA
    J Immunol 158:5988-96. 1997
    ..The Fas-Tg mice are a novel model for understanding the immunologic mechanisms leading to secondary amyloidosis...
  37. pmc Treatment of arthritis by macrophage depletion and immunomodulation: testing an apoptosis-mediated therapy in a humanized death receptor mouse model
    Jun Li
    University of Alabama at Birmingham, AL, USA
    Arthritis Rheum 64:1098-109. 2012
    ..To determine the therapeutic efficacy and immunomodulatory effect of an anti-human death receptor 5 (DR5) antibody, TRA-8, in eliminating macrophage subsets in a mouse model of type II collagen-induced arthritis (CIA)...
  38. pmc Optimization of capsid-incorporated antigens for a novel adenovirus vaccine approach
    Qiana L Matthews
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, USA
    Virol J 5:98. 2008
    ..Our study describes antigen placement and optimization within the context of the capsid incorporation approach of Ad vaccine employment, thereby broadening this new methodology...
  39. pmc Cytokine regulation of B-cell migratory behavior favors formation of germinal centers in autoimmune disease
    John D Mountz
    Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Discov Med 11:76-85. 2011
    ..This promotes a prolonged stable interaction of B and T cells in the GC that induces high levels of activation-induced cytidine deaminase (AICDA) thereby enabling development of pathogenic autoantibody-producing B cells...
  40. ncbi request reprint Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice
    Hui Chen Hsu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 9:166-75. 2008
    ..These findings suggest a mechanism by which IL-17 drives autoimmune responses by promoting the formation of spontaneous GCs...
  41. ncbi request reprint Genetic regulation of thymic involution
    Hui Chen Hsu
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, 701 South 19th Street, LHRB 473, Birmingham, AL 35294, USA
    Mech Ageing Dev 126:87-97. 2005
    ..Our results suggest the possibility to identify the complex molecular network that can be associated with the regulation of thymic involution in aged mice using a high-dimensional functional genomics approach...
  42. ncbi request reprint IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγt
    Hao Li
    1 Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA 2 Department Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Commun 5:4259. 2014
    ..These results extend the action of IL-23 beyond its peripheral effects to a unique role in TCR-mediated negative selection including elimination of natural T regulatory cells in the thymus. ..
  43. ncbi request reprint Quantitative trait locus (QTL) mapping in aging systems
    Hui Chen Hsu
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA
    Methods Mol Biol 371:321-48. 2007
    ....
  44. pmc Therapeutic potential of mesenchymal stem cells producing interferon-alpha in a mouse melanoma lung metastasis model
    Changchun Ren
    Department of Pathology, LHRB 513, 701 19th Street South, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Stem Cells 26:2332-8. 2008
    ..These data demonstrate the potential of adult MSC constitutively producing IFN-alpha to reduce the growth of lung metastasis in melanoma...
  45. ncbi request reprint Impaired apoptosis and immune senescence - cause or effect?
    Hui Chen Hsu
    Department of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, 35294, USA
    Immunol Rev 205:130-46. 2005
    ..Based on the accumulating evidence, we propose that the emergence of the FasL(lo) AICD-senescent T cells is not only an effect of immune aging but also an important cause of T-cell proliferative senescence in both humans and mice...
  46. pmc Addition of six-His-tagged peptide to the C terminus of adeno-associated virus VP3 does not affect viral tropism or production
    Huang Ge Zhang
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Virol 76:12023-31. 2002
    ..These observations demonstrate the feasibility of producing high-titer AAV containing a 6xHis-tagged AAV VP3 capsid protein and to utilize the 6xHis-tagged VP3 capsid to achieve high-affinity purification of this recombinant AAV...
  47. ncbi request reprint Targeted and shielded adenovectors for cancer therapy
    Susan J Hedley
    VectorLogics, Inc, Birmingham, AL 35294, USA
    Cancer Immunol Immunother 55:1412-9. 2006
    ....
  48. pmc Managing macrophages in rheumatoid arthritis by reform or removal
    Jun Li
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, SHEL Bldg, Suite 337, 1825 University Blvd, Birmingham, AL 35294 2182, USA
    Curr Rheumatol Rep 14:445-54. 2012
    ....
  49. pmc Metabolic syndrome, hormones, and maintenance of T cells during aging
    Hui Chen Hsu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Curr Opin Immunol 22:541-8. 2010
    ..Therefore, better understanding of metabolic syndrome, T-cell metabolism, hormones, and microbiota may lead to new insights into the maintenance of proper immune responses in old age...
  50. ncbi request reprint Origin of late-onset autoimmune disease
    Hui Chen Hsu
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, 701 South 19th Street, Lyons Harrison Research Building 473, Birmingham, AL 35294, USA
    Immunol Allergy Clin North Am 23:65-82, vi. 2003
    ..A decreased T-cell activation response that occurs with age leads to several defects that diminish the immune response...
  51. pmc Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice
    T Zhou
    Veterans Administration Medical Center, Birmingham, Alabama, USA
    J Exp Med 182:129-37. 1995
    ..These results suggest that T cell senescence with age is associated with defective apoptosis, and that the CD2-fas transgene allows maintenance of Fas apoptosis function and T cell function in aged mice comparable to that of young mice...
  52. pmc The interdependent, overlapping, and differential roles of type I and II IFNs in the pathogenesis of experimental autoimmune encephalomyelitis
    Rodrigo Naves
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 191:2967-77. 2013
    ..Collectively, our data show that type I and II IFNs function in an integrated manner to regulate pathogenesis in EAE. ..
  53. ncbi request reprint Regulation of apoptosis proteins in cancer cells by ubiquitin
    Huang Ge Zhang
    Department of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Oncogene 23:2009-15. 2004
    ....
  54. ncbi request reprint Nur77 family of nuclear hormone receptors
    Hui Chen Hsu
    The University of Alabama at Birmingham, Department of Medicine, Division of Clinical Immunology and Rheumatology, Birmingham, Alabama 35294, USA
    Curr Drug Targets Inflamm Allergy 3:413-23. 2004
    ....
  55. ncbi request reprint Age-related thymic involution in C57BL/6J x DBA/2J recombinant-inbred mice maps to mouse chromosomes 9 and 10
    H C Hsu
    Department of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, AL, USA
    Genes Immun 4:402-10. 2003
    ..5 cM) and Chr 3 (D3Mit127 at 70.3 cM). The present study suggests that the initial thymus size and the rate of thymic involution may be influenced by a relatively small number of genetic loci...
  56. ncbi request reprint Effect of age and apoptosis on the mouse homologue of the huWRN gene
    J Wu
    University of Alabama at Birmingham, Birmingham Veterans Administration Medical Center, 35294 0007, USA
    Mech Ageing Dev 103:27-44. 1998
    ..These results indicate that the WS helicase is involved in certain pathways of apoptosis, and defective WS gene expression leads to accumulation of cells that are highly susceptibility to Fas-induced apoptosis...
  57. ncbi request reprint Phenotype of genetically regulated thymic involution in young BXD RI strains of mice
    X Wang
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, 701 South 19th Street, Birmingham, AL 35294, USA
    Scand J Immunol 64:287-94. 2006
    ....
  58. ncbi request reprint Apoptosis defects analyzed in TcR transgenic and fas transgenic lpr mice
    J D Mountz
    Department of Medicine, University of Alabama at Birmingham
    Int Rev Immunol 11:321-42. 1994
    ..The challenge in the future will be to determine the role of defective apoptosis in other autoimmune diseases...
  59. ncbi request reprint Depletion of collagen II-reactive T cells and blocking of B cell activation prevents collagen II-induced arthritis in DBA/1j mice
    Huang Ge Zhang
    University of Alabama, Birmingham, AL 35294, USA
    J Immunol 168:4164-72. 2002
    ..These results indicate that the CII-reactive T cells play a crucial role in the development of CII-induced arthritis and that the anti-CII Abs act to enhance the development of CII-induced arthritis...
  60. ncbi request reprint Hematopoietic cell protein-tyrosine phosphatase-deficient motheaten mice exhibit T cell apoptosis defect
    X Su
    Department of Medicine, The University of Alabama at Birmingham, AL 35294, USA
    J Immunol 156:4198-208. 1996
    ..Thus, T cells from me(v)/me(v) mice are resistant to Fas-mediated apoptosis which results in lymphoproliferative disease and tissue infiltration...
  61. pmc Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells
    T Zhou
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, USA
    J Exp Med 183:1879-92. 1996
    ..These results indicate that inhibition of Nur77/Nurr1 DNA binding in T cells leads to inefficient thymic clonal deletion, but T cell tolerance is maintained by Fas-dependent clonal deletion in LN and spleen...
  62. pmc Differential expression of human Fas mRNA species upon peripheral blood mononuclear cell activation
    C Liu
    Department of Medicine, University of Alabama at Birmingham, USA
    Biochem J 310:957-63. 1995
    ..These results suggest that differential expression of alternatively spliced Fas mRNAs may play a role in regulation of Fas function via regulation of the production of the membrane-bound and the soluble, secreted Fas protein products...
  63. ncbi request reprint Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt
    H G Zhang
    The University of Alabama at Birmingham, 35294, USA
    Arthritis Rheum 44:1555-67. 2001
    ..This effect was not observed in OASF and may reflect the pathophysiologic changes associated with the proliferating synovium in rheumatoid arthritis...
  64. ncbi request reprint Normal T-cell response and in vivo magnetic resonance imaging of T cells loaded with HIV transactivator-peptide-derived superparamagnetic nanoparticles
    C H Dodd
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, 35294, USA
    J Immunol Methods 256:89-105. 2001
    ....
  65. ncbi request reprint Cellular mechanism of thymic involution
    L Li
    Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Scand J Immunol 57:410-22. 2003
    ..These results suggest that, in D2 mice, both the thymocytes and stromal cells exhibit age-related defects, and that the genetic background of mice plays an important role in determining age-related alterations in thymic involution...
  66. ncbi request reprint Activated CD8(+) T cells from aged mice exhibit decreased activation-induced cell death
    H C Hsu
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mech Ageing Dev 122:1663-84. 2001
    ..Our results suggest that there is a dysregulation in T-cell homeostasis in aged mice associated with a decrease in AICD of CD8(+) T cells...
  67. ncbi request reprint Increased susceptibility of fas mutant MRL-lpr/lpr mice to staphylococcal enterotoxin B-induced septic shock
    J D Mountz
    Department of Medicine, University of Alabama at Birmingham, USA
    J Immunol 155:4829-37. 1995
    ..These data indicate that SAG-induced septic shock is dependent on interactions with the TCR and MHC class II Ags, and they also suggest a critical role for a functional fas and/or fas ligand in resistance to SAG-induced septic shock...
  68. ncbi request reprint Defective Fas ligand-mediated apoptosis predisposes to development of a chronic erosive arthritis subsequent to Mycoplasma pulmonis infection
    H C Hsu
    The University of Alabama at Birmingham, 35294-0007, USA
    Arthritis Rheum 44:2146-59. 2001
    ..In vivo lpr-APC-AdFasL cell-gene therapy is a safe and effective method for inhibiting the development of this arthritis...
  69. ncbi request reprint Characterization of human Fas gene. Exon/intron organization and promoter region
    J Cheng
    Department of Medicine, University of Alabama at Birmingham
    J Immunol 154:1239-45. 1995
    ..These data provide the first characterization of the human Fas gene and insight into its regulatory region...
  70. ncbi request reprint Genetic segregation of spontaneous erosive arthritis and generalized autoimmune disease in the BXD2 recombinant inbred strain of mice
    J D Mountz
    Department of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, AL 35294, USA
    Scand J Immunol 61:128-38. 2005
    ....
  71. ncbi request reprint Defective clearance of adenovirus in IRF-1 mice associated with defects in NK and T cells but not macrophages
    X Xu
    Department of Medicine, The University of Alabama at Birmingham, 701 S 19th Street, Birmingham, AL 35294 0007, USA
    Scand J Immunol 60:89-99. 2004
    ..These results indicate that delayed clearance of Ad is associated with partial correction of defects of the NK, NK-T and CD8 T cells and increased production of IFN-gamma and IL-18 in IRF-1(-/-) mice...
  72. ncbi request reprint Identification of multiple genetic loci that regulate adenovirus gene therapy
    H G Zhang
    Department of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Gene Ther 11:4-14. 2004
    ..0 cM) and Chr 8 (52 and 73.0 cM). These results indicate that different strains of mice exhibit different pathways for effective clearance of AdLacZ depending on genetic polymorphisms and interactions at multiple genetic loci...
  73. ncbi request reprint Origin of CD4-CD8-B220+ T cells in MRL-lpr/lpr mice. Clues from a T cell receptor beta transgenic mouse
    T Zhou
    Department of Medicine, University of Alabama, Birmingham
    J Immunol 150:3651-67. 1993
    ..They further suggest that in lpr mice, which express a mutated Fas Ag, the "neglected" thymocytes are able to continually escape to the periphery, where they proliferate...
  74. ncbi request reprint Aged mice exhibit in vivo defective peripheral clonal deletion of D(b)/H-Y reactive CD8(+) T cells
    H C Hsu
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, 701 South 19th Street, LHRB 473, Birmingham, AL 35294 0007, USA
    Mech Ageing Dev 122:305-26. 2001
    ....
  75. pmc Cancer gene therapy using mesenchymal stem cells expressing interferon-beta in a mouse prostate cancer lung metastasis model
    C Ren
    Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Gene Ther 15:1446-53. 2008
    ..Systemic level of IFN-beta was not significantly elevated from this targeted cell therapy. These data demonstrate the potential of MSC-based IFN-beta therapy for prostate cancer lung metastasis...
  76. pmc Antigen presenting cells expressing Fas ligand down-modulate chronic inflammatory disease in Fas ligand-deficient mice
    H G Zhang
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama Birmingham, Birmingham, Alabama 35294, USA
    J Clin Invest 105:813-21. 2000
    ..This organwide effect of APC-AdFasL appears to be mediated by elimination of activated T lymphocytes in the spleen before their emigration to the target organs...
  77. ncbi request reprint Defective expression of hematopoietic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas-mediated apoptosis
    X Su
    Department of Medicine, University of Alabama at Birmingham, USA
    Immunity 2:353-62. 1995
    ..Thus, HCP-mediated protein dephosphorylation is involved in the delivery of the Fas apoptosis signal in lymphoid cells...
  78. ncbi request reprint Altered expression of self-reactive T cell receptor V beta regions in autoimmune mice
    J D Mountz
    Veterans Administration Medical Center, Birmingham, AL 35294
    J Immunol 144:2159-66. 1990
    ..This supports the hypothesis that in lpr/lpr mice, self-reactive CD4+ T cells are eliminated in the thymus, and that these cells lose expression of CD4 and acquire expression of 6B2 in the periphery...
  79. ncbi request reprint Primary adenovirus-specific cytotoxic T lymphocyte response occurs after viral clearance and liver enzyme elevation
    J Chen
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Gene Ther 12:1079-88. 2005
    ..These results indicated that the primary peak response of tetramer+ CTLs does not correlate with the elimination of adenovirus or liver cytotoxic response...
  80. ncbi request reprint Greatly accelerated lymphadenopathy and autoimmune disease in lpr mice lacking tumor necrosis factor receptor I
    T Zhou
    Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham 35294, USA
    J Immunol 156:2661-5. 1996
    ....
  81. ncbi request reprint Soluble Fas gene therapy protects against Fas-mediated apoptosis of hepatocytes but not the lethal effects of Fas-induced TNF-alpha production by Kupffer cells
    Y Matsuki
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, 35294 0007, USA
    Cell Death Differ 9:626-35. 2002
    ....
  82. pmc Increased expression of activation-induced cytidine deaminase is associated with anti-CCP and rheumatoid factor in rheumatoid arthritis
    X Xu
    Department of Physiology and Physics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Scand J Immunol 70:309-16. 2009
    ....
  83. ncbi request reprint Regulation of c-myb oncogene expression in immature and mature murine T cells
    J D Mountz
    Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham
    Mol Immunol 30:787-95. 1993
    ..Our data indicate that the c-myb oncogene promoter is constitutively expressed is highly dependent on a limited region of the 5' myb gene, requires two DNA elements for optimal activity, and is functional in diverse T cell lines...
  84. ncbi request reprint Mature but not immature Fas ligand (CD95L)-transduced human monocyte-derived dendritic cells are protected from Fas-mediated apoptosis and can be used as killer APC
    Sabine Hoves
    Department of Internal Medicine I, Regensburg, Germany
    J Immunol 170:5406-13. 2003
    ..Our results support the strategy to use killer APCs as immunomodulatory cells for the treatment of autoimmune disease and allograft rejection...
  85. ncbi request reprint Elimination of activated but not resting primary human CD4+ and CD8+ T cells by Fas ligand (FasL/CD95L)-expressing Killer-dendritic cells
    Sabine Hoves
    The University of Regensburg, Department of Internal Medicine I, 93042 Regensburg, Germany
    Immunobiology 208:463-75. 2004
    ....
  86. pmc Physical activity in aging: comparison among young, aged, and nonagenarian individuals
    Darcy L Johannsen
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    J Appl Physiol (1985) 105:495-501. 2008
    ..Interestingly, PA was similar between young volunteers and those who were in their 60s and 70s, likely due to the sedentary nature of our society, particularly in young adults...
  87. ncbi request reprint Significance of increased circulating proteasome in autoimmune disease
    John D Mountz
    J Rheumatol 29:2027-30. 2002
  88. ncbi request reprint Soluble human p55 and p75 tumor necrosis factor receptors reverse spontaneous arthritis in transgenic mice expressing transmembrane tumor necrosis factor alpha
    Carl K Edwards
    Amgen, Inc, Thousand Oaks, California, USA
    Arthritis Rheum 54:2872-85. 2006
    ....
  89. pmc The nature and identification of quantitative trait loci: a community's view
    Oduola Abiola
    Nat Rev Genet 4:911-6. 2003
    ..Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?..
  90. ncbi request reprint TRAIL-R2 (DR5) mediates apoptosis of synovial fibroblasts in rheumatoid arthritis
    Kimihisa Ichikawa
    Biomedical Research Laboratories, Sankyo Company, Limited, Tokyo, Japan
    J Immunol 171:1061-9. 2003
    ....
  91. ncbi request reprint Local production of complement proteins in rheumatoid arthritis synovium
    Elena Neumann
    University of Regensburg, Regensburg, Germany
    Arthritis Rheum 46:934-45. 2002
    ..This study was undertaken to characterize the expression of complement proteins and receptors in RA SF and ST...